Variants in GLIS3 and CRY2 are associated with type 2 diabetes and impaired fasting glucose in Chinese Hans.

PubWeight™: 0.98‹?› | Rank: Top 15%

🔗 View Article (PMC 3126830)

Published in PLoS One on June 29, 2011

Authors

Chen Liu1, Huaixing Li, Lu Qi, Ruth J F Loos, Qibin Qi, Ling Lu, Wei Gan, Xu Lin

Author Affiliations

1: Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China.

Articles citing this

A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans. Diabetes (2012) 1.47

Circadian control of glucose metabolism. Mol Metab (2014) 1.05

Sustained expression of the transcription factor GLIS3 is required for normal beta cell function in adults. EMBO Mol Med (2012) 0.95

Cross-sectional and longitudinal replication analyses of genome-wide association loci of type 2 diabetes in Han Chinese. PLoS One (2014) 0.89

CRY1 circadian gene variant interacts with carbohydrate intake for insulin resistance in two independent populations: Mediterranean and North American. Chronobiol Int (2014) 0.88

Pancreas-specific deletion of Prox1 affects development and disrupts homeostasis of the exocrine pancreas. Gastroenterology (2011) 0.87

The Krüppel-like protein Gli-similar 3 (Glis3) functions as a key regulator of insulin transcription. Mol Endocrinol (2013) 0.87

The Uyghur population and genetic susceptibility to type 2 diabetes: potential role for variants in CDKAL1, JAZF1, and IGF1 genes. OMICS (2015) 0.81

Gene-Environment Interactions of Circadian-Related Genes for Cardiometabolic Traits. Diabetes Care (2015) 0.81

Fatty acid desaturase 1 knockout mice are lean with improved glycemic control and decreased development of atheromatous plaque. Diabetes Metab Syndr Obes (2016) 0.80

Interaction between a common variant in FADS1 and erythrocyte polyunsaturated fatty acids on lipid profile in Chinese Hans. J Lipid Res (2013) 0.80

Clock genes, pancreatic function, and diabetes. Trends Mol Med (2014) 0.80

Chronobiology and obesity: Interactions between circadian rhythms and energy regulation. Adv Nutr (2014) 0.79

Meta-analysis of genome-wide association study of homeostasis model assessment β cell function and insulin resistance in an East Asian population and the European results. Mol Genet Genomics (2014) 0.78

Monogenic Diabetes: What It Teaches Us on the Common Forms of Type 1 and Type 2 Diabetes. Endocr Rev (2016) 0.78

Nutrigenetics and Nutrimiromics of the Circadian System: The Time for Human Health. Int J Mol Sci (2016) 0.75

Articles cited by this

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89

Diagnosis and classification of diabetes mellitus. Diabetes Care (2004) 8.66

Correct homeostasis model assessment (HOMA) evaluation uses the computer program. Diabetes Care (1998) 8.29

Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. Nat Genet (2009) 5.43

Genomic dissection of population substructure of Han Chinese and its implication in association studies. Am J Hum Genet (2009) 2.93

Genome-wide association studies in type 2 diabetes. Curr Diab Rep (2009) 2.60

Distributions of C-reactive protein and its association with metabolic syndrome in middle-aged and older Chinese people. J Am Coll Cardiol (2007) 2.00

Defects of the insulin receptor substrate (IRS) system in human metabolic disorders. FASEB J (2001) 1.78

Insulin resistance: interactions between obesity and a common variant of insulin receptor substrate-1. Lancet (1995) 1.58

Transcription factor Glis3, a novel critical player in the regulation of pancreatic beta-cell development and insulin gene expression. Mol Cell Biol (2009) 1.52

Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated beta cell function in middle-aged Danish people. Diabetologia (2010) 1.27

Variants from GIPR, TCF7L2, DGKB, MADD, CRY2, GLIS3, PROX1, SLC30A8 and IGF1 are associated with glucose metabolism in the Chinese. PLoS One (2010) 1.23

IRS1 G972R polymorphism and type 2 diabetes: a paradigm for the difficult ascertainment of the contribution to disease susceptibility of 'low-frequency-low-risk' variants. Diabetologia (2009) 0.96

Mendelian randomisation studies of type 2 diabetes: future prospects. Diabetologia (2008) 0.91

Articles by these authors

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06

Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35

Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96

Genome-wide association analysis identifies 20 loci that influence adult height. Nat Genet (2008) 16.92

Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25

Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09

Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85

Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet (2010) 8.89

Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet (2010) 8.55

Correlates of physical activity: why are some people physically active and others not? Lancet (2012) 8.19

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66

LDL-cholesterol concentrations: a genome-wide association study. Lancet (2008) 6.44

The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits. PLoS Genet (2012) 6.15

Sugar-sweetened beverages and genetic risk of obesity. N Engl J Med (2012) 5.98

Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81

Loss-of-function mutations in APOC3, triglycerides, and coronary disease. N Engl J Med (2014) 5.47

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73

Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet (2012) 4.63

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet (2012) 4.37

Rapid infancy weight gain and subsequent obesity: systematic reviews and hopeful suggestions. Acta Paediatr (2006) 4.24

Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size. PLoS Genet (2009) 4.24

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13

Genome-wide association study identifies five loci associated with lung function. Nat Genet (2009) 4.10

Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscler Thromb Vasc Biol (2010) 4.08

Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07

Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med (2011) 3.94

Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease. N Engl J Med (2016) 3.88

Genetic loci influencing kidney function and chronic kidney disease. Nat Genet (2010) 3.75

Joint effects of common genetic variants on the risk for type 2 diabetes in U.S. men and women of European ancestry. Ann Intern Med (2009) 3.68

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet (2011) 3.40

Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet (2010) 3.37

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21

Plasma 25-hydroxyvitamin D concentration and metabolic syndrome among middle-aged and elderly Chinese individuals. Diabetes Care (2009) 3.20

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet (2011) 3.18

New gene functions in megakaryopoiesis and platelet formation. Nature (2011) 3.14

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet (2012) 3.04

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet (2011) 3.03

Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet (2013) 2.92

Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population. Diabetes (2007) 2.83

Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet (2013) 2.83

FTO genotype is associated with phenotypic variability of body mass index. Nature (2012) 2.77

Seventy-five genetic loci influencing the human red blood cell. Nature (2012) 2.77

Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies. Am J Clin Nutr (2009) 2.74

Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat Genet (2011) 2.73

Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Med (2013) 2.73

Meta-analysis identifies common variants associated with body mass index in east Asians. Nat Genet (2012) 2.70

CUBN is a gene locus for albuminuria. J Am Soc Nephrol (2011) 2.70

Identification of new genetic risk variants for type 2 diabetes. PLoS Genet (2010) 2.62

Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population. Diabetes (2008) 2.46

Variant of transcription factor 7-like 2 (TCF7L2) gene and the risk of type 2 diabetes in large cohorts of U.S. women and men. Diabetes (2006) 2.45

Novel biomarkers for pre-diabetes identified by metabolomics. Mol Syst Biol (2012) 2.39

Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. PLoS Genet (2012) 2.34

Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study. PLoS Med (2010) 2.25

Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension. PLoS Genet (2010) 2.24

Life course variations in the associations between FTO and MC4R gene variants and body size. Hum Mol Genet (2009) 2.22

Consumption of whole grains and cereal fiber and total and cause-specific mortality: prospective analysis of 367,442 individuals. BMC Med (2015) 2.22

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. Diabetes (2011) 2.21

Genetic history of hepatitis C virus in East Asia. J Virol (2008) 2.20

Physical activity attenuates the body mass index-increasing influence of genetic variation in the FTO gene. Am J Clin Nutr (2009) 2.14

A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PLoS Genet (2009) 2.09

Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function. Am J Respir Crit Care Med (2011) 2.07

Prevention and reversal of cardiac hypertrophy by soluble epoxide hydrolase inhibitors. Proc Natl Acad Sci U S A (2006) 2.07

Fried food consumption, genetic risk, and body mass index: gene-diet interaction analysis in three US cohort studies. BMJ (2014) 2.06

Intake of added sugar and sugar-sweetened drink and serum uric acid concentration in US men and women. Hypertension (2007) 2.05

Differential expression of small-conductance Ca2+-activated K+ channels SK1, SK2, and SK3 in mouse atrial and ventricular myocytes. Am J Physiol Heart Circ Physiol (2005) 2.03

Whole-grain, cereal fiber, bran, and germ intake and the risks of all-cause and cardiovascular disease-specific mortality among women with type 2 diabetes mellitus. Circulation (2010) 2.02

Distributions of C-reactive protein and its association with metabolic syndrome in middle-aged and older Chinese people. J Am Coll Cardiol (2007) 2.00

QSPR modeling of bioconcentration factor of nonionic compounds using Gaussian processes and theoretical descriptors derived from electrostatic potentials on molecular surface. Chemosphere (2011) 2.00

Variability in the heritability of body mass index: a systematic review and meta-regression. Front Endocrinol (Lausanne) (2012) 1.94

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. Nat Genet (2012) 1.90