Published in Trends Mol Med on November 05, 2014
Replacing SNAP-25b with SNAP-25a expression results in metabolic disease. Proc Natl Acad Sci U S A (2015) 0.76
Taurine Treatment Modulates Circadian Rhythms in Mice Fed A High Fat Diet. Sci Rep (2016) 0.75
Obesity, the deadly quartet and the contribution of the neglected daily organ rest - a new dimension of un-health and its prevention. Hepatobiliary Surg Nutr (2015) 0.75
Sleep Problems as Predictors in Attention-Deficit Hyperactivity Disorder: Causal Mechanisms, Consequences and Treatment. Clin Psychopharmacol Neurosci (2017) 0.75
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Impact of sleep debt on metabolic and endocrine function. Lancet (1999) 14.89
Coordinated transcription of key pathways in the mouse by the circadian clock. Cell (2002) 14.07
Obesity and metabolic syndrome in circadian Clock mutant mice. Science (2005) 12.66
Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index. PLoS Med (2004) 11.17
A serum shock induces circadian gene expression in mammalian tissue culture cells. Cell (1998) 10.92
The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell (2002) 9.92
Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus. Genes Dev (2000) 8.19
BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis. PLoS Biol (2004) 6.72
Adverse metabolic and cardiovascular consequences of circadian misalignment. Proc Natl Acad Sci U S A (2009) 6.67
The mammalian circadian timing system: organization and coordination of central and peripheral clocks. Annu Rev Physiol (2010) 6.63
Mechanisms of disease:Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes. Nat Rev Mol Cell Biol (2008) 6.23
System-driven and oscillator-dependent circadian transcription in mice with a conditionally active liver clock. PLoS Biol (2007) 6.23
Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Nature (2010) 5.97
Physiological significance of a peripheral tissue circadian clock. Proc Natl Acad Sci U S A (2008) 5.94
High-fat diet disrupts behavioral and molecular circadian rhythms in mice. Cell Metab (2007) 4.93
Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nat Genet (2008) 4.84
Central and peripheral circadian clocks in mammals. Annu Rev Neurosci (2012) 4.73
Health disorders of shift workers. Occup Med (Lond) (2003) 4.20
Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand. Nature (2011) 4.19
Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β. Nature (2012) 4.15
Effects of poor and short sleep on glucose metabolism and obesity risk. Nat Rev Endocrinol (2009) 4.09
Rotating night shift work and risk of type 2 diabetes: two prospective cohort studies in women. PLoS Med (2011) 3.88
Circadian timing of food intake contributes to weight gain. Obesity (Silver Spring) (2009) 3.44
Is there an association between shift work and having a metabolic syndrome? Results from a population based study of 27,485 people. Occup Environ Med (2001) 3.31
Brain and muscle Arnt-like protein-1 (BMAL1), a component of the molecular clock, regulates adipogenesis. Proc Natl Acad Sci U S A (2005) 3.12
Multiple signaling pathways elicit circadian gene expression in cultured Rat-1 fibroblasts. Curr Biol (2000) 3.12
Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature (2012) 2.67
Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. Nat Med (2010) 2.65
Circadian rhythms, sleep, and metabolism. J Clin Invest (2011) 2.60
Roles of circadian rhythmicity and sleep in human glucose regulation. Endocr Rev (1997) 2.39
Cryptochromes mediate rhythmic repression of the glucocorticoid receptor. Nature (2011) 2.34
A daily rhythm in glucose tolerance: a role for the suprachiasmatic nucleus. Diabetes (2001) 2.07
A single night of partial sleep deprivation induces insulin resistance in multiple metabolic pathways in healthy subjects. J Clin Endocrinol Metab (2010) 1.98
Identification of small molecule activators of cryptochrome. Science (2012) 1.95
PER2 controls lipid metabolism by direct regulation of PPARγ. Cell Metab (2010) 1.91
Multitissue circadian expression of rat period homolog (rPer2) mRNA is governed by the mammalian circadian clock, the suprachiasmatic nucleus in the brain. J Biol Chem (1998) 1.86
Evidence for a circadian rhythm of insulin secretion. Am J Physiol (1996) 1.86
Aryl hydrocarbon receptor nuclear translocator-like (BMAL1) is associated with susceptibility to hypertension and type 2 diabetes. Proc Natl Acad Sci U S A (2007) 1.84
Epidemiological evidence for the links between sleep, circadian rhythms and metabolism. Obes Rev (2009) 1.83
Independent circadian and sleep/wake regulation of adipokines and glucose in humans. J Clin Endocrinol Metab (2005) 1.81
An intrinsic circadian clock of the pancreas is required for normal insulin release and glucose homeostasis in mice. Diabetologia (2010) 1.69
Effect of shift work on body mass index: results of a study performed in 319 glucose-tolerant men working in a Southern Italian industry. Int J Obes Relat Metab Disord (2003) 1.69
Treatment of obesity with extension of sleep duration: a randomized, prospective, controlled trial. Clin Trials (2010) 1.67
Physiology of the pancreatic alpha-cell and glucagon secretion: role in glucose homeostasis and diabetes. J Endocrinol (2008) 1.66
Circadian disruption leads to insulin resistance and obesity. Curr Biol (2013) 1.66
Circadian misalignment augments markers of insulin resistance and inflammation, independently of sleep loss. Diabetes (2014) 1.62
Genetic variants of Clock transcription factor are associated with individual susceptibility to obesity. Am J Clin Nutr (2008) 1.60
High-fat diet-induced hyperinsulinemia and tissue-specific insulin resistance in Cry-deficient mice. Am J Physiol Endocrinol Metab (2013) 1.57
The orphan nuclear receptor, RORalpha, regulates gene expression that controls lipid metabolism: staggerer (SG/SG) mice are resistant to diet-induced obesity. J Biol Chem (2008) 1.48
Evidence for a circadian rhythm of insulin sensitivity in patients with NIDDM caused by cyclic changes in hepatic glucose production. Diabetes (1996) 1.45
REV-ERB and ROR nuclear receptors as drug targets. Nat Rev Drug Discov (2014) 1.43
Food intake during the normal activity phase prevents obesity and circadian desynchrony in a rat model of night work. Endocrinology (2010) 1.39
Disruption of circadian rhythms accelerates development of diabetes through pancreatic beta-cell loss and dysfunction. J Biol Rhythms (2011) 1.36
Loss of melatonin signalling and its impact on circadian rhythms in mouse organs regulating blood glucose. Eur J Pharmacol (2009) 1.25
Evidence for a circadian rhythm of insulin release from perifused rat pancreatic islets. Diabetologia (1998) 1.25
CLOCK genetic variation and metabolic syndrome risk: modulation by monounsaturated fatty acids. Am J Clin Nutr (2009) 1.24
Bmal1 and β-cell clock are required for adaptation to circadian disruption, and their loss of function leads to oxidative stress-induced β-cell failure in mice. Mol Cell Biol (2013) 1.22
Circadian variation in the response to the glucose challenge test in pregnancy: implications for screening for gestational diabetes mellitus. Diabetes Care (2012) 1.22
Identification of SR3335 (ML-176): a synthetic RORα selective inverse agonist. ACS Chem Biol (2010) 1.22
A suprachiasmatic nucleus generated rhythm in basal glucose concentrations. J Neuroendocrinol (1999) 1.19
Detrimental effects of constant light exposure and high-fat diet on circadian energy metabolism and insulin sensitivity. FASEB J (2013) 1.17
Circadian regulation of islet genes involved in insulin production and secretion. Mol Cell Endocrinol (2004) 1.16
NPAS2 and PER2 are linked to risk factors of the metabolic syndrome. J Circadian Rhythms (2009) 1.15
Partial sleep restriction decreases insulin sensitivity in type 1 diabetes. Diabetes Care (2010) 1.14
Consequences of exposure to light at night on the pancreatic islet circadian clock and function in rats. Diabetes (2013) 1.12
Disruption of circadian insulin secretion is associated with reduced glucose uptake in first-degree relatives of patients with type 2 diabetes. Diabetes (1999) 1.11
Study of shift work and risk of coronary events. J R Soc Promot Health (2007) 1.10
Loss of Bmal1 leads to uncoupling and impaired glucose-stimulated insulin secretion in β-cells. Islets (2011) 1.09
Impairment of peripheral circadian clocks precedes metabolic abnormalities in ob/ob mice. Endocrinology (2011) 1.08
Indication of circadian oscillations in the rat pancreas. FEBS Lett (2004) 1.08
Circadian clocks and metabolism. Handb Exp Pharmacol (2013) 1.07
Altered body mass regulation in male mPeriod mutant mice on high-fat diet. Chronobiol Int (2010) 1.05
Melatonin receptor 1 B polymorphisms associated with the risk of gestational diabetes mellitus. BMC Med Genet (2011) 1.05
Genetic variants in human CLOCK associate with total energy intake and cytokine sleep factors in overweight subjects (GOLDN population). Eur J Hum Genet (2009) 1.04
Daily rhythms in glucose metabolism: suprachiasmatic nucleus output to peripheral tissue. J Neuroendocrinol (2003) 1.03
PERIOD2 variants are associated with abdominal obesity, psycho-behavioral factors, and attrition in the dietary treatment of obesity. J Am Diet Assoc (2010) 1.03
The clock gene Rev-erbα regulates pancreatic β-cell function: modulation by leptin and high-fat diet. Endocrinology (2011) 1.00
Relationship between AMPK and the transcriptional balance of clock-related genes in skeletal muscle. Am J Physiol Endocrinol Metab (2008) 0.99
The daily rhythm in plasma glucagon concentrations in the rat is modulated by the biological clock and by feeding behavior. Diabetes (2003) 0.99
Circadian control of insulin secretion is independent of the temporal distribution of feeding. Physiol Behav (1998) 0.99
Variants in GLIS3 and CRY2 are associated with type 2 diabetes and impaired fasting glucose in Chinese Hans. PLoS One (2011) 0.98
Nutrient sensing and the circadian clock. Trends Endocrinol Metab (2012) 0.98
Rotating shift-work as an independent risk factor for overweight Italian workers: a cross-sectional study. PLoS One (2013) 0.97
Involvement of the clock gene Rev-erb alpha in the regulation of glucagon secretion in pancreatic alpha-cells. PLoS One (2013) 0.97
The hypothalamic clock and its control of glucose homeostasis. Trends Endocrinol Metab (2010) 0.96
Interactions between light, mealtime and calorie restriction to control daily timing in mammals. J Comp Physiol B (2010) 0.95
Isolated mouse islets respond to glucose with an initial peak of glucagon release followed by pulses of insulin and somatostatin in antisynchrony with glucagon. Biochem Biophys Res Commun (2011) 0.94
Diurnal changes in sympathetic activity. Relation to food intake and to insulin injected into the ventromedial or suprachiasmatic nucleus. J Clin Invest (1988) 0.92
Chronobiological analysis of circadian patterns in transcription of seven key clock genes in six peripheral tissues in mice. Chronobiol Int (2007) 0.92
Autonomous and self-sustained circadian oscillators displayed in human islet cells. Diabetologia (2012) 0.89
How to fix a broken clock. Trends Pharmacol Sci (2013) 0.88
Retinoic acid-related orphan receptor γ (RORγ): a novel participant in the diurnal regulation of hepatic gluconeogenesis and insulin sensitivity. PLoS Genet (2014) 0.87
Regulation of core clock genes in human islets. Metabolism (2012) 0.87
Circadian changes of ether-a-go-go-related-gene (Erg) potassium channel transcripts in the rat pancreas and beta-cell. Cell Mol Life Sci (2007) 0.86
Hypertension due to loss of clock: novel insight from the molecular analysis of Cry1/Cry2-deleted mice. Curr Hypertens Rep (2011) 0.85
Differential and day-time dependent expression of nuclear receptors RORα, RORβ, RORγ and RXRα in the rodent pancreas and islet. Mol Cell Endocrinol (2012) 0.85
Circadian and age-dependent expression patterns of GLUT2 and glucokinase in the pancreatic beta-cell of diabetic and nondiabetic rats. Horm Metab Res (2007) 0.84
Clock-controlled output gene Dbp is a regulator of Arnt/Hif-1β gene expression in pancreatic islet β-cells. Biochem Biophys Res Commun (2013) 0.82
The major circadian pacemaker ARNT-like protein-1 (BMAL1) is associated with susceptibility to gestational diabetes mellitus. Diabetes Res Clin Pract (2012) 0.82