Activation of the Nrf2-ARE pathway in hepatocytes protects against steatosis in nutritionally induced non-alcoholic steatohepatitis in mice.

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Published in Toxicol Sci on October 06, 2014

Authors

Lung-Yi Lee1, Ulrike A Köhler1, Li Zhang1, Drew Roenneburg1, Sabine Werner1, Jeffrey A Johnson2, David P Foley3

Author Affiliations

1: *Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726, Department of Biology, Institute of Molecular Health Sciences, Swiss Federal Institute of Technology (ETH) Zurich, 8093 Zurich, Switzerland, Divisions of Pharmaceutical Sciences, Molecular and Environmental Toxicology Center, Center for Neuroscience, Waisman Center, University of Wisconsin, Madison, Wisconsin 53705 and Veterans Administration Surgical Services, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin.
2: *Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726, Department of Biology, Institute of Molecular Health Sciences, Swiss Federal Institute of Technology (ETH) Zurich, 8093 Zurich, Switzerland, Divisions of Pharmaceutical Sciences, Molecular and Environmental Toxicology Center, Center for Neuroscience, Waisman Center, University of Wisconsin, Madison, Wisconsin 53705 and Veterans Administration Surgical Services, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin *Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726, Department of Biology, Institute of Molecular Health Sciences, Swiss Federal Institute of Technology (ETH) Zurich, 8093 Zurich, Switzerland, Divisions of Pharmaceutical Sciences, Molecular and Environmental Toxicology Center, Center for Neuroscience, Waisman Center, University of Wisconsin, Madison, Wisconsin 53705 and Veterans Administration Surgical Services, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin *Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726, Department of Biology, Institute of Molecular Health Sciences, Swiss Federal Institute of Technology (ETH) Zurich, 8093 Zurich, Switzerland, Divisions of Pharmaceutical Sciences, Molecular and Environmental Toxicology Center, Center for Neuroscience, Waisman Center, University of Wisconsin, Madison, Wisconsin 53705 and Veterans Administration Surgical Services, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin *Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726, Department of Biology, Institute of Molecular Health Sciences, Swiss Federal Institute of Technology (ETH) Zurich, 8093 Zurich, Switzerland, Divisions of Pharmaceutical Sciences, Molecular and Environmental Toxicology Center, Center for Neuroscience, Waism
3: *Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726, Department of Biology, Institute of Molecular Health Sciences, Swiss Federal Institute of Technology (ETH) Zurich, 8093 Zurich, Switzerland, Divisions of Pharmaceutical Sciences, Molecular and Environmental Toxicology Center, Center for Neuroscience, Waisman Center, University of Wisconsin, Madison, Wisconsin 53705 and Veterans Administration Surgical Services, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin *Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726, Department of Biology, Institute of Molecular Health Sciences, Swiss Federal Institute of Technology (ETH) Zurich, 8093 Zurich, Switzerland, Divisions of Pharmaceutical Sciences, Molecular and Environmental Toxicology Center, Center for Neuroscience, Waisman Center, University of Wisconsin, Madison, Wisconsin 53705 and Veterans Administration Surgical Services, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin foley@surgery.wisc.edu.

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