Published in Cell Adh Migr on January 01, 2014
Eph/ephrin-B-mediated cell-to-cell interactions govern MTS20(+) thymic epithelial cell development. Histochem Cell Biol (2016) 0.87
Partial denervation of sub-basal axons persists following debridement wounds to the mouse cornea. Lab Invest (2015) 0.83
Transcriptional profiling of ectoderm specification to keratinocyte fate in human embryonic stem cells. PLoS One (2015) 0.80
Increased epithelial-free areas in thymuses with altered EphB-mediated thymocyte-thymic epithelial cell interactions. Histochem Cell Biol (2017) 0.79
Therapy of pancreatic cancer via an EphA2 receptor-targeted delivery of gemcitabine. Oncotarget (2016) 0.77
Role of autophagy in the regulation of epithelial cell junctions. Tissue Barriers (2016) 0.75
Autophagy and Macropinocytosis: Keeping an Eye on the Corneal/Limbal Epithelia. Invest Ophthalmol Vis Sci (2017) 0.75
A novel DLX3-PKC integrated signaling network drives keratinocyte differentiation. Cell Death Differ (2017) 0.75
Novel Roles and Mechanism for Krüppel-like Factor 16 (KLF16) Regulation of Neurite Outgrowth and Ephrin Receptor A5 (EphA5) Expression in Retinal Ganglion Cells. J Biol Chem (2016) 0.75
Comparative Analysis of RNAi-Based Methods to Down-Regulate Expression of Two Genes Expressed at Different Levels in Myzus persicae. Viruses (2016) 0.75
EphA2 proteomics in human keratinocytes reveals a novel association with afadin and epidermal tight junctions. J Cell Sci (2016) 0.75
Asymmetry at cell-cell interfaces direct cell sorting, boundary formation, and tissue morphogenesis. Exp Cell Res (2017) 0.75
Lessons from hereditary colorectal cancer. Cell (1996) 25.73
Defining the epithelial stem cell niche in skin. Science (2003) 14.93
The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell (2002) 13.92
Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis. Cell (1990) 12.13
A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science (1990) 9.90
Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB. Cell (2002) 8.08
Epidermal homeostasis: a balancing act of stem cells in the skin. Nat Rev Mol Cell Biol (2009) 7.95
Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling. Nat Neurosci (2004) 4.22
Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. Neuron (1996) 4.12
Restriction of receptor movement alters cellular response: physical force sensing by EphA2. Science (2010) 3.72
p63 regulates proliferation and differentiation of developmentally mature keratinocytes. Genes Dev (2006) 3.66
EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt. Cancer Cell (2009) 3.40
EphA2 overexpression causes tumorigenesis of mammary epithelial cells. Cancer Res (2001) 3.24
Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors. Proc Natl Acad Sci U S A (2007) 3.20
The intestinal crypt, a prototype stem cell compartment. Cell (2013) 3.00
EphB receptor activity suppresses colorectal cancer progression. Nature (2005) 2.84
Mammary epithelial stem cells. Microsc Res Tech (2001) 2.45
Tyrosine phosphorylation of transmembrane ligands for Eph receptors. Science (1997) 2.40
The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals. Nature (2001) 2.34
EphB-ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cells. Nat Genet (2007) 2.33
EphrinB phosphorylation and reverse signaling: regulation by Src kinases and PTP-BL phosphatase. Mol Cell (2002) 2.31
Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region. Cell (2001) 2.31
Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. Cell (1997) 2.31
EphB receptors coordinate migration and proliferation in the intestinal stem cell niche. Cell (2006) 2.22
Invasiveness of breast carcinoma cells and transcript profile: Eph receptors and ephrin ligands as molecular markers of potential diagnostic and prognostic application. Biochem Biophys Res Commun (2004) 2.17
Eph/ephrin signaling: networks. Genes Dev (2008) 2.13
Candidate regulators of mammary branching morphogenesis identified by genome-wide transcript analysis. Dev Dyn (2006) 2.03
E-cadherin regulates the function of the EphA2 receptor tyrosine kinase. Cell Growth Differ (1999) 2.01
Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesis. Nat Rev Mol Cell Biol (2011) 1.94
Live and let die in the intestinal epithelium. Curr Opin Cell Biol (2003) 1.85
Oligomeric structure of the human EphB2 receptor SAM domain. Science (1999) 1.83
Receptor tyrosine kinase EphB4 is a survival factor in breast cancer. Am J Pathol (2006) 1.83
Architecture of Eph receptor clusters. Proc Natl Acad Sci U S A (2010) 1.82
Desmoglein 1-dependent suppression of EGFR signaling promotes epidermal differentiation and morphogenesis. J Cell Biol (2009) 1.73
Dissociation of EphB2 signaling pathways mediating progenitor cell proliferation and tumor suppression. Cell (2009) 1.68
The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif. J Biol Chem (1999) 1.66
Disruption of EphA2 receptor tyrosine kinase leads to increased susceptibility to carcinogenesis in mouse skin. Cancer Res (2006) 1.64
c-Cbl-dependent EphA2 protein degradation is induced by ligand binding. Mol Cancer Res (2002) 1.57
Eph-ephrin signalling in adult tissues and cancer. Curr Opin Cell Biol (2008) 1.52
Recruitment of Eph receptors into signaling clusters does not require ephrin contact. J Cell Biol (2004) 1.52
Activation of the EGFR gene target EphA2 inhibits epidermal growth factor-induced cancer cell motility. Mol Cancer Res (2007) 1.52
Expression of two novel eph-related receptor protein tyrosine kinases in mammary gland development and carcinogenesis. Oncogene (1994) 1.51
Overexpression of EPHA2 receptor destabilizes adherens junctions via a RhoA-dependent mechanism. J Cell Sci (2008) 1.48
Effects of tumor necrosis factor-alpha (TNF alpha) in epidermal keratinocytes revealed using global transcriptional profiling. J Biol Chem (2004) 1.48
Phosphorylation of tyrosine residues in the kinase domain and juxtamembrane region regulates the biological and catalytic activities of Eph receptors. Mol Cell Biol (2000) 1.47
ZNF750 is a p63 target gene that induces KLF4 to drive terminal epidermal differentiation. Dev Cell (2012) 1.47
Elevation of receptor tyrosine kinase EphA2 mediates resistance to trastuzumab therapy. Cancer Res (2009) 1.44
EphA2 phosphorylates the cytoplasmic tail of Claudin-4 and mediates paracellular permeability. J Biol Chem (2005) 1.43
Ephrins and Eph receptors in stem cells and cancer. Curr Opin Cell Biol (2010) 1.42
Regulation of EphA2 receptor endocytosis by SHIP2 lipid phosphatase via phosphatidylinositol 3-Kinase-dependent Rac1 activation. J Biol Chem (2006) 1.41
EphA2 promotes epithelial-mesenchymal transition through the Wnt/β-catenin pathway in gastric cancer cells. Oncogene (2013) 1.41
Cleavage of E-cadherin by ADAM10 mediates epithelial cell sorting downstream of EphB signalling. Nat Cell Biol (2011) 1.38
B61 is a ligand for the ECK receptor protein-tyrosine kinase. Nature (1994) 1.37
Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation. Cell Metab (2006) 1.36
Altered mammary epithelial development, pattern formation and involution in transgenic mice expressing the EphB4 receptor tyrosine kinase. J Cell Sci (2002) 1.34
Serine phosphorylation of ephrinB2 regulates trafficking of synaptic AMPA receptors. Nat Neurosci (2008) 1.34
Erk1/2 MAP kinases are required for epidermal G2/M progression. J Cell Biol (2009) 1.32
EphA kinase activation regulates HGF-induced epithelial branching morphogenesis. J Cell Biol (2003) 1.32
Coexpression of ephrin-Bs and their receptors in colon carcinoma. Cancer (2002) 1.29
Transforming growth factor-beta mediates intestinal healing and susceptibility to injury in vitro and in vivo through epithelial cells. Am J Pathol (2003) 1.29
Cell-type specific and estrogen dependent expression of the receptor tyrosine kinase EphB4 and its ligand ephrin-B2 during mammary gland morphogenesis. J Cell Sci (1998) 1.27
Complex formation between EphB2 and Src requires phosphorylation of tyrosine 611 in the EphB2 juxtamembrane region. Oncogene (1998) 1.26
Identification and functional analysis of phosphorylated tyrosine residues within EphA2 receptor tyrosine kinase. J Biol Chem (2008) 1.24
Putative dual role of ephrin-Eph receptor interactions in inflammation. IUBMB Life (2006) 1.24
Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism. J Cell Biol (2010) 1.24
Eph/ephrin profiling in human breast cancer reveals significant associations between expression level and clinical outcome. PLoS One (2011) 1.22
Negative regulation of EphA2 receptor by Cbl. Biochem Biophys Res Commun (2002) 1.21
Phosphorylation of ephrin-B1 via the interaction with claudin following cell-cell contact formation. EMBO J (2005) 1.21
Pathway-specific profiling identifies the NF-kappa B-dependent tumor necrosis factor alpha-regulated genes in epidermal keratinocytes. J Biol Chem (2005) 1.21
Expression profile of Eph receptors and ephrin ligands in human skin and downregulation of EphA1 in nonmelanoma skin cancer. Mod Pathol (2006) 1.20
Hair follicle stem cells. J Investig Dermatol Symp Proc (2003) 1.19
The biological actions of estrogens on skin. Exp Dermatol (2002) 1.18
Multiple in vivo tyrosine phosphorylation sites in EphB receptors. Biochemistry (1999) 1.17
A small molecule agonist of EphA2 receptor tyrosine kinase inhibits tumor cell migration in vitro and prostate cancer metastasis in vivo. PLoS One (2012) 1.15
PTP1B regulates Eph receptor function and trafficking. J Cell Biol (2010) 1.14
Eph/ephrin signaling in epithelial development and homeostasis. Int J Biochem Cell Biol (2008) 1.14
Concepts and consequences of Eph receptor clustering. Semin Cell Dev Biol (2012) 1.13
Regulation of mammary gland branching morphogenesis by EphA2 receptor tyrosine kinase. Mol Biol Cell (2009) 1.13
The role of Eph receptors and ephrin ligands in colorectal cancer. Int J Cancer (2010) 1.12
Distinct roles of the three Akt isoforms in lactogenic differentiation and involution. J Cell Physiol (2008) 1.10
Krüppel-like factor 5 is important for maintenance of crypt architecture and barrier function in mouse intestine. Gastroenterology (2011) 1.10
Eph-dependent cell-cell adhesion and segregation in development and cancer. Cell Mol Life Sci (2011) 1.09
Eph receptor function is modulated by heterooligomerization of A and B type Eph receptors. J Cell Biol (2011) 1.08
EphrinA1 repulsive response is regulated by an EphA2 tyrosine phosphatase. J Biol Chem (2005) 1.08
EphA2 cleavage by MT1-MMP triggers single cancer cell invasion via homotypic cell repulsion. J Cell Biol (2013) 1.06
EphA2 overexpression decreases estrogen dependence and tamoxifen sensitivity. Cancer Res (2003) 1.05
Estrogen and Myc negatively regulate expression of the EphA2 tyrosine kinase. J Cell Biochem (2002) 1.05
The Eph/Ephrin family in cancer metastasis: communication at the service of invasion. Cancer Metastasis Rev (2012) 1.04
Frequent epigenetic inactivation of the receptor tyrosine kinase EphA5 by promoter methylation in human breast cancer. Hum Pathol (2009) 1.04
The SAM domains of Anks family proteins are critically involved in modulating the degradation of EphA receptors. Mol Cell Biol (2010) 1.04
Cytoplasmic relaxation of active Eph controls ephrin shedding by ADAM10. PLoS Biol (2009) 1.03
EphA2 is an essential mediator of UV radiation-induced apoptosis. Cancer Res (2008) 1.02
Eph/Ephrin signaling in injury and inflammation. Am J Pathol (2012) 1.00
Identification of phosphotyrosine binding domain-containing proteins as novel downstream targets of the EphA8 signaling function. Mol Cell Biol (2007) 0.99
On the role of Wnt/β-catenin signaling in stem cells. Biochim Biophys Acta (2012) 0.99
Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions. Oncogene (1998) 0.98
Ligand targeting of EphA2 enhances keratinocyte adhesion and differentiation via desmoglein 1. Mol Biol Cell (2010) 0.97
Ephrin-B2 is differentially expressed in the intestinal epithelium in Crohn's disease and contributes to accelerated epithelial wound healing in vitro. World J Gastroenterol (2005) 0.96
Reverse endocytosis of transmembrane ephrin-B ligands via a clathrin-mediated pathway. Biochem Biophys Res Commun (2004) 0.96
Ephrins negatively regulate cell proliferation in the epidermis and hair follicle. Stem Cells (2010) 0.95
Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development. Sci Signal (2013) 2.78
MicroRNA-184 antagonizes microRNA-205 to maintain SHIP2 levels in epithelia. Proc Natl Acad Sci U S A (2008) 2.25
Intercellular junction assembly, dynamics, and homeostasis. Cold Spring Harb Perspect Biol (2010) 1.96
FibronectinEDA promotes chronic cutaneous fibrosis through Toll-like receptor signaling. Sci Transl Med (2014) 1.72
Epidermal growth factor receptor inhibition promotes desmosome assembly and strengthens intercellular adhesion in squamous cell carcinoma cells. J Biol Chem (2004) 1.37
Plakoglobin suppresses keratinocyte motility through both cell-cell adhesion-dependent and -independent mechanisms. Proc Natl Acad Sci U S A (2005) 1.29
Cadherin switching in ovarian cancer progression. Int J Cancer (2003) 1.25
MicroRNA-205 promotes keratinocyte migration via the lipid phosphatase SHIP2. FASEB J (2010) 1.22
The differentiation-dependent desmosomal cadherin desmoglein 1 is a novel caspase-3 target that regulates apoptosis in keratinocytes. J Biol Chem (2005) 1.17
Mechanisms of plakoglobin-dependent adhesion: desmosome-specific functions in assembly and regulation by epidermal growth factor receptor. J Biol Chem (2005) 1.15
Syncytiotrophoblast is a barrier to maternal-fetal transmission of herpes simplex virus. Biol Reprod (2002) 1.14
microRNA-31/factor-inhibiting hypoxia-inducible factor 1 nexus regulates keratinocyte differentiation. Proc Natl Acad Sci U S A (2012) 1.11
RNA interference in keratinocytes and an organotypic model of human epidermis. Methods Mol Biol (2010) 1.10
Keratinocyte expression of calcitonin gene-related peptide β: implications for neuropathic and inflammatory pain mechanisms. Pain (2011) 1.09
EGFR and ADAMs cooperate to regulate shedding and endocytic trafficking of the desmosomal cadherin desmoglein 2. Mol Biol Cell (2008) 1.07
The barrier function of skin: how to keep a tight lid on water loss. Trends Cell Biol (2002) 1.06
p63 control of desmosome gene expression and adhesion is compromised in AEC syndrome. Hum Mol Genet (2012) 1.04
Ligand targeting of EphA2 enhances keratinocyte adhesion and differentiation via desmoglein 1. Mol Biol Cell (2010) 0.97
Plakoglobin rescues adhesive defects induced by ectodomain truncation of the desmosomal cadherin desmoglein 1: implications for exfoliative toxin-mediated skin blistering. Am J Pathol (2010) 0.95
Enhancement of UVB-induced apoptosis by apigenin in human keratinocytes and organotypic keratinocyte cultures. Cancer Res (2008) 0.94
Multifactorial ERβ and NOTCH1 control of squamous differentiation and cancer. J Clin Invest (2014) 0.92
Plakoglobin deficiency protects keratinocytes from apoptosis. J Invest Dermatol (2006) 0.89
EphA2/Ephrin-A1 signaling complexes restrict corneal epithelial cell migration. Invest Ophthalmol Vis Sci (2012) 0.86
Alteration of the EphA2/Ephrin-A signaling axis in psoriatic epidermis. J Invest Dermatol (2012) 0.84
Desmosome regulation and signaling in disease. Cell Tissue Res (2015) 0.84
Eph/ephrin signaling in epidermal differentiation and disease. Semin Cell Dev Biol (2011) 0.82
microRNA-103/107 Family Regulates Multiple Epithelial Stem Cell Characteristics. Stem Cells (2015) 0.81
The retinoid-related orphan receptor RORα promotes keratinocyte differentiation via FOXN1. PLoS One (2013) 0.79
Insights from a desmoplakin mutation identified in lethal acantholytic epidermolysis bullosa. J Invest Dermatol (2010) 0.77