Published in Arthritis Rheum on October 01, 2002
Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development. Arthritis Rheum (2009) 3.61
Cartilage homeostasis in health and rheumatic diseases. Arthritis Res Ther (2009) 2.44
MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses. Arthritis Rheum (2009) 1.99
Aggrecanases and cartilage matrix degradation. Arthritis Res Ther (2003) 1.97
The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis. Arthritis Res Ther (2006) 1.93
Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis. Eur Cell Mater (2011) 1.84
Defining the roles of inflammatory and anabolic cytokines in cartilage metabolism. Ann Rheum Dis (2008) 1.82
Proteases involved in cartilage matrix degradation in osteoarthritis. Biochim Biophys Acta (2011) 1.73
Exuberant expression of chemokine genes by adult human articular chondrocytes in response to IL-1beta. Osteoarthritis Cartilage (2008) 1.49
Differential expression of GADD45beta in normal and osteoarthritic cartilage: potential role in homeostasis of articular chondrocytes. Arthritis Rheum (2008) 1.33
Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic chondrocytes. Ann Rheum Dis (2008) 1.31
TNF/TNFR signal transduction pathway-mediated anti-apoptosis and anti-inflammatory effects of sodium ferulate on IL-1β-induced rat osteoarthritis chondrocytes in vitro. Arthritis Res Ther (2012) 1.30
Activation of interleukin-1 signaling cascades in normal and osteoarthritic articular cartilage. Am J Pathol (2007) 1.28
Early-onset osteoarthritis of mouse temporomandibular joint induced by partial discectomy. Osteoarthritis Cartilage (2009) 1.14
Most recent developments in strategies to reduce the progression of structural changes in osteoarthritis: today and tomorrow. Arthritis Res Ther (2006) 1.11
Alterations in periarticular bone and cross talk between subchondral bone and articular cartilage in osteoarthritis. Ther Adv Musculoskelet Dis (2012) 1.09
Differential effects of ADAMTS-1, -4, and -5 in the trabecular meshwork. Invest Ophthalmol Vis Sci (2009) 1.06
Molecular changes in articular cartilage and subchondral bone in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis. BMC Musculoskelet Disord (2011) 1.06
ESE-1 is a potent repressor of type II collagen gene (COL2A1) transcription in human chondrocytes. J Cell Physiol (2008) 1.06
E74-like factor 3 (ELF3) impacts on matrix metalloproteinase 13 (MMP13) transcriptional control in articular chondrocytes under proinflammatory stress. J Biol Chem (2011) 1.04
The role of ADAMTSs in arthritis. Protein Cell (2010) 1.03
Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis. Mod Rheumatol (2009) 1.03
Matrix metalloproteinase 13 loss associated with impaired extracellular matrix remodeling disrupts chondrocyte differentiation by concerted effects on multiple regulatory factors. Arthritis Rheum (2010) 0.99
A 3D cartilage - inflammatory cell culture system for the modeling of human osteoarthritis. Biomaterials (2011) 0.99
LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage. FASEB J (2012) 0.98
Effect of small interference RNA (siRNA) for ADAMTS5 on intervertebral disc degeneration in the rabbit anular needle-puncture model. Arthritis Res Ther (2009) 0.98
Lactoferricin mediates anti-inflammatory and anti-catabolic effects via inhibition of IL-1 and LPS activity in the intervertebral disc. J Cell Physiol (2013) 0.96
Lessons from genetic forms of osteoarthritis for the pathogenesis of the disease. Osteoarthritis Cartilage (2007) 0.96
The regulation of aggrecanase ADAMTS-4 expression in human Achilles tendon and tendon-derived cells. Matrix Biol (2008) 0.96
Role of mitogen-activated protein kinases and NFkappaB on IL-1beta-induced effects on collagen type II, MMP-1 and 13 mRNA expression in normal articular human chondrocytes. Rheumatol Int (2006) 0.95
Comparison of modern marker proteins in serum and synovial fluid in patients with advanced osteoarthrosis and rheumatoid arthritis. Rheumatol Int (2005) 0.93
The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases. Arthritis Res Ther (2005) 0.93
Oncostatin M in combination with tumour necrosis factor {alpha} induces a chondrocyte membrane associated aggrecanase that is distinct from ADAMTS aggrecanase-1 or -2. Ann Rheum Dis (2005) 0.93
Inhibition of histone deacetylases antagonized FGF2 and IL-1beta effects on MMP expression in human articular chondrocytes. Growth Factors (2009) 0.93
Carprofen inhibits the release of matrix metalloproteinases 1, 3, and 13 in the secretome of an explant model of articular cartilage stimulated with interleukin 1β. Arthritis Res Ther (2013) 0.93
The accumulation of intracellular ITEGE and DIPEN neoepitopes in bovine articular chondrocytes is mediated by CD44 internalization of hyaluronan. Arthritis Rheum (2006) 0.90
Dual regulation of metalloproteinase expression in chondrocytes by Wnt-1-inducible signaling pathway protein 3/CCN6. Arthritis Rheum (2012) 0.89
Selective and non-selective metalloproteinase inhibitors reduce IL-1-induced cartilage degradation and loss of mechanical properties. Matrix Biol (2006) 0.86
Matrilin-3 induction of IL-1 receptor antagonist is required for up-regulating collagen II and aggrecan and down-regulating ADAMTS-5 gene expression. Arthritis Res Ther (2012) 0.86
High resistance of the mechanical properties of the chondrocyte pericellular matrix to proteoglycan digestion by chondroitinase, aggrecanase, or hyaluronidase. J Mech Behav Biomed Mater (2013) 0.85
Aggrecanases in the human synovial fluid at different stages of osteoarthritis. Clin Rheumatol (2013) 0.85
Effect of Angelica sinensis Polysaccharides on Osteoarthritis In Vivo and In Vitro: A Possible Mechanism to Promote Proteoglycans Synthesis. Evid Based Complement Alternat Med (2013) 0.85
Roles of metalloproteinase-3 and aggrecanase 1 and 2 in aggrecan cleavage during human meniscus degeneration. Orthop Rev (Pavia) (2009) 0.85
Repression of anti-proliferative factor Tob1 in osteoarthritic cartilage. Arthritis Res Ther (2005) 0.84
Rose hip and its constituent galactolipids confer cartilage protection by modulating cytokine, and chemokine expression. BMC Complement Altern Med (2011) 0.84
Human chondrocyte cultures as models of cartilage-specific gene regulation. Methods Mol Med (2005) 0.83
Reduced EGFR signaling enhances cartilage destruction in a mouse osteoarthritis model. Bone Res (2014) 0.82
Implication of interleukin 18 in production of matrix metalloproteinases in articular chondrocytes in arthritis: direct effect on chondrocytes may not be pivotal. Ann Rheum Dis (2005) 0.82
Differential effects of p38MAP kinase inhibitors on the expression of inflammation-associated genes in primary, interleukin-1beta-stimulated human chondrocytes. Br J Pharmacol (2010) 0.81
Histone Deacetylase Inhibitor Vorinostat (SAHA) Suppresses IL-1β-Induced Matrix Metallopeptidase-13 Expression by Inhibiting IL-6 in Osteoarthritis Chondrocyte. Am J Pathol (2016) 0.81
The triterpenoid CDDO inhibits expression of matrix metalloproteinase-1, matrix metalloproteinase-13 and Bcl-3 in primary human chondrocytes. Arthritis Res Ther (2003) 0.81
Design of a microsphere-based high-throughput gene expression assay to determine estrogenic potential. Environ Health Perspect (2005) 0.80
The roles of catabolic factors in the development of osteoarthritis. Tissue Eng Part B Rev (2013) 0.79
Cordycepin modulates inflammatory and catabolic gene expression in interleukin-1beta-induced human chondrocytes from advanced-stage osteoarthritis: an in vitro study. Int J Clin Exp Pathol (2014) 0.79
Role of Sp1 transcription factor in Interleukin-1-induced ADAMTS-4 (aggrecanase-1) gene expression in human articular chondrocytes. Rheumatol Int (2011) 0.79
Prostaglandin E2 receptor type 2-selective agonist prevents the degeneration of articular cartilage in rabbit knees with traumatic instability. Arthritis Res Ther (2011) 0.79
The regional sensitivity of chondrocyte gene expression to coactive mechanical load and exogenous TNF-α stimuli. J Biomech Eng (2014) 0.78
An ovine in vitro model for chondrocyte-based scaffold-assisted cartilage grafts. J Orthop Surg Res (2012) 0.78
Paracrine effects of human adipose-derived mesenchymal stem cells in inflammatory stress-induced senescence features of osteoarthritic chondrocytes. Aging (Albany NY) (2016) 0.78
MicroRNA-222 regulates MMP-13 via targeting HDAC-4 during osteoarthritis pathogenesis. BBA Clin (2014) 0.78
Cytokine networking of chondrocyte dedifferentiation in vitro and its implications for cell-based cartilage therapy. Am J Transl Res (2015) 0.77
Inhibition of TAK1 and/or JAK can rescue impaired chondrogenic differentiation of human mesenchymal stem cells in osteoarthritis-like conditions. Tissue Eng Part A (2014) 0.77
Effects of the mycotoxin nivalenol on bovine articular chondrocyte metabolism in vitro. PLoS One (2014) 0.76
A Three-Dimensional Chondrocyte-Macrophage Coculture System to Probe Inflammation in Experimental Osteoarthritis. Tissue Eng Part A (2016) 0.75
Syndecan-4 in intervertebral disc and cartilage: Saint or synner? Matrix Biol (2016) 0.75
What is the effect of nicotinic acetylcholine receptor stimulation on osteoarthritis in a rodent animal model? SAGE Open Med (2016) 0.75
Correlating high-resolution magic angle spinning NMR spectroscopy and gene analysis in osteoarthritic cartilage. NMR Biomed (2015) 0.75
FGF2 High Molecular Weight Isoforms Contribute to Osteoarthropathy in Male Mice. Endocrinology (2016) 0.75
Sphingosine 1-phosphate counteracts the effects of interleukin-1β in human chondrocytes. Arthritis Rheum (2013) 0.75
MMP-13 is one of the critical mediators of the effect of HDAC4 deletion on the skeleton. Bone (2016) 0.75
Hypoxia Is a Critical Parameter for Chondrogenic Differentiation of Human Umbilical Cord Blood Mesenchymal Stem Cells in Type I/III Collagen Sponges. Int J Mol Sci (2017) 0.75
Biochemical markers of cartilage metabolism are associated with walking biomechanics 6-months following anterior cruciate ligament reconstruction. J Orthop Res (2017) 0.75
Premature induction of hypertrophy during in vitro chondrogenesis of human mesenchymal stem cells correlates with calcification and vascular invasion after ectopic transplantation in SCID mice. Arthritis Rheum (2006) 4.16
Human laminin beta2 deficiency causes congenital nephrosis with mesangial sclerosis and distinct eye abnormalities. Hum Mol Genet (2004) 2.67
Histological assessment of cartilage repair: a report by the Histology Endpoint Committee of the International Cartilage Repair Society (ICRS). J Bone Joint Surg Am (2003) 2.24
Association between crystals and cartilage degeneration in the ankle. J Rheumatol (2008) 2.15
Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis. Arthritis Rheum (2006) 2.13
Repair of chronic osteochondral defects using predifferentiated mesenchymal stem cells in an ovine model. Am J Sports Med (2010) 1.81
Mechanisms of disease: role of chondrocytes in the pathogenesis of osteoarthritis--structure, chaos and senescence. Nat Clin Pract Rheumatol (2007) 1.74
Articular cartilage repair by gene therapy using growth factor-producing mesenchymal cells. Arthritis Rheum (2003) 1.59
NEK1 mutations cause short-rib polydactyly syndrome type majewski. Am J Hum Genet (2011) 1.56
Molecular characterization of commonly used cell lines for bone tumor research: a trans-European EuroBoNet effort. Genes Chromosomes Cancer (2010) 1.50
A requirement for the CD44 cytoplasmic domain for hyaluronan binding, pericellular matrix assembly, and receptor-mediated endocytosis in COS-7 cells. J Biol Chem (2002) 1.34
Differential expression of GADD45beta in normal and osteoarthritic cartilage: potential role in homeostasis of articular chondrocytes. Arthritis Rheum (2008) 1.33
Activation of interleukin-1 signaling cascades in normal and osteoarthritic articular cartilage. Am J Pathol (2007) 1.28
Freshly isolated osteoarthritic chondrocytes are catabolically more active than normal chondrocytes, but less responsive to catabolic stimulation with interleukin-1beta. Arthritis Rheum (2005) 1.23
Identification of markers to characterize and sort human articular chondrocytes with enhanced in vitro chondrogenic capacity. Arthritis Rheum (2007) 1.20
Stimulation of GCMa and syncytin via cAMP mediated PKA signaling in human trophoblastic cells under normoxic and hypoxic conditions. FEBS Lett (2005) 1.13
Discrete integration of collagen XVI into tissue-specific collagen fibrils or beaded microfibrils. Matrix Biol (2003) 1.10
Prognostic and putative predictive biomarkers of gastric cancer for personalized medicine. Diagn Mol Pathol (2013) 1.09
Neurodevelopmental deficits in Pierson (microcoria-congenital nephrosis) syndrome. Am J Med Genet A (2007) 1.09
Parosteal lipoma of the thigh with cartilaginous and osseous differentiation: an osteochondrolipoma. Ann Diagn Pathol (2006) 1.07
Regulation of type II collagen synthesis during osteoarthritis by prolyl-4-hydroxylases: possible influence of low oxygen levels. Am J Pathol (2006) 1.07
Human papillomavirus infection in head and neck cancer: the role of the secretory leukocyte protease inhibitor. Oncol Rep (2013) 1.06
Transforming growth factor alpha suppression of articular chondrocyte phenotype and Sox9 expression in a rat model of osteoarthritis. Arthritis Rheum (2007) 1.04
Transgene-activated mesenchymal cells for articular cartilage repair: a comparison of primary bone marrow-, perichondrium/periosteum- and fat-derived cells. J Gene Med (2006) 1.04
Evidence for a role of the amyloid precursor protein in thyroid carcinogenesis. J Endocrinol (2008) 1.03
Population doublings and percentage of S100-positive cells as predictors of in vitro chondrogenicity of expanded human articular chondrocytes. J Cell Physiol (2010) 1.02
Proteomic analysis of synovial fluid from the osteoarthritic knee: comparison with transcriptome analyses of joint tissues. Arthritis Rheum (2013) 1.00
Cleavage site specificity of cathepsin K toward cartilage proteoglycans and protease complex formation. Biol Chem (2003) 1.00
IL-1beta induction of IL-6 and LIF in normal articular human chondrocytes involves the ERK, p38 and NFkappaB signaling pathways. Cytokine (2004) 1.00
Matrix-associated implantation of predifferentiated mesenchymal stem cells versus articular chondrocytes: in vivo results of cartilage repair after 1 year. Am J Sports Med (2011) 0.99
Gene expression profiling of serum- and interleukin-1 beta-stimulated primary human adult articular chondrocytes--a molecular analysis based on chondrocytes isolated from one donor. Cytokine (2005) 0.98
Functional in vivo imaging of cysteine cathepsin activity in murine model of inflammation. Bioorg Med Chem (2010) 0.97
Quantification of expression levels of cellular differentiation markers does not support a general shift in the cellular phenotype of osteoarthritic chondrocytes. J Orthop Res (2003) 0.96
Antisense inhibition of osteogenic protein 1 disturbs human articular cartilage integrity. Arthritis Rheum (2005) 0.96
HPV DNA, E6*I-mRNA expression and p16INK4A immunohistochemistry in head and neck cancer - how valid is p16INK4A as surrogate marker? Cancer Lett (2012) 0.95
KRAS, NRAS, PIK3CA exon 20, and BRAF genotypes in synchronous and metachronous primary colorectal cancers diagnostic and therapeutic implications. J Mol Diagn (2011) 0.95
Role of mitogen-activated protein kinases and NFkappaB on IL-1beta-induced effects on collagen type II, MMP-1 and 13 mRNA expression in normal articular human chondrocytes. Rheumatol Int (2006) 0.95
Bone morphogenetic protein and transforming growth factor beta inhibitory Smads 6 and 7 are expressed in human adult normal and osteoarthritic cartilage in vivo and are differentially regulated in vitro by interleukin-1beta. Arthritis Rheum (2004) 0.94
SOX gene expression in human osteoarthritic cartilage. Pathobiology (2008) 0.93
Osteomyelitis of the ulna caused by Porphyromonas gingivalis. J Clin Microbiol (2006) 0.92
HPV status in patients with head and neck of carcinoma of unknown primary site: HPV, tobacco smoking, and outcome. Oral Oncol (2012) 0.92
FOXO3a: a novel player in thyroid carcinogenesis? Endocr Relat Cancer (2008) 0.92
Type II collagen as specific marker for mesenchymal chondrosarcomas compared to other small cell sarcomas of the skeleton. Mod Pathol (2005) 0.91
Bone morphogenetic protein-mediating receptor-associated Smads as well as common Smad are expressed in human articular chondrocytes but not up-regulated or down-regulated in osteoarthritic cartilage. J Bone Miner Res (2002) 0.91
Residual lymph node metastasis in stage 4 neuroblastoma--advantage of radio-guided surgery? Pediatr Hematol Oncol (2010) 0.90
Regulation of chondrocyte gene expression by osteogenic protein-1. Arthritis Res Ther (2011) 0.90
Jun activation domain-binding protein 1 binds Smad5 and inhibits bone morphogenetic protein signaling. Arthritis Rheum (2006) 0.88
Homeostatic effects of the metalloproteinase disintegrin ADAM15 in degenerative cartilage remodeling. Arthritis Rheum (2005) 0.88
Functional genomics of osteoarthritis: on the way to evaluate disease hypotheses. Clin Orthop Relat Res (2004) 0.88
Clinicopathologic Characteristics of Microsatellite Instable Gastric Carcinomas Revisited: Urgent Need for Standardization. Appl Immunohistochem Mol Morphol (2017) 0.85
ADAMTS-1, a gene product of articular chondrocytes in vivo and in vitro, is downregulated by interleukin 1beta. J Rheumatol (2004) 0.85
TAK1 downregulation reduces IL-1beta induced expression of MMP13, MMP1 and TNF-alpha. Biomed Pharmacother (2005) 0.85
Down-regulation of the GTPase RhoB might be involved in the pre-apoptotic phenotype of osteoarthritic chondrocytes. Front Biosci (2004) 0.85
The role of the antileukoprotease SLPI in smoking-induced human papillomavirus-independent head and neck squamous cell carcinomas. Int J Cancer (2013) 0.84
ADAM15 exerts an antiapoptotic effect on osteoarthritic chondrocytes via up-regulation of the X-linked inhibitor of apoptosis. Arthritis Rheum (2010) 0.84
Repression of anti-proliferative factor Tob1 in osteoarthritic cartilage. Arthritis Res Ther (2005) 0.84
Analysis of glomerular VEGF mRNA and protein expression in murine mesangioproliferative glomerulonephritis. Virchows Arch (2006) 0.83
E-cadherin as a reliable cell surface marker for the identification of liver specific stem cells. J Mol Histol (2007) 0.82
Functional and morphologic characterization of eosinophils in the lower intestinal mucosa of patients with food allergy. Am J Gastroenterol (2003) 0.82
EBV-associated post-transplantation B-cell lymphoproliferative disorder following allogenic stem cell transplantation for acute lymphoblastic leukaemia: tumor regression after reduction of immunosuppression--a case report. Diagn Pathol (2010) 0.82
Monitoring recovery from iron deficiency using total hemoglobin mass. Med Sci Sports Exerc (2015) 0.82
Analysis of differential gene expression in healthy and osteoarthritic cartilage and isolated chondrocytes by microarray analysis. Methods Mol Med (2004) 0.82
Mixed hepatoblastoma and teratoma of the liver in a 3-year-old child: a unique combination and clinical challenge. Diagn Pathol (2009) 0.82
Phenotypic characterization of human chondrocyte cell line C-20/A4: a comparison between monolayer and alginate suspension culture. Cells Tissues Organs (2004) 0.81
Matrix biochemistry and cell biology of dedifferentiated chondrosarcomas. Pathol Int (2010) 0.81
Outcome of patients with pre-existing portal vein thrombosis undergoing arterialization of the portal vein during liver transplantation. Transpl Int (2002) 0.81
Infiltration of the pes anserinus complex by an extraarticular diffuse-type giant cell tumor (D-TGCT). Arch Orthop Trauma Surg (2007) 0.81
Hepatocyte growth factor/scatter factor is not a potent regulator of anabolic and catabolic gene expression in adult human articular chondrocytes. Biochem Biophys Res Commun (2004) 0.81
Normalization and gene p-value estimation: issues in microarray data processing. Bioinform Biol Insights (2008) 0.80
Klinefelter syndrome and mediastinal germ cell tumors. Am J Med Genet A (2006) 0.80
Melanomas of unknown primary frequently harbor TERT-promoter mutations. Melanoma Res (2014) 0.80
ATTR amyloid in the carpal tunnel ligament is frequently of wildtype transthyretin origin. Amyloid (2012) 0.79
Identification of calponin 3 as a novel Smad-binding modulator of BMP signaling expressed in cartilage. Exp Cell Res (2007) 0.79
Analysis of protein distribution in cartilage using immunofluorescence and laser confocal scanning microscopy. Methods Mol Med (2004) 0.78
Functional genomics of osteoarthritis. Pharmacogenomics (2002) 0.78
Quantification of mRNA expression levels in articular chondrocytes with PCR technologies. Methods Mol Med (2004) 0.78
Malignant fibrous histiocytoma at the site of a total hip arthroplasty. Clin Orthop Relat Res (2004) 0.78
Insulin-like growth factor-binding protein-3 in osteosarcomas and normal bone tissues. Anticancer Res (2009) 0.78
Response of HEK293 and CHO cells overexpressing fusiogenic syncytin-1 to mitochondrion-mediated apoptosis induced by antimycin A. J Cell Biochem (2008) 0.78
Soft tissue metastasis of thyroid carcinoma in the knee region mimicking a paraarticular inflammatory lesion. Arch Orthop Trauma Surg (2010) 0.78
Posterior fibrous pseudometaplasia of lens epithelial cells in phacic eyes filled with silicone oil. Graefes Arch Clin Exp Ophthalmol (2002) 0.77
Nanomedicine: AFM tackles osteoarthritis. Nat Nanotechnol (2009) 0.77
Hgs physically interacts with Smad5 and attenuates BMP signaling. Exp Cell Res (2006) 0.77
The human chondrosarcoma HCS-2/8 cell line is responsive to BMP-7, but not to IL-1beta. Front Biosci (2005) 0.77
Metalloproteinases in juvenile angiofibroma--a collagen rich tumor. Hum Pathol (2007) 0.77