Published in J Cell Sci on February 01, 2015
Role of Microenvironment in Resistance to Therapy in AML. Curr Hematol Malig Rep (2015) 0.92
Cellular processes associated with LRRK2 function and dysfunction. FEBS J (2015) 0.86
LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate. Mol Neurodegener (2016) 0.83
The function of orthologues of the human Parkinson's disease gene LRRK2 across species: implications for disease modelling in preclinical research. Biochem J (2016) 0.79
LRRK2 Regulates Voltage-Gated Calcium Channel Function. Front Mol Neurosci (2016) 0.79
Altered Development of Synapse Structure and Function in Striatum Caused by Parkinson's Disease-Linked LRRK2-G2019S Mutation. J Neurosci (2016) 0.79
mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1. Sci Rep (2016) 0.78
LRRK2 Kinase Inhibition as a Therapeutic Strategy for Parkinson's Disease, Where Do We Stand? Curr Neuropharmacol (2016) 0.76
Endophilin-A Deficiency Induces the Foxo3a-Fbxo32 Network in the Brain and Causes Dysregulation of Autophagy and the Ubiquitin-Proteasome System. Cell Rep (2016) 0.76
LRRK2 at the interface of autophagosomes, endosomes and lysosomes. Mol Neurodegener (2016) 0.76
A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci. Nat Genet (2017) 0.75
Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses and Triggers Dystrophic Changes in Dopaminergic Axons. Neuron (2017) 0.75
Regulation of LRRK2 promoter activity and gene expression by Sp1. Mol Brain (2016) 0.75
Dynasore blocks evoked release while augmenting spontaneous synaptic transmission from primary visceral afferents. PLoS One (2017) 0.75
Effects of LRRK2 Inhibitors on Nigrostriatal Dopaminergic Neurotransmission. CNS Neurosci Ther (2016) 0.75
Parkin Deficiency Reduces Hippocampal Glutamatergic Neurotransmission by Impairing AMPA Receptor Endocytosis. J Neurosci (2016) 0.75
Endogenous Leucine-Rich Repeat Kinase 2 Slows Synaptic Vesicle Recycling in Striatal Neurons. Front Synaptic Neurosci (2017) 0.75
A time course of orchestrated endophilin action in sensing, bending, and stabilizing curved membranes. Mol Biol Cell (2016) 0.75
A proteomic analysis of LRRK2 binding partners reveals interactions with multiple signaling components of the WNT/PCP pathway. Mol Neurodegener (2017) 0.75
Parkinson disease-associated LRRK2 G2019S transgene disrupts marrow myelopoiesis and peripheral Th17 response. J Leukoc Biol (2017) 0.75
OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion. Cell (2006) 7.72
PRIDE: the proteomics identifications database. Proteomics (2005) 7.52
Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling. Cell (2006) 5.51
Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression. Proc Natl Acad Sci U S A (2008) 5.24
The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes. Nat Neurosci (2012) 4.92
The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics. Nat Rev Drug Discov (2011) 4.24
Human Proteinpedia enables sharing of human protein data. Nat Biotechnol (2008) 4.21
Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations. Cell (2006) 4.10
Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans. Proc Natl Acad Sci U S A (2009) 4.09
Morphological and biochemical characterization of a human liver in a uPA-SCID mouse chimera. Hepatology (2005) 3.72
Improved visualization of protein consensus sequences by iceLogo. Nat Methods (2009) 3.64
Large-scale identification of N-terminal peptides in the halophilic archaea Halobacterium salinarum and Natronomonas pharaonis. J Proteome Res (2007) 3.30
The v-ATPase V0 subunit a1 is required for a late step in synaptic vesicle exocytosis in Drosophila. Cell (2005) 3.05
Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms. J Neurochem (2006) 3.03
Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress. Development (2004) 3.03
Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis. Neuron (2008) 2.99
Alterations of the microRNA network cause neurodegenerative disease. Trends Neurosci (2009) 2.96
Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin. Nat Cell Biol (2005) 2.91
Caspase-14 protects against epidermal UVB photodamage and water loss. Nat Cell Biol (2007) 2.82
Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila. Development (2002) 2.82
The mechanism of γ-Secretase dysfunction in familial Alzheimer disease. EMBO J (2012) 2.72
Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activity. PLoS Biol (2006) 2.70
Vitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiency. Science (2012) 2.65
Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes. Mol Cell Proteomics (2008) 2.64
HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1-induced Charcot-Marie-Tooth disease. Nat Med (2011) 2.60
Listeria monocytogenes impairs SUMOylation for efficient infection. Nature (2010) 2.57
Comparison and meta-analysis of microarray data: from the bench to the computer desk. Trends Genet (2003) 2.54
Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease. Alzheimers Res Ther (2011) 2.51
LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis. Neuron (2012) 2.49
Dap160/intersectin acts as a stabilizing scaffold required for synaptic development and vesicle endocytosis. Neuron (2004) 2.47
gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease. Science (2009) 2.43
LNCipedia: a database for annotated human lncRNA transcript sequences and structures. Nucleic Acids Res (2012) 2.40
Lipids revert inert Abeta amyloid fibrils to neurotoxic protofibrils that affect learning in mice. EMBO J (2007) 2.39
The miR-17-92 microRNA cluster regulates multiple components of the TGF-β pathway in neuroblastoma. Mol Cell (2010) 2.38
Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis. Cell (2002) 2.37
The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons. Science (2009) 2.35
Mutations in Drosophila sec15 reveal a function in neuronal targeting for a subset of exocyst components. Neuron (2005) 2.33
Caspase-specific and nonspecific in vivo protein processing during Fas-induced apoptosis. Nat Methods (2005) 2.33
Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio. EMBO J (2010) 2.26
Identification and functional characterization of N-terminally acetylated proteins in Drosophila melanogaster. PLoS Biol (2009) 2.25
Protein N-terminal acetyltransferases: when the start matters. Trends Biochem Sci (2012) 2.19
beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase. J Biol Chem (2005) 2.15
Presynaptic induction of heterosynaptic associative plasticity in the mammalian brain. Nature (2003) 2.13
The POU proteins Brn-2 and Oct-6 share important functions in Schwann cell development. Genes Dev (2003) 2.10
Normocalcemia is maintained in mice under conditions of calcium malabsorption by vitamin D-induced inhibition of bone mineralization. J Clin Invest (2012) 2.10
Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice. J Biol Chem (2005) 2.03
Transgenic mice overexpressing glycogen synthase kinase 3beta: a putative model of hyperactivity and mania. J Neurosci (2006) 2.01
Analysis of protein processing by N-terminal proteomics reveals novel species-specific substrate determinants of granzyme B orthologs. Mol Cell Proteomics (2008) 2.01
The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1. J Biol Chem (2003) 1.99
Glial cells in the mouse enteric nervous system can undergo neurogenesis in response to injury. J Clin Invest (2011) 1.99
A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP. Proc Natl Acad Sci U S A (2002) 1.97
Global analysis of the mitochondrial N-proteome identifies a processing peptidase critical for protein stability. Cell (2009) 1.96
Mapping Drosophila mutations with molecularly defined P element insertions. Proc Natl Acad Sci U S A (2003) 1.94
Caspase-14 is required for filaggrin degradation to natural moisturizing factors in the skin. J Invest Dermatol (2011) 1.93
A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis. Proc Natl Acad Sci U S A (2003) 1.92
Cell-matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca(2+) influx and PKC activation. J Cell Biol (2004) 1.90
Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function. EMBO Mol Med (2009) 1.89
MicroRNA regulation of Alzheimer's Amyloid precursor protein expression. Neurobiol Dis (2008) 1.89
The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex. J Neurosci (2010) 1.85
ELP3 controls active zone morphology by acetylating the ELKS family member Bruchpilot. Neuron (2011) 1.83
Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration. Hum Mol Genet (2010) 1.83
Requirement of central ghrelin signaling for alcohol reward. Proc Natl Acad Sci U S A (2009) 1.82
Improved recovery of proteome-informative, protein N-terminal peptides by combined fractional diagonal chromatography (COFRADIC). Proteomics (2008) 1.81
gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation. J Cell Sci (2003) 1.79
A cell biological perspective on Alzheimer's disease. Annu Rev Cell Dev Biol (2002) 1.79
Drosophila fragile X protein, DFXR, regulates neuronal morphology and function in the brain. Neuron (2002) 1.76
Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes. EMBO Rep (2006) 1.72
A cell biological perspective on mitochondrial dysfunction in Parkinson disease and other neurodegenerative diseases. J Cell Sci (2007) 1.70
Active gamma-secretase complexes contain only one of each component. J Biol Chem (2007) 1.69
Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo. Proc Natl Acad Sci U S A (2005) 1.69
The amyloid-beta precursor protein: integrating structure with biological function. EMBO J (2005) 1.68
Neuronal membrane cholesterol loss enhances amyloid peptide generation. J Cell Biol (2004) 1.66
Redistribution of GABAB(1) protein and atypical GABAB responses in GABAB(2)-deficient mice. J Neurosci (2004) 1.66
Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway. J Cell Biol (2004) 1.65
Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation. Dev Cell (2005) 1.62
ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1. Proc Natl Acad Sci U S A (2011) 1.60
Nerve activity recordings in routine human intestinal biopsies. Gut (2012) 1.59
Role of presenilins in neuronal calcium homeostasis. J Neurosci (2010) 1.59
Amyloid-beta precursor protein processing in neurodegeneration. Curr Opin Neurobiol (2004) 1.59
NatF contributes to an evolutionary shift in protein N-terminal acetylation and is important for normal chromosome segregation. PLoS Genet (2011) 1.57
Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity. Neurobiol Dis (2004) 1.56
Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain. EMBO J (2005) 1.56
Presenilin-1 maintains a nine-transmembrane topology throughout the secretory pathway. J Biol Chem (2006) 1.55
Alteration of the microRNA network during the progression of Alzheimer's disease. EMBO Mol Med (2013) 1.54
Vesicular glutamate transporter VGLUT2 expression levels control quantal size and neuropathic pain. J Neurosci (2006) 1.54
β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease. Nat Med (2012) 1.54
Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models". Science (2013) 1.54