Antibody-cytokine fusion proteins for treatment of cancer: engineering cytokines for improved efficacy and safety.

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Published in Semin Oncol on August 12, 2014

Authors

Patricia A Young1, Sherie L Morrison2, John M Timmerman3

Author Affiliations

1: Division of Hematology & Oncology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA.
2: Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA.
3: Division of Hematology & Oncology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA. Electronic address: jtimmerman@mednet.ucla.edu.

Associated clinical trials:

NHS-IL12 for Solid Tumors | NCT01417546

Combination Therapy of F16IL2 and Paclitaxel in Solid Tumour Patients | NCT01134250

A Dose Finding Pharmacokinetic Study of the Tumour-targeting Human L19IL2 Monoclonal Antibody-Cytokine Fusion Protein in Patients With Advanced Solid Tumours | NCT01058538

F16IL2 Plus Paclitaxel in Metastatic Merkel Cell Carcinoma | NCT02054884

Combination Therapy of F16IL2 and Doxorubicin in Solid Tumour Patients | NCT01131364

Combination Therapy of L19IL2 and Gemcitabine in Advanced Pancreatic Cancer Patients | NCT01198522

Pilot hu14.18-IL2 in Resectable Recurrent Stage III or Stage IV Melanoma | NCT00590824

Intratumoral Administration of L19IL2/L19TNF | NCT02076633

hu14.18-Interleukin-2 Fusion Protein in Treating Young Patients With Recurrent or Refractory Neuroblastoma | NCT00082758

Fusion Protein Cytokine Therapy After Rituximab in Treating Patients With B-Cell Non-Hodgkin Lymphoma | NCT00720135

Phase 1 Dose-finding Study of L19TNFα Plus Melphalan Using Isolated Inferior Limb Perfusion (ILP) in Subjects With Intransit Stage III/IV Melanoma | NCT01213732

Biological Therapy in Treating Children With Refractory or Recurrent Neuroblastoma or Other Tumors | NCT00003750

Study of AS1409 in Patients With Either Metastatic Renal Cell Carcinoma or Metastatic Malignant Melanoma | NCT00625768

L19TNFα in Combination With Doxorubicin in Patients With Advanced Solid Tumours | NCT02076620

L19TNFα in Patients With Advanced Solid Tumors | NCT01253837

Clinical Study Phase II of L19IL2 in Combination With Dacarbazine in Patients With Metastatic Melanoma | NCT01055522

EMD 521873 Plus Radiotherapy in Non Small Cell Lung Cancer (NSCLC) | NCT00879866

Intratumoral Application of L19IL2 in Patients With Malignant Melanoma | NCT01253096

Phase I/II Study of De-immunized DI-Leu16-IL2 Immunocytokine Administered Subcutaneously in Patients With B-cell NHL (DI-Leu16-IL2) | NCT01874288

EMD 273066 in Patients With Recurrent EpCAM Positive Ovarian, Prostate, Colorectal or Non-small Cell Lung Cancers When First Given Cyclophosphamide | NCT00132522

Hu14.18-Interleukin-2 Fusion Protein in Treating Patients With Advanced Melanoma | NCT00109863

Determine if Either of 2 Doses of Study Drug Given With a Low-dose of Cyclophosphamide After a Complete or Partial Response to a Platinum-based Second-line Therapy in Women With Recurrent Ovarian Carcinoma Results in a Longer Time to Progression When Compared to the First Time to Progression. | NCT00408967

EMD 521873 in Advanced Solid Tumors, MTD Finding | NCT01032681

Interleukin-2 Combined With Monoclonal Antibody Therapy in Treating Patients With Kidney, Bladder, or Lung Cancer That Has Not Responded to Previous Treatment | NCT00016237

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