MHC class II molecules are not required for survival of newly generated CD4+ T cells, but affect their long-term life span.

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Published in Immunity on September 01, 1996

Authors

S Takeda1, H R Rodewald, H Arakawa, H Bluethmann, T Shimizu

Author Affiliations

1: Basel Institute for Immunology, Switzerland.

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Differentiation of follicular dendritic cells and full antibody responses require tumor necrosis factor receptor-1 signaling. J Exp Med (1996) 1.93

Adherence of Bordetella bronchiseptica to swine nasal epithelial cells and its possible role in virulence. Res Vet Sci (1979) 1.93

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Leukotriene A4 hydrolase in human leukocytes. Purification and properties. J Biol Chem (1984) 1.70

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Volume-sensitive chloride channels involved in apoptotic volume decrease and cell death. J Membr Biol (2006) 1.68

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Mutation spectrum of the retinoblastoma gene in osteosarcomas. Cancer Res (1994) 1.66

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Multivalent structure of an alphabetaT cell receptor. Proc Natl Acad Sci U S A (1999) 1.52

Studies on the epidemiology of nontuberculous mycobacteriosis in Japan. Am Rev Respir Dis (1988) 1.51

Teratoma in a feline unilateral cryptorchid testis. Vet Pathol (2001) 1.51

Central effect of ghrelin, an endogenous growth hormone secretagogue, on hypothalamic peptide gene expression. Endocrinology (2000) 1.51

Effective control of Epstein-Barr virus-related hemophagocytic lymphohistiocytosis with immunochemotherapy. Histiocyte Society. Blood (1999) 1.51

Oral immunization of interleukin-4 (IL-4) knockout mice with a recombinant Salmonella strain or cholera toxin reveals that CD4+ Th2 cells producing IL-6 and IL-10 are associated with mucosal immunoglobulin A responses. Infect Immun (1996) 1.50

CSF hypocretin levels in Guillain-Barré syndrome and other inflammatory neuropathies. Neurology (2003) 1.50

Bacterial translocation and tumor necrosis factor-alpha gene expression in experimental hemorrhagic shock. Crit Care Med (2000) 1.49

Endovascular therapy of 500 small asymptomatic unruptured intracranial aneurysms. AJNR Am J Neuroradiol (2012) 1.49