Published in J Biol Chem on November 25, 2014
Identification of a lipid scrambling domain in ANO6/TMEM16F. Elife (2015) 1.12
Four basic residues critical for the ion selectivity and pore blocker sensitivity of TMEM16A calcium-activated chloride channels. Proc Natl Acad Sci U S A (2015) 0.92
ANO1 interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer. Oncotarget (2015) 0.89
Influence of intracellular Ca2+ and alternative splicing on the pharmacological profile of ANO1 channels. Am J Physiol Cell Physiol (2016) 0.80
Gating modes of calcium-activated chloride channels TMEM16A and TMEM16B. J Physiol (2015) 0.80
Role of volume-regulated and calcium-activated anion channels in cell volume homeostasis, cancer and drug resistance. Channels (Austin) (2015) 0.78
Anoctamin Calcium-Activated Chloride Channels May Modulate Inhibitory Transmission in the Cerebellar Cortex. PLoS One (2015) 0.76
High Throughput Random Mutagenesis and Single Molecule Real Time Sequencing of the Muscle Nicotinic Acetylcholine Receptor. PLoS One (2016) 0.75
TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity. Science (2008) 8.74
TMEM16A confers receptor-activated calcium-dependent chloride conductance. Nature (2008) 8.40
Expression cloning of TMEM16A as a calcium-activated chloride channel subunit. Cell (2008) 7.79
Molecular structure and physiological function of chloride channels. Physiol Rev (2002) 6.09
Two physically distinct pores in the dimeric ClC-0 chloride channel. Nature (1996) 3.58
Expression of anoctamin 1/TMEM16A by interstitial cells of Cajal is fundamental for slow wave activity in gastrointestinal muscles. J Physiol (2009) 3.02
Ano1 is a selective marker of interstitial cells of Cajal in the human and mouse gastrointestinal tract. Am J Physiol Gastrointest Liver Physiol (2009) 2.96
TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells. J Biol Chem (2010) 2.66
SWELL1, a plasma membrane protein, is an essential component of volume-regulated anion channel. Cell (2014) 2.47
Mechanism and cellular applications of a green fluorescent protein-based halide sensor. J Biol Chem (2000) 2.38
Studies on expression and function of the TMEM16A calcium-activated chloride channel. Proc Natl Acad Sci U S A (2009) 2.33
The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons. Nat Neurosci (2012) 2.28
TMEM16B induces chloride currents activated by calcium in mammalian cells. Pflugers Arch (2009) 2.20
Bimodal control of a Ca(2+)-activated Cl(-) channel by different Ca(2+) signals. J Gen Physiol (2000) 2.11
Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. Proc Natl Acad Sci U S A (2012) 1.97
Chloride channels: often enigmatic, rarely predictable. Annu Rev Physiol (2010) 1.94
Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel. Mol Pharmacol (2007) 1.85
Activation of calcium-dependent chloride channels in rat parotid acinar cells. J Gen Physiol (1996) 1.82
Recessive mutations in the putative calcium-activated chloride channel Anoctamin 5 cause proximal LGMD2L and distal MMD3 muscular dystrophies. Am J Hum Genet (2010) 1.81
Voltage- and calcium-dependent gating of TMEM16A/Ano1 chloride channels are physically coupled by the first intracellular loop. Proc Natl Acad Sci U S A (2011) 1.79
Mutations in ANO3 cause dominant craniocervical dystonia: ion channel implicated in pathogenesis. Am J Hum Genet (2012) 1.78
Calmodulin-dependent activation of the epithelial calcium-dependent chloride channel TMEM16A. FASEB J (2010) 1.78
TMEM16A/anoctamin 1 protein mediates calcium-activated chloride currents in pulmonary arterial smooth muscle cells. J Physiol (2010) 1.74
Explaining calcium-dependent gating of anoctamin-1 chloride channels requires a revised topology. Circ Res (2012) 1.69
Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling. Proc Natl Acad Sci U S A (2013) 1.66
Dynamic modulation of ANO1/TMEM16A HCO3(-) permeability by Ca2+/calmodulin. Proc Natl Acad Sci U S A (2012) 1.63
Characterization of the oligomeric structure of the Ca(2+)-activated Cl- channel Ano1/TMEM16A. J Biol Chem (2010) 1.58
Structure and function of TMEM16 proteins (anoctamins). Physiol Rev (2014) 1.56
Anoctamin 6 is an essential component of the outwardly rectifying chloride channel. Proc Natl Acad Sci U S A (2011) 1.46
Phylogeny of the TMEM16 protein family: some members are overexpressed in cancer. Int J Mol Med (2005) 1.46
Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction. FASEB J (2011) 1.45
TMEM16A(a)/anoctamin-1 shares a homodimeric architecture with CLC chloride channels. Mol Cell Proteomics (2010) 1.43
Purified TMEM16A is sufficient to form Ca2+-activated Cl- channels. Proc Natl Acad Sci U S A (2013) 1.41
Targeted next-generation sequencing of a 12.5 Mb homozygous region reveals ANO10 mutations in patients with autosomal-recessive cerebellar ataxia. Am J Hum Genet (2010) 1.40
Topology of NGEP, a prostate-specific cell:cell junction protein widely expressed in many cancers of different grade level. Cancer Res (2008) 1.34
Calmodulin-dependent activation and inactivation of anoctamin calcium-gated chloride channels. J Gen Physiol (2013) 1.30
Activation of the Ano1 (TMEM16A) chloride channel by calcium is not mediated by calmodulin. J Gen Physiol (2014) 1.24
A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity. Elife (2014) 1.23
Increased TMEM16A-encoded calcium-activated chloride channel activity is associated with pulmonary hypertension. Am J Physiol Cell Physiol (2012) 1.15
Small molecule-facilitated degradation of ANO1 protein: a new targeting approach for anticancer therapeutics. J Biol Chem (2014) 1.03
Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC). Proc Natl Acad Sci U S A (2013) 1.02
Rotavirus toxin NSP4 induces diarrhea by activation of TMEM16A and inhibition of Na+ absorption. Pflugers Arch (2011) 1.00
TMEM16A-TMEM16B chimaeras to investigate the structure-function relationship of calcium-activated chloride channels. Biochem J (2013) 0.97
Development and application of automatic high-resolution light microscopy for cell-based screens. Methods Enzymol (2006) 0.96
ANO5 gene analysis in a large cohort of patients with anoctaminopathy: confirmation of male prevalence and high occurrence of the common exon 5 gene mutation. Hum Mutat (2013) 0.95
The transmembrane protein 16A Ca(2+)-activated Cl- channel in airway smooth muscle contributes to airway hyperresponsiveness. Am J Respir Crit Care Med (2012) 0.93
Binding of plasma membrane lipids recruits the yeast integral membrane protein Ist2 to the cortical ER. Traffic (2009) 0.92
Novel 5-substituted benzyloxy-2-arylbenzofuran-3-carboxylic acids as calcium activated chloride channel inhibitors. Bioorg Med Chem (2012) 0.91
Non-canonical translation start sites in the TMEM16A chloride channel. Biochim Biophys Acta (2013) 0.90
A signal comprising a basic cluster and an amphipathic alpha-helix interacts with lipids and is required for the transport of Ist2 to the yeast cortical ER. J Cell Sci (2009) 0.88
The TMEM16A chloride channel as an alternative therapeutic target in cystic fibrosis. Int J Biochem Cell Biol (2014) 0.87
The calcium-activated chloride channel Anoctamin 1 contributes to the regulation of renal function. Kidney Int (2014) 0.87
Functional swapping between transmembrane proteins TMEM16A and TMEM16F. J Biol Chem (2014) 0.81
ANO1: an additional key player in cyst growth. Kidney Int (2014) 0.80
High throughput mutagenesis for identification of residues regulating human prostacyclin (hIP) receptor expression and function. PLoS One (2014) 0.79
The development of automated patch clamp assays for canonical transient receptor potential channels TRPC3, 6, and 7. Assay Drug Dev Technol (2014) 0.76