Published in Mol Cell Biol on November 01, 2003
A molecular marker of artemisinin-resistant Plasmodium falciparum malaria. Nature (2013) 11.03
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Mol Cell Biol (2004) 8.94
Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. Mol Cell Biol (2004) 6.93
The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. J Biol Chem (2009) 5.80
Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell Signal (2012) 5.65
Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers. Proc Natl Acad Sci U S A (2004) 5.54
The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase. Mol Cell Biol (2004) 5.47
Signal transduction by reactive oxygen species. J Cell Biol (2011) 5.21
Nrf2:INrf2 (Keap1) signaling in oxidative stress. Free Radic Biol Med (2009) 4.26
Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1. Mol Cell Biol (2006) 3.97
p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription. J Biol Chem (2010) 3.84
Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response. Mol Cell (2009) 3.50
Dual roles of Nrf2 in cancer. Pharmacol Res (2008) 3.41
The emerging role of the Nrf2-Keap1 signaling pathway in cancer. Genes Dev (2013) 3.40
Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1. Circ Res (2008) 3.12
Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family. EMBO J (2004) 3.07
Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes. Proc Natl Acad Sci U S A (2004) 2.94
Molecular mechanisms of Nrf2-mediated antioxidant response. Mol Carcinog (2009) 2.94
A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62. Mol Cell Biol (2010) 2.93
Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2. Proc Natl Acad Sci U S A (2005) 2.92
Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol Cell (2009) 2.84
Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling. EMBO J (2006) 2.67
The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds. Mol Cell Biol (2008) 2.57
The Nrf2/ARE pathway as a potential therapeutic target in neurodegenerative disease. Antioxid Redox Signal (2009) 2.49
Protein damage by reactive electrophiles: targets and consequences. Chem Res Toxicol (2007) 2.31
Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth. Mol Cancer Ther (2010) 2.21
Structural assembly of cullin-RING ubiquitin ligase complexes. Curr Opin Struct Biol (2010) 2.17
Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity. Mol Cell Biol (2008) 2.15
Activation of the Keap1/Nrf2 pathway for neuroprotection by electrophilic [correction of electrophillic] phase II inducers. Proc Natl Acad Sci U S A (2006) 2.15
Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2. Mol Cell Biol (2007) 2.12
Nuclear oncoprotein prothymosin alpha is a partner of Keap1: implications for expression of oxidative stress-protecting genes. Mol Cell Biol (2005) 2.10
SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner. Mol Cell Biol (2011) 2.08
Generation and biological activities of oxidized phospholipids. Antioxid Redox Signal (2010) 2.04
Regulation of the Caenorhabditis elegans oxidative stress defense protein SKN-1 by glycogen synthase kinase-3. Proc Natl Acad Sci U S A (2005) 2.04
Retracted Prothymosin-alpha mediates nuclear import of the INrf2/Cul3 Rbx1 complex to degrade nuclear Nrf2. J Biol Chem (2009) 1.92
Targeting NRF2 signaling for cancer chemoprevention. Toxicol Appl Pharmacol (2009) 1.88
Formation and signaling actions of electrophilic lipids. Chem Rev (2011) 1.82
Basic principles and emerging concepts in the redox control of transcription factors. Antioxid Redox Signal (2011) 1.82
Regulation of Nrf2-an update. Free Radic Biol Med (2013) 1.81
Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response. Mol Cell Biol (2009) 1.80
Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders. Antioxid Redox Signal (2010) 1.77
Keap1 regulates the oxidation-sensitive shuttling of Nrf2 into and out of the nucleus via a Crm1-dependent nuclear export mechanism. Mol Cell Biol (2005) 1.77
Nrf2 signaling and cell survival. Toxicol Appl Pharmacol (2009) 1.72
Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agents. Med Res Rev (2012) 1.72
Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals. Proc Natl Acad Sci U S A (2010) 1.72
Heme oxygenase-1 induction by NRF2 requires inactivation of the transcriptional repressor BACH1. Nucleic Acids Res (2007) 1.67
PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria. Exp Cell Res (2008) 1.64
Retracted Phosphorylation and dephosphorylation of tyrosine 141 regulate stability and degradation of INrf2: a novel mechanism in Nrf2 activation. J Biol Chem (2008) 1.61
Activation of NRF2 by nitrosative agents and H2O2 involves KEAP1 disulfide formation. J Biol Chem (2010) 1.60
Heme oxygenase-1 couples activation of mitochondrial biogenesis to anti-inflammatory cytokine expression. J Biol Chem (2011) 1.59
Retracted Antioxidant-induced modification of INrf2 cysteine 151 and PKC-delta-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistance. J Cell Sci (2009) 1.58
Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy. Autophagy (2010) 1.58
Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases. Physiol Rev (2014) 1.57
Environmental toxicity, redox signaling and lung inflammation: the role of glutathione. Mol Aspects Med (2008) 1.56
The cancer chemopreventive actions of phytochemicals derived from glucosinolates. Eur J Nutr (2008) 1.55
Antiviral activity of Nrf2 in a murine model of respiratory syncytial virus disease. Am J Respir Crit Care Med (2008) 1.53
Mutations in Plasmodium falciparum K13 propeller gene from Bangladesh (2009-2013). Malar J (2014) 1.48
Heme induces ubiquitination and degradation of the transcription factor Bach1. Mol Cell Biol (2007) 1.43
Phosphorylation of Nrf2 at multiple sites by MAP kinases has a limited contribution in modulating the Nrf2-dependent antioxidant response. PLoS One (2009) 1.42
Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection. Prog Neurobiol (2012) 1.41
Activation of Nrf2 by arsenite and monomethylarsonous acid is independent of Keap1-C151: enhanced Keap1-Cul3 interaction. Toxicol Appl Pharmacol (2008) 1.39
The transcription factor NF-E2-related factor 2 (Nrf2): a protooncogene? FASEB J (2012) 1.37
Electrophilic tuning of the chemoprotective natural product sulforaphane. Proc Natl Acad Sci U S A (2010) 1.37
The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses. EMBO J (2010) 1.36
Sites of alkylation of human Keap1 by natural chemoprevention agents. J Am Soc Mass Spectrom (2007) 1.36
Thiol chemistry in peroxidase catalysis and redox signaling. Antioxid Redox Signal (2008) 1.35
Electrophilic nitro-fatty acids activate NRF2 by a KEAP1 cysteine 151-independent mechanism. J Biol Chem (2011) 1.34
Regulation of NF-E2-related factor 2 signaling for cancer chemoprevention: antioxidant coupled with antiinflammatory. Antioxid Redox Signal (2010) 1.33
The antioxidant transcription factor Nrf2 negatively regulates autophagy and growth arrest induced by the anticancer redox agent mitoquinone. J Biol Chem (2010) 1.33
Oridonin confers protection against arsenic-induced toxicity through activation of the Nrf2-mediated defensive response. Environ Health Perspect (2008) 1.32
Keap1-nrf2 signaling: a target for cancer prevention by sulforaphane. Top Curr Chem (2013) 1.31
Redox homeostasis: the linchpin in stem cell self-renewal and differentiation. Cell Death Dis (2013) 1.31
Nrf2 plays an important role in coordinated regulation of Phase II drug metabolism enzymes and Phase III drug transporters. Biopharm Drug Dispos (2009) 1.30
PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function. Mol Cell Biol (2012) 1.30
The absence of the pro-antioxidant transcription factor Nrf2 exacerbates experimental autoimmune encephalomyelitis. Toxicol Sci (2009) 1.30
The Marburg virus VP24 protein interacts with Keap1 to activate the cytoprotective antioxidant response pathway. Cell Rep (2014) 1.29
Nutraceutical antioxidants as novel neuroprotective agents. Molecules (2010) 1.29
CAND1-mediated substrate adaptor recycling is required for efficient repression of Nrf2 by Keap1. Mol Cell Biol (2006) 1.27
The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation. Mol Cell Biol (2005) 1.26
Role of glutathione in the regulation of Cisplatin resistance in cancer chemotherapy. Met Based Drugs (2010) 1.25
Mitochondrial mechanisms of estrogen neuroprotection. Biochim Biophys Acta (2009) 1.25
A systems biology perspective on Nrf2-mediated antioxidant response. Toxicol Appl Pharmacol (2009) 1.25
Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex. Proc Natl Acad Sci U S A (2013) 1.25
Dihydro-CDDO-trifluoroethyl amide (dh404), a novel Nrf2 activator, suppresses oxidative stress in cardiomyocytes. PLoS One (2009) 1.24
Nuclear transport, oxidative stress, and neurodegeneration. Int J Clin Exp Pathol (2011) 1.22
Mitochondrial reactive oxygen species and cancer. Cancer Metab (2014) 1.20
How do nutritional antioxidants really work: nucleophilic tone and para-hormesis versus free radical scavenging in vivo. Free Radic Biol Med (2013) 1.19
Validation of the multiple sensor mechanism of the Keap1-Nrf2 system. Free Radic Biol Med (2012) 1.18
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease. Free Radic Biol Med (2015) 1.17
Modification of keap1 cysteine residues by sulforaphane. Chem Res Toxicol (2011) 1.17
Cysteine-based regulation of the CUL3 adaptor protein Keap1. Toxicol Appl Pharmacol (2009) 1.17
NRF2, cancer and calorie restriction. Oncogene (2010) 1.17
Redox signaling in cardiovascular health and disease. Free Radic Biol Med (2013) 1.16
Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis. Genes Dev (2014) 1.16
Evaluating oxidative stress in human cardiovascular disease: methodological aspects and considerations. Curr Med Chem (2012) 1.15
Cinnamoyl-based Nrf2-activators targeting human skin cell photo-oxidative stress. Free Radic Biol Med (2008) 1.14
The Nrf2-ARE pathway: a valuable therapeutic target for the treatment of neurodegenerative diseases. Recent Pat CNS Drug Discov (2012) 1.13
Nrf2 responses and the therapeutic selectivity of electrophilic compounds in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A (2010) 1.11
Mechanisms underlying ubiquitination. Annu Rev Biochem (2001) 18.87
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev (1999) 13.43
Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain. Cell (1994) 8.65
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc Natl Acad Sci U S A (2002) 8.01
Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proc Natl Acad Sci U S A (2001) 6.78
Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region. Proc Natl Acad Sci U S A (1994) 6.72
Regulatory mechanisms controlling gene expression mediated by the antioxidant response element. Annu Rev Pharmacol Toxicol (2002) 6.22
Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence. Nutr Cancer (1992) 6.12
Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade. Nature (1995) 5.89
Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression. J Biol Chem (2003) 5.67
Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res (2002) 5.43
Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles. Genes Cells (2003) 4.47
The kelch repeat superfamily of proteins: propellers of cell function. Trends Cell Biol (2000) 4.15
Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival. J Biol Chem (2002) 4.14
Functional antioxidant responsive elements. Proc Natl Acad Sci U S A (1997) 4.05
A thiol peroxidase is an H2O2 receptor and redox-transducer in gene activation. Cell (2002) 3.94
Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription. J Biol Chem (2002) 3.81
Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26 S proteasome. J Biol Chem (2002) 3.43
Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors. Gene (2002) 3.33
Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium. J Biol Chem (2002) 3.26
Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups. Proc Natl Acad Sci U S A (2001) 3.17
Inhibition of carcinogenesis by dietary polyphenolic compounds. Annu Rev Nutr (2001) 3.11
Nrf2-deficient female mice develop lupus-like autoimmune nephritis. Kidney Int (2001) 2.90
Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter. Mol Cell Biol (2002) 2.82
Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism. J Nutr (2001) 2.70
Manipulation of oxidative protein folding and PDI redox state in mammalian cells. EMBO J (2001) 2.59
The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin. Biochem Soc Trans (2000) 2.40
Impaired expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein. Biochim Biophys Acta (2000) 2.34
Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene. Oncogene (2001) 2.21
Retracted SUMO-1 modification of Mdm2 prevents its self-ubiquitination and increases Mdm2 ability to ubiquitinate p53. Cell (2000) 2.12
Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione. Mol Med (2001) 2.10
Antioxidants and oxidants regulated signal transduction pathways. Biochem Pharmacol (2002) 2.08
Activation of mitogen-activated protein kinase pathways induces antioxidant response element-mediated gene expression via a Nrf2-dependent mechanism. J Biol Chem (2000) 1.90
Phosphatidylinositol 3-kinase, not extracellular signal-regulated kinase, regulates activation of the antioxidant-responsive element in IMR-32 human neuroblastoma cells. J Biol Chem (2001) 1.74
Progress in cancer chemoprevention: development of diet-derived chemopreventive agents. J Nutr (2000) 1.69
Nrf2 degradation by the ubiquitin proteasome pathway is inhibited by KIAA0132, the human homolog to INrf2. Oncogene (2002) 1.65
Induction of xenobiotic enzymes by the MAP kinase pathway and the antioxidant or electrophile response element (ARE/EpRE). Drug Metab Rev (2001) 1.63
Microarray analysis reveals an antioxidant responsive element-driven gene set involved in conferring protection from an oxidative stress-induced apoptosis in IMR-32 cells. J Biol Chem (2001) 1.39
Chemoprotection by organosulfur inducers of phase 2 enzymes: dithiolethiones and dithiins. Drug Metabol Drug Interact (2000) 1.34
Crystal structure of the precursor of galactose oxidase: an unusual self-processing enzyme. Proc Natl Acad Sci U S A (2001) 1.17
Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. Mol Cell Biol (2004) 6.93
Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol Cell Biol (2003) 4.77
Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling. EMBO J (2006) 2.67
Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway. J Biol Chem (2005) 2.45
Crystal structure of the Kelch domain of human Keap1. J Biol Chem (2004) 2.04
PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex. J Biol Chem (2006) 1.78
Kelch-like homologue 9 mutation is associated with an early onset autosomal dominant distal myopathy. Brain (2010) 1.76
PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria. Exp Cell Res (2008) 1.64
Identification of oxygen-sensitive transcriptional programs in human embryonic stem cells. Stem Cells Dev (2008) 1.35
CAND1-mediated substrate adaptor recycling is required for efficient repression of Nrf2 by Keap1. Mol Cell Biol (2006) 1.27
Dihydro-CDDO-trifluoroethyl amide (dh404), a novel Nrf2 activator, suppresses oxidative stress in cardiomyocytes. PLoS One (2009) 1.24
Distinct signaling pathways for induction of type II NOS by IFNgamma and LPS in BV-2 microglial cells. Neurochem Int (2005) 1.14
Nitric oxide stimulates heme oxygenase-1 gene transcription via the Nrf2/ARE complex to promote vascular smooth muscle cell survival. Cardiovasc Res (2007) 1.11
Effects of interventions on oxidative stress and inflammation of cardiovascular diseases. World J Cardiol (2011) 1.11
Fiber type-specific nitric oxide protects oxidative myofibers against cachectic stimuli. PLoS One (2008) 1.10
Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1. Biochem J (2009) 1.09
Modulation of phototropic responsiveness in Arabidopsis through ubiquitination of phototropin 1 by the CUL3-Ring E3 ubiquitin ligase CRL3(NPH3). Plant Cell (2011) 1.09
Characterization of the nuclear import and export functions of Ikappa B(epsilon). J Biol Chem (2002) 1.00
Conserved solvent and side-chain interactions in the 1.35 Angstrom structure of the Kelch domain of Keap1. Acta Crystallogr D Biol Crystallogr (2005) 0.99
Ceramide synthase 1 is regulated by proteasomal mediated turnover. Biochim Biophys Acta (2009) 0.95
Disruption of the Keap1-containing ubiquitination complex as an antioxidant therapy. Curr Top Med Chem (2007) 0.89
Coordinate regulation of basal and cyclic 5'-adenosine monophosphate (cAMP)-activated expression of human chorionic gonadotropin-alpha by Ets-2 and cAMP-responsive element binding protein. Mol Endocrinol (2005) 0.89
ERRbeta: a potent inhibitor of Nrf2 transcriptional activity. Mol Cell Endocrinol (2007) 0.87
Stress-induced ER to Golgi translocation of ceramide synthase 1 is dependent on proteasomal processing. Exp Cell Res (2009) 0.87
Gold nanoparticle-mediated detection of circulating cancer cells. Clin Lab Med (2012) 0.86
Molecular imaging of bcl-2 expression in small lymphocytic lymphoma using 111In-labeled PNA-peptide conjugates. J Nucl Med (2008) 0.84
Radiometal-labeled peptide-PNA conjugates for targeting bcl-2 expression: preparation, characterization, and in vitro mRNA binding. Bioconjug Chem (2002) 0.84
Synthesis of radiometal-labeled and fluorescent cell-permeating peptide-PNA conjugates for targeting the bcl-2 proto-oncogene. Bioconjug Chem (2003) 0.84
Molecular mechanisms that regulate transcription factor localization suggest new targets for drug development. Adv Drug Deliv Rev (2003) 0.81
Crystallization and initial crystallographic analysis of the Kelch domain from human Keap1. Acta Crystallogr D Biol Crystallogr (2004) 0.80
Discovery of putative oocyte quality markers by comparative ExacTag proteomics. Proteomics Clin Appl (2010) 0.79
CRM1-mediated nuclear export is present during porcine embryogenesis, but is not required for early cleavage. Biol Reprod (2002) 0.78
Elongation factor 1 alpha1 and genes associated with Usher syndromes are downstream targets of GBX2. PLoS One (2012) 0.77