Published in Science on October 26, 2007
A TALE nuclease architecture for efficient genome editing. Nat Biotechnol (2010) 26.47
Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription. Nat Biotechnol (2011) 12.86
Plant immunity: towards an integrated view of plant-pathogen interactions. Nat Rev Genet (2010) 7.56
A transcription activator-like effector toolbox for genome engineering. Nat Protoc (2012) 6.81
Regulation of selected genome loci using de novo-engineered transcription activator-like effector (TALE)-type transcription factors. Proc Natl Acad Sci U S A (2010) 5.65
The crystal structure of TAL effector PthXo1 bound to its DNA target. Science (2012) 3.69
Structural basis for sequence-specific recognition of DNA by TAL effectors. Science (2012) 3.64
Transcriptional activators of human genes with programmable DNA-specificity. PLoS One (2011) 3.16
Assembly of designer TAL effectors by Golden Gate cloning. PLoS One (2011) 3.05
From Guard to Decoy: a new model for perception of plant pathogen effectors. Plant Cell (2008) 2.62
Finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity, and stealth pathogenesis. PLoS Genet (2011) 2.58
A single plant resistance gene promoter engineered to recognize multiple TAL effectors from disparate pathogens. Proc Natl Acad Sci U S A (2009) 2.22
Conserved C-terminal motifs required for avirulence and suppression of cell death by Phytophthora sojae effector Avr1b. Plant Cell (2008) 2.15
Rice xa13 recessive resistance to bacterial blight is defeated by induction of the disease susceptibility gene Os-11N3. Plant Cell (2010) 2.15
Recognition of AvrBs3-like proteins is mediated by specific binding to promoters of matching pepper Bs3 alleles. Plant Physiol (2009) 2.13
The Ustilago maydis effector Pep1 suppresses plant immunity by inhibition of host peroxidase activity. PLoS Pathog (2012) 2.05
Phytopathogen type III effector weaponry and their plant targets. Curr Opin Plant Biol (2008) 1.98
Phytoplasma protein effector SAP11 enhances insect vector reproduction by manipulating plant development and defense hormone biosynthesis. Proc Natl Acad Sci U S A (2011) 1.67
XopD SUMO protease affects host transcription, promotes pathogen growth, and delays symptom development in xanthomonas-infected tomato leaves. Plant Cell (2008) 1.62
Targeted transcriptional repression using a chimeric TALE-SRDX repressor protein. Plant Mol Biol (2011) 1.57
Epigenetics and bacterial infections. Cold Spring Harb Perspect Med (2012) 1.56
Lymphoid regeneration from gene-corrected SCID-X1 subject-derived iPSCs. Cell Stem Cell (2015) 1.52
Rational diversification of a promoter providing fine-tuned expression and orthogonal regulation for synthetic biology. PLoS One (2012) 1.52
Transcriptional programming and functional interactions within the Phytophthora sojae RXLR effector repertoire. Plant Cell (2011) 1.47
Disease resistance or growth: the role of plant hormones in balancing immune responses and fitness costs. Front Plant Sci (2013) 1.46
The TAL effector PthA4 interacts with nuclear factors involved in RNA-dependent processes including a HMG protein that selectively binds poly(U) RNA. PLoS One (2012) 1.44
Host and pathogen factors controlling the rice-Xanthomonas oryzae interaction. Plant Physiol (2009) 1.41
The bacterial pathogen Xanthomonas oryzae overcomes rice defenses by regulating host copper redistribution. Plant Cell (2010) 1.39
Dissection of TALE-dependent gene activation reveals that they induce transcription cooperatively and in both orientations. PLoS One (2017) 1.37
Autoacetylation of the Ralstonia solanacearum effector PopP2 targets a lysine residue essential for RRS1-R-mediated immunity in Arabidopsis. PLoS Pathog (2010) 1.36
TALEs of genome targeting. Nat Biotechnol (2011) 1.35
Xanthomonas T3S Effector XopN Suppresses PAMP-Triggered Immunity and Interacts with a Tomato Atypical Receptor-Like Kinase and TFT1. Plant Cell (2009) 1.33
Recognition of methylated DNA by TAL effectors. Cell Res (2012) 1.23
Loss of susceptibility as a novel breeding strategy for durable and broad-spectrum resistance. Mol Breed (2009) 1.20
The Xanthomonas type III effector XopD targets the Arabidopsis transcription factor MYB30 to suppress plant defense. Plant Cell (2011) 1.16
Intervention of Phytohormone Pathways by Pathogen Effectors. Plant Cell (2014) 1.14
Nuclear jasmonate and salicylate signaling and crosstalk in defense against pathogens. Front Plant Sci (2013) 1.12
Nuclear dynamics during plant innate immunity. Plant Physiol (2011) 1.08
An improved method for TAL effectors DNA-binding sites prediction reveals functional convergence in TAL repertoires of Xanthomonas oryzae strains. PLoS One (2013) 1.07
Allele-specific virulence attenuation of the Pseudomonas syringae HopZ1a type III effector via the Arabidopsis ZAR1 resistance protein. PLoS Genet (2010) 1.06
RNA-seq pinpoints a Xanthomonas TAL-effector activated resistance gene in a large-crop genome. Proc Natl Acad Sci U S A (2012) 1.06
The rice TAL effector-dependent resistance protein XA10 triggers cell death and calcium depletion in the endoplasmic reticulum. Plant Cell (2014) 1.04
Computational predictions provide insights into the biology of TAL effector target sites. PLoS Comput Biol (2013) 1.04
Code-assisted discovery of TAL effector targets in bacterial leaf streak of rice reveals contrast with bacterial blight and a novel susceptibility gene. PLoS Pathog (2014) 1.00
TAL effectors: function, structure, engineering and applications. Curr Opin Struct Biol (2012) 0.99
A pathogen type III effector with a novel E3 ubiquitin ligase architecture. PLoS Pathog (2013) 0.99
Nonhost resistance of barley to different fungal pathogens is associated with largely distinct, quantitative transcriptional responses. Plant Physiol (2010) 0.98
Mouse genetics: catalogue and scissors. BMB Rep (2012) 0.97
Less is more: strategies to remove marker genes from transgenic plants. BMC Biotechnol (2013) 0.96
Detection and functional characterization of a 215 amino acid N-terminal extension in the Xanthomonas type III effector XopD. PLoS One (2010) 0.95
Lateral organ boundaries 1 is a disease susceptibility gene for citrus bacterial canker disease. Proc Natl Acad Sci U S A (2014) 0.95
On the front line: structural insights into plant-pathogen interactions. Nat Rev Microbiol (2013) 0.95
Quantitative and qualitative stem rust resistance factors in barley are associated with transcriptional suppression of defense regulons. PLoS Genet (2011) 0.95
Molecular dynamics simulations of DNA-free and DNA-bound TAL effectors. PLoS One (2013) 0.94
Determining the specificities of TALENs, Cas9, and other genome-editing enzymes. Methods Enzymol (2014) 0.93
Comparative analysis of the XopD type III secretion (T3S) effector family in plant pathogenic bacteria. Mol Plant Pathol (2011) 0.92
Characterization and DNA-binding specificities of Ralstonia TAL-like effectors. Mol Plant (2013) 0.92
Unifying themes in microbial associations with animal and plant hosts described using the gene ontology. Microbiol Mol Biol Rev (2010) 0.91
Regulation of cell wall-bound invertase in pepper leaves by Xanthomonas campestris pv. vesicatoria type three effectors. PLoS One (2012) 0.90
Enabling functional genomics with genome engineering. Genome Res (2015) 0.90
Genomic editing tools to model human diseases with isogenic pluripotent stem cells. Stem Cells Dev (2014) 0.89
The grape berry-specific basic helix-loop-helix transcription factor VvCEB1 affects cell size. J Exp Bot (2013) 0.88
Identification of putative TAL effector targets of the citrus canker pathogens shows functional convergence underlying disease development and defense response. BMC Genomics (2014) 0.88
Repeat 1 of TAL effectors affects target specificity for the base at position zero. Nucleic Acids Res (2014) 0.88
From perception to activation: the molecular-genetic and biochemical landscape of disease resistance signaling in plants. Arabidopsis Book (2010) 0.87
TAL effectors and activation of predicted host targets distinguish Asian from African strains of the rice pathogen Xanthomonas oryzae pv. oryzicola while strict conservation suggests universal importance of five TAL effectors. Front Plant Sci (2015) 0.87
TAL effector specificity for base 0 of the DNA target is altered in a complex, effector- and assay-dependent manner by substitutions for the tryptophan in cryptic repeat -1. PLoS One (2013) 0.87
An RNA virus-encoded zinc-finger protein acts as a plant transcription factor and induces a regulator of cell size and proliferation in two tobacco species. Plant Cell (2013) 0.87
Characterization of Xanthomonas oryzae-responsive cis-acting element in the promoter of rice race-specific susceptibility gene Xa13. Mol Plant (2011) 0.86
Information processing without brains--the power of intercellular regulators in plants. Development (2010) 0.85
Genome-Wide Identification and Validation of Reference Genes in Infected Tomato Leaves for Quantitative RT-PCR Analyses. PLoS One (2015) 0.85
The potential of effector-target genes in breeding for plant innate immunity. Microb Biotechnol (2012) 0.85
Dynamics of defense responses and cell fate change during Arabidopsis-Pseudomonas syringae interactions. PLoS One (2013) 0.85
Go in for the kill. Virulence (2014) 0.85
A simple and efficient method for assembling TALE protein based on plasmid library. PLoS One (2013) 0.85
Precision genetic modifications: a new era in molecular biology and crop improvement. Planta (2014) 0.83
The Genomes of Three Uneven Siblings: Footprints of the Lifestyles of Three Trichoderma Species. Microbiol Mol Biol Rev (2016) 0.82
Functional characterization of the type III secretion substrate specificity switch protein HpaC from Xanthomonas campestris pv. vesicatoria. Infect Immun (2011) 0.82
TAL effectors and the executor R genes. Front Plant Sci (2015) 0.82
MorTAL Kombat: the story of defense against TAL effectors through loss-of-susceptibility. Front Plant Sci (2015) 0.82
TAL effectors target the C-terminal domain of RNA polymerase II (CTD) by inhibiting the prolyl-isomerase activity of a CTD-associated cyclophilin. PLoS One (2012) 0.81
Designed transcription activator-like effector proteins efficiently induced the expression of latent HIV-1 in latently infected cells. AIDS Res Hum Retroviruses (2015) 0.81
Phytohormone pathways as targets of pathogens to facilitate infection. Plant Mol Biol (2016) 0.80
Transcription activator-like effectors: a toolkit for synthetic biology. ACS Synth Biol (2014) 0.80
An Oomycete CRN Effector Reprograms Expression of Plant HSP Genes by Targeting their Promoters. PLoS Pathog (2015) 0.80
Bacterial effectors target the plant cell nucleus to subvert host transcription. Plant Signal Behav (2012) 0.80
TALE-PvuII fusion proteins--novel tools for gene targeting. PLoS One (2013) 0.80
TALEs from a spring--superelasticity of Tal effector protein structures. PLoS One (2014) 0.80
Gene therapy using stem cells. Cold Spring Harb Perspect Med (2014) 0.80
Small-molecule regulators that mimic transcription factors. Biochim Biophys Acta (2010) 0.80
Human induced pluripotent stem cells for monogenic disease modelling and therapy. World J Stem Cells (2016) 0.80
Fortunella margarita transcriptional reprogramming triggered by Xanthomonas citri subsp. citri. BMC Plant Biol (2011) 0.79
Stem cells and modeling of autism spectrum disorders. Exp Neurol (2012) 0.79
Refined requirements for protein regions important for activity of the TALE AvrBs3. PLoS One (2015) 0.79
RNAseq analysis of cassava reveals similar plant responses upon infection with pathogenic and non-pathogenic strains of Xanthomonas axonopodis pv. manihotis. Plant Cell Rep (2014) 0.79
Long read and single molecule DNA sequencing simplifies genome assembly and TAL effector gene analysis of Xanthomonas translucens. BMC Genomics (2016) 0.78
DNA-binding proteins from marine bacteria expand the known sequence diversity of TALE-like repeats. Nucleic Acids Res (2015) 0.78
A plethora of virulence strategies hidden behind nuclear targeting of microbial effectors. Front Plant Sci (2011) 0.78
Differential Roles of Two Homologous Cyclin-Dependent Kinase Inhibitor Genes in Regulating Cell Cycle and Innate Immunity in Arabidopsis. Plant Physiol (2015) 0.78
Phytopathogen type III effectors as probes of biological systems. Microb Biotechnol (2013) 0.78
Breaking the code of DNA binding specificity of TAL-type III effectors. Science (2009) 22.33
Xanthomonas AvrBs3 family-type III effectors: discovery and function. Annu Rev Phytopathol (2010) 7.70
Plant pathogen recognition mediated by promoter activation of the pepper Bs3 resistance gene. Science (2007) 4.39
Lipoprotein particles are required for Hedgehog and Wingless signalling. Nature (2005) 4.38
Pax7 directs postnatal renewal and propagation of myogenic satellite cells but not their specification. EMBO J (2004) 3.62
Hexagonal packing of Drosophila wing epithelial cells by the planar cell polarity pathway. Dev Cell (2005) 3.26
Transcriptional activators of human genes with programmable DNA-specificity. PLoS One (2011) 3.16
Insights into genome plasticity and pathogenicity of the plant pathogenic bacterium Xanthomonas campestris pv. vesicatoria revealed by the complete genome sequence. J Bacteriol (2005) 3.12
Detailed analysis of the DNA recognition motifs of the Xanthomonas type III effectors AvrBs3 and AvrBs3Deltarep16. Plant J (2009) 2.44
Recognition of AvrBs3-like proteins is mediated by specific binding to promoters of matching pepper Bs3 alleles. Plant Physiol (2009) 2.13
How Xanthomonas type III effectors manipulate the host plant. Curr Opin Microbiol (2009) 2.11
Pivotal role of AtSUVH2 in heterochromatic histone methylation and gene silencing in Arabidopsis. EMBO J (2005) 2.04
Sex determination in honeybees: two separate mechanisms induce and maintain the female pathway. PLoS Biol (2009) 1.98
Type III-dependent translocation of the Xanthomonas AvrBs3 protein into the plant cell. Mol Microbiol (2002) 1.77
Greatly increased toughness of infiltrated spider silk. Science (2009) 1.71
The wound response in tomato--role of jasmonic acid. J Plant Physiol (2005) 1.68
The xanthomonas type III effector protein AvrBs3 modulates plant gene expression and induces cell hypertrophy in the susceptible host. Mol Plant Microbe Interact (2002) 1.67
Regulation and secretion of Xanthomonas virulence factors. FEMS Microbiol Rev (2009) 1.64
Port of entry--the type III secretion translocon. Trends Microbiol (2002) 1.58
Getting across--bacterial type III effector proteins on their way to the plant cell. EMBO J (2002) 1.53
Two novel type III-secreted proteins of Xanthomonas campestris pv. vesicatoria are encoded within the hrp pathogenicity island. J Bacteriol (2002) 1.53
Characterization of AvrBs3-like effectors from a Brassicaceae pathogen reveals virulence and avirulence activities and a protein with a novel repeat architecture. Mol Plant Microbe Interact (2005) 1.49
Mis-expression of the CLV3/ESR-like gene CLE19 in Arabidopsis leads to a consumption of root meristem. Gene (2004) 1.46
Specific binding of the Xanthomonas campestris pv. vesicatoria AraC-type transcriptional activator HrpX to plant-inducible promoter boxes. J Bacteriol (2006) 1.45
Antimalarial responses in Anopheles gambiae: from a complement-like protein to a complement-like pathway. Cell Host Microbe (2008) 1.45
Common infection strategies of plant and animal pathogenic bacteria. Curr Opin Plant Biol (2003) 1.41
The major yolk protein vitellogenin interferes with the anti-plasmodium response in the malaria mosquito Anopheles gambiae. PLoS Biol (2010) 1.34
Functional analysis of HrpF, a putative type III translocon protein from Xanthomonas campestris pv. vesicatoria. J Bacteriol (2002) 1.33
Haplo-insufficiency of MPK3 in MPK6 mutant background uncovers a novel function of these two MAPKs in Arabidopsis ovule development. Plant Cell (2008) 1.32
Type III effector proteins from the plant pathogen Xanthomonas and their role in the interaction with the host plant. J Plant Physiol (2005) 1.29
Expression levels of avrBs3-like genes affect recognition specificity in tomato Bs4- but not in pepper Bs3-mediated perception. Mol Plant Microbe Interact (2005) 1.27
Dimerization of the bacterial effector protein AvrBs3 in the plant cell cytoplasm prior to nuclear import. Plant J (2005) 1.27
Genome-wide transcriptome analysis of the plant pathogen Xanthomonas identifies sRNAs with putative virulence functions. Nucleic Acids Res (2011) 1.25
Pyroglutamate formation influences solubility and amyloidogenicity of amyloid peptides. Biochemistry (2009) 1.25
Who comes first? How plant pathogenic bacteria orchestrate type III secretion. Curr Opin Microbiol (2006) 1.22
Endocytosis is essential for pathogenic development in the corn smut fungus Ustilago maydis. Plant Cell (2006) 1.22
Conventional kinesin mediates microtubule-microtubule interactions in vivo. Mol Biol Cell (2005) 1.21
A novel family of plasmid-transferred anti-sense ncRNAs. RNA Biol (2010) 1.18
Targeted mutagenesis in the malaria mosquito using TALE nucleases. PLoS One (2013) 1.17
Enzymes of jasmonate biosynthesis occur in tomato sieve elements. Plant Cell Physiol (2003) 1.14
XopC and XopJ, two novel type III effector proteins from Xanthomonas campestris pv. vesicatoria. J Bacteriol (2003) 1.13
Functional analysis of the final steps of the 1-deoxy-D-xylulose 5-phosphate (DXP) pathway to isoprenoids in plants using virus-induced gene silencing. Plant Physiol (2004) 1.11
The type III-dependent Hrp pilus is required for productive interaction of Xanthomonas campestris pv. vesicatoria with pepper host plants. J Bacteriol (2005) 1.11
New type III effectors from Xanthomonas campestris pv. vesicatoria trigger plant reactions dependent on a conserved N-myristoylation motif. Mol Plant Microbe Interact (2007) 1.11
Occurrence and localization of apocarotenoids in arbuscular mycorrhizal plant roots. Plant Cell Physiol (2002) 1.11
The Arabidopsis NHL3 gene encodes a plasma membrane protein and its overexpression correlates with increased resistance to Pseudomonas syringae pv. tomato DC3000. Plant Physiol (2003) 1.11
HpaB from Xanthomonas campestris pv. vesicatoria acts as an exit control protein in type III-dependent protein secretion. Mol Microbiol (2004) 1.10
TAL effectors--pathogen strategies and plant resistance engineering. New Phytol (2014) 1.08
Suppression of the AvrBs1-specific hypersensitive response by the YopJ effector homolog AvrBsT from Xanthomonas depends on a SNF1-related kinase. New Phytol (2010) 1.07
Functional characterization of the Xcs and Xps type II secretion systems from the plant pathogenic bacterium Xanthomonas campestris pv vesicatoria. New Phytol (2010) 1.07
PspA can form large scaffolds in Escherichia coli. FEBS Lett (2008) 1.06
Computational predictions provide insights into the biology of TAL effector target sites. PLoS Comput Biol (2013) 1.04
Detection and identification of bacteria intimately associated with fungi of the order Sebacinales. Cell Microbiol (2008) 1.03
N-Terminal pyroglutamate formation of Aβ38 and Aβ40 enforces oligomer formation and potency to disrupt hippocampal long-term potentiation. J Neurochem (2012) 1.01
Targeting of two effector protein classes to the type III secretion system by a HpaC- and HpaB-dependent protein complex from Xanthomonas campestris pv. vesicatoria. Mol Microbiol (2006) 0.99
A pathogen type III effector with a novel E3 ubiquitin ligase architecture. PLoS Pathog (2013) 0.99
A novel Arabidopsis thaliana protein is a functional peripheral-type benzodiazepine receptor. Plant Cell Physiol (2004) 0.98
Role of cis-12-oxo-phytodienoic acid in tomato embryo development. Plant Physiol (2012) 0.98
Basal defenses induced in pepper by lipopolysaccharides are suppressed by Xanthomonas campestris pv. vesicatoria. Mol Plant Microbe Interact (2004) 0.95
In vivo transport of folded EGFP by the DeltapH/TAT-dependent pathway in chloroplasts of Arabidopsis thaliana. J Exp Bot (2004) 0.95
Analysis of new type III effectors from Xanthomonas uncovers XopB and XopS as suppressors of plant immunity. New Phytol (2012) 0.95
Aquincola tertiaricarbonis gen. nov., sp. nov., a tertiary butyl moiety-degrading bacterium. Int J Syst Evol Microbiol (2007) 0.94
Localization and in vitro binding studies suggest that the cytoplasmic/nuclear tobacco lectin can interact in situ with high-mannose and complex N-glycans. FEBS Lett (2006) 0.94
Immunoabsorbent nanoparticles based on a tobamovirus displaying protein A. Proc Natl Acad Sci U S A (2006) 0.93
Characterization of the nonconserved hpaB-hrpF region in the hrp pathogenicity island from Xanthomonas campestris pv. vesicatoria. Mol Plant Microbe Interact (2007) 0.93
HpaC controls substrate specificity of the Xanthomonas type III secretion system. PLoS Pathog (2008) 0.93
ELPylated haemagglutinins produced in tobacco plants induce potentially neutralizing antibodies against H5N1 viruses in mice. Plant Biotechnol J (2013) 0.92
Activation of defense against Phytophthora infestans in potato by down-regulation of syntaxin gene expression. New Phytol (2012) 0.92
Recombinant expression of tatABC and tatAC results in the formation of interacting cytoplasmic TatA tubes in Escherichia coli. J Biol Chem (2008) 0.92
H+-peptide cotransport in the human bile duct epithelium cell line SK-ChA-1. Am J Physiol Gastrointest Liver Physiol (2002) 0.91
Visualization of novel virulence activities of the Xanthomonas type III effectors AvrBs1, AvrBs3 and AvrBs4. Mol Plant Pathol (2009) 0.91
CENH3 distribution and differential chromatin modifications during pollen development in rye (Secale cereale L.). Chromosome Res (2011) 0.90
HpaA from Xanthomonas is a regulator of type III secretion. Mol Microbiol (2008) 0.90
Characterization of chloroplast protein import without Tic56, a component of the 1-megadalton translocon at the inner envelope membrane of chloroplasts. Plant Physiol (2015) 0.89
Small RNA sX13: a multifaceted regulator of virulence in the plant pathogen Xanthomonas. PLoS Pathog (2013) 0.89
Genomic approaches in Xanthomonas campestris pv. vesicatoria allow fishing for virulence genes. J Biotechnol (2003) 0.89
Characterization of scaffolds for tissue engineering by benchtop-magnetic resonance imaging. Tissue Eng Part C Methods (2009) 0.86
Influence of copper resistance determinants on gold transformation by Cupriavidus metallidurans strain CH34. J Bacteriol (2013) 0.86
Spatial distribution of arsenic and heavy metals in willow roots from a contaminated floodplain soil measured by X-ray fluorescence spectroscopy. Sci Total Environ (2011) 0.86
Membrane topology of conserved components of the type III secretion system from the plant pathogen Xanthomonas campestris pv. vesicatoria. Microbiology (2010) 0.86
Physicochemical characterization of curcuminoid-loaded solid lipid nanoparticles. Int J Pharm (2011) 0.85
The hemibiotroph Colletotrichum graminicola locally induces photosynthetically active green islands but globally accelerates senescence on aging maize leaves. Mol Plant Microbe Interact (2010) 0.85
The a2 mating-type-locus gene lga2 of Ustilago maydis interferes with mitochondrial dynamics and fusion, partially in dependence on a Dnm1-like fission component. J Cell Sci (2009) 0.85
Characterization of HrpB2 from Xanthomonas campestris pv. vesicatoria identifies protein regions that are essential for type III secretion pilus formation. Microbiology (2012) 0.84
Refinement of the Xanthomonas campestris pv. vesicatoria hrpD and hrpE operon structure. Mol Plant Microbe Interact (2007) 0.83