Notch and the awesome power of genetics.

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Published in Genetics on July 01, 2012

Authors

Iva Greenwald1

Author Affiliations

1: Department of Biochemistry and Molecular Biophysics, Department of Genetics and Development, Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. isg4@columbia.edu

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Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature (1998) 10.58

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature (1999) 10.36

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature (1998) 7.43

Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats. Cell (1985) 6.93

Notch signaling is essential for vascular morphogenesis in mice. Genes Dev (2000) 6.88

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Identification and characterization of 22 genes that affect the vulval cell lineages of the nematode Caenorhabditis elegans. Genetics (1985) 5.83

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Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei. Genes Dev (1993) 3.86

The suppressor of hairless protein participates in notch receptor signaling. Cell (1994) 3.81

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Evidence for a transposon in Caenorhabditis elegans. Cell (1983) 3.65

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Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane. Cell (1997) 3.47

Genomic and cDNA clones of the homeotic locus Antennapedia in Drosophila. EMBO J (1983) 3.47

Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H). Curr Biol (1995) 3.46

Nucleotide sequence of epidermal growth factor cDNA predicts a 128,000-molecular weight protein precursor. Nature (1983) 3.43

Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor. Cell (1993) 3.35

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene. Nature (1995) 3.33

The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling. Genes Dev (1995) 3.24

The Epstein-Barr virus immortalizing protein EBNA-2 is targeted to DNA by a cellular enhancer-binding protein. Proc Natl Acad Sci U S A (1993) 3.22

A homoeotic mutation transforming leg to antenna in Drosophila. Nature (1981) 3.19

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Structure of a mouse submaxillary messenger RNA encoding epidermal growth factor and seven related proteins. Science (1983) 2.97

Suppressor of Hairless, the Drosophila homolog of the mouse recombination signal-binding protein gene, controls sensory organ cell fates. Cell (1992) 2.95

lin-12, a nematode homeotic gene, is homologous to a set of mammalian proteins that includes epidermal growth factor. Cell (1985) 2.86

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glp-1 and lin-12, genes implicated in distinct cell-cell interactions in C. elegans, encode similar transmembrane proteins. Cell (1989) 2.63

Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands. Genes Dev (1992) 2.59

Abnormal cell lineages in mutants of the nematode Caenorhabditis elegans. Dev Biol (1981) 2.55

Closely related transcripts encoded by the neurogenic gene complex enhancer of split of Drosophila melanogaster. EMBO J (1989) 2.54

An activated Notch receptor blocks cell-fate commitment in the developing Drosophila eye. Nature (1993) 2.49

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Oncogenic and tumor suppressor functions of Notch in cancer: it's NOTCH what you think. J Exp Med (2011) 2.40

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Two homologous regulatory genes, lin-12 and glp-1, have overlapping functions. Development (1991) 2.30

Mouse mammary tumor gene int-3: a member of the notch gene family transforms mammary epithelial cells. J Virol (1992) 2.29

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The neurogenic gene Delta of Drosophila melanogaster is expressed in neurogenic territories and encodes a putative transmembrane protein with EGF-like repeats. EMBO J (1987) 2.23

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Molecular cloning of Notch, a locus affecting neurogenesis in Drosophila melanogaster. Proc Natl Acad Sci U S A (1983) 2.17

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos. Proc Natl Acad Sci U S A (2002) 2.16

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Frizzled regulation of Notch signalling polarizes cell fate in the Drosophila eye. Nature (1999) 2.09

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The Notch signalling pathway is required for Enhancer of split bHLH protein expression during neurogenesis in the Drosophila embryo. Development (1994) 2.07

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Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signalling in Drosophila. Development (1996) 1.86

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Delta, a Drosophila neurogenic gene, is transcriptionally complex and encodes a protein related to blood coagulation factors and epidermal growth factor of vertebrates. Genes Dev (1988) 1.78

Indirect evidence for Delta-dependent intracellular processing of notch in Drosophila embryos. Curr Biol (1998) 1.76

Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila. Proc Natl Acad Sci U S A (2001) 1.74

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Asymmetric Notch activation specifies photoreceptors R3 and R4 and planar polarity in the Drosophila eye. Nature (1999) 1.68

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