Published in Int J Clin Exp Pathol on September 15, 2014
Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal Biochem (1982) 27.26
A direct spectrophotometric microassay for sulfated glycosaminoglycans in cartilage cultures. Connect Tissue Res (1982) 7.12
Matrix metalloproteinases: role in arthritis. Front Biosci (2006) 4.52
Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage. J Clin Invest (1997) 4.31
ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro. Nature (2005) 4.24
Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kappaB: differential regulation of collagenase 1 and collagenase 3. Arthritis Rheum (2000) 3.23
The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes. A role in osteoarthritis. J Clin Invest (1996) 2.58
Interleukin-1 beta-modulated gene expression in immortalized human chondrocytes. J Clin Invest (1994) 2.42
Degradation of cartilage aggrecan by collagenase-3 (MMP-13). FEBS Lett (1996) 1.97
Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints. J Clin Invest (1997) 1.97
Relative messenger RNA expression profiling of collagenases and aggrecanases in human articular chondrocytes in vivo and in vitro. Arthritis Rheum (2002) 1.97
Aggrecanases and cartilage matrix degradation. Arthritis Res Ther (2003) 1.97
Effects of Cordyceps militaris extract on angiogenesis and tumor growth. Acta Pharmacol Sin (2004) 1.93
Human cathepsin K cleaves native type I and II collagens at the N-terminal end of the triple helix. Biochem J (1998) 1.85
Induction of aggrecanase 1 (ADAM-TS4) by interleukin-1 occurs through activation of constitutively produced protein. Arthritis Rheum (2003) 1.82
Nitric oxide mediates suppression of cartilage proteoglycan synthesis by interleukin-1. Biochem Biophys Res Commun (1994) 1.74
Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage. J Biol Chem (2002) 1.63
The modulation of matrix metalloproteinase and ADAM gene expression in human chondrocytes by interleukin-1 and oncostatin M: a time-course study using real-time quantitative reverse transcription-polymerase chain reaction. Arthritis Rheum (2002) 1.52
Cordycepin inhibits lipopolysaccharide-induced inflammation by the suppression of NF-kappaB through Akt and p38 inhibition in RAW 264.7 macrophage cells. Eur J Pharmacol (2006) 1.51
Reduced progression of experimental osteoarthritis in vivo by selective inhibition of inducible nitric oxide synthase. Arthritis Rheum (1998) 1.44
Comparison of cathepsins K and S expression within the rheumatoid and osteoarthritic synovium. Arthritis Rheum (2002) 1.34
Anti-inflammatory and related pharmacological activities of cultured mycelia and fruiting bodies of Cordyceps militaris. J Ethnopharmacol (2004) 1.28
Expression of rat cathepsin S in phagocytic cells. J Biol Chem (1996) 1.27
Effect of nitric oxide on mitochondrial respiratory activity of human articular chondrocytes. Ann Rheum Dis (2005) 1.16
Evaluation of the anti-inflammatory and anti-proliferation tumoral cells activities of Antrodia camphorata, Cordyceps sinensis, and Cinnamomum osmophloeum bark extracts. J Ethnopharmacol (2007) 1.07
Cordycepin inhibits IL-1beta-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts. Rheumatology (Oxford) (2009) 1.01
n-3 fatty acids specifically modulate catabolic factors involved in articular cartilage degradation. J Biol Chem (2000) 1.01
Effect of inhibition of matrix metalloproteinases on cartilage loss in vitro and in a guinea pig model of osteoarthritis. Arthritis Rheum (2005) 1.01
Curcumin inhibits pro-inflammatory mediators and metalloproteinase-3 production by chondrocytes. Inflamm Res (2009) 1.00
Cleavage site specificity of cathepsin K toward cartilage proteoglycans and protease complex formation. Biol Chem (2003) 1.00
Cordycepin causes p21WAF1-mediated G2/M cell-cycle arrest by regulating c-Jun N-terminal kinase activation in human bladder cancer cells. Arch Biochem Biophys (2009) 0.99
The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases. Arthritis Res Ther (2005) 0.93
Signaling pathways implicated in oncostatin M-induced aggrecanase-1 and matrix metalloproteinase-13 expression in human articular chondrocytes. Biochim Biophys Acta (2006) 0.93
Plasminogen activators in synovial fluid and plasma from patients with arthritis. Ann Rheum Dis (1992) 0.92
Anti-arthritic action mechanisms of natural chondroitin sulfate in human articular chondrocytes and synovial fibroblasts. Biol Pharm Bull (2010) 0.89
Cordycepin inhibits UVB-induced matrix metalloproteinase expression by suppressing the NF-kappaB pathway in human dermal fibroblasts. Exp Mol Med (2009) 0.89
Glucosamine affects intracellular signalling through inhibition of mitogen-activated protein kinase phosphorylation in human chondrocytes. Arthritis Res Ther (2007) 0.88
Evidence to suggest that cathepsin K degrades articular cartilage in naturally occurring equine osteoarthritis. Osteoarthritis Cartilage (2008) 0.87
COX-2 and iNOS are critical in advanced glycation end product-activated chondrocytes in vitro. Eur J Clin Invest (2009) 0.83
Collagen degradation induced by the combination of IL-1alpha and plasminogen in rabbit articular cartilage explant culture. J Biochem (1997) 0.82
Cordycepin inhibits TPA-induced matrix metalloproteinase-9 expression by suppressing the MAPK/AP-1 pathway in MCF-7 human breast cancer cells. Int J Mol Med (2010) 0.81
Production of pure cordycepin (3'-deoxyadenosine) from Cordyceps militaris. J Pharm Pharmacol (1972) 0.80
Natural chondroitin sulphates increase aggregation of proteoglycan complexes and decrease ADAMTS-5 expression in interleukin 1 beta-treated chondrocytes. Ann Rheum Dis (2007) 0.79