Published in AIDS Res Hum Retroviruses on January 01, 2015
CRISPR/gRNA-directed synergistic activation mediator (SAM) induces specific, persistent and robust reactivation of the HIV-1 latent reservoirs. Sci Rep (2015) 0.98
CRISPR-mediated Activation of Latent HIV-1 Expression. Mol Ther (2015) 0.88
Functional screening of guide RNAs targeting the regulatory and structural HIV-1 viral genome for a cure of AIDS. AIDS (2016) 0.82
Specific Reactivation of Latent HIV-1 by dCas9-SunTag-VP64-mediated Guide RNA Targeting the HIV-1 Promoter. Mol Ther (2016) 0.81
HIV-1 Latency and Eradication: Past, Present and Future. Curr HIV Res (2016) 0.80
Reactivation of Latent HIV-1 Expression by Engineered TALE Transcription Factors. PLoS One (2016) 0.77
A TALE nuclease architecture for efficient genome editing. Nat Biotechnol (2010) 26.47
Breaking the code of DNA binding specificity of TAL-type III effectors. Science (2009) 22.33
A simple cipher governs DNA recognition by TAL effectors. Science (2009) 19.99
Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science (1997) 18.10
Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting. Nucleic Acids Res (2011) 16.53
Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription. Nat Biotechnol (2011) 12.86
Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells. Nat Med (2003) 9.75
The challenge of finding a cure for HIV infection. Science (2009) 8.41
TAL effectors: finding plant genes for disease and defense. Curr Opin Plant Biol (2010) 7.13
HIV reproducibly establishes a latent infection after acute infection of T cells in vitro. EMBO J (2003) 6.11
Plant pathogen recognition mediated by promoter activation of the pepper Bs3 resistance gene. Science (2007) 4.39
A bacterial effector acts as a plant transcription factor and induces a cell size regulator. Science (2007) 4.27
The site of HIV-1 integration in the human genome determines basal transcriptional activity and response to Tat transactivation. EMBO J (2001) 3.80
Synergistic and tunable human gene activation by combinations of synthetic transcription factors. Nat Methods (2013) 3.26
Robust, synergistic regulation of human gene expression using TALE activators. Nat Methods (2013) 2.89
Targeted transcriptional activation of silent oct4 pluripotency gene by combining designer TALEs and inhibition of epigenetic modifiers. Nucleic Acids Res (2012) 2.83
HIV-1 proviral DNA excision using an evolved recombinase. Science (2007) 2.81
Harnessing the CRISPR/Cas9 system to disrupt latent HIV-1 provirus. Sci Rep (2013) 2.48
Barriers to a cure for HIV: new ways to target and eradicate HIV-1 reservoirs. Lancet (2013) 2.11
The control of HIV transcription: keeping RNA polymerase II on track. Cell Host Microbe (2011) 2.05
Prospects for treatment of latent HIV. Clin Pharmacol Ther (2012) 1.91
Viral reservoirs, residual viremia, and the potential of highly active antiretroviral therapy to eradicate HIV infection. J Allergy Clin Immunol (2008) 1.91
TAL effector-DNA specificity. Virulence (2010) 1.49
Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cells. Nucleic Acids Res (2013) 1.48
Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator. IUBMB Life (2001) 1.37
Activation of HIV transcription by the viral Tat protein requires a demethylation step mediated by lysine-specific demethylase 1 (LSD1/KDM1). PLoS Pathog (2011) 1.31
Transcription activator-like effector proteins induce the expression of the frataxin gene. Hum Gene Ther (2012) 1.31
Histone deacetylase inhibitors for purging HIV-1 from the latent reservoir. Mol Med (2011) 1.30
Exploring strategies for the design of artificial transcription factors: targeting sites proximal to known regulatory regions for the induction of gamma-globin expression and the treatment of sickle cell disease. J Biol Chem (2004) 1.30
Functions of Tat: the versatile protein of human immunodeficiency virus type 1. J Gen Virol (2009) 1.29
Attenuation of HIV-1 replication in primary human cells with a designed zinc finger transcription factor. J Biol Chem (2004) 1.24
Regulation of HIV-1 gene expression by the transactivator protein Tat. Curr Top Microbiol Immunol (1995) 1.19
Transcriptional suppression of in vitro-integrated human immunodeficiency virus type 1 does not correlate with proviral DNA methylation. J Virol (2003) 1.15
Eradication of HIV: current challenges and new directions. J Antimicrob Chemother (2008) 1.08
Inhibition of human immunodeficiency virus type 1 replication with artificial transcription factors targeting the highly conserved primer-binding site. J Virol (2006) 1.07
Nonclinical safety assessment of the histone deacetylase inhibitor vorinostat. Int J Toxicol (2009) 1.01
Reservoirs of HIV-1 in vivo: implications for antiretroviral therapy. AIDS Rev (2003) 0.97
Human immunodeficiency virus (HIV) latency: the major hurdle in HIV eradication. Mol Med (2012) 0.96
Involvement of histone methyltransferase GLP in HIV-1 latency through catalysis of H3K9 dimethylation. Virology (2013) 0.89
HIV reservoirs: the new frontier. AIDS Rev (2011) 0.87
Specific reactivation of latent HIV-1 with designer zinc-finger transcription factors targeting the HIV-1 5'-LTR promoter. Gene Ther (2014) 0.85
A lentiviral vector that activates latent human immunodeficiency virus-1 proviruses by the overexpression of tat and that kills the infected cells. Hum Gene Ther (2009) 0.84
As2O3 synergistically reactivate latent HIV-1 by induction of NF-κB. Antiviral Res (2013) 0.83
A suicide gene approach using the human pro-apoptotic protein tBid inhibits HIV-1 replication. BMC Biotechnol (2011) 0.82
Selective histonedeacetylase inhibitor M344 intervenes in HIV-1 latency through increasing histone acetylation and activation of NF-kappaB. PLoS One (2012) 0.81
Assignment of orthologous genes via genome rearrangement. IEEE/ACM Trans Comput Biol Bioinform (2006) 1.66
Deficiency of FLCN in mouse kidney led to development of polycystic kidneys and renal neoplasia. PLoS One (2008) 1.64
RKIP sensitizes prostate and breast cancer cells to drug-induced apoptosis. J Biol Chem (2004) 1.61
Mechanism of constitutive phosphoinositide 3-kinase activation by oncogenic mutants of the p85 regulatory subunit. J Biol Chem (2005) 1.57
Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cells. Nucleic Acids Res (2013) 1.48
Loss of parafibromin immunoreactivity is a distinguishing feature of parathyroid carcinoma. Clin Cancer Res (2004) 1.47
Activation of the receptor for advanced glycation end products (RAGE) exacerbates experimental autoimmune myasthenia gravis symptoms. Clin Immunol (2011) 1.42
Prognostic role of microRNA-21 in various carcinomas: a systematic review and meta-analysis. Eur J Clin Invest (2011) 1.42
PET-based biodistribution and radiation dosimetry of epidermal growth factor receptor-selective tracer 11C-PD153035 in humans. J Nucl Med (2009) 1.39
Synthetic studies of complex immunostimulants from Quillaja saponaria: synthesis of the potent clinical immunoadjuvant QS-21Aapi. J Am Chem Soc (2006) 1.39
Identification of the proliferation/differentiation switch in the cellular network of multicellular organisms. PLoS Comput Biol (2006) 1.32
Improved spatial learning performance of fat-1 mice is associated with enhanced neurogenesis and neuritogenesis by docosahexaenoic acid. Proc Natl Acad Sci U S A (2009) 1.32
Prognostic role of systemic inflammatory response in renal cell carcinoma: a systematic review and meta-analysis. J Cancer Res Clin Oncol (2010) 1.27
The biology of a prostate cancer metastasis suppressor protein: Raf kinase inhibitor protein. J Cell Biochem (2005) 1.25
Prognostic value of 18F-FDG PET-CT metabolic index for nasopharyngeal carcinoma. J Cancer Res Clin Oncol (2009) 1.25
New sensing mechanisms for design of fluorescent chemosensors emerging in recent years. Chem Soc Rev (2011) 1.21
18F-FDG PET or PET-CT to evaluate prognosis for head and neck cancer: a meta-analysis. J Cancer Res Clin Oncol (2011) 1.19
The role of Raf kinase inhibitor protein (RKIP) in health and disease. Biochem Pharmacol (2004) 1.18
Comparison of tumor volumes as determined by pathologic examination and FDG-PET/CT images of non-small-cell lung cancer: a pilot study. Int J Radiat Oncol Biol Phys (2009) 1.17
Using 18F-fluorodeoxyglucose positron emission tomography to estimate the length of gross tumor in patients with squamous cell carcinoma of the esophagus. Int J Radiat Oncol Biol Phys (2008) 1.16
Prognostic role of C-reactive protein in breast cancer: a systematic review and meta-analysis. Int J Biol Markers (2011) 1.15
Raf kinase inhibitory protein inhibits beta-cell proliferation. Surgery (2004) 1.12
NMR implementation of a molecular hydrogen quantum simulation with adiabatic state preparation. Phys Rev Lett (2010) 1.09
Raf kinase inhibitor protein: a prostate cancer metastasis suppressor gene. Cancer Lett (2004) 1.09
Additional value of PET/CT over PET in assessment of locoregional lymph nodes in thoracic esophageal squamous cell cancer. J Nucl Med (2006) 1.07
Impacts of protein-protein interaction domains on organism and network complexity. Genome Res (2008) 1.05
Comparison of (18)F-fluorothymidine and (18)F-fluorodeoxyglucose PET/CT in delineating gross tumor volume by optimal threshold in patients with squamous cell carcinoma of thoracic esophagus. Int J Radiat Oncol Biol Phys (2009) 1.03
Diagnostic and prognostic value of 18F-FDG PET/CT for patients with suspected recurrence from squamous cell carcinoma of the esophagus. J Nucl Med (2007) 1.03
Low-cost wavelength measurement based on a macrobending single-mode fiber. Opt Lett (2006) 1.02
Drug interactions with Bacillus anthracis topoisomerase IV: biochemical basis for quinolone action and resistance. Biochemistry (2011) 1.01
A computerized system for signal detection in spontaneous reporting system of Shanghai China. Pharmacoepidemiol Drug Saf (2009) 1.01
Improved thermal performance of Thermomyces lanuginosus GH11 xylanase by engineering of an N-terminal disulfide bridge. Bioresour Technol (2012) 1.01
Three-dimensional positron emission tomography image texture analysis of esophageal squamous cell carcinoma: relationship between tumor 18F-fluorodeoxyglucose uptake heterogeneity, maximum standardized uptake value, and tumor stage. Nucl Med Commun (2013) 1.00
The highly modified microcin peptide plantazolicin is associated with nematicidal activity of Bacillus amyloliquefaciens FZB42. Appl Microbiol Biotechnol (2013) 0.99
Observation of an anomalous decoherence effect in a quantum bath at room temperature. Nat Commun (2011) 0.99
Value of dual-time-point FDG PET/CT for mediastinal nodal staging in non-small-cell lung cancer patients with lung comorbidity. Clin Nucl Med (2011) 0.98
Characterization of the enzymes encoded by the anthrose biosynthetic operon of Bacillus anthracis. J Bacteriol (2010) 0.98
Single-mode tunable laser emission in the single-exciton regime from colloidal nanocrystals. Nat Commun (2013) 0.98
Value of PET/CT versus enhanced CT for locoregional lymph nodes in non-small cell lung cancer. Lung Cancer (2008) 0.98
Biweekly oxaliplatin in combination with continuous infusional 5-fluorouracil and leucovorin (modified FOLFOX-4 regimen) as first-line chemotherapy for elderly patients with advanced gastric cancer. Am J Clin Oncol (2008) 0.97
Polyethylene glycosylated curcumin conjugate inhibits pancreatic cancer cell growth through inactivation of Jab1. Mol Pharmacol (2009) 0.97
Novel thermally activated delayed fluorescence materials-thioxanthone derivatives and their applications for highly efficient OLEDs. Adv Mater (2014) 0.97
N-acetyl-L-cysteine protects against cadmium-induced neuronal apoptosis by inhibiting ROS-dependent activation of Akt/mTOR pathway in mouse brain. Neuropathol Appl Neurobiol (2014) 0.97
Fiber refractometer based on a fiber Bragg grating and single-mode-multimode-single-mode fiber structure. Opt Lett (2011) 0.96
Histonedeacetylase inhibitor Oxamflatin increase HIV-1 transcription by inducing histone modification in latently infected cells. Mol Biol Rep (2010) 0.95
The suppressive effect of triptolide on chronic colitis and TNF-alpha/TNFR2 signal pathway in interleukin-10 deficient mice. Clin Immunol (2008) 0.94
Isolation and characterization of a Chinese strain of Tembusu virus from Hy-Line Brown layers with acute egg-drop syndrome in Fujian, China. Arch Virol (2013) 0.93
Imaging of proliferation with 18F-FLT PET/CT versus 18F-FDG PET/CT in non-small-cell lung cancer. Eur J Nucl Med Mol Imaging (2010) 0.92
Over-expression of the p110beta but not p110alpha isoform of PI 3-kinase inhibits motility in breast cancer cells. Cell Motil Cytoskeleton (2004) 0.91
Resolution investigation of a ratiometric wavelength measurement system. Appl Opt (2007) 0.91
Dual-time-point FDG PET for the evaluation of locoregional lymph nodes in thoracic esophageal squamous cell cancer. Eur J Radiol (2008) 0.90
Arsenic trioxide exerts synergistic effects with cisplatin on non-small cell lung cancer cells via apoptosis induction. J Exp Clin Cancer Res (2009) 0.90
Involvement of histone methyltransferase GLP in HIV-1 latency through catalysis of H3K9 dimethylation. Virology (2013) 0.89
Electric communication between the inner part of a cell and an electrode: the way to look inside a cell. Anal Chem (2009) 0.89
Growth of alloy MoS(2x)Se2(1-x) nanosheets with fully tunable chemical compositions and optical properties. J Am Chem Soc (2014) 0.89
Prognostic role of microRNA-155 in various carcinomas: results from a meta-analysis. Dis Markers (2013) 0.88
Coherence-protected quantum gate by continuous dynamical decoupling in diamond. Phys Rev Lett (2012) 0.88
Osteoprotegerin abrogates chronic alcohol ingestion-induced bone loss in mice. J Bone Miner Res (2002) 0.88
Relationship between primary tumor fluorodeoxyglucose uptake and nodal or distant metastases at presentation in T1 stage non-small cell lung cancer. Lung Cancer (2008) 0.88
Different efficacy of EGFR tyrosine kinase inhibitors and prognosis in patients with subtypes of EGFR-mutated advanced non-small cell lung cancer: a meta-analysis. J Cancer Res Clin Oncol (2014) 0.88
Wheat germ agglutinin-grafted lipid nanoparticles: preparation and in vitro evaluation of the association with Caco-2 monolayers. Int J Pharm (2010) 0.87
A prospective study of biomarker-guided chemotherapy in patients with non-small cell lung cancer. Cancer Chemother Pharmacol (2014) 0.87
Delta-6-desaturase activity and arachidonic acid synthesis are increased in human breast cancer tissue. Cancer Sci (2013) 0.86
Upregulation of PHLDA2 in Dicer knockdown HEK293 cells. Biochim Biophys Acta (2007) 0.86
A modified model of the abdominal compartment syndrome. J Trauma (2011) 0.85
Wavelength-converted/selective waveguiding based on composition-graded semiconductor nanowires. Nano Lett (2012) 0.85
QM/MM refinement and analysis of protein bound retinoic acid. J Comput Chem (2011) 0.85
Asymmetric light propagation in composition-graded semiconductor nanowires. Sci Rep (2012) 0.85
Experimental study of the inhibition of human hepatocarcinoma Bel7402 cells by the tripeptide tyroserleutide(YSL). Cancer Chemother Pharmacol (2005) 0.85
[Necessity of applying pharmacovigilance in post-marketing safety monitoring of traditional Chinese medicine injections]. Zhongguo Zhong Yao Za Zhi (2008) 0.84
A microfiber coupler tip thermometer. Opt Express (2012) 0.84
Multi-enzyme co-embedded organic-inorganic hybrid nanoflowers: synthesis and application as a colorimetric sensor. Nanoscale (2013) 0.84
Imaging proliferation of ¹⁸F-FLT PET/CT correlated with the expression of microvessel density of tumour tissue in non-small-cell lung cancer. Eur J Nucl Med Mol Imaging (2012) 0.84
As2O3 synergistically reactivate latent HIV-1 by induction of NF-κB. Antiviral Res (2013) 0.83
Inter- and intramolecular stereoselective protonation of enols(1,2). J Org Chem (2002) 0.83
The role of oxygen-free radical in the apoptosis of enterocytes and bacterial translocation in abdominal compartment syndrome. Free Radic Res (2009) 0.83
Superparamagnetic MFe2O 4 (M = Ni, Co, Zn, Mn) nanoparticles: synthesis, characterization, induction heating and cell viability studies for cancer hyperthermia applications. J Mater Sci Mater Med (2015) 0.83
Room-temperature dual-wavelength lasing from single-nanoribbon lateral heterostructures. J Am Chem Soc (2012) 0.82
Quasi-periodic gratings: diffraction orders accelerate along curves. Opt Lett (2013) 0.82
Microscopic and ultrastructural changes of the intestine in abdominal compartment syndrome. J Invest Surg (2009) 0.82
Development of trityl-based photolabile hydroxyl protecting groups. J Org Chem (2011) 0.82
Mitochondria-targeting properties and photodynamic activities of porphyrin derivatives bearing cationic pendant. J Photochem Photobiol B (2009) 0.82
Distinct expression patterns of ICK/MAK/MOK protein kinases in the intestine implicate functional diversity. PLoS One (2013) 0.82
Clinical applications of 18F-fluorodeoxyglucose positron emission tomography/computed tomography in carcinoma of unknown primary. Chin Med J (Engl) (2011) 0.82
Proteomic analysis reveals the strategies of Bacillus thuringiensis YBT-1520 for survival under long-term heat stress. Proteomics (2011) 0.82
Two novel myocilin mutations in a Chinese family with primary open-angle glaucoma. Mol Vis (2008) 0.82
Effects of IL-17A on the occurrence of lung adenocarcinoma. Cancer Biol Ther (2011) 0.82
Effect of CCR5-Δ32 heterozygosity on HIV-1 susceptibility: a meta-analysis. PLoS One (2012) 0.81
Selective histonedeacetylase inhibitor M344 intervenes in HIV-1 latency through increasing histone acetylation and activation of NF-kappaB. PLoS One (2012) 0.81
Intestinal cell kinase (ICK) promotes activation of mTOR complex 1 (mTORC1) through phosphorylation of Raptor Thr-908. J Biol Chem (2012) 0.81
Semiconductor alloy nanoribbon lateral heterostructures for high-performance photodetectors. Adv Mater (2014) 0.81
A colorimetric and ratiometric fluorescent probe for thiols and its bioimaging applications. Chem Commun (Camb) (2010) 0.81