Lymphocyte Activation Gene 3 (LAG-3) modulates the ability of CD4 T-cells to be suppressed in vivo.

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Published in PLoS One on November 05, 2014

Authors

Nicholas M Durham1, Christopher J Nirschl1, Christopher M Jackson1, Jimmy Elias1, Christina M Kochel1, Robert A Anders2, Charles G Drake1

Author Affiliations

1: Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
2: Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America; Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

Associated clinical trials:

Safety Study of Anti-LAG-3 With and Without Anti-PD-1 in the Treatment of Solid Tumors | NCT01968109

Biomarkers For Immune Checkpoint Inhibitors | NCT04204434

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