Published in Diabetes on November 27, 2012
Gene regulatory networks governing pancreas development. Dev Cell (2013) 1.25
Islet-1 Is essential for pancreatic β-cell function. Diabetes (2014) 0.89
LIM domain-binding 1 maintains the terminally differentiated state of pancreatic β cells. J Clin Invest (2016) 0.87
Endocrine pancreatic development: impact of obesity and diet. Front Physiol (2013) 0.85
Dynamic recruitment of functionally distinct Swi/Snf chromatin remodeling complexes modulates Pdx1 activity in islet β cells. Cell Rep (2015) 0.83
Retinoic acid receptor signaling is required to maintain glucose-stimulated insulin secretion and β-cell mass. FASEB J (2014) 0.83
Ldb1 is essential for development of Nkx2.1 lineage derived GABAergic and cholinergic neurons in the telencephalon. Dev Biol (2013) 0.81
Cell type and tissue specific function of islet genes in zebrafish pancreas development. Dev Biol (2013) 0.81
Islet 1 specifies the identity of hypothalamic melanocortin neurons and is critical for normal food intake and adiposity in adulthood. Proc Natl Acad Sci U S A (2015) 0.80
SSBP3 Interacts With Islet-1 and Ldb1 to Impact Pancreatic β-Cell Target Genes. Mol Endocrinol (2015) 0.76
Insulin-like genes in ascidians: findings in Ciona and hypotheses on the evolutionary origins of the pancreas. Genesis (2014) 0.75
A novel TGFβ modulator that uncouples R-Smad/I-Smad-mediated negative feedback from R-Smad/ligand-driven positive feedback. PLoS Biol (2015) 0.75
Retracted Connective tissue growth factor is critical for proper β-cell function and pregnancy-induced β-cell hyperplasia in adult mice. Am J Physiol Endocrinol Metab (2016) 0.75
Transcription factor regulation of pancreatic organogenesis, differentiation and maturation. Islets (2015) 0.75
Alpha TC1 and Beta-TC-6 genomic profiling uncovers both shared and distinct transcriptional regulatory features with their primary islet counterparts. Sci Rep (2017) 0.75
Ldb1 Regulates Energy Homeostasis During Diet-Induced Obesity. Endocrinology (2016) 0.75
Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Res (1989) 22.73
Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development (2002) 12.21
PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development (1996) 9.58
The biology of incretin hormones. Cell Metab (2006) 8.92
neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci U S A (2000) 8.34
The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nat Genet (2002) 8.28
The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. EMBO J (1997) 6.36
Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages. Development (2000) 5.30
Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and beta-pancreatic islet cells. Cell (1988) 5.18
Developmental biology of the pancreas. Development (1995) 5.14
Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas. Development (2000) 4.58
Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas. Nature (1997) 4.58
Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells. Nature (1997) 4.01
Opposing actions of Arx and Pax4 in endocrine pancreas development. Genes Dev (2003) 4.00
Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development. Genes Dev (1997) 3.75
The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas. Genes Dev (1998) 3.42
On the origin of the beta cell. Genes Dev (2008) 3.34
Pancreas organogenesis: from bud to plexus to gland. Dev Dyn (2011) 3.14
Synchronization of neurogenesis and motor neuron specification by direct coupling of bHLH and homeodomain transcription factors. Neuron (2003) 3.08
LIM factor Lhx3 contributes to the specification of motor neuron and interneuron identity through cell-type-specific protein-protein interactions. Cell (2002) 2.94
Active suppression of interneuron programs within developing motor neurons revealed by analysis of homeodomain factor HB9. Neuron (1999) 2.83
Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins. Nature (1996) 2.57
Stabilization of beta-catenin impacts pancreas growth. Development (2006) 2.44
A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins. Genes Dev (1997) 2.35
Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice. Nat Genet (1999) 2.31
Nuclear LIM interactor, a rhombotin and LIM homeodomain interacting protein, is expressed early in neuronal development. Proc Natl Acad Sci U S A (1996) 2.29
The MafA transcription factor appears to be responsible for tissue-specific expression of insulin. Proc Natl Acad Sci U S A (2004) 2.14
The homeodomain LIM protein Isl-1 is expressed in subsets of neurons and endocrine cells in the adult rat. Neuron (1991) 2.07
MafB: an activator of the glucagon gene expressed in developing islet alpha- and beta-cells. Diabetes (2006) 2.01
The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas. Development (2005) 1.98
Identification of a TAL1 target gene reveals a positive role for the LIM domain-binding protein Ldb1 in erythroid gene expression and differentiation. Mol Cell Biol (2003) 1.92
Transcriptomes of the major human pancreatic cell types. Diabetologia (2011) 1.90
LIM-domain-binding protein 1: a multifunctional cofactor that interacts with diverse proteins. EMBO Rep (2003) 1.86
Conditional inactivation of Pax6 in the pancreas causes early onset of diabetes. Dev Biol (2004) 1.78
The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation. Proc Natl Acad Sci U S A (1997) 1.76
Functional ablation of the mouse Ldb1 gene results in severe patterning defects during gastrulation. Development (2003) 1.73
Covalent histone modifications underlie the developmental regulation of insulin gene transcription in pancreatic beta cells. J Biol Chem (2003) 1.71
pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis. Dev Biol (2007) 1.68
Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47. Mol Cell Biol (2002) 1.61
Gata6 is an important regulator of mouse pancreas development. Dev Biol (2006) 1.58
FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site. Mol Cell Biol (2006) 1.58
Methyltransferase Set7/9 maintains transcription and euchromatin structure at islet-enriched genes. Diabetes (2008) 1.46
p300 mediates transcriptional stimulation by the basic helix-loop-helix activators of the insulin gene. Mol Cell Biol (1998) 1.41
LIM-homeodomain proteins Lhx1 and Lhx5, and their cofactor Ldb1, control Purkinje cell differentiation in the developing cerebellum. Proc Natl Acad Sci U S A (2007) 1.41
Bridge-1, a novel PDZ-domain coactivator of E2A-mediated regulation of insulin gene transcription. Mol Cell Biol (1999) 1.38
Mosaic Cre-mediated recombination in pancreas using the pdx-1 enhancer/promoter. Genesis (2000) 1.37
LIM-homeodomain genes in mammalian development and human disease. Mol Biol Rep (2005) 1.35
Islet-1 is required for the maturation, proliferation, and survival of the endocrine pancreas. Diabetes (2009) 1.33
GSK-3-mediated phosphorylation enhances Maf-transforming activity. Mol Cell (2007) 1.31
Pancreatic GLP-1 receptor activation is sufficient for incretin control of glucose metabolism in mice. J Clin Invest (2011) 1.27
Glucose regulation of insulin gene expression requires the recruitment of p300 by the beta-cell-specific transcription factor Pdx-1. Mol Endocrinol (2004) 1.25
Transcription factor GATA-6 is expressed in the endocrine and GATA-4 in the exocrine pancreas. Mol Cell Endocrinol (2004) 1.23
The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity. Dev Biol (2004) 1.14
LIM homeobox transcription factors integrate signaling events that control three-dimensional limb patterning and growth. Development (2009) 1.13
Identification of PCIF1, a POZ domain protein that inhibits PDX-1 (MODY4) transcriptional activity. Mol Cell Biol (2004) 1.04
Islet-1 regulates Arx transcription during pancreatic islet alpha-cell development. J Biol Chem (2011) 0.98
RNA profiling and chromatin immunoprecipitation-sequencing reveal that PTF1a stabilizes pancreas progenitor identity via the control of MNX1/HLXB9 and a network of other transcription factors. Mol Cell Biol (2012) 0.94
Pancreatic-specific expression of the glucose transporter type 2 gene: identification of cis-elements and islet-specific trans-acting factors. Mol Endocrinol (1995) 0.89
Isl1 and Ldb co-regulators of transcription are essential early determinants of mouse limb development. Dev Dyn (2012) 0.85
Hnf1α (MODY3) regulates β-cell-enriched MafA transcription factor expression. Mol Endocrinol (2010) 0.84
Cellular senescence in aging primates. Science (2006) 6.24
FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction. Cell Metab (2005) 4.14
Accumulation of senescent cells in mitotic tissue of aging primates. Mech Ageing Dev (2006) 3.14
Members of the large Maf transcription family regulate insulin gene transcription in islet beta cells. Mol Cell Biol (2003) 2.64
Profound impairment in social recognition and reduction in anxiety-like behavior in vasopressin V1a receptor knockout mice. Neuropsychopharmacology (2004) 2.26
Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes. Nat Genet (2006) 2.21
Inactivation of specific β cell transcription factors in type 2 diabetes. J Clin Invest (2013) 2.18
The MafA transcription factor appears to be responsible for tissue-specific expression of insulin. Proc Natl Acad Sci U S A (2004) 2.14
MafB is required for islet beta cell maturation. Proc Natl Acad Sci U S A (2007) 2.13
Distinct molecular pathways for development of telencephalic interneuron subtypes revealed through analysis of Lhx6 mutants. J Comp Neurol (2008) 2.09
Characterization of a mouse strain expressing Cre recombinase from the 3' untranslated region of the dopamine transporter locus. Genesis (2006) 2.08
MafA and MafB regulate genes critical to beta-cells in a unique temporal manner. Diabetes (2010) 2.01
MafB: an activator of the glucagon gene expressed in developing islet alpha- and beta-cells. Diabetes (2006) 2.01
A functional floxed allele of Pkd1 that can be conditionally inactivated in vivo. J Am Soc Nephrol (2004) 1.97
A mouse model for the Carney complex tumor syndrome develops neoplasia in cyclic AMP-responsive tissues. Cancer Res (2005) 1.94
Oogenesis requires germ cell-specific transcriptional regulators Sohlh1 and Lhx8. Proc Natl Acad Sci U S A (2006) 1.87
Oxidative stress-mediated, post-translational loss of MafA protein as a contributing mechanism to loss of insulin gene expression in glucotoxic beta cells. J Biol Chem (2005) 1.86
The LIM-homeobox gene Lhx8 is required for the development of many cholinergic neurons in the mouse forebrain. Proc Natl Acad Sci U S A (2003) 1.85
Frcp1 and Frcp2, two novel fibronectin type III repeat containing genes. Gene (2002) 1.83
Functional ablation of the mouse Ldb1 gene results in severe patterning defects during gastrulation. Development (2003) 1.73
The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription. J Biol Chem (2005) 1.73
Regulation of MafA expression in pancreatic beta-cells in db/db mice with diabetes. Diabetes (2010) 1.72
Defining pancreatic endocrine precursors and their descendants. Diabetes (2007) 1.65
Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47. Mol Cell Biol (2002) 1.61
FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site. Mol Cell Biol (2006) 1.58
MafA and MafB activity in pancreatic β cells. Trends Endocrinol Metab (2011) 1.44
Nuclear adaptor Ldb1 regulates a transcriptional program essential for the maintenance of hematopoietic stem cells. Nat Immunol (2010) 1.43
Nitric oxide negatively regulates mammalian adult neurogenesis. Proc Natl Acad Sci U S A (2003) 1.42
Azoospermia in patients heterozygous for a mutation in SYCP3. Lancet (2003) 1.41
LIM-homeodomain proteins Lhx1 and Lhx5, and their cofactor Ldb1, control Purkinje cell differentiation in the developing cerebellum. Proc Natl Acad Sci U S A (2007) 1.41
Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density. Mol Cell Biol (2008) 1.41
Conserved transcriptional regulatory domains of the pdx-1 gene. Mol Endocrinol (2003) 1.41
Dkk2 plays an essential role in the corneal fate of the ocular surface epithelium. Development (2006) 1.41
Impaired neutrophil activity and increased susceptibility to bacterial infection in mice lacking glucose-6-phosphatase-beta. J Clin Invest (2007) 1.41
Analysis of the in vivo functions of Mrp3. Mol Pharmacol (2005) 1.37
Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity. PLoS Genet (2013) 1.37
Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1alpha, and Hnf-3beta. Proc Natl Acad Sci U S A (2002) 1.36
MafA regulates expression of genes important to islet beta-cell function. Mol Endocrinol (2007) 1.35
Lhx6 and Lhx8 coordinately induce neuronal expression of Shh that controls the generation of interneuron progenitors. Neuron (2011) 1.35
Regulation of the insulin gene by glucose and fatty acids. J Nutr (2006) 1.34
The islet beta cell-enriched RIPE3b1/Maf transcription factor regulates pdx-1 expression. J Biol Chem (2003) 1.34
Transcription factor occupancy of the insulin gene in vivo. Evidence for direct regulation by Nkx2.2. J Biol Chem (2002) 1.33
Islet-1 is required for the maturation, proliferation, and survival of the endocrine pancreas. Diabetes (2009) 1.33
Intraflagellar transport protein 172 is essential for primary cilia formation and plays a vital role in patterning the mammalian brain. Dev Biol (2008) 1.30
Ssdp proteins interact with the LIM-domain-binding protein Ldb1 to regulate development. Proc Natl Acad Sci U S A (2002) 1.28
Generation and characterization of dickkopf3 mutant mice. Mol Cell Biol (2006) 1.26
Mice lacking D5 dopamine receptors have increased sympathetic tone and are hypertensive. J Neurosci (2002) 1.25
Lhx1 and Lhx5 maintain the inhibitory-neurotransmitter status of interneurons in the dorsal spinal cord. Development (2006) 1.22
Conserved sequences in a tissue-specific regulatory region of the pdx-1 gene mediate transcription in Pancreatic beta cells: role for hepatocyte nuclear factor 3 beta and Pax6. Mol Cell Biol (2002) 1.18
Impaired glucose homeostasis, neutrophil trafficking and function in mice lacking the glucose-6-phosphate transporter. Hum Mol Genet (2003) 1.15
MODY7 gene, KLF11, is a novel p300-dependent regulator of Pdx-1 (MODY4) transcription in pancreatic islet beta cells. J Biol Chem (2009) 1.15
LIM homeobox transcription factors integrate signaling events that control three-dimensional limb patterning and growth. Development (2009) 1.13
Transcriptional analysis of intracytoplasmically stained, FACS-purified cells by high-throughput, quantitative nuclease protection. Nat Biotechnol (2009) 1.13
Ssdp1 regulates head morphogenesis of mouse embryos by activating the Lim1-Ldb1 complex. Development (2005) 1.12
Insulin promoter factor-1 mutations and diabetes in Trinidad: identification of a novel diabetes-associated mutation (E224K) in an Indo-Trinidadian family. J Clin Endocrinol Metab (2004) 1.12
Nkx2.2 and Arx genetically interact to regulate pancreatic endocrine cell development and endocrine hormone expression. Dev Biol (2011) 1.10
FoxP4, a novel forkhead transcription factor. Biochim Biophys Acta (2003) 1.09
The podocyte-specific inactivation of Lmx1b, Ldb1 and E2a yields new insight into a transcriptional network in podocytes. Dev Biol (2007) 1.08
Disruption of a novel Kruppel-like transcription factor p300-regulated pathway for insulin biosynthesis revealed by studies of the c.-331 INS mutation found in neonatal diabetes mellitus. J Biol Chem (2011) 1.06
Simultaneous absence of dopamine D1 and D2 receptor-mediated signaling is lethal in mice. Proc Natl Acad Sci U S A (2004) 1.05
Pancreatic α-cell specific deletion of mouse Arx leads to α-cell identity loss. PLoS One (2013) 1.05
H3K9 histone acetylation predicts pluripotency and reprogramming capacity of ES cells. Nucleus (2011) 1.04
Multidrug resistance protein 4 protects bone marrow, thymus, spleen, and intestine from nucleotide analogue-induced damage. Cancer Res (2007) 1.04
Dkk1 and Wnt3 interact to control head morphogenesis in the mouse. Development (2008) 1.04
MafA is a dedicated activator of the insulin gene in vivo. J Endocrinol (2008) 1.03
Contribution of Abcc10 (Mrp7) to in vivo paclitaxel resistance as assessed in Abcc10(-/-) mice. Cancer Res (2011) 1.01
Reduced expression of the LIM-homeobox gene Lhx3 impairs growth and differentiation of Rathke's pouch and increases cell apoptosis during mouse pituitary development. Mech Dev (2006) 1.00
Dkk1 and noggin cooperate in mammalian head induction. Genes Dev (2003) 1.00
Islet beta-cell-specific MafA transcription requires the 5'-flanking conserved region 3 control domain. Mol Cell Biol (2010) 0.99
Rho family Guanine nucleotide exchange factor Brx couples extracellular signals to the glucocorticoid signaling system. J Biol Chem (2006) 0.99
Arx is required for normal enteroendocrine cell development in mice and humans. Dev Biol (2012) 0.98
Islet-1 regulates Arx transcription during pancreatic islet alpha-cell development. J Biol Chem (2011) 0.98
Effects of cerebral ischemia in mice deficient in Persephin. Proc Natl Acad Sci U S A (2002) 0.98
The Rho guanine nucleotide exchange factor AKAP13 (BRX) is essential for cardiac development in mice. J Biol Chem (2010) 0.97
Melanoma antigen-11 inhibits the hypoxia-inducible factor prolyl hydroxylase 2 and activates hypoxic response. Cancer Res (2009) 0.96
BETA2 activates transcription from the upstream glucokinase gene promoter in islet beta-cells and gut endocrine cells. Diabetes (2003) 0.96
Interactions between areas I and II direct pdx-1 expression specifically to islet cell types of the mature and developing pancreas. J Biol Chem (2005) 0.95
Maintenance of hepatic nuclear factor 6 in postnatal islets impairs terminal differentiation and function of beta-cells. Diabetes (2006) 0.95
Glucose induced MAPK signalling influences NeuroD1-mediated activation and nuclear localization. FEBS Lett (2002) 0.95
Gdnf haploinsufficiency causes Hirschsprung-like intestinal obstruction and early-onset lethality in mice. Am J Hum Genet (2002) 0.94
The stability and transactivation potential of the mammalian MafA transcription factor are regulated by serine 65 phosphorylation. J Biol Chem (2008) 0.94
The Ldb1 and Ldb2 transcriptional cofactors interact with the Ste20-like kinase SLK and regulate cell migration. Mol Biol Cell (2009) 0.94
Identification of a novel PDX-1 binding site in the human insulin gene enhancer. J Biol Chem (2004) 0.93
Vasopressin receptor 1a-mediated negative regulation of B cell receptor signaling. J Neuroimmunol (2003) 0.92
FoxO feedback control of basal IRS-2 expression in pancreatic β-cells is distinct from that in hepatocytes. Diabetes (2011) 0.91
Involvement of PDX-1 in activation of human insulin gene transcription. J Endocrinol (2006) 0.91
A role of the LIM-homeobox gene Lhx2 in the regulation of pituitary development. Dev Biol (2009) 0.90
Stringent requirement of a proper level of canonical WNT signalling activity for head formation in mouse embryo. Development (2011) 0.90
Liver-specific Ldb1 deletion results in enhanced liver cancer development. J Hepatol (2010) 0.90
Phosphorylation within the MafA N terminus regulates C-terminal dimerization and DNA binding. J Biol Chem (2010) 0.90
The neuronal differentiation potential of Ldb1-null mutant embryonic stem cells is dependent on extrinsic influences. Stem Cells (2008) 0.89
Acetylation of the BETA2 transcription factor by p300-associated factor is important in insulin gene expression. J Biol Chem (2003) 0.88
The B55α-containing PP2A holoenzyme dephosphorylates FOXO1 in islet β-cells under oxidative stress. Biochem J (2012) 0.88
Dkk1 and Dkk2 regulate epicardial specification during mouse heart development. Int J Cardiol (2010) 0.88
LIM domain-binding 1 maintains the terminally differentiated state of pancreatic β cells. J Clin Invest (2016) 0.87