Published in Genesis on November 12, 2014
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The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas. Nature (1997) 4.69
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Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. Development (1998) 4.08
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Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development. Genes Dev (1997) 3.75
The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas. Genes Dev (1998) 3.42
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Regulatory blueprint for a chordate embryo. Science (2006) 2.67
The insulin signalling system and the IRS proteins. Diabetologia (1997) 2.44
Characterization of a notochord-specific enhancer from the Brachyury promoter region of the ascidian, Ciona intestinalis. Development (1997) 2.38
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Sox17 regulates organ lineage segregation of ventral foregut progenitor cells. Dev Cell (2009) 2.14
MafB is required for islet beta cell maturation. Proc Natl Acad Sci U S A (2007) 2.13
Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3. Mol Cell Biol (2000) 2.11
The ParaHox gene cluster is an evolutionary sister of the Hox gene cluster. Nature (1998) 2.09
The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity. J Cell Biol (2001) 1.98
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The transcription factor HNF3beta is required in visceral endoderm for normal primitive streak morphogenesis. Development (1998) 1.85
The zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells. Genes Dev (2006) 1.81
Improved genome assembly and evidence-based global gene model set for the chordate Ciona intestinalis: new insight into intron and operon populations. Genome Biol (2008) 1.75
Neuropeptides in the nervous system of Drosophila and other insects: multiple roles as neuromodulators and neurohormones. Prog Neurobiol (2002) 1.71
A genomic view of the sea urchin nervous system. Dev Biol (2006) 1.68
A cDNA resource from the basal chordate Ciona intestinalis. Genesis (2002) 1.65
Foxa2 controls Pdx1 gene expression in pancreatic beta-cells in vivo. Diabetes (2002) 1.60
Impaired glucose homeostasis and neonatal mortality in hepatocyte nuclear factor 3alpha-deficient mice. Proc Natl Acad Sci U S A (1999) 1.56
The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing. Philos Trans R Soc Lond B Biol Sci (2011) 1.55
Nkx6.1 is essential for maintaining the functional state of pancreatic beta cells. Cell Rep (2013) 1.55
An integrated database of the ascidian, Ciona intestinalis: towards functional genomics. Zoolog Sci (2005) 1.54
Regulation of pancreatic beta-cell function by the forkhead protein FoxO1. Diabetes Obes Metab (2007) 1.47
The ascidian Mesp gene specifies heart precursor cells. Development (2004) 1.45
Hepatocyte nuclear factor 4alpha regulates the expression of pancreatic beta -cell genes implicated in glucose metabolism and nutrient-induced insulin secretion. J Biol Chem (2000) 1.41
GATA4 and GATA6 control mouse pancreas organogenesis. J Clin Invest (2012) 1.41
Neurogenin3: a master regulator of pancreatic islet differentiation and regeneration. Islets (2010) 1.36
Evolutionary origins of the vertebrate heart: Specification of the cardiac lineage in Ciona intestinalis. Proc Natl Acad Sci U S A (2003) 1.34
Brachyury downstream notochord differentiation in the ascidian embryo. Genes Dev (1999) 1.32
Brain-gut axis and its role in the control of food intake. J Physiol Pharmacol (2004) 1.32
Early chordate origins of the vertebrate second heart field. Science (2010) 1.31
(beta)-catenin mediates the specification of endoderm cells in ascidian embryos. Development (2000) 1.26
The evolutionary origin of animal cellulose synthase. Dev Genes Evol (2004) 1.23
Regulation of motor neuron subtype identity by repressor activity of Mnx class homeodomain proteins. Development (2003) 1.23
Epidermal homeostasis: the role of the growth hormone and insulin-like growth factor systems. Endocr Rev (2003) 1.22
Development of Ciona intestinalis juveniles (through 2nd ascidian stage). Zoolog Sci (2004) 1.21
Development of the human pancreas from foregut to endocrine commitment. Diabetes (2013) 1.21
Growth and development of the laboratory cultured sea urchin. Biol Bull (1969) 1.20
sox4b is a key player of pancreatic alpha cell differentiation in zebrafish. Dev Biol (2005) 1.20
Ephrin signaling establishes asymmetric cell fates in an endomesoderm lineage of the Ciona embryo. Development (2008) 1.20
Gene expression profiles in Ciona intestinalis tailbud embryos. Development (2001) 1.18
Evolutionary crossroads in developmental biology: cyclostomes (lamprey and hagfish). Development (2012) 1.18
Multiple functions of a Zic-like gene in the differentiation of notochord, central nervous system and muscle in Ciona savignyi embryos. Development (2002) 1.16
Insulin-producing cells in the brain of adult Drosophila are regulated by the serotonin 5-HT1A receptor. Cell Mol Life Sci (2011) 1.14
The Krüppel-like zinc finger protein Glis3 directly and indirectly activates insulin gene transcription. Nucleic Acids Res (2009) 1.13
Unfolding a chordate developmental program, one cell at a time: invariant cell lineages, short-range inductions and evolutionary plasticity in ascidians. Dev Biol (2009) 1.12
Gene regulatory networks underlying the compartmentalization of the Ciona central nervous system. Development (2008) 1.12
INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases. Biochem J (2006) 1.12
From notochord formation to hereditary chordoma: the many roles of Brachyury. Biomed Res Int (2013) 1.12
Molecular evidence from Ciona intestinalis for the evolutionary origin of vertebrate sensory placodes. Dev Biol (2005) 1.11
Ciona intestinalis: chordate development made simple. Dev Dyn (2005) 1.11
A genomewide survey of developmentally relevant genes in Ciona intestinalis. II. Genes for homeobox transcription factors. Dev Genes Evol (2003) 1.11
LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function. Genes Dev (2011) 1.10
Genomic cis-regulatory networks in the early Ciona intestinalis embryo. Development (2010) 1.10
Chromosomal mapping of 170 BAC clones in the ascidian Ciona intestinalis. Genome Res (2005) 1.09
The regulation of forkhead/HNF-3beta expression in the Ciona embryo. Dev Biol (2001) 1.08
Developmental fates of larval tissues after metamorphosis in ascidian Halocynthia roretzi. I. Origin of mesodermal tissues of the juvenile. Dev Biol (1997) 1.06
Transposon-mediated insertional mutagenesis revealed the functions of animal cellulose synthase in the ascidian Ciona intestinalis. Proc Natl Acad Sci U S A (2005) 1.05
Pancreatic α-cell specific deletion of mouse Arx leads to α-cell identity loss. PLoS One (2013) 1.05
Cellular morphogenesis in ascidians: how to shape a simple tadpole. Curr Opin Genet Dev (2006) 1.05
Cloning of ascidian homeobox genes provides evidence for a primordial chordate cluster. Gene (1995) 1.04
Brn-4 transcription factor expression targeted to the early developing mouse pancreas induces ectopic glucagon gene expression in insulin-producing beta cells. J Biol Chem (2002) 1.04
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Zebrafish IGF genes: gene duplication, conservation and divergence, and novel roles in midline and notochord development. PLoS One (2009) 1.02
Gata6 is required for complete acinar differentiation and maintenance of the exocrine pancreas in adult mice. Gut (2012) 1.02
Regulation of Ci-tropomyosin-like, a Brachyury target gene in the ascidian, Ciona intestinalis. Development (1999) 0.99
Analyzing gene regulation in ascidian embryos: new tools for new perspectives. Differentiation (2002) 0.99
Trunk lateral cells are neural crest-like cells in the ascidian Ciona intestinalis: insights into the ancestry and evolution of the neural crest. Dev Biol (2008) 0.98
Gene expression profiles in young adult Ciona intestinalis. Dev Genes Evol (2002) 0.97
A conserved role for the MEK signalling pathway in neural tissue specification and posteriorisation in the invertebrate chordate, the ascidian Ciona intestinalis. Development (2003) 0.97
Cdx4 is required in the endoderm to localize the pancreas and limit beta-cell number. Development (2008) 0.97
Ependymal cells of chordate larvae are stem-like cells that form the adult nervous system. Nature (2011) 0.97
Brachyury-downstream gene sets in a chordate, Ciona intestinalis: integrating notochord specification, morphogenesis and chordate evolution. Evol Dev (2008) 0.97
Homeodomain protein IDX-1: a master regulator of pancreas development and insulin gene expression. Trends Endocrinol Metab (2008) 0.96
Primordial germ cells originate from the endodermal strand cells in the ascidian Ciona intestinalis. Dev Genes Evol (2002) 0.96
Stomodeal and neurohypophysial placodes in Ciona intestinalis: insights into the origin of the pituitary gland. J Exp Zool B Mol Dev Evol (2005) 0.96
Islet α-, β-, and δ-cell development is controlled by the Ldb1 coregulator, acting primarily with the islet-1 transcription factor. Diabetes (2012) 0.95
Role of the transcription factor sox4 in insulin secretion and impaired glucose tolerance. Diabetes (2008) 0.95
Early embryonic expression of FGF4/6/9 gene and its role in the induction of mesenchyme and notochord in Ciona savignyi embryos. Development (2002) 0.95
β-Catenin-driven binary fate specification segregates germ layers in ascidian embryos. Curr Biol (2013) 0.95
Novel functions for insulin in bone. Bone (2011) 0.95
FGF8/17/18 functions together with FGF9/16/20 during formation of the notochord in Ciona embryos. Dev Biol (2006) 0.94
Lineage-independent mosaic expression and regulation of the Ciona multidom gene in the ancestral notochord. Dev Dyn (2007) 0.94
Glucose decreases Na+,K+-ATPase activity in pancreatic beta-cells. An effect mediated via Ca2+-independent phospholipase A2 and protein kinase C-dependent phosphorylation of the alpha-subunit. J Biol Chem (1999) 0.94
The draft genome of Ciona intestinalis: insights into chordate and vertebrate origins. Science (2002) 11.11
From notochord formation to hereditary chordoma: the many roles of Brachyury. Biomed Res Int (2013) 1.12
Ciona intestinalis: chordate development made simple. Dev Dyn (2005) 1.11
A genomewide survey of developmentally relevant genes in Ciona intestinalis. II. Genes for homeobox transcription factors. Dev Genes Evol (2003) 1.11
Live imaging of fluorescent proteins in chordate embryos: from ascidians to mice. Microsc Res Tech (2006) 0.99
Unusual number and genomic organization of Hox genes in the tunicate Ciona intestinalis. Gene (2003) 0.96
Lineage-independent mosaic expression and regulation of the Ciona multidom gene in the ancestral notochord. Dev Dyn (2007) 0.94
The evolutionarily conserved leprecan gene: its regulation by Brachyury and its role in the developing Ciona notochord. Dev Biol (2009) 0.92
Evolutionary changes in the notochord genetic toolkit: a comparative analysis of notochord genes in the ascidian Ciona and the larvacean Oikopleura. BMC Evol Biol (2011) 0.92
Pbx1/Pbx2 govern axial skeletal development by controlling Polycomb and Hox in mesoderm and Pax1/Pax9 in sclerotome. Dev Biol (2008) 0.91
Conservation of notochord gene expression across chordates: insights from the Leprecan gene family. Genesis (2008) 0.91
Simple chordates exhibit a proton-independent function of acid-sensing ion channels. FASEB J (2008) 0.90
Evolutionary conservation of vertebrate notochord genes in the ascidian Ciona intestinalis. Genesis (2008) 0.89
Direct activation of a notochord cis-regulatory module by Brachyury and FoxA in the ascidian Ciona intestinalis. Development (2009) 0.88
Dynamic and polarized muscle cell behaviors accompany tail morphogenesis in the ascidian Ciona intestinalis. PLoS One (2007) 0.86
The identification of transcription factors expressed in the notochord of Ciona intestinalis adds new potential players to the brachyury gene regulatory network. Dev Dyn (2011) 0.85
A saturation screen for cis-acting regulatory DNA in the Hox genes of Ciona intestinalis. Proc Natl Acad Sci U S A (2005) 0.85
Temporal regulation of the muscle gene cascade by Macho1 and Tbx6 transcription factors in Ciona intestinalis. J Cell Sci (2010) 0.85
Tbx2/3 is an essential mediator within the Brachyury gene network during Ciona notochord development. Development (2013) 0.84
Functional Brachyury binding sites establish a temporal read-out of gene expression in the Ciona notochord. PLoS Biol (2013) 0.83
Live imaging and morphometric analysis of embryonic development in the ascidian Ciona intestinalis. Genesis (2005) 0.81
Optimization of a method for chromatin immunoprecipitation assays in the marine invertebrate chordate Ciona. Mar Biotechnol (NY) (2013) 0.76