Published in Proc Natl Acad Sci U S A on September 05, 2003
Site-specific transformation of Drosophila via phiC31 integrase-mediated cassette exchange. Genetics (2006) 3.94
Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling. Cell (2008) 3.09
The v-ATPase V0 subunit a1 is required for a late step in synaptic vesicle exocytosis in Drosophila. Cell (2005) 3.05
Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activity. PLoS Biol (2006) 2.70
Genetic manipulation of genes and cells in the nervous system of the fruit fly. Neuron (2011) 2.54
Using Drosophila melanogaster as a Model for Genotoxic Chemical Mutational Studies with a New Program, SnpSift. Front Genet (2012) 2.21
A synaptic vesicle-associated Ca2+ channel promotes endocytosis and couples exocytosis to endocytosis. Cell (2009) 1.98
Mutations in the mitochondrial methionyl-tRNA synthetase cause a neurodegenerative phenotype in flies and a recessive ataxia (ARSAL) in humans. PLoS Biol (2012) 1.80
vps25 mosaics display non-autonomous cell survival and overgrowth, and autonomous apoptosis. Development (2006) 1.79
Aberrant lysosomal carbohydrate storage accompanies endocytic defects and neurodegeneration in Drosophila benchwarmer. J Cell Biol (2005) 1.52
Lethal giant discs, a novel C2-domain protein, restricts notch activation during endocytosis. Curr Biol (2006) 1.52
Exon junction complex subunits are required to splice Drosophila MAP kinase, a large heterochromatic gene. Cell (2010) 1.46
Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration. Hum Mol Genet (2008) 1.46
Massively parallel resequencing of the isogenic Drosophila melanogaster strain w(1118); iso-2; iso-3 identifies hotspots for mutations in sensory perception genes. Fly (Austin) (2009) 1.41
Huntingtin-interacting protein 14, a palmitoyl transferase required for exocytosis and targeting of CSP to synaptic vesicles. J Cell Biol (2007) 1.37
An essential Drosophila glutamate receptor subunit that functions in both central neuropil and neuromuscular junction. J Neurosci (2005) 1.36
Ero1L, a thiol oxidase, is required for Notch signaling through cysteine bridge formation of the Lin12-Notch repeats in Drosophila melanogaster. J Cell Biol (2008) 1.32
Rapid identification of heterozygous mutations in Drosophila melanogaster using genomic capture sequencing. Genome Res (2010) 1.26
The Arp2/3 complex and WASp are required for apical trafficking of Delta into microvilli during cell fate specification of sensory organ precursors. Nat Cell Biol (2009) 1.23
straightjacket is required for the synaptic stabilization of cacophony, a voltage-gated calcium channel alpha1 subunit. J Cell Biol (2008) 1.20
A molecularly defined duplication set for the X chromosome of Drosophila melanogaster. Genetics (2010) 1.17
A genetic screen in Drosophila for identifying novel components of the hedgehog signaling pathway. Genetics (2005) 1.14
The E1 ubiquitin-activating enzyme Uba1 in Drosophila controls apoptosis autonomously and tissue growth non-autonomously. Development (2007) 1.14
Myopic acts in the endocytic pathway to enhance signaling by the Drosophila EGF receptor. Development (2008) 1.06
Tweek, an evolutionarily conserved protein, is required for synaptic vesicle recycling. Neuron (2009) 1.02
Genome-wide P-element screen for Drosophila synaptogenesis mutants. J Neurobiol (2006) 1.01
Fruit flies in biomedical research. Genetics (2015) 1.00
Drosophila variable nurse cells encodes arrest defective 1 (ARD1), the catalytic subunit of the major N-terminal acetyltransferase complex. Dev Dyn (2010) 0.99
Large-scale identification of chemically induced mutations in Drosophila melanogaster. Genome Res (2014) 0.98
Drosophila Strip serves as a platform for early endosome organization during axon elongation. Nat Commun (2014) 0.92
The dominant cold-sensitive Out-cold mutants of Drosophila melanogaster have novel missense mutations in the voltage-gated sodium channel gene paralytic. Genetics (2008) 0.92
A genetic screen in Drosophila for genes interacting with senseless during neuronal development identifies the importin moleskin. Genetics (2006) 0.91
Localization, mobility and fidelity of retrotransposed Group II introns in rRNA genes. Nucleic Acids Res (2005) 0.90
dEHBP1 controls exocytosis and recycling of Delta during asymmetric divisions. J Cell Biol (2012) 0.88
A genetic screen for mutations affecting gonad formation in Drosophila reveals a role for the slit/robo pathway. Dev Biol (2011) 0.87
The enhancer of trithorax and polycomb gene Caf1/p55 is essential for cell survival and patterning in Drosophila development. Development (2011) 0.87
Importin 13 regulates neurotransmitter release at the Drosophila neuromuscular junction. J Neurosci (2009) 0.85
Rich regulates target specificity of photoreceptor cells and N-cadherin trafficking in the Drosophila visual system via Rab6. Neuron (2011) 0.85
Chemical mutagens, transposons, and transgenes to interrogate gene function in Drosophila melanogaster. Methods (2014) 0.84
A screen for X-linked mutations affecting Drosophila photoreceptor differentiation identifies Casein kinase 1α as an essential negative regulator of wingless signaling. Genetics (2011) 0.84
The kinesin-3, unc-104 regulates dendrite morphogenesis and synaptic development in Drosophila. Genetics (2013) 0.83
A Systematic Genetic Screen to Dissect the MicroRNA Pathway in Drosophila. G3 (Bethesda) (2012) 0.83
The molecular chaperone Hsp90 is required for cell cycle exit in Drosophila melanogaster. PLoS Genet (2013) 0.82
Mutations in the transcription elongation factor SPT5 disrupt a reporter for dosage compensation in Drosophila. PLoS Genet (2012) 0.82
Multiple functions of the SNARE protein Snap29 in autophagy, endocytic, and exocytic trafficking during epithelial formation in Drosophila. Autophagy (2014) 0.82
The transcriptional co-factor Chip acts with LIM-homeodomain proteins to set the boundary of the eye field in Drosophila. Development (2010) 0.81
Sequoia regulates cell fate decisions in the external sensory organs of adult Drosophila. EMBO Rep (2009) 0.81
Survival of the fittest tools. Genetics (2014) 0.79
Strategies for gene disruption in Drosophila. Cell Biosci (2014) 0.78
Post-transcriptional regulation of myotube elongation and myogenesis by Hoi Polloi. Development (2013) 0.78
Rapid recombination mapping for high-throughput genetic screens in Drosophila. G3 (Bethesda) (2013) 0.78
Staying alive: dalmation mediated blocking of apoptosis is essential for tissue maintenance. Dev Dyn (2010) 0.77
An extensive allelic series of Drosophila kae1 mutants reveals diverse and tissue-specific requirements for t6A biogenesis. RNA (2015) 0.77
The Gyc76C Receptor Guanylyl Cyclase and the Foraging cGMP-Dependent Kinase Regulate Extracellular Matrix Organization and BMP Signaling in the Developing Wing of Drosophila melanogaster. PLoS Genet (2015) 0.77
Drosophila Vps4 promotes Epidermal growth factor receptor signaling independently of its role in receptor degradation. Development (2015) 0.76
Missense variants in the middle domain of DNM1L in cases of infantile encephalopathy alter peroxisomes and mitochondria when assayed in Drosophila. Hum Mol Genet (2016) 0.76
The gang of four gene regulates growth and patterning of the developing Drosophila eye. Fly (Austin) (2010) 0.75
Lithium-Responsive Seizure-Like Hyperexcitability Is Caused by a Mutation in the Drosophila Voltage-Gated Sodium Channel Gene paralytic. eNeuro (2016) 0.75
Whole-Genome Sequencing and iPLEX MassARRAY Genotyping Map an EMS-Induced Mutation Affecting Cell Competition in Drosophila melanogaster. G3 (Bethesda) (2016) 0.75
The extracellular metalloprotease AdamTS-A anchors neural lineages in place within and preserves the architecture of the central nervous system. Development (2017) 0.75
Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol (2000) 128.08
The genome sequence of Drosophila melanogaster. Science (2000) 74.32
The FlyBase database of the Drosophila genome projects and community literature. Nucleic Acids Res (2003) 15.27
The Berkeley Drosophila Genome Project gene disruption project: Single P-element insertions mutating 25% of vital Drosophila genes. Genetics (1999) 7.56
A rapid method for detecting and mapping homology between heterologous DNAs. Evaluation of polyomavirus genomes. J Biol Chem (1979) 5.32
Genetic mapping with SNP markers in Drosophila. Nat Genet (2001) 3.02
Differences in crossover frequency and distribution among three sibling species of Drosophila. Genetics (1996) 2.97
Extension of the limits of the XDH structural element in Drosophila melanogaster. Genetics (1976) 2.71
Mapping of Drosophila mutations using site-specific male recombination. Genetics (1998) 1.67
Integrated platform for detection of DNA sequence variants using capillary array electrophoresis. Electrophoresis (2002) 1.64
Identification of genes controlling germ cell migration and embryonic gonad formation in Drosophila. Development (1998) 1.54
A rapid method to map mutations in Drosophila. Genome Biol (2001) 1.20
High-resolution SNP mapping by denaturing HPLC. Proc Natl Acad Sci U S A (2002) 0.97
The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes. Genetics (2004) 8.40
P[acman]: a BAC transgenic platform for targeted insertion of large DNA fragments in D. melanogaster. Science (2006) 7.03
The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis. Nat Cell Biol (2005) 6.74
Synaptic mitochondria are critical for mobilization of reserve pool vesicles at Drosophila neuromuscular junctions. Neuron (2005) 4.87
Hrs regulates endosome membrane invagination and tyrosine kinase receptor signaling in Drosophila. Cell (2002) 3.72
Versatile P[acman] BAC libraries for transgenesis studies in Drosophila melanogaster. Nat Methods (2009) 3.35
Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling. Cell (2008) 3.09
The v-ATPase V0 subunit a1 is required for a late step in synaptic vesicle exocytosis in Drosophila. Cell (2005) 3.05
Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress. Development (2004) 3.03
Synaptojanin is recruited by endophilin to promote synaptic vesicle uncoating. Neuron (2003) 2.96
Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation. Genes Dev (2005) 2.94
Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila. Development (2002) 2.82
The dragon strikes: lessons from the Wenchuan earthquake. Anesth Analg (2010) 2.78
MiMIC: a highly versatile transposon insertion resource for engineering Drosophila melanogaster genes. Nat Methods (2011) 2.76
Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activity. PLoS Biol (2006) 2.70
Vitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiency. Science (2012) 2.65
Sec15 interacts with Rab11 via a novel domain and affects Rab11 localization in vivo. Nat Struct Mol Biol (2005) 2.61
Genetic manipulation of genes and cells in the nervous system of the fruit fly. Neuron (2011) 2.54
LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis. Neuron (2012) 2.49
Emerging technologies for gene manipulation in Drosophila melanogaster. Nat Rev Genet (2005) 2.49
Drosophila Crumbs is a positional cue in photoreceptor adherens junctions and rhabdomeres. Nature (2002) 2.48
Dap160/intersectin acts as a stabilizing scaffold required for synaptic development and vesicle endocytosis. Neuron (2004) 2.47
Thirty-one flavors of Drosophila rab proteins. Genetics (2007) 2.46
The Drosophila gene disruption project: progress using transposons with distinctive site specificities. Genetics (2011) 2.45
Endophilin mutations block clathrin-mediated endocytosis but not neurotransmitter release. Cell (2002) 2.43
The amyotrophic lateral sclerosis 8 protein VAPB is cleaved, secreted, and acts as a ligand for Eph receptors. Cell (2008) 2.40
The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival. Development (2003) 2.38
A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. Cell (2010) 2.37
Mutations in Drosophila sec15 reveal a function in neuronal targeting for a subset of exocyst components. Neuron (2005) 2.33
Sec15, a component of the exocyst, promotes notch signaling during the asymmetric division of Drosophila sensory organ precursors. Dev Cell (2005) 2.31
Tilting the balance between facilitatory and inhibitory functions of mammalian and Drosophila Complexins orchestrates synaptic vesicle exocytosis. Neuron (2009) 2.26
Synaptotagmin I, a Ca2+ sensor for neurotransmitter release. Trends Neurosci (2003) 2.17
Meaningless minis? Mechanisms of neurotransmitter-receptor clustering. Trends Neurosci (2002) 2.09
The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins. Cell (2005) 2.09
NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration. Nature (2008) 2.01
Systematic discovery of Rab GTPases with synaptic functions in Drosophila. Curr Biol (2011) 1.99
A synaptic vesicle-associated Ca2+ channel promotes endocytosis and couples exocytosis to endocytosis. Cell (2009) 1.98
The nicotinic acetylcholine receptor Dalpha7 is required for an escape behavior in Drosophila. PLoS Biol (2006) 1.97
Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function. EMBO Mol Med (2009) 1.89
Transgenesis upgrades for Drosophila melanogaster. Development (2007) 1.86
A Notch updated. J Cell Biol (2009) 1.86
The architecture of the active zone in the presynaptic nerve terminal. Physiology (Bethesda) (2004) 1.84
GASZ is essential for male meiosis and suppression of retrotransposon expression in the male germline. PLoS Genet (2009) 1.83
ELP3 controls active zone morphology by acetylating the ELKS family member Bruchpilot. Neuron (2011) 1.83
Mapping and identification of essential gene functions on the X chromosome of Drosophila. EMBO Rep (2001) 1.83
Internalization is required for proper Wingless signaling in Drosophila melanogaster. J Cell Biol (2006) 1.82
Serum and urine metabolite profiling reveals potential biomarkers of human hepatocellular carcinoma. Mol Cell Proteomics (2011) 1.81
Mutations in the mitochondrial methionyl-tRNA synthetase cause a neurodegenerative phenotype in flies and a recessive ataxia (ARSAL) in humans. PLoS Biol (2012) 1.80
The circadian clock in the retina controls rod-cone coupling. Neuron (2008) 1.79
Senseless acts as a binary switch during sensory organ precursor selection. Genes Dev (2003) 1.79
Quantitative analysis of bristle number in Drosophila mutants identifies genes involved in neural development. Curr Biol (2003) 1.76
Quantitative trait loci affecting starvation resistance in Drosophila melanogaster. Genetics (2004) 1.76
Drosophila fragile X protein, DFXR, regulates neuronal morphology and function in the brain. Neuron (2002) 1.76
Drosophila VAP-33A directs bouton formation at neuromuscular junctions in a dosage-dependent manner. Neuron (2002) 1.74
A short Nur77-derived peptide converts Bcl-2 from a protector to a killer. Cancer Cell (2008) 1.66
EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis. Mol Cell (2012) 1.65
Eps15 and Dap160 control synaptic vesicle membrane retrieval and synapse development. J Cell Biol (2007) 1.64
Aberrant lysosomal carbohydrate storage accompanies endocytic defects and neurodegeneration in Drosophila benchwarmer. J Cell Biol (2005) 1.52
When cell biology meets development: endocytic regulation of signaling pathways. Genes Dev (2002) 1.51
Activity-independent prespecification of synaptic partners in the visual map of Drosophila. Curr Biol (2006) 1.50