Published in Epigenomics on January 01, 2014
Functional Insights into Chromatin Remodelling from Studies on CHARGE Syndrome. Trends Genet (2015) 0.86
Chromodomain helicase DNA-binding proteins in stem cells and human developmental diseases. Stem Cells Dev (2015) 0.81
In silico molecular cytogenetics: a bioinformatic approach to prioritization of candidate genes and copy number variations for basic and clinical genome research. Mol Cytogenet (2014) 0.81
Marked for death: targeting epigenetic changes in cancer. Nat Rev Drug Discov (2017) 0.76
CHD7 promotes proliferation of neural stem cells mediated by MIF. Mol Brain (2016) 0.75
Integrative genomic and transcriptomic analysis for pinpointing recurrent alterations of plant homeodomain genes and their clinical significance in breast cancer. Oncotarget (2016) 0.75
Unique epigenetic gene profiles define human breast cancers with poor prognosis. Oncotarget (2016) 0.75
Genotranscriptomic meta-analysis of the CHD family chromatin remodelers in human cancers: initial evidence of an oncogenic role for CHD7. Mol Oncol (2017) 0.75
Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing. Nat Genet (2008) 43.63
A small-cell lung cancer genome with complex signatures of tobacco exposure. Nature (2009) 18.39
Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell (2009) 18.31
Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations. Nature (2012) 14.76
The genomic complexity of primary human prostate cancer. Nature (2011) 14.06
Patterns and rates of exonic de novo mutations in autism spectrum disorders. Nature (2012) 13.71
The mutational landscape of lethal castration-resistant prostate cancer. Nature (2012) 11.82
DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature (2007) 11.14
A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling. Nature (2006) 10.73
The biology of chromatin remodeling complexes. Annu Rev Biochem (2009) 10.02
Range of genetic mutations associated with severe non-syndromic sporadic intellectual disability: an exome sequencing study. Lancet (2012) 8.42
Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF. Nature (2006) 7.70
Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2. Nature (2006) 7.52
De novo mutations in epileptic encephalopathies. Nature (2013) 7.42
Multiplex targeted sequencing identifies recurrently mutated genes in autism spectrum disorders. Science (2012) 6.21
Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder. Nat Genet (2011) 5.73
Double chromodomains cooperate to recognize the methylated histone H3 tail. Nature (2005) 5.53
CHD5 is a tumor suppressor at human 1p36. Cell (2007) 4.90
Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression. Nature (2007) 4.49
Chd1 regulates open chromatin and pluripotency of embryonic stem cells. Nature (2009) 4.13
Characterization of the CHD family of proteins. Proc Natl Acad Sci U S A (1997) 3.76
Targeted resequencing in epileptic encephalopathies identifies de novo mutations in CHD2 and SYNGAP1. Nat Genet (2013) 3.64
An evidence-based approach to establish the functional and clinical significance of copy number variants in intellectual and developmental disabilities. Genet Med (2011) 3.51
Sequencing chromosomal abnormalities reveals neurodevelopmental loci that confer risk across diagnostic boundaries. Cell (2012) 3.21
CHARGE syndrome: the phenotypic spectrum of mutations in the CHD7 gene. J Med Genet (2005) 3.03
Convergence of genes and cellular pathways dysregulated in autism spectrum disorders. Am J Hum Genet (2014) 2.84
Increased risk of cancer among azoospermic men. Fertil Steril (2013) 2.82
Distinct activities of CHD1 and ACF in ATP-dependent chromatin assembly. Nat Struct Mol Biol (2005) 2.80
A mammalian DNA-binding protein that contains a chromodomain and an SNF2/SWI2-like helicase domain. Proc Natl Acad Sci U S A (1993) 2.77
Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes. Nat Genet (2012) 2.71
The Chd family of chromatin remodelers. Mutat Res (2007) 2.69
The SANT domain: a unique histone-tail-binding module? Nat Rev Mol Cell Biol (2004) 2.63
The chromatin remodeler Mi-2beta is required for CD4 expression and T cell development. Immunity (2004) 2.54
Detection of clinically relevant genetic variants in autism spectrum disorder by whole-genome sequencing. Am J Hum Genet (2013) 2.47
From neural development to cognition: unexpected roles for chromatin. Nat Rev Genet (2013) 2.42
Genomic distribution of CHD7 on chromatin tracks H3K4 methylation patterns. Genome Res (2009) 2.31
Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4. EMBO J (2010) 2.25
The ups and downs of Wnt signaling in prevalent neurological disorders. Oncogene (2006) 2.12
CHD8 is an ATP-dependent chromatin remodeling factor that regulates beta-catenin target genes. Mol Cell Biol (2008) 2.10
Cancer biology and NuRD: a multifaceted chromatin remodelling complex. Nat Rev Cancer (2011) 2.10
Landscape of somatic single-nucleotide and copy-number mutations in uterine serous carcinoma. Proc Natl Acad Sci U S A (2013) 2.02
The quest for the 1p36 tumor suppressor. Cancer Res (2008) 1.95
The dMi-2 chromodomains are DNA binding modules important for ATP-dependent nucleosome mobilization. EMBO J (2002) 1.91
CHD proteins: a diverse family with strong ties. Biochem Cell Biol (2007) 1.90
The chromatin remodeler CHD7 regulates adult neurogenesis via activation of SoxC transcription factors. Cell Stem Cell (2013) 1.85
The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage. J Cell Biol (2010) 1.82
The PHD finger: a versatile epigenome reader. Trends Biochem Sci (2011) 1.81
Causes of death in autism. J Autism Dev Disord (2001) 1.80
KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response. Nat Struct Mol Biol (2011) 1.77
CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis. Nat Cell Biol (2009) 1.75
Mutation update on the CHD7 gene involved in CHARGE syndrome. Hum Mutat (2012) 1.74
CHD5, a tumor suppressor gene deleted from 1p36.31 in neuroblastomas. J Natl Cancer Inst (2008) 1.71
The PHD and chromo domains regulate the ATPase activity of the human chromatin remodeler CHD4. J Mol Biol (2012) 1.69
Handpicking epigenetic marks with PHD fingers. Nucleic Acids Res (2011) 1.69
CHD5, a new member of the chromodomain gene family, is preferentially expressed in the nervous system. Oncogene (2003) 1.65
The association between Mi-2 antibodies and dermatomyositis. Arthritis Rheum (1985) 1.62
De novo mutations in schizophrenia implicate chromatin remodeling and support a genetic overlap with autism and intellectual disability. Mol Psychiatry (2014) 1.62
Chromatin remodeling and cancer, Part II: ATP-dependent chromatin remodeling. Trends Mol Med (2007) 1.59
Binding of the CHD4 PHD2 finger to histone H3 is modulated by covalent modifications. Biochem J (2009) 1.59
Loss of Chd7 function in gene-trapped reporter mice is embryonic lethal and associated with severe defects in multiple developing tissues. Mamm Genome (2007) 1.58
CHD7 gene polymorphisms are associated with susceptibility to idiopathic scoliosis. Am J Hum Genet (2007) 1.56
Plant homeodomain (PHD) fingers of CHD4 are histone H3-binding modules with preference for unmodified H3K4 and methylated H3K9. J Biol Chem (2011) 1.55
Identification of novel CHD1-associated collaborative alterations of genomic structure and functional assessment of CHD1 in prostate cancer. Oncogene (2011) 1.50
CHD7 mutations and CHARGE syndrome: the clinical implications of an expanding phenotype. J Med Genet (2011) 1.45
CHD1 is a 5q21 tumor suppressor required for ERG rearrangement in prostate cancer. Cancer Res (2013) 1.42
De novo loss-of-function mutations in CHD2 cause a fever-sensitive myoclonic epileptic encephalopathy sharing features with Dravet syndrome. Am J Hum Genet (2013) 1.40
Bivalent recognition of nucleosomes by the tandem PHD fingers of the CHD4 ATPase is required for CHD4-mediated repression. Proc Natl Acad Sci U S A (2012) 1.37
MicroRNA-211 expression promotes colorectal cancer cell growth in vitro and in vivo by targeting tumor suppressor CHD5. PLoS One (2012) 1.35
Recurrent deletion of CHD1 in prostate cancer with relevance to cell invasiveness. Oncogene (2011) 1.33
NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex. J Biol Chem (2006) 1.28
CHD5 is down-regulated through promoter hypermethylation in gastric cancer. J Biomed Sci (2009) 1.25
Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer. Cancer Res (2014) 1.24
Mutation of the SNF2 family member Chd2 affects mouse development and survival. J Cell Physiol (2006) 1.23
Chromatin remodeling factor CHD5 is silenced by promoter CpG island hypermethylation in human cancer. Epigenetics (2008) 1.23
The chromatin remodeler Mi-2beta is required for establishment of the basal epidermis and normal differentiation of its progeny. Development (2007) 1.21
The role of Wnt signaling in neuronal dysfunction in Alzheimer's Disease. Mol Neurodegener (2008) 1.20
A novel beta-catenin-binding protein inhibits beta-catenin-dependent Tcf activation and axis formation. J Biol Chem (2000) 1.20
CHD8 associates with human Staf and contributes to efficient U6 RNA polymerase III transcription. Mol Cell Biol (2007) 1.20
The chromatin remodeling factor CHD8 interacts with elongating RNA polymerase II and controls expression of the cyclin E2 gene. Nucleic Acids Res (2009) 1.16
Chromatin remodeling by the CHD7 protein is impaired by mutations that cause human developmental disorders. Proc Natl Acad Sci U S A (2012) 1.15
JMJD2A promotes cellular transformation by blocking cellular senescence through transcriptional repression of the tumor suppressor CHD5. Cell Rep (2012) 1.14
Role of chromodomain helicase DNA-binding protein 2 in DNA damage response signaling and tumorigenesis. Oncogene (2009) 1.14
CHD7 functions in the nucleolus as a positive regulator of ribosomal RNA biogenesis. Hum Mol Genet (2010) 1.13
Chd2 interacts with H3.3 to determine myogenic cell fate. EMBO J (2012) 1.12
CHD5, a brain-specific paralog of Mi2 chromatin remodeling enzymes, regulates expression of neuronal genes. PLoS One (2011) 1.11
CHD6 is a DNA-dependent ATPase and localizes at nuclear sites of mRNA synthesis. FEBS Lett (2006) 1.10
Genetic and expressional alterations of CHD genes in gastric and colorectal cancers. Histopathology (2011) 1.09
Molecular karyotyping by array CGH in a Russian cohort of children with intellectual disability, autism, epilepsy and congenital anomalies. Mol Cytogenet (2012) 1.09
CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and polycomb gene repression. Dev Cell (2013) 1.06
Investigations of CHD1 function in transcription and development of Drosophila melanogaster. Genetics (2008) 1.06
Expression of the neuron-specific protein CHD5 is an independent marker of outcome in neuroblastoma. Mol Cancer (2010) 1.03
Functionally distinct Gata3/Chd4 complexes coordinately establish T helper 2 (Th2) cell identity. Proc Natl Acad Sci U S A (2013) 1.01
CHD5, a tumor suppressor that is epigenetically silenced in lung cancer. Lung Cancer (2011) 1.01
Chd5 orchestrates chromatin remodelling during sperm development. Nat Commun (2014) 1.01
Deletion of the RMGA and CHD2 genes in a child with epilepsy and mental deficiency. Eur J Med Genet (2011) 1.01
CHD chromatin remodelling enzymes and the DNA damage response. Mutat Res (2013) 1.01
Mechanisms of CHD5 Inactivation in neuroblastomas. Clin Cancer Res (2012) 1.00
Epigenetic silencing of CHD5, a novel tumor-suppressor gene, occurs in early colorectal cancer stages. Cancer (2013) 1.00
Autistic-like behavior in CHARGE syndrome. Am J Med Genet A (2005) 1.00
The involvement of CHD5 hypermethylation in laryngeal squamous cell carcinoma. Oral Oncol (2011) 0.99
Dicer is essential for mouse development. Nat Genet (2003) 15.87
p63 is the molecular switch for initiation of an epithelial stratification program. Genes Dev (2004) 6.40
CHD5 is a tumor suppressor at human 1p36. Cell (2007) 4.90
Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model. Nat Genet (2008) 3.76
p63 regulates an adhesion programme and cell survival in epithelial cells. Nat Cell Biol (2006) 3.37
p63 deficiency activates a program of cellular senescence and leads to accelerated aging. Genes Dev (2005) 3.02
Perp is a p63-regulated gene essential for epithelial integrity. Cell (2005) 2.58
p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation. Development (2006) 2.23
TAp63 induces senescence and suppresses tumorigenesis in vivo. Nat Cell Biol (2009) 2.15
p63 is an essential proapoptotic protein during neural development. Neuron (2005) 2.06
Role of p63 and basal cells in the prostate. Development (2004) 2.00
The quest for the 1p36 tumor suppressor. Cancer Res (2008) 1.95
Dosage-dependent phenotypes in models of 16p11.2 lesions found in autism. Proc Natl Acad Sci U S A (2011) 1.82
ΔNp63α is an oncogene that targets chromatin remodeler Lsh to drive skin stem cell proliferation and tumorigenesis. Cell Stem Cell (2011) 1.75
A regulatory feedback loop involving p63 and IRF6 links the pathogenesis of 2 genetically different human ectodermal dysplasias. J Clin Invest (2010) 1.73
Regulation of Dlx5 and Dlx6 gene expression by p63 is involved in EEC and SHFM congenital limb defects. Development (2008) 1.55
Differential expression of p63 isoforms in female reproductive organs. Mech Dev (2005) 1.55
Neural potential of a stem cell population in the hair follicle. Cell Cycle (2007) 1.53
p63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors. Proc Natl Acad Sci U S A (2006) 1.48
A targeted X-linked CMV-Cre line. Genesis (2002) 1.36
DeltaNp63 plays an anti-apoptotic role in ventral bladder development. Development (2006) 1.29
Roles of p63 in the diethylstilbestrol-induced cervicovaginal adenosis. Development (2004) 1.26
FANCD2 activates transcription of TAp63 and suppresses tumorigenesis. Mol Cell (2013) 1.11
FGFR2 signaling underlies p63 oncogenic function in squamous cell carcinoma. J Clin Invest (2013) 1.07
Abnormal urethra formation in mouse models of split-hand/split-foot malformation type 1 and type 4. Eur J Hum Genet (2007) 1.04
A mouse chromosome 4 balancer ENU-mutagenesis screen isolates eleven lethal lines. BMC Genet (2009) 1.00
p63: a new link between senescence and aging. Cell Cycle (2006) 0.99
Getting around lethality with inducible Cre-mediated excision. Semin Cell Dev Biol (2002) 0.98
p63, cellular senescence and tumor development. Cell Cycle (2007) 0.95
Chd5 requires PHD-mediated histone 3 binding for tumor suppression. Cell Rep (2013) 0.92
The tumor suppressor Chd5 is induced during neuronal differentiation in the developing mouse brain. Gene Expr Patterns (2013) 0.86
An allelic series of Trp63 mutations defines TAp63 as a modifier of EEC syndrome. Am J Med Genet A (2013) 0.81
Inducible systems see the light. Trends Biotechnol (2003) 0.81
Diethylstilbestrol induces vaginal adenosis by disrupting SMAD/RUNX1-mediated cell fate decision in the Müllerian duct epithelium. Dev Biol (2013) 0.80
{Delta}Np73{beta} puts the brakes on DNA repair. Genes Dev (2010) 0.77