PubRank

T Shenk

Author PubWeight™ 358.31‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 An adenovirus type 5 early gene function regulates expression of other early viral genes. Proc Natl Acad Sci U S A 1979 13.21
2 The sequence 5'-AAUAAA-3'forms parts of the recognition site for polyadenylation of late SV40 mRNAs. Cell 1981 12.26
3 Isolation of adenovirus type 5 host range deletion mutants defective for transformation of rat embryo cells. Cell 1979 10.95
4 Transcriptional repression by YY1, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein. Cell 1991 8.31
5 The adenovirus type 5 E1A transcriptional control region contains a duplicated enhancer element. Cell 1983 8.19
6 Helper-free stocks of recombinant adeno-associated viruses: normal integration does not require viral gene expression. J Virol 1989 6.69
7 Second-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectors. J Virol 1996 6.22
8 Adenovirus VAI RNA is required for efficient translation of viral mRNAs at late times after infection. Cell 1982 5.80
9 Transcriptional control regions of the adenovirus VAI RNA gene. Cell 1980 5.64
10 Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein. EMBO J 1998 4.98
11 Adenovirus VAI RNA antagonizes the antiviral action of interferon by preventing activation of the interferon-induced eIF-2 alpha kinase. Cell 1986 4.72
12 A recombinant plasmid from which an infectious adeno-associated virus genome can be excised in vitro and its use to study viral replication. J Virol 1987 4.57
13 Adenovirus early region 4 encodes functions required for efficient DNA replication, late gene expression, and host cell shutoff. J Virol 1985 4.35
14 Cellular gene expression altered by human cytomegalovirus: global monitoring with oligonucleotide arrays. Proc Natl Acad Sci U S A 1998 4.33
15 YY1 is an initiator sequence-binding protein that directs and activates transcription in vitro. Nature 1991 4.30
16 Isolation of deletion and substitution mutants of adenovirus type 5. Cell 1978 4.29
17 New region of the simian virus 40 genome required for efficient viral transformation. Proc Natl Acad Sci U S A 1978 4.24
18 Human cytomegalovirus IE1 and IE2 proteins block apoptosis. J Virol 1995 4.22
19 Wild-type p53 binds to the TATA-binding protein and represses transcription. Proc Natl Acad Sci U S A 1992 4.06
20 Adenovirus virus-associated RNA and translation control. J Virol 1991 3.77
21 A 64 kd nuclear protein binds to RNA segments that include the AAUAAA polyadenylation motif. Cell 1988 3.44
22 A multisubunit factor, CstF, is required for polyadenylation of mammalian pre-mRNAs. Genes Dev 1990 3.43
23 A poly(A) addition site and a downstream termination region are required for efficient cessation of transcription by RNA polymerase II in the mouse beta maj-globin gene. Proc Natl Acad Sci U S A 1987 3.38
24 Adenovirus early region 1B 58,000-dalton tumor antigen is physically associated with an early region 4 25,000-dalton protein in productively infected cells. J Virol 1984 3.38
25 The adenovirus E1B-55K transforming polypeptide modulates transport or cytoplasmic stabilization of viral and host cell mRNAs. Mol Cell Biol 1986 3.36
26 Definition of the boundaries of the origin of DNA replication in simian virus 40. Nucleic Acids Res 1978 3.32
27 Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: induction of interferon-responsive RNAs. Proc Natl Acad Sci U S A 1997 3.25
28 Altered cellular mRNA levels in human cytomegalovirus-infected fibroblasts: viral block to the accumulation of antiviral mRNAs. J Virol 2001 3.22
29 A subset of viral transcripts packaged within human cytomegalovirus particles. Science 2000 3.19
30 Human cytomegalovirus tegument protein pp71 (ppUL82) enhances the infectivity of viral DNA and accelerates the infectious cycle. J Virol 1997 3.16
31 Functional analysis of adenovirus-5 host-range deletion mutants defective for transformation of rat embryo cells. Cold Spring Harb Symp Quant Biol 1980 3.15
32 Adenovirus tripartite leader sequence enhances translation of mRNAs late after infection. Proc Natl Acad Sci U S A 1984 3.11
33 Adenovirus VAI RNA prevents phosphorylation of the eukaryotic initiation factor 2 alpha subunit subsequent to infection. Proc Natl Acad Sci U S A 1985 3.09
34 A 32-kilodalton protein binds to AU-rich domains in the 3' untranslated regions of rapidly degraded mRNAs. Mol Cell Biol 1991 3.05
35 Proteins associated with purified human cytomegalovirus particles. J Virol 1996 3.01
36 Conversion of the lac repressor into an allosterically regulated transcriptional activator for mammalian cells. Mol Cell Biol 1990 3.00
37 Impact of virus infection on host cell protein synthesis. Annu Rev Biochem 1987 2.98
38 The 64-kilodalton subunit of the CstF polyadenylation factor binds to pre-mRNAs downstream of the cleavage site and influences cleavage site location. Mol Cell Biol 1994 2.94
39 Interaction between transcription factors Sp1 and YY1. Nature 1993 2.87
40 Transcriptional control regions: nucleotide sequence requirements for initiation by RNA polymerase II and III. Curr Top Microbiol Immunol 1981 2.85
41 Adenovirus VAI RNA facilitates the initiation of translation in virus-infected cells. Cell 1984 2.76
42 TATA-binding protein-independent initiation: YY1, TFIIB, and RNA polymerase II direct basal transcription on supercoiled template DNA. Cell 1994 2.68
43 Blockage by adenovirus E4orf6 of transcriptional activation by the p53 tumor suppressor. Science 1996 2.56
44 Nuclear export of the E1B 55-kDa and E4 34-kDa adenoviral oncoproteins mediated by a rev-like signal sequence. EMBO J 1997 2.44
45 A uridylate tract mediates efficient heterogeneous nuclear ribonucleoprotein C protein-RNA cross-linking and functionally substitutes for the downstream element of the polyadenylation signal. Mol Cell Biol 1990 2.43
46 Human cytomegalovirus infection inhibits cell cycle progression at multiple points, including the transition from G1 to S. J Virol 1996 2.41
47 Replication of wild-type and mutant human cytomegalovirus in life-extended human diploid fibroblasts. J Virol 2000 2.41
48 Deletion of the gene encoding the adenovirus 5 early region 1b 21,000-molecular-weight polypeptide leads to degradation of viral and host cell DNA. J Virol 1984 2.39
49 A chimeric mammalian transactivator based on the lac repressor that is regulated by temperature and isopropyl beta-D-thiogalactopyranoside. Proc Natl Acad Sci U S A 1991 2.35
50 Dissection of overlapping functions within the adenovirus type 5 E1A gene. EMBO J 1984 2.30
51 Fragments of the simian virus 40 transforming gene facilitate transformation of rat embryo cells. Proc Natl Acad Sci U S A 1982 2.29
52 Transcription termination within the E1A gene of adenovirus induced by insertion of the mouse beta-major globin terminator element. Cell 1985 2.29
53 Nucleotide sequence analysis of viable deletion mutants lacking segments of the simian virus 40 genome coding for small t antigen. J Virol 1979 2.28
54 Adenovirus E1A protein paradigm viral transactivator. Annu Rev Genet 1989 2.23
55 Analysis of adenovirus early region 4-encoded polypeptides synthesized in productively infected cells. J Virol 1987 2.20
56 Cocrystal structure of YY1 bound to the adeno-associated virus P5 initiator. Proc Natl Acad Sci U S A 1996 2.16
57 The human 64-kDa polyadenylylation factor contains a ribonucleoprotein-type RNA binding domain and unusual auxiliary motifs. Proc Natl Acad Sci U S A 1992 2.15
58 The adenovirus type 5 E1A enhancer contains two functionally distinct domains: one is specific for E1A and the other modulates all early units in cis. Cell 1986 2.14
59 The C proteins of heterogeneous nuclear ribonucleoprotein complexes interact with RNA sequences downstream of polyadenylation cleavage sites. Mol Cell Biol 1988 2.14
60 Adenoviral control regions activated by E1A and the cAMP response element bind to the same factor. Proc Natl Acad Sci U S A 1988 2.14
61 Viral transactivating proteins. Annu Rev Genet 1997 2.12
62 DNA binding sites for the transcriptional activator/repressor YY1. Nucleic Acids Res 1995 2.10
63 Identification of a repeated sequence element required for efficient encapsidation of the adenovirus type 5 chromosome. J Virol 1987 2.09
64 The adenovirus E4 17-kilodalton protein complexes with the cellular transcription factor E2F, altering its DNA-binding properties and stimulating E1A-independent accumulation of E2 mRNA. J Virol 1990 2.07
65 Adenovirus type 5 virions can be assembled in vivo in the absence of detectable polypeptide IX. J Virol 1981 2.07
66 Functional analysis of point mutations in the AAUAAA motif of the SV40 late polyadenylation signal. Nucleic Acids Res 1989 1.99
67 Adenovirus E4orf4 protein binds to protein phosphatase 2A, and the complex down regulates E1A-enhanced junB transcription. J Virol 1993 1.98
68 Increased anxiety of mice lacking the serotonin1A receptor. Proc Natl Acad Sci U S A 1998 1.97
69 Adeno-associated virus P5 promoter contains an adenovirus E1A-inducible element and a binding site for the major late transcription factor. J Virol 1989 1.96
70 The MDM2 oncoprotein binds specifically to RNA through its RING finger domain. Mol Med 1996 1.94
71 Human cytomegalovirus UL69 protein is required for efficient accumulation of infected cells in the G1 phase of the cell cycle. Proc Natl Acad Sci U S A 2000 1.91
72 Sequence-independent autoregulation of the adenovirus type 5 E1A transcription unit. Mol Cell Biol 1985 1.90
73 Human cytomagalovirus IE1 and IE2 proteins are mutagenic and mediate "hit-and-run" oncogenic transformation in cooperation with the adenovirus E1A proteins. Proc Natl Acad Sci U S A 1997 1.85
74 A multicomponent complex is required for the AAUAAA-dependent cross-linking of a 64-kilodalton protein to polyadenylation substrates. Mol Cell Biol 1990 1.84
75 Localization of the adenovirus early region 1B 55-kilodalton protein during lytic infection: association with nuclear viral inclusions requires the early region 4 34-kilodalton protein. J Virol 1991 1.84
76 E1B 55-kilodalton-associated protein: a cellular protein with RNA-binding activity implicated in nucleocytoplasmic transport of adenovirus and cellular mRNAs. J Virol 1998 1.83
77 Construction of a viable SV40 variant containing two functional origins of DNA replication. Cell 1978 1.83
78 An adenovirus early region 4 gene product is required for induction of the infection-specific form of cellular E2F activity. Genes Dev 1989 1.82
79 Human cytomegalovirus UL36 protein is dispensable for viral replication in cultured cells. J Virol 1999 1.80
80 Characterization of the human cytomegalovirus irs1 and trs1 genes: a second immediate-early transcription unit within irs1 whose product antagonizes transcriptional activation. J Virol 1997 1.79
81 Early viral proteins in HeLa cells infected with adenovirus type 5 host range mutants. Virology 1980 1.79
82 Oncogenic potential of the adenovirus E4orf6 protein. Proc Natl Acad Sci U S A 1996 1.78
83 A mutation which alters initiation of transcription by RNA polymerase III on the Ad5 chromosome. Cell 1979 1.75
84 Adenovirus terminal protein mediates both nuclear matrix association and efficient transcription of adenovirus DNA. Genes Dev 1990 1.74
85 Two domains of p53 interact with the TATA-binding protein, and the adenovirus 13S E1A protein disrupts the association, relieving p53-mediated transcriptional repression. Mol Cell Biol 1995 1.73
86 Human cytomegalovirus UL69 protein induces cells to accumulate in G1 phase of the cell cycle. J Virol 1999 1.72
87 Adenovirus L1 52- and 55-kilodalton proteins are required for assembly of virions. J Virol 1989 1.71
88 Relief of p53-mediated transcriptional repression by the adenovirus E1B 19-kDa protein or the cellular Bcl-2 protein. Proc Natl Acad Sci U S A 1994 1.69
89 The adenovirus E1B 55 kd protein influences mRNA transport via an intranuclear effect on RNA metabolism. EMBO J 1989 1.67
90 Simian virus 40 agnoprotein facilitates normal nuclear location of the major capsid polypeptide and cell-to-cell spread of virus. J Virol 1986 1.67
91 Genetic analysis of adenoviruses. Curr Top Microbiol Immunol 1984 1.66
92 Adenovirus early region 4 34-kilodalton protein directs the nuclear localization of the early region 1B 55-kilodalton protein in primate cells. J Virol 1996 1.65
93 Adenovirus E4orf4 protein reduces phosphorylation of c-Fos and E1A proteins while simultaneously reducing the level of AP-1. J Virol 1992 1.61
94 pIRS1 and pTRS1 are present in human cytomegalovirus virions. J Virol 1997 1.61
95 Use of a membrane-localized green fluorescent protein allows simultaneous identification of transfected cells and cell cycle analysis by flow cytometry. Cytometry 1997 1.56
96 Adenovirus E1A proteins interact with the cellular YY1 transcription factor. J Virol 1995 1.52
97 SV40 mutant tsA1499 is heat-sensitive for lytic growth but generates cold-sensitive rat-cell transformants. Cold Spring Harb Symp Quant Biol 1980 1.52
98 Adenovirus E1B 55-Mr polypeptide facilitates timely cytoplasmic accumulation of adeno-associated virus mRNAs. J Virol 1988 1.48
99 Protection against apoptosis by the vaccinia virus SPI-2 (B13R) gene product. J Virol 1996 1.48
100 Integration in vivo into simian virus 40 DNA of a sequence that resembles a certain family of genomic interspersed repeated sequences. Proc Natl Acad Sci U S A 1980 1.46
101 Human adenovirus type 9-induced rat mammary tumors. J Virol 1991 1.43
102 In silico structural and functional analysis of the human cytomegalovirus (HHV5) genome. J Mol Biol 2001 1.42
103 Induction of transcription factor AP-1 by adenovirus E1A protein and cAMP. Genes Dev 1989 1.42
104 Requirement for the adenovirus type 9 E4 region in production of mammary tumors. Science 1992 1.41
105 E2F from adenovirus-infected cells binds cooperatively to DNA containing two properly oriented and spaced recognition sites. Mol Cell Biol 1989 1.40
106 Efficient replication of adeno-associated virus type 2 vectors: a cis-acting element outside of the terminal repeats and a minimal size. J Virol 2000 1.40
107 The adenovirus DNA-binding protein stimulates the rate of transcription directed by adenovirus and adeno-associated virus promoters. J Virol 1990 1.39
108 cAMP acts in synergy with E1A protein to activate transcription of the adenovirus early genes E4 and E1A. Genes Dev 1988 1.38
109 The serotonin 1a receptor gene contains a TATA-less promoter that responds to MAZ and Sp1. J Biol Chem 1996 1.37
110 Human cytomegalovirus genome. Curr Top Microbiol Immunol 2008 1.37
111 In vitro selection of RNA ligands for the ribosomal L22 protein associated with Epstein-Barr virus-expressed RNA by using randomized and cDNA-derived RNA libraries. J Virol 1995 1.34
112 Adenovirus L1 52- and 55-kilodalton proteins are present within assembling virions and colocalize with nuclear structures distinct from replication centers. J Virol 1992 1.34
113 Human cytomegalovirus inhibits transcription of the CC chemokine MCP-1 gene. J Virol 1999 1.31
114 A viable simian virus 40 variant that carries a newly generated sequence reiteration in place of the normal duplicated enhancer element. Proc Natl Acad Sci U S A 1984 1.29
115 Functional analysis of the nucleotide sequence surrounding the cap site for adenovirus type 5 region E1A messenger RNAs. J Mol Biol 1983 1.29
116 A biochemical method for increasing the size of deletion mutations in simian virus 40 DNA. J Mol Biol 1977 1.28
117 Physical location of host-range mutations of adenovirus type 5; deletion and marker-rescue mapping. Virology 1980 1.27
118 YY1 transcriptional initiator: protein interactions and association with a DNA site containing unpaired strands. Proc Natl Acad Sci U S A 1996 1.27
119 A second domain of simian virus 40 T antigen in which mutations can alter the cellular localization of the antigen. Mol Cell Biol 1986 1.25
120 An adenovirus mutant unable to express VAI RNA displays different growth responses and sensitivity to interferon in various host cell lines. Mol Cell Biol 1986 1.22
121 The adenovirus L3 23-kilodalton proteinase cleaves the amino-terminal head domain from cytokeratin 18 and disrupts the cytokeratin network of HeLa cells. J Virol 1993 1.20
122 Induced heat shock mRNAs escape the nucleocytoplasmic transport block in adenovirus-infected HeLa cells. Mol Cell Biol 1987 1.19
123 In vivo identification of sequence elements required for normal function of the adenovirus major late transcriptional control region. Nucleic Acids Res 1986 1.17
124 Interaction between YY1 and the retinoblastoma protein. Regulation of cell cycle progression in differentiated cells. J Biol Chem 2000 1.16
125 A polymerase chain reaction mediated by a single primer: cloning of genomic sequences adjacent to a serotonin receptor protein coding region. Nucleic Acids Res 1991 1.15
126 Transformation by adenovirus early region 2A temperature-sensitive mutants and their revertants. Virology 1981 1.13
127 A protein kinase is present in a complex with adenovirus E1A proteins. Proc Natl Acad Sci U S A 1991 1.09
128 Metabolomics in drug target discovery. Cold Spring Harb Symp Quant Biol 2011 1.05
129 Isolation of differentially expressed cDNAs from p53-dependent apoptotic cells: activation of the human homologue of the Drosophila peroxidasin gene. Biochem Biophys Res Commun 1999 1.04
130 Activation of the adenovirus major late promoter by transcription factors MAZ and Sp1. J Virol 1997 1.00
131 Transcription of adenovirus and HeLa cell genes in the presence of drugs that inhibit topoisomerase I and II function. Nucleic Acids Res 1990 0.98
132 The adenovirus type 5 i-leader open reading frame functions in cis to reduce the half-life of L1 mRNAs. J Virol 1990 0.98
133 Induction of c-fos mRNA and AP-1 DNA-binding activity by cAMP in cooperation with either the adenovirus 243- or the adenovirus 289-amino acid E1A protein. Proc Natl Acad Sci U S A 1991 0.98
134 Topoisomerase I and II cleavage of adenovirus DNA in vivo: both topoisomerase activities appear to be required for adenovirus DNA replication. J Virol 1990 0.96
135 Mammary tumors induced by human adenovirus type 9: a role for the viral early region 4 gene. Breast Cancer Res Treat 1996 0.96
136 C-terminal domain of the adenovirus E1A oncogene product is required for induction of cytotoxic T lymphocytes and tumor-specific transplantation immunity. Virology 1989 0.96
137 Adenovirus E4orf6 oncoprotein modulates the function of the p53-related protein, p73. Proc Natl Acad Sci U S A 1998 0.93
138 Selection of sequence elements that substitute for the standard AATAAA motif which signals 3' processing and polyadenylation of late simian virus 40 mRNAs. Nucleic Acids Res 1985 0.91
139 Transcriptional and translational control of adenovirus gene expression. Microbiol Rev 1982 0.91
140 Molecular cloning of the cDNA and chromosome localization of the gene for human ubiquitin-conjugating enzyme 9. J Biol Chem 1996 0.89
141 Adenovirus DNA replication facilitates binding of the MLTF/USF transcription factor to the viral major late promoter within infected cells. Nucleic Acids Res 1992 0.88
142 Adenovirus type 5 and adenovirus type 12 recombinant viruses containing heterologous E1 genes are viable, transform rat cells, but are not tumorigenic in rats. Virology 1988 0.85
143 The adenovirus tripartite leader sequence can alter nuclear and cytoplasmic metabolism of a non-adenovirus mRNA within infected cells. Nucleic Acids Res 1988 0.81
144 Adenovirus terminal protein mediates efficient and timely activation of viral transcription. Curr Top Microbiol Immunol 1989 0.81
145 The site at which late mRNAs are polyadenylated is altered in SV40 mutant dl882. Ann N Y Acad Sci 1980 0.77
146 Antagonist-mediated down-regulation of 5-hydroxytryptamine type 2 receptor gene expression: modulation of transcription. Mol Pharmacol 1994 0.77
147 Tumorigenicity of adenovirus-transformed cells: collagen interaction and cell surface laminin are controlled by the serotype origin of the E1A and E1B genes. J Virol 1988 0.77
148 Adenovirus E1A expression controlled by the red pigment promoter in transgenic mice: a model for developmental abnormalities of the eye. Cell Growth Differ 1994 0.76
149 Adenovirus E1A protein activates transcription of the E1A gene subsequent to transcription complex formation. J Virol 1991 0.75
150 Paul Berg, on his 65th birthday. Nucleic Acids Res 1991 0.75
151 Glial cell-specific expression of the serotonin 2 receptor gene: selective reactivation of a repressed promoter. Brain Res Mol Brain Res 1993 0.75
152 The 5' flanking region of the serotonin 2 receptor gene directs brain specific expression in transgenic animals. Brain Res Mol Brain Res 1994 0.75
153 3. RNA of uninfected and Sindbis virus-infected Aedes albopictus cells. Curr Top Microbiol Immunol 1971 0.75
154 Differentiation is induced in three-dimensional cultures of brain cells immortalized by the LAP mammalian regulatory system. J Neurosci Res 1995 0.75