Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections.

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Published in Antimicrob Agents Chemother on October 27, 2014

Authors

Karen O'Dwyer1, Aaron T Spivak2, Karen Ingraham1, Sharon Min1, David J Holmes1, Charles Jakielaszek1, Stephen Rittenhouse1, Alan L Kwan3, George P Livi3, Ganesh Sathe3, Elizabeth Thomas3, Stephanie Van Horn3, Linda A Miller4, Monique Twynholm5, John Tomayko4, Marybeth Dalessandro4, Madelyn Caltabiano4, Nicole E Scangarella-Oman4, James R Brown6

Author Affiliations

1: Antibacterial Discovery Performance Unit, GlaxoSmithKline R&D, Collegeville, Pennsylvania, USA.
2: Computational Biology, Quantitative Sciences, GlaxoSmithKline R&D, Collegeville, Pennsylvania, USA.
3: Platform Technology and Science, GlaxoSmithKline R&D, Collegeville, Pennsylvania, USA.
4: Infectious Diseases Therapy Area Unit, GlaxoSmithKline R&D, Collegeville, Pennsylvania, USA.
5: Infectious Diseases Therapy Area Unit, GlaxoSmithKline R&D, Uxbridge, United Kingdom.
6: Computational Biology, Quantitative Sciences, GlaxoSmithKline R&D, Collegeville, Pennsylvania, USA James.R.Brown@gsk.com.

Associated clinical trials:

GSK2251052 in Complicated Urinary Tract Infection | NCT01381549

GSK2251052 in the Treatment of Complicated Intra-abdominal Infections | NCT01381562

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