Published in Neoplasia on December 01, 2014
CCN1 induces hepatic ductular reaction through integrin αvβ₅-mediated activation of NF-κB. J Clin Invest (2015) 1.00
Notch signaling: its roles and therapeutic potential in hematological malignancies. Oncotarget (2016) 0.87
Prolyl-isomerase Pin1 controls Notch3 protein expression and regulates T-ALL progression. Oncogene (2016) 0.76
Cascade: an RNA-seq visualization tool for cancer genomics. BMC Genomics (2016) 0.75
Maml1 acts cooperatively with Gli proteins to regulate sonic hedgehog signaling pathway. Cell Death Dis (2017) 0.75
Notch signaling: cell fate control and signal integration in development. Science (1999) 28.83
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science (2004) 18.84
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature (1998) 10.58
Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain. Proc Natl Acad Sci U S A (1996) 4.13
Activating Notch1 mutations in mouse models of T-ALL. Blood (2005) 3.08
Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin. J Exp Med (2007) 3.05
The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog. J Biol Chem (2001) 2.89
Delta-1 activation of notch-1 signaling results in HES-1 transactivation. Mol Cell Biol (1998) 2.75
Processing of the notch ligand delta by the metalloprotease Kuzbanian. Science (1999) 2.71
JAGGED1 expression is associated with prostate cancer metastasis and recurrence. Cancer Res (2004) 2.59
The many facets of Notch ligands. Oncogene (2008) 2.57
Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers. Cancer Res (2007) 2.54
Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice. EMBO J (2000) 2.41
Jagged-1 and Notch3 juxtacrine loop regulates ovarian tumor growth and adhesion. Cancer Res (2008) 2.26
The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments. J Biol Chem (2003) 2.22
Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1. Cancer Cell (2013) 1.93
Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila. Proc Natl Acad Sci U S A (2001) 1.74
p66Shc/Notch-3 interplay controls self-renewal and hypoxia survival in human stem/progenitor cells of the mammary gland expanded in vitro as mammospheres. Stem Cells (2006) 1.72
Constitutive pre-TCR signaling promotes differentiation through Ca2+ mobilization and activation of NF-kappaB and NFAT. Nat Immunol (2001) 1.59
Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis. Proc Natl Acad Sci U S A (2002) 1.54
The C-terminal PDZ-ligand of JAGGED1 is essential for cellular transformation. J Biol Chem (2002) 1.40
Retracted Down-regulation of Jagged-1 induces cell growth inhibition and S phase arrest in prostate cancer cells. Int J Cancer (2006) 1.22
Notch3 and the Notch3-upregulated RNA-binding protein HuD regulate Ikaros alternative splicing. EMBO J (2007) 1.20
Notch signaling and diseases: an evolutionary journey from a simple beginning to complex outcomes. Biochim Biophys Acta (2008) 1.19
Pre-TCR-triggered ERK signalling-dependent downregulation of E2A activity in Notch3-induced T-cell lymphoma. EMBO Rep (2003) 1.18
ADAM proteases: ligand processing and modulation of the Notch pathway. Cell Mol Life Sci (2008) 1.12
Notch and NF-kB signaling pathways regulate miR-223/FBXW7 axis in T-cell acute lymphoblastic leukemia. Leukemia (2014) 1.07
Tumor necrosis factor-alpha converting enzyme is processed by proprotein-convertases to its mature form which is degraded upon phorbol ester stimulation. Eur J Biochem (2003) 1.04
High Jagged1 expression predicts poor outcome in clear cell renal cell carcinoma. Jpn J Clin Oncol (2010) 1.02
Notch and the awesome power of genetics. Genetics (2012) 0.99
Silencing of Jagged1 inhibits cell growth and invasion in colorectal cancer. Cell Death Dis (2014) 0.98
Regulation of expression of T cell gamma chain, L3T4 and Ly-2 messages in Abelson/Moloney virus-transformed T cell lines. Eur J Immunol (1988) 0.96
Ectodomain shedding of the Notch ligand Jagged1 is mediated by ADAM17, but is not a lipid-raft-associated event. Biochem J (2010) 0.93
Glucocorticoid sensitivity of T-cell lymphoblastic leukemia/lymphoma is associated with glucocorticoid receptor-mediated inhibition of Notch1 expression. Leukemia (2012) 0.89
The intracellular domain of Jagged-1 interacts with Notch1 intracellular domain and promotes its degradation through Fbw7 E3 ligase. Exp Cell Res (2011) 0.86
Up-regulated expression of Notch1 and Jagged1 in human colon adenocarcinoma. Pathol Biol (Paris) (2010) 0.84
Inhibition of γ-secretase induces G2/M arrest and triggers apoptosis in renal cell carcinoma. Oncol Lett (2014) 0.82
Differential subcellular localization regulates c-Cbl E3 ligase activity upon Notch3 protein in T-cell leukemia. Oncogene (2009) 0.82
Suppression of tongue squamous cell carcinoma growth by inhibition of Jagged1 in vitro and in vivo. J Oral Pathol Med (2012) 0.76
Protected from the inside: endogenous histone deacetylase inhibitors and the road to cancer. Biochim Biophys Acta (2011) 1.06
Targeted therapy against chemoresistant colorectal cancers: Inhibition of p38α modulates the effect of cisplatin in vitro and in vivo through the tumor suppressor FoxO3A. Cancer Lett (2013) 0.91
The epigenetic factor BORIS/CTCFL regulates the NOTCH3 gene expression in cancer cells. Biochim Biophys Acta (2014) 0.82
Targeting of hyperactivated mTOR signaling in high-risk acute lymphoblastic leukemia in a pre-clinical model. Oncotarget (2015) 0.77
The loss of ATP2C1 impairs the DNA damage response and induces altered skin homeostasis: Consequences for epidermal biology in Hailey-Hailey disease. Sci Rep (2016) 0.75
The mazy case of Notch and immunoregulatory cells. J Leukoc Biol (2017) 0.75