Published in Genes Dev on August 17, 2005
Four faces of cellular senescence. J Cell Biol (2011) 6.86
TAp73 knockout shows genomic instability with infertility and tumor suppressor functions. Genes Dev (2008) 4.85
T-helper-1-cell cytokines drive cancer into senescence. Nature (2013) 4.47
Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation. Genes Dev (2006) 3.72
p63 regulates proliferation and differentiation of developmentally mature keratinocytes. Genes Dev (2006) 3.66
Fat tissue, aging, and cellular senescence. Aging Cell (2010) 3.34
TAp63 prevents premature aging by promoting adult stem cell maintenance. Cell Stem Cell (2009) 3.15
Notch tumor suppressor function. Oncogene (2008) 2.26
p63 and p73, the ancestors of p53. Cold Spring Harb Perspect Biol (2010) 2.16
TAp63 induces senescence and suppresses tumorigenesis in vivo. Nat Cell Biol (2009) 2.15
DNA damage, cellular senescence and organismal ageing: causal or correlative? Nucleic Acids Res (2007) 2.09
The E3 ubiquitin ligase Itch controls the protein stability of p63. Proc Natl Acad Sci U S A (2006) 2.01
Metabolic regulation by p53 family members. Cell Metab (2013) 2.00
20 years studying p53 functions in genetically engineered mice. Nat Rev Cancer (2009) 2.00
p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53. Cell Death Differ (2011) 1.94
The alpha/beta carboxy-terminal domains of p63 are required for skin and limb development. New insights from the Brdm2 mouse which is not a complete p63 knockout but expresses p63 gamma-like proteins. Cell Death Differ (2009) 1.93
Cellular senescence and organismal aging. Mech Ageing Dev (2008) 1.92
The Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage. PLoS One (2009) 1.83
The p53 family and programmed cell death. Oncogene (2008) 1.81
ΔNp63α is an oncogene that targets chromatin remodeler Lsh to drive skin stem cell proliferation and tumorigenesis. Cell Stem Cell (2011) 1.75
An active role of the DeltaN isoform of p63 in regulating basal keratin genes K5 and K14 and directing epidermal cell fate. PLoS One (2009) 1.69
Cooperation between the transcription factors p63 and IRF6 is essential to prevent cleft palate in mice. J Clin Invest (2010) 1.67
p53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells. PLoS Biol (2012) 1.63
Opposing roles for calcineurin and ATF3 in squamous skin cancer. Nature (2010) 1.57
Rescue of key features of the p63-null epithelial phenotype by inactivation of Ink4a and Arf. EMBO J (2009) 1.54
G1 to S phase cell cycle transition in somatic and embryonic stem cells. J Anat (2008) 1.48
p63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors. Proc Natl Acad Sci U S A (2006) 1.48
TAp73 depletion accelerates aging through metabolic dysregulation. Genes Dev (2012) 1.45
p63-microRNA feedback in keratinocyte senescence. Proc Natl Acad Sci U S A (2012) 1.41
mTOR regulates autophagy-associated genes downstream of p73. Autophagy (2009) 1.31
The identification of zebrafish mutants showing alterations in senescence-associated biomarkers. PLoS Genet (2008) 1.30
MicroRNA 203 expression in keratinocytes is dependent on regulation of p53 levels by E6. J Virol (2010) 1.26
Critical and distinct roles of p16 and telomerase in regulating the proliferative life span of normal human prostate epithelial progenitor cells. J Biol Chem (2008) 1.23
Basal cell signaling by p63 controls luminal progenitor function and lactation via NRG1. Dev Cell (2014) 1.21
A microRNA-dependent program controls p53-independent survival and chemosensitivity in human and murine squamous cell carcinoma. J Clin Invest (2011) 1.19
Reciprocal intraepithelial interactions between TP63 and hedgehog signaling regulate quiescence and activation of progenitor elaboration by mammary stem cells. Stem Cells (2008) 1.15
iASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epithelia. EMBO J (2011) 1.12
FANCD2 activates transcription of TAp63 and suppresses tumorigenesis. Mol Cell (2013) 1.11
p63 and p73 coordinate p53 function to determine the balance between survival, cell death, and senescence in adult neural precursor cells. Cell Death Differ (2014) 1.11
Using mice to examine p53 functions in cancer, aging, and longevity. Cold Spring Harb Perspect Biol (2009) 1.10
FGFR2 signaling underlies p63 oncogenic function in squamous cell carcinoma. J Clin Invest (2013) 1.07
Genetics and epigenetics of aging and longevity. Cell Cycle (2014) 1.07
Ubiquitin and ubiquitin-like modifications of the p53 family. Neoplasia (2006) 1.05
p63 Suppresses non-epidermal lineage markers in a bone morphogenetic protein-dependent manner via repression of Smad7. J Biol Chem (2009) 1.04
Aberrant cytoplasmic expression of p63 and prostate cancer mortality. Cancer Epidemiol Biomarkers Prev (2009) 1.03
MicroRNAs and p63 in epithelial stemness. Cell Death Differ (2014) 1.03
Regulation of skin aging and heart development by TAp63. Cell Death Differ (2011) 1.02
Senescent keratinocytes die by autophagic programmed cell death. Am J Pathol (2009) 1.01
MYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiency. Mol Cancer Res (2012) 0.99
p63 Regulates adult neural precursor and newly born neuron survival to control hippocampal-dependent Behavior. J Neurosci (2013) 0.99
The Regulation of Aging and Longevity: A New and Complex Role of p53. Genes Cancer (2011) 0.97
Tumor suppression by p53: making cells senescent. Histol Histopathol (2010) 0.96
Zebrafish as a genetic model in biological and behavioral gerontology: where development meets aging in vertebrates--a mini-review. Gerontology (2009) 0.96
ΔNp63 targets cytoglobin to inhibit oxidative stress-induced apoptosis in keratinocytes and lung cancer. Oncogene (2015) 0.95
Novel ARF/p53-independent senescence pathways in cancer repression. J Mol Med (Berl) (2011) 0.95
DeltaNp63α protein triggers epithelial-mesenchymal transition and confers stem cell properties in normal human keratinocytes. J Biol Chem (2011) 0.94
The midregion, nuclear localization sequence, and C terminus of PTHrP regulate skeletal development, hematopoiesis, and survival in mice. FASEB J (2010) 0.93
ΔNp63α promotes cellular quiescence via induction and activation of Notch3. Cell Cycle (2011) 0.92
Role of p63 in Development, Tumorigenesis and Cancer Progression. Cancer Microenviron (2012) 0.91
MnSOD upregulation induces autophagic programmed cell death in senescent keratinocytes. PLoS One (2010) 0.91
Stxbp4 regulates DeltaNp63 stability by suppression of RACK1-dependent degradation. Mol Cell Biol (2009) 0.90
Premature aging with impaired oxidative stress defense in mice lacking TR4. Am J Physiol Endocrinol Metab (2011) 0.90
Androgen receptor drives cellular senescence. PLoS One (2012) 0.89
Role of the p63-FoxN1 regulatory axis in thymic epithelial cell homeostasis during aging. Cell Death Dis (2013) 0.89
ΔNp63 promotes pediatric neuroblastoma and osteosarcoma by regulating tumor angiogenesis. Cancer Res (2013) 0.89
Senescence regulation by the p53 protein family. Methods Mol Biol (2013) 0.88
DeltaNp63 transcriptionally regulates ATM to control p53 Serine-15 phosphorylation. Mol Cancer (2010) 0.88
MicroRNA-191 triggers keratinocytes senescence by SATB1 and CDK6 downregulation. Biochem Biophys Res Commun (2012) 0.88
DNA repair and aging: the impact of the p53 family. Aging (Albany NY) (2015) 0.87
ΔNp63α regulates Erk signaling via MKP3 to inhibit cancer metastasis. Oncogene (2012) 0.86
Treasure or artifact: a decade of p63 research speaks for itself. Cell Death Differ (2010) 0.86
MiR203 mediates subversion of stem cell properties during mammary epithelial differentiation via repression of ΔNP63α and promotes mesenchymal-to-epithelial transition. Cell Death Dis (2013) 0.86
P63 regulates tubular formation via epithelial-to-mesenchymal transition. Oncogene (2013) 0.86
Phospho-ΔNp63α/Rpn13-dependent regulation of LKB1 degradation modulates autophagy in cancer cells. Aging (Albany NY) (2010) 0.86
p63 is an alternative p53 repressor in melanoma that confers chemoresistance and a poor prognosis. J Exp Med (2013) 0.85
Transcription factor p63 controls the reserve status but not the stemness of horizontal basal cells in the olfactory epithelium. Proc Natl Acad Sci U S A (2015) 0.84
Tracing the protectors path from the germ line to the genome. Proc Natl Acad Sci U S A (2010) 0.84
Androgen deprivation-induced senescence promotes outgrowth of androgen-refractory prostate cancer cells. PLoS One (2013) 0.83
Dysregulated ΔNp63α inhibits expression of Ink4a/arf, blocks senescence, and promotes malignant conversion of keratinocytes. PLoS One (2011) 0.83
Regulation of Fertility by the p53 Family Members. Genes Cancer (2011) 0.82
PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasis. Mol Cell Biol (2010) 0.82
Aberrant autolysosomal regulation is linked to the induction of embryonic senescence: differential roles of Beclin 1 and p53 in vertebrate Spns1 deficiency. PLoS Genet (2014) 0.81
p63 supports aerobic respiration through hexokinase II. Proc Natl Acad Sci U S A (2015) 0.81
Dynamic involvement of ATG5 in cellular stress responses. Cell Death Dis (2014) 0.81
Delineating Molecular Mechanisms of Squamous Tissue Homeostasis and Neoplasia: Focus on p63. J Skin Cancer (2013) 0.80
Long-term α1B-adrenergic receptor activation shortens lifespan, while α1A-adrenergic receptor stimulation prolongs lifespan in association with decreased cancer incidence. Age (Dordr) (2014) 0.80
The human promyelocytic leukemia protein is a tumor suppressor for murine skin carcinogenesis. Mol Carcinog (2009) 0.79
TAp63: The fountain of youth. Aging (Albany NY) (2009) 0.78
MicroRNA-20a-5p contributes to hepatic glycogen synthesis through targeting p63 to regulate p53 and PTEN expression. J Cell Mol Med (2016) 0.78
Molecular and chemical genetic approaches to developmental origins of aging and disease in zebrafish. Biochim Biophys Acta (2013) 0.78
Perspectives on cellular senescence and short term dietary restriction in adults. Aging (Albany NY) (2010) 0.78
The signaling involved in autophagy machinery in keratinocytes and therapeutic approaches for skin diseases. Oncotarget (2016) 0.78
Phosphorylation of ΔNp63α via a novel TGFβ/ALK5 signaling mechanism mediates the anti-clonogenic effects of TGFβ. PLoS One (2012) 0.78
{Delta}Np73{beta} puts the brakes on DNA repair. Genes Dev (2010) 0.77
Dual regulation of TERT activity through transcription and splicing by DeltaNP63alpha. Aging (Albany NY) (2008) 0.76
Protection of CD4+ T cells from hepatitis C virus infection-associated senescence via ΔNp63-miR-181a-Sirt1 pathway. J Leukoc Biol (2016) 0.75
In the quest to stymie time, will laboratory data stand up in man? J Clin Invest (2005) 0.75
ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis. Cancer Cell (2016) 0.75
Autolysosome biogenesis and developmental senescence are regulated by both Spns1 and v-ATPase. Autophagy (2016) 0.75
Using zebrafish models to explore genetic and epigenetic impacts on evolutionary developmental origins of aging. Transl Res (2013) 0.75
A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A (1995) 32.89
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell (1997) 29.13
THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS. Exp Cell Res (1965) 21.61
p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature (1999) 14.38
p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature (1999) 13.21
Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell (2005) 12.73
Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature (2004) 11.59
p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell (1998) 11.54
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell (2003) 11.40
p53 mutant mice that display early ageing-associated phenotypes. Nature (2002) 10.05
Ink4a/Arf expression is a biomarker of aging. J Clin Invest (2004) 8.30
Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging. Proc Natl Acad Sci U S A (2001) 7.93
p53 isoforms can regulate p53 transcriptional activity. Genes Dev (2005) 6.76
A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Cell (2002) 6.76
p63 is the molecular switch for initiation of an epithelial stratification program. Genes Dev (2004) 6.40
An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo. Nat Genet (2003) 5.82
PML regulates p53 acetylation and premature senescence induced by oncogenic Ras. Nature (2000) 4.90
Cellular senescence as a tumor-suppressor mechanism. Trends Cell Biol (2001) 4.81
Getting under the skin of epidermal morphogenesis. Nat Rev Genet (2002) 4.54
Modulation of mammalian life span by the short isoform of p53. Genes Dev (2004) 4.52
Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells. Proc Natl Acad Sci U S A (2001) 4.51
AIS is an oncogene amplified in squamous cell carcinoma. Proc Natl Acad Sci U S A (2000) 4.37
Premature aging in mice deficient in DNA repair and transcription. Science (2002) 3.82
Bmi1, stem cells, and senescence regulation. J Clin Invest (2004) 3.80
Aging and genome maintenance: lessons from the mouse? Science (2003) 3.72
A transcriptional profile of aging in the human kidney. PLoS Biol (2004) 3.69
PML is induced by oncogenic ras and promotes premature senescence. Genes Dev (2000) 3.35
The role of PML in tumor suppression. Cell (2002) 3.28
Association of p63 with proliferative potential in normal and neoplastic human keratinocytes. J Invest Dermatol (1999) 3.15
The Delta Np63 alpha phosphoprotein binds the p21 and 14-3-3 sigma promoters in vivo and has transcriptional repressor activity that is reduced by Hay-Wells syndrome-derived mutations. Mol Cell Biol (2003) 3.00
Telomeres, stem cells, senescence, and cancer. J Clin Invest (2004) 2.87
Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform. Genes Dev (2003) 2.78
DeltaNp63alpha and TAp63alpha regulate transcription of genes with distinct biological functions in cancer and development. Cancer Res (2003) 2.46
PML regulates p53 stability by sequestering Mdm2 to the nucleolus. Nat Cell Biol (2004) 2.45
PML is a direct p53 target that modulates p53 effector functions. Mol Cell (2004) 2.40
p63 and the epithelial stem cell: more than status quo? Genes Dev (2004) 2.08
A dominant-negative form of p63 is required for epidermal proliferation in zebrafish. Dev Cell (2002) 1.98
Down-regulation of p63 is required for epidermal UV-B-induced apoptosis. Cancer Res (2000) 1.88
Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG. Genes Dev (2004) 1.84
Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation. Proc Natl Acad Sci U S A (2001) 1.79
DeltaNp63 induces beta-catenin nuclear accumulation and signaling. Cancer Cell (2002) 1.51
p16 INK4a can initiate an autonomous senescence program. Oncogene (2000) 1.50
The role of p63 in development and differentiation of the epidermis. J Dermatol Sci (2004) 1.37
Roles of p63 in the diethylstilbestrol-induced cervicovaginal adenosis. Development (2004) 1.26
Ubiquitin-dependent degradation of p73 is inhibited by PML. J Exp Med (2004) 1.24
Conditional inactivation of p63 by Cre-mediated excision. Genesis (2002) 1.16
p53 associates with and targets Delta Np63 into a protein degradation pathway. Proc Natl Acad Sci U S A (2001) 1.15
In utero activation of K5.CrePR1 induces gene deletion. Genesis (2002) 1.14
Characterization of mammalian synemin, an intermediate filament protein present in all four classes of muscle cells and some neuroglial cells: co-localization and interaction with type III intermediate filament proteins and keratins. Cell Tissue Res (2003) 0.91
Thymic hyperplasia and lung carcinomas in a line of mice transgenic for keratin 5-driven HPV16 E6/E7 oncogenes. Oncogene (2001) 0.89
A microRNA polycistron as a potential human oncogene. Nature (2005) 40.21
A microRNA component of the p53 tumour suppressor network. Nature (2007) 19.25
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature (2007) 16.95
Dicer is essential for mouse development. Nat Genet (2003) 15.87
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell (2006) 12.72
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature (2011) 11.44
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell (2003) 11.40
Probing tumor phenotypes using stable and regulated synthetic microRNA precursors. Nat Genet (2005) 8.99
Senescence of activated stellate cells limits liver fibrosis. Cell (2008) 8.98
Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy. Nature (2004) 8.76
Apoptosis: a link between cancer genetics and chemotherapy. Cell (2002) 7.86
A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Cell (2002) 6.76
p63 is the molecular switch for initiation of an epithelial stratification program. Genes Dev (2004) 6.40
Dissecting p53 tumor suppressor functions in vivo. Cancer Cell (2002) 6.24
The gene encoding the splicing factor SF2/ASF is a proto-oncogene. Nat Struct Mol Biol (2007) 6.16
Origin and diversity of novel avian influenza A H7N9 viruses causing human infection: phylogenetic, structural, and coalescent analyses. Lancet (2013) 6.10
Mad2 overexpression promotes aneuploidy and tumorigenesis in mice. Cancer Cell (2006) 5.88
An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo. Nat Genet (2003) 5.82
Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin. Proc Natl Acad Sci U S A (2006) 5.78
Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J (2003) 5.61
An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer. Cell (2008) 5.47
microRNAs join the p53 network--another piece in the tumour-suppression puzzle. Nat Rev Cancer (2007) 5.38
Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants. Nature (2005) 4.97
Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery. Proc Natl Acad Sci U S A (2008) 4.97
miR-19 is a key oncogenic component of mir-17-92. Genes Dev (2009) 4.95
CHD5 is a tumor suppressor at human 1p36. Cell (2007) 4.90
Mosaic analysis with double markers reveals tumor cell of origin in glioma. Cell (2011) 4.78
A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation. Cell (2006) 4.74
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nat Genet (2011) 4.50
The microcosmos of cancer. Nature (2012) 4.50
Control of apoptosis by p53. Oncogene (2003) 4.46
Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control. Nature (2004) 4.41
RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments. Genes Dev (2007) 4.16
miR-221 overexpression contributes to liver tumorigenesis. Proc Natl Acad Sci U S A (2009) 4.15
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13
Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells. Blood (2005) 4.10
Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell (2012) 4.09
NFKBIA deletion in glioblastomas. N Engl J Med (2010) 3.96
Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med (2011) 3.94
Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature (2006) 3.90
Dissecting the unique role of the retinoblastoma tumor suppressor during cellular senescence. Cancer Cell (2010) 3.81
Plasma microRNA panel to diagnose hepatitis B virus-related hepatocellular carcinoma. J Clin Oncol (2011) 3.80
Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model. Nat Genet (2008) 3.76
Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice. J Clin Invest (2010) 3.74
A rapid and scalable system for studying gene function in mice using conditional RNA interference. Cell (2011) 3.69
Apoptosis and melanoma chemoresistance. Oncogene (2003) 3.58
Dissecting eIF4E action in tumorigenesis. Genes Dev (2007) 3.53
Yes-associated protein is an independent prognostic marker in hepatocellular carcinoma. Cancer (2009) 3.52
A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma. Nat Biotechnol (2009) 3.44
Suppression of tumorigenesis by the p53 target PUMA. Proc Natl Acad Sci U S A (2004) 3.42
p63 regulates an adhesion programme and cell survival in epithelial cells. Nat Cell Biol (2006) 3.37
Transcriptional profiling of aging in human muscle reveals a common aging signature. PLoS Genet (2006) 3.34
Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi. Nat Biotechnol (2010) 3.33
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Neuronal activity promotes oligodendrogenesis and adaptive myelination in the mammalian brain. Science (2014) 3.11
Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner. Mol Cell Biol (2002) 3.08
Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity. Genes Dev (2011) 3.05
Stem cells: The promises and perils of p53. Nature (2009) 3.01
Direct coupling of the cell cycle and cell death machinery by E2F. Nat Cell Biol (2002) 3.00
Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet (2013) 2.92
A network model of a cooperative genetic landscape in brain tumors. JAMA (2009) 2.86
A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions. Proc Natl Acad Sci U S A (2012) 2.85
Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population. Diabetes (2007) 2.83
Functional identification of optimized RNAi triggers using a massively parallel sensor assay. Mol Cell (2011) 2.82
Mouse models of human AML accurately predict chemotherapy response. Genes Dev (2009) 2.75
Randomized trial of a parent intervention: parents can make a difference in long-term adolescent risk behaviors, perceptions, and knowledge. Arch Pediatr Adolesc Med (2004) 2.68
Electrical hyperexcitation of lateral ventral pacemaker neurons desynchronizes downstream circadian oscillators in the fly circadian circuit and induces multiple behavioral periods. J Neurosci (2006) 2.65
Oncogenic ras and p53 cooperate to induce cellular senescence. Mol Cell Biol (2002) 2.61
DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma. Genes Dev (2008) 2.60
Perp is a p63-regulated gene essential for epithelial integrity. Cell (2005) 2.58
Identification of a therapeutic strategy targeting amplified FGF19 in liver cancer by Oncogenomic screening. Cancer Cell (2011) 2.56
Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model. Cancer Cell (2009) 2.54
Tissue-specific and reversible RNA interference in transgenic mice. Nat Genet (2007) 2.54
Functional network analysis reveals extended gliomagenesis pathway maps and three novel MYC-interacting genes in human gliomas. Cancer Res (2005) 2.54
Topoisomerase levels determine chemotherapy response in vitro and in vivo. Proc Natl Acad Sci U S A (2008) 2.53
mTORC1 promotes survival through translational control of Mcl-1. Proc Natl Acad Sci U S A (2008) 2.50
Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia. Genes Dev (2012) 2.44
PML is a direct p53 target that modulates p53 effector functions. Mol Cell (2004) 2.40
Non-cell-autonomous tumor suppression by p53. Cell (2013) 2.40
Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model. J Clin Invest (2008) 2.40
Senescence comes of age. Nat Med (2005) 2.39
An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance. Genes Dev (2011) 2.38
Differential regulation of noxa in normal melanocytes and melanoma cells by proteasome inhibition: therapeutic implications. Cancer Res (2005) 2.37
A mutation in TGFB3 associated with a syndrome of low muscle mass, growth retardation, distal arthrogryposis and clinical features overlapping with Marfan and Loeys-Dietz syndrome. Am J Med Genet A (2013) 2.35
Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses. Science (2013) 2.34
Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53. Cancer Cell (2012) 2.29
HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase. Nature (2010) 2.23
p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation. Development (2006) 2.23
Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23. Nat Genet (2002) 2.23
The retinoblastoma tumor suppressor modifies the therapeutic response of breast cancer. J Clin Invest (2006) 2.18
Molecular and clinical characteristics of MSH6 variants: an analysis of 25 index carriers of a germline variant. Am J Hum Genet (2002) 2.17
Wnt-mediated self-renewal of neural stem/progenitor cells. Proc Natl Acad Sci U S A (2008) 2.15
TAp63 induces senescence and suppresses tumorigenesis in vivo. Nat Cell Biol (2009) 2.15
Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition. Genes Dev (2013) 2.12