Published in Cell on June 29, 1990
Defining the epithelial stem cell niche in skin. Science (2003) 14.93
Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. Cell (2008) 9.92
Epidermal homeostasis: a balancing act of stem cells in the skin. Nat Rev Mol Cell Biol (2009) 7.95
Coexistence of quiescent and active adult stem cells in mammals. Science (2010) 7.54
p63 identifies keratinocyte stem cells. Proc Natl Acad Sci U S A (2001) 6.07
c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation. Genes Dev (2004) 5.83
A two-step mechanism for stem cell activation during hair regeneration. Cell Stem Cell (2009) 5.40
Hair follicle stem cells are specified and function in early skin morphogenesis. Cell Stem Cell (2008) 5.02
Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU. Nature (2007) 4.62
Scratching the surface of skin development. Nature (2007) 4.61
Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells. Nat Biotechnol (2008) 4.41
Conditional telomerase induction causes proliferation of hair follicle stem cells. Nature (2005) 4.16
Dynamics between stem cells, niche, and progeny in the hair follicle. Cell (2011) 4.14
Epithelial stem cells: turning over new leaves. Cell (2007) 4.10
Epidermal stem cells of the skin. Annu Rev Cell Dev Biol (2006) 3.92
The tortoise and the hair: slow-cycling cells in the stem cell race. Cell (2009) 3.90
NFATc1 balances quiescence and proliferation of skin stem cells. Cell (2008) 3.81
Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis. J Clin Invest (2004) 3.70
Defining the impact of beta-catenin/Tcf transactivation on epithelial stem cells. Genes Dev (2005) 3.67
The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles. Curr Biol (2006) 3.64
Location and clonal analysis of stem cells and their differentiated progeny in the human ocular surface. J Cell Biol (1999) 3.59
Live imaging of stem cell and progeny behaviour in physiological hair-follicle regeneration. Nature (2012) 3.53
Lrig1 expression defines a distinct multipotent stem cell population in mammalian epidermis. Cell Stem Cell (2009) 3.44
Distinct contribution of stem and progenitor cells to epidermal maintenance. Nature (2012) 3.44
Characterization and isolation of stem cell-enriched human hair follicle bulge cells. J Clin Invest (2006) 3.41
Nerve-derived sonic hedgehog defines a niche for hair follicle stem cells capable of becoming epidermal stem cells. Cell Stem Cell (2011) 3.19
Enrichment for murine keratinocyte stem cells based on cell surface phenotype. Proc Natl Acad Sci U S A (2000) 3.12
Nestin expression in hair follicle sheath progenitor cells. Proc Natl Acad Sci U S A (2003) 3.07
Molecular regulation of stem cell quiescence. Nat Rev Mol Cell Biol (2013) 3.07
Unravelling cancer stem cell potential. Nat Rev Cancer (2013) 3.06
GATA-3: an unexpected regulator of cell lineage determination in skin. Genes Dev (2003) 2.97
Proximal location of mouse prostate epithelial stem cells: a model of prostatic homeostasis. J Cell Biol (2002) 2.96
Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence. Proc Natl Acad Sci U S A (2006) 2.91
Multiple classes of stem cells in cutaneous epithelium: a lineage analysis of adult mouse skin. EMBO J (2001) 2.89
TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program. PLoS Genet (2007) 2.84
Genome-wide maps of histone modifications unwind in vivo chromatin states of the hair follicle lineage. Cell Stem Cell (2011) 2.80
Progressive squamous epithelial neoplasia in K14-human papillomavirus type 16 transgenic mice. J Virol (1994) 2.73
Long-term renewal of hair follicles from clonogenic multipotent stem cells. Proc Natl Acad Sci U S A (2005) 2.67
Skin stem cells: rising to the surface. J Cell Biol (2008) 2.66
Epidermal stem cells: properties, markers, and location. Proc Natl Acad Sci U S A (2000) 2.66
Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA. J Cell Biol (2003) 2.65
EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair. Genes Dev (2011) 2.63
The Hedgehog's tale: developing strategies for targeting cancer. Nat Rev Cancer (2011) 2.60
Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance. Nature (2014) 2.52
Spatial organization within a niche as a determinant of stem-cell fate. Nature (2013) 2.49
Wnt signaling, lgr5, and stem cells in the intestine and skin. Am J Pathol (2009) 2.45
The international workshop on meibomian gland dysfunction: report of the subcommittee on anatomy, physiology, and pathophysiology of the meibomian gland. Invest Ophthalmol Vis Sci (2011) 2.44
BMP signaling in dermal papilla cells is required for their hair follicle-inductive properties. Genes Dev (2008) 2.41
Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin. Nat Immunol (2012) 2.40
Understanding cancer stem cell heterogeneity and plasticity. Cell Res (2012) 2.39
Localization of putative stem cells in dental epithelium and their association with Notch and FGF signaling. J Cell Biol (1999) 2.39
Basal cell carcinomas arise from hair follicle stem cells in Ptch1(+/-) mice. Cancer Cell (2011) 2.38
The longest telomeres: a general signature of adult stem cell compartments. Genes Dev (2008) 2.38
Implanted hair follicle stem cells form Schwann cells that support repair of severed peripheral nerves. Proc Natl Acad Sci U S A (2005) 2.22
Repair of injured proximal tubule does not involve specialized progenitors. Proc Natl Acad Sci U S A (2011) 2.22
Stem cells of the skin epithelium. Proc Natl Acad Sci U S A (2003) 2.20
Epidermal stem cells: markers, patterning and the control of stem cell fate. Philos Trans R Soc Lond B Biol Sci (1998) 2.19
Maintenance and repair of the bronchiolar epithelium. Proc Am Thorac Soc (2008) 2.15
Quantitative proliferation dynamics and random chromosome segregation of hair follicle stem cells. EMBO J (2008) 2.14
Epidermal stem cell diversity and quiescence. EMBO Mol Med (2009) 2.14
Isolation of a novel population of multipotent adult stem cells from human hair follicles. Am J Pathol (2006) 2.13
Acne Treatment Based on Selective Photothermolysis of Sebaceous Follicles with Topically Delivered Light-Absorbing Gold Microparticles. J Invest Dermatol (2015) 2.10
Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes. EMBO J (2011) 2.08
Key roles for transforming growth factor beta in melanocyte stem cell maintenance. Cell Stem Cell (2010) 2.06
A distinct population of clonogenic and multipotent murine follicular keratinocytes residing in the upper isthmus. J Cell Sci (2008) 2.06
Stem cells and the niche: a dynamic duo. Cell Stem Cell (2010) 2.06
Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation. Cell (2017) 2.03
Nascent blood vessels in the skin arise from nestin-expressing hair-follicle cells. Proc Natl Acad Sci U S A (2004) 2.00
Paracrine TGF-β signaling counterbalances BMP-mediated repression in hair follicle stem cell activation. Cell Stem Cell (2012) 1.99
Stem cell plasticity. Plasticity of epithelial stem cells in tissue regeneration. Science (2014) 1.99
More than one way to skin . . . Genes Dev (2008) 1.95
Coordinated activation of Wnt in epithelial and melanocyte stem cells initiates pigmented hair regeneration. Cell (2011) 1.92
A family business: stem cell progeny join the niche to regulate homeostasis. Nat Rev Mol Cell Biol (2012) 1.91
Doublecortin and CaM kinase-like-1 and leucine-rich-repeat-containing G-protein-coupled receptor mark quiescent and cycling intestinal stem cells, respectively. Stem Cells (2009) 1.89
The germline stem cell niche unit in mammalian testes. Physiol Rev (2012) 1.86
Stem cells with neural crest characteristics derived from the bulge region of cultured human hair follicles. J Invest Dermatol (2009) 1.85
Evo-Devo of amniote integuments and appendages. Int J Dev Biol (2004) 1.84
Sustained Hedgehog signaling is required for basal cell carcinoma proliferation and survival: conditional skin tumorigenesis recapitulates the hair growth cycle. Genes Dev (2004) 1.84
Analysis of apoptosis during hair follicle regression (catagen) Am J Pathol (1997) 1.82
Bald scalp in men with androgenetic alopecia retains hair follicle stem cells but lacks CD200-rich and CD34-positive hair follicle progenitor cells. J Clin Invest (2011) 1.81
p21(WAF1/Cip1) functions as a suppressor of malignant skin tumor formation and a determinant of keratinocyte stem-cell potential. Proc Natl Acad Sci U S A (1999) 1.79
Phenotypic plasticity and epithelial-mesenchymal transitions in cancer and normal stem cells? Int J Cancer (2011) 1.79
25 years of epidermal stem cell research. J Invest Dermatol (2011) 1.70
'Cyclic alopecia' in Msx2 mutants: defects in hair cycling and hair shaft differentiation. Development (2003) 1.70
A subpopulation of mouse esophageal basal cells has properties of stem cells with the capacity for self-renewal and lineage specification. J Clin Invest (2008) 1.69
Adaptation to the sky: Defining the feather with integument fossils from mesozoic China and experimental evidence from molecular laboratories. J Exp Zool B Mol Dev Evol (2003) 1.69
Wounding mobilizes hair follicle stem cells to form tumors. Proc Natl Acad Sci U S A (2011) 1.68
Cancer stem cells and human malignant melanoma. Pigment Cell Melanoma Res (2008) 1.65
Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins. EMBO J (2012) 1.63
Quiescent, slow-cycling stem cell populations in cancer: a review of the evidence and discussion of significance. J Oncol (2010) 1.63
Isolation and culture of epithelial stem cells. Methods Mol Biol (2009) 1.63
Biomimetic platforms for human stem cell research. Cell Stem Cell (2011) 1.58
Tracking adult stem cells. EMBO Rep (2011) 1.56
CD34 expression by hair follicle stem cells is required for skin tumor development in mice. Cancer Res (2007) 1.55
β-Catenin activation regulates tissue growth non-cell autonomously in the hair stem cell niche. Science (2014) 1.55
Unravelling stem cell dynamics by lineage tracing. Nat Rev Mol Cell Biol (2013) 1.53
Competitive balance of intrabulge BMP/Wnt signaling reveals a robust gene network ruling stem cell homeostasis and cyclic activation. Proc Natl Acad Sci U S A (2013) 1.52
Isolation and characterization of functional mammary gland stem cells. Cell Prolif (2003) 1.49
Epithelial Wnt ligand secretion is required for adult hair follicle growth and regeneration. J Invest Dermatol (2012) 1.48
Compartmentalized organization: a common and required feature of stem cell niches? Development (2010) 1.48
Involvement of follicular stem cells in forming not only the follicle but also the epidermis. Cell (2000) 6.93
Existence of slow-cycling limbal epithelial basal cells that can be preferentially stimulated to proliferate: implications on epithelial stem cells. Cell (1989) 6.49
Differentiation-related expression of a major 64K corneal keratin in vivo and in culture suggests limbal location of corneal epithelial stem cells. J Cell Biol (1986) 5.96
Immunofluorescent staining of keratin fibers in cultured cells. Cell (1978) 4.25
Monoclonal antibody analysis of keratin expression in epidermal diseases: a 48- and 56-kdalton keratin as molecular markers for hyperproliferative keratinocytes. J Cell Biol (1984) 4.00
Keratin filaments of cultured human epidermal cells. Formation of intermolecular disulfide bonds during terminal differentiation. J Biol Chem (1978) 3.82
Correlation of specific keratins with different types of epithelial differentiation: monoclonal antibody studies. Cell (1982) 3.54
Immunolocalization of keratin polypeptides in human epidermis using monoclonal antibodies. J Cell Biol (1982) 3.47
Keratin cytoskeletons in epithelial cells of internal organs. Proc Natl Acad Sci U S A (1979) 3.45
Differentiation of the epidermal keratinocyte in cell culture: formation of the cornified envelope. Cell (1976) 3.30
Classification of human epithelia and their neoplasms using monoclonal antibodies to keratins: strategies, applications, and limitations. Lab Invest (1985) 3.03
Strategies of epithelial repair: modulation of stem cell and transit amplifying cell proliferation. J Cell Sci (1998) 2.78
Epidermal stem cells: properties, markers, and location. Proc Natl Acad Sci U S A (2000) 2.66
The 50- and 58-kdalton keratin classes as molecular markers for stratified squamous epithelia: cell culture studies. J Cell Biol (1983) 2.58
Classification of epidermal keratins according to their immunoreactivity, isoelectric point, and mode of expression. J Cell Biol (1984) 2.48
In vitro binding of type 1-fimbriated Escherichia coli to uroplakins Ia and Ib: relation to urinary tract infections. Proc Natl Acad Sci U S A (1996) 2.35
Heterogeneity in epidermal basal keratinocytes: morphological and functional correlations. Science (1982) 2.28
Cultured epithelial cells of cornea, conjunctiva and skin: absence of marked intrinsic divergence of their differentiated states. Nature (1977) 2.17
Methyl 4-mercaptobutyrimidate as a cleavable cross-linking reagent and its application to the Escherichia coli 30S ribosome. Biochemistry (1973) 2.14
Uroplakin Ia is the urothelial receptor for uropathogenic Escherichia coli: evidence from in vitro FimH binding. J Cell Sci (2001) 2.13
Intrinsic and extrinsic regulation of the differentiation of skin, corneal and esophageal epithelial cells. Cell (1980) 2.11
Ablation of uroplakin III gene results in small urothelial plaques, urothelial leakage, and vesicoureteral reflux. J Cell Biol (2000) 2.11
Mammalian uroplakins. A group of highly conserved urothelial differentiation-related membrane proteins. J Biol Chem (1994) 2.07
The role of keratin subfamilies and keratin pairs in the formation of human epidermal intermediate filaments. J Cell Biol (1986) 2.04
Acidic and basic hair/nail ("hard") keratins: their colocalization in upper cortical and cuticle cells of the human hair follicle and their relationship to "soft" keratins. J Cell Biol (1986) 1.91
Large scale purification and immunolocalization of bovine uroplakins I, II, and III. Molecular markers of urothelial differentiation. J Biol Chem (1990) 1.88
Epidermal stem cells. J Invest Dermatol (1983) 1.86
Desmoglein 3 anchors telogen hair in the follicle. J Cell Sci (1998) 1.77
Keratin classes: molecular markers for different types of epithelial differentiation. J Invest Dermatol (1983) 1.76
The fibrillar substructure of keratin filaments unraveled. J Cell Biol (1983) 1.75
The bladder as a bioreactor: urothelium production and secretion of growth hormone into urine. Nat Biotechnol (1998) 1.71
Expression of epidermal keratins and filaggrin during human fetal skin development. J Cell Biol (1985) 1.68
Uroplakins Ia and Ib, two major differentiation products of bladder epithelium, belong to a family of four transmembrane domain (4TM) proteins. J Cell Biol (1994) 1.67
Degranulation of human mast cells induces an endothelial antigen central to leukocyte adhesion. Proc Natl Acad Sci U S A (1989) 1.67
Urothelium-specific expression of an oncogene in transgenic mice induced the formation of carcinoma in situ and invasive transitional cell carcinoma. Cancer Res (1999) 1.62
In vitro growth and differentiation of rabbit bulbar, fornix, and palpebral conjunctival epithelia. Implications on conjunctival epithelial transdifferentiation and stem cells. Invest Ophthalmol Vis Sci (1993) 1.61
Selective interactions of UPIa and UPIb, two members of the transmembrane 4 superfamily, with distinct single transmembrane-domained proteins in differentiated urothelial cells. J Biol Chem (1995) 1.56
Molecular cloning of a 47 kDa tissue-specific and differentiation-dependent urothelial cell surface glycoprotein. J Cell Sci (1993) 1.56
The use of antikeratin antiserum as a diagnostic tool: thymoma versus lymphoma. Hum Pathol (1980) 1.48
The use of monoclonal antibody to keratin in human epidermal disease: alterations in immunohistochemical staining pattern. J Invest Dermatol (1983) 1.48
Primary uroepithelial cultures. A model system to analyze umbrella cell barrier function. J Biol Chem (1999) 1.43
Three-dimensional analysis of the 16 nm urothelial plaque particle: luminal surface exposure, preferential head-to-head interaction, and hinge formation. J Mol Biol (1999) 1.42
Monoclonal antibody studies of mammalian epithelial keratins: a review. Ann N Y Acad Sci (1985) 1.39
Relative proliferative rates of limbal and corneal epithelia. Implications of corneal epithelial migration, circadian rhythm, and suprabasally located DNA-synthesizing keratinocytes. Invest Ophthalmol Vis Sci (1991) 1.38
Structural alterations in exposed and unexposed aged skin. J Invest Dermatol (1979) 1.37
Cornea-specific expression of K12 keratin during mouse development. Curr Eye Res (1993) 1.36
Formation of horny cells: the fate of cell organelles and differentiation products in ruminal epithelium. J Cell Biol (1970) 1.35
Interaction of trichohyalin with intermediate filaments: three immunologically defined stages of trichohyalin maturation. J Invest Dermatol (1992) 1.34
Human corneal basement membrane heterogeneity: topographical differences in the expression of type IV collagen and laminin isoforms. Lab Invest (1995) 1.33
Precursor sequence, processing, and urothelium-specific expression of a major 15-kDa protein subunit of asymmetric unit membrane. J Biol Chem (1994) 1.33
Role of Ha-ras activation in superficial papillary pathway of urothelial tumor formation. Oncogene (2001) 1.33
Cells within the bulge region of mouse hair follicle transiently proliferate during early anagen: heterogeneity and functional differences of various hair cycles. Differentiation (1994) 1.32
Organization of uroplakin subunits: transmembrane topology, pair formation and plaque composition. Biochem J (2001) 1.31
Towards the molecular architecture of the asymmetric unit membrane of the mammalian urinary bladder epithelium: a closed "twisted ribbon" structure. J Mol Biol (1995) 1.31
Plakoglobin suppresses epithelial proliferation and hair growth in vivo. J Cell Biol (2000) 1.30
Comparison of limbal and conjunctival autograft transplantation in corneal surface reconstruction in rabbits. Ophthalmology (1990) 1.29
Identification of a chymotrypsin-like proteinase in human mast cells. J Immunol (1986) 1.29
Uroplakin I: a 27-kD protein associated with the asymmetric unit membrane of mammalian urothelium. J Cell Biol (1990) 1.27
Hair follicle stem cells: their location, role in hair cycle, and involvement in skin tumor formation. J Invest Dermatol (1993) 1.26
Assessing the differentiation state of cultured bovine urothelial cells: elevated synthesis of stratification-related K5 and K6 keratins and persistent expression of uroplakin I. J Cell Sci (1990) 1.25
Hair follicular stem cells: the bulge-activation hypothesis. J Invest Dermatol (1991) 1.25
Label-retaining cells are preferentially located in fornical epithelium: implications on conjunctival epithelial homeostasis. Invest Ophthalmol Vis Sci (1995) 1.24
Aged skin: a study by light, transmission electron, and scanning electron microscopy. J Invest Dermatol (1987) 1.24
EGF-R dependent regulation of keratinocyte survival. J Cell Sci (1997) 1.23
Identification of mouse mammary epithelial cells by immunofluorescence with rabbit and guinea pig antikeratin antisera. Proc Natl Acad Sci U S A (1981) 1.23
Rapid modulation of keratinocyte differentiation by the external environment. J Invest Dermatol (1983) 1.21
Control of a cell surface major glycoprotein by epidermal growth factor. Science (1977) 1.21
Down-regulation of Notch signaling during corneal epithelial proliferation. Mol Vis (2008) 1.20
Transient synthesis of K6 and K16 keratins in regenerating rabbit corneal epithelium: keratin markers for an alternative pathway of keratinocyte differentiation. Differentiation (1989) 1.18
Possible mechanisms for the loss of goblet cells in mucin-deficient disorders. Ophthalmology (1984) 1.17
Rabbit conjunctival and corneal epithelial cells belong to two separate lineages. Invest Ophthalmol Vis Sci (1996) 1.16
Expression of keratin and vimentin intermediate filaments in rabbit bladder epithelial cells at different stages of benzo[a]pyrene-induced neoplastic progression. J Cell Biol (1981) 1.16
Cutaneous mast cell depletion results from topical corticosteroid usage. J Immunol (1985) 1.15
Reaction of mast cell proteases tryptase and chymase with protease activated receptors (PARs) on keratinocytes and fibroblasts. J Cell Physiol (1998) 1.15
Regulation of K3 keratin gene transcription by Sp1 and AP-2 in differentiating rabbit corneal epithelial cells. Mol Cell Biol (1997) 1.14
Mouse skin is particularly susceptible to tumor initiation during early anagen of the hair cycle: possible involvement of hair follicle stem cells. J Invest Dermatol (1993) 1.14
Human epithelial cells cultured from urine: growth properties and keratin staining. In Vitro (1980) 1.14
Properties of an epithelial cell type in culture: the epidermal keratinocyte and its dependence on products of the fibroblast. Prog Clin Biol Res (1977) 1.14
CFTR suppresses tumor progression through miR-193b targeting urokinase plasminogen activator (uPA) in prostate cancer. Oncogene (2012) 1.14
Uroplakins, specific membrane proteins of urothelial umbrella cells, as histological markers of metastatic transitional cell carcinomas. Am J Pathol (1995) 1.12
Expression of specific keratin markers by rabbit corneal, conjunctival, and esophageal epithelia during vitamin A deficiency. J Cell Biol (1984) 1.12
Expression of hair-related keratins in a soft epithelium: subpopulations of human and mouse dorsal tongue keratinocytes express keratin markers for hair-, skin- and esophageal-types of differentiation. Exp Cell Res (1989) 1.12
Epithelialization of the corneal endothelium in posterior polymorphous dystrophy. Invest Ophthalmol Vis Sci (1980) 1.11
Substance P induces the expression of an endothelial-leukocyte adhesion molecule by microvascular endothelium. J Invest Dermatol (1990) 1.10
Re-epithelialization of porcine skin by the sweat apparatus. J Invest Dermatol (1998) 1.09
Upper human hair follicle contains a subpopulation of keratinocytes with superior in vitro proliferative potential. J Invest Dermatol (1993) 1.09
Thrombin potentiates the mitogenic response of cultured fibroblasts to serum and other growth promoting agents. J Cell Physiol (1977) 1.09