Published in Exp Biol Med (Maywood) on December 22, 2014
Tumor Suppressor WWOX inhibits osteosarcoma metastasis by modulating RUNX2 function. Sci Rep (2015) 0.85
Functions and Epigenetic Regulation of Wwox in Bone Metastasis from Breast Carcinoma: Comparison with Primary Tumors. Int J Mol Sci (2017) 0.78
Tumor Suppressor WWOX Contributes to the Elimination of Tumorigenic Cells in Drosophila melanogaster. PLoS One (2015) 0.78
Genomic Alteration in Head and Neck Squamous Cell Carcinoma (HNSCC) Cell Lines Inferred from Karyotyping, Molecular Cytogenetics, and Array Comparative Genomic Hybridization. PLoS One (2016) 0.76
HYAL-2-WWOX-SMAD4 Signaling in Cell Death and Anticancer Response. Front Cell Dev Biol (2016) 0.76
Role of WW Domain-containing Oxidoreductase WWOX in Driving T Cell Acute Lymphoblastic Leukemia Maturation. J Biol Chem (2016) 0.76
Hyaluronan activates Hyal-2/WWOX/Smad4 signaling and causes bubbling cell death when the signaling complex is overexpressed. Oncotarget (2016) 0.75
Wwox-Brca1 interaction: role in DNA repair pathway choice. Oncogene (2016) 0.75
Fragile sites in cancer: more than meets the eye. Nat Rev Cancer (2017) 0.75
The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers. Cell (1996) 15.19
Signatures of mutation and selection in the cancer genome. Nature (2010) 9.75
Mapping of DNA instability at the fragile X to a trinucleotide repeat sequence p(CCG)n. Science (1991) 5.99
Heritable fragile sites on human chromosomes I. Factors affecting expression in lymphocyte culture. Am J Hum Genet (1979) 5.18
Chromosome fragile sites. Annu Rev Genet (2007) 4.95
WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer. Cancer Res (2000) 4.07
Constitutive fragile sites and cancer. Science (1984) 3.30
DNA polymerase alpha inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes. Hum Genet (1984) 2.92
Hereditary renal-cell carcinoma associated with a chromosomal translocation. N Engl J Med (1979) 2.82
WWOX: a candidate tumor suppressor gene involved in multiple tumor types. Proc Natl Acad Sci U S A (2001) 2.79
Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site. Nature (2011) 2.69
Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells. Hum Mol Genet (2000) 2.56
Targeted deletion of Wwox reveals a tumor suppressor function. Proc Natl Acad Sci U S A (2007) 2.37
Muir-Torre-like syndrome in Fhit-deficient mice. Proc Natl Acad Sci U S A (2000) 2.15
Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: role of Ack1 in polyubiquitination of tumor suppressor Wwox. Cancer Res (2005) 1.97
WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function. Cancer Res (2005) 1.91
Functional association between Wwox tumor suppressor protein and p73, a p53 homolog. Proc Natl Acad Sci U S A (2004) 1.91
Fragile genes as biomarkers: epigenetic control of WWOX and FHIT in lung, breast and bladder cancer. Oncogene (2005) 1.90
Oncogene-induced replication stress preferentially targets common fragile sites in preneoplastic lesions. A genome-wide study. Oncogene (2007) 1.85
Molecular basis for expression of common and rare fragile sites. Mol Cell Biol (2003) 1.78
Physical and functional interactions between the Wwox tumor suppressor protein and the AP-2gamma transcription factor. Cancer Res (2004) 1.74
The molecular basis of common and rare fragile sites. Cancer Lett (2005) 1.68
Genetic alterations of the tumor suppressor gene WWOX in esophageal squamous cell carcinoma. Cancer Res (2002) 1.62
Loss of WWOX expression in gastric carcinoma. Clin Cancer Res (2004) 1.55
WWOX: its genomics, partners, and functions. J Cell Biochem (2009) 1.52
The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma. Cancer (2004) 1.49
WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins. Oncogene (2004) 1.47
A role for the WWOX gene in prostate cancer. Cancer Res (2006) 1.45
The tumor suppressor gene WWOX at FRA16D is involved in pancreatic carcinogenesis. Clin Cancer Res (2004) 1.45
WW domain-containing oxidoreductase: a candidate tumor suppressor. Trends Mol Med (2006) 1.44
WW domain containing oxidoreductase gene expression is altered in non-small cell lung cancer. Cancer Res (2003) 1.42
Common fragile sites are conserved features of human and mouse chromosomes and relate to large active genes. Genome Res (2006) 1.40
Heritable fragile sites on human chromosomes. VIII. Preliminary population cytogenetic data on the folic-acid-sensitive fragile sites. Am J Hum Genet (1982) 1.38
Expression of FRA16D/WWOX and FRA3B/FHIT genes in hematopoietic malignancies. Mol Cancer Res (2003) 1.32
Cancer and the FRA3B/FHIT fragile locus: it's a HIT. Br J Cancer (2003) 1.32
Common fragile site profiling in epithelial and erythroid cells reveals that most recurrent cancer deletions lie in fragile sites hosting large genes. Cell Rep (2013) 1.31
Alternative transcripts of the candidate tumor suppressor gene, WWOX, are expressed at high levels in human breast tumors. Oncogene (2002) 1.31
WWOX, the common chromosomal fragile site, FRA16D, cancer gene. Cytogenet Genome Res (2003) 1.28
Deletion map of chromosome 16q in ductal carcinoma in situ of the breast: refining a putative tumor suppressor gene region. Cancer Res (1996) 1.28
An opposing view on WWOX protein function as a tumor suppressor. Cancer Res (2003) 1.27
WW domain-containing oxidoreductase's role in myriad cancers: clinical significance and future implications. Exp Biol Med (Maywood) (2014) 1.27
Initiation of genome instability and preneoplastic processes through loss of Fhit expression. PLoS Genet (2012) 1.27
WWOX gene expression abolishes ovarian cancer tumorigenicity in vivo and decreases attachment to fibronectin via integrin alpha3. Cancer Res (2009) 1.25
Wwox and Ap2gamma expression levels predict tamoxifen response. Clin Cancer Res (2007) 1.22
WWOX protein expression varies among ovarian carcinoma histotypes and correlates with less favorable outcome. BMC Cancer (2005) 1.22
The common fragile site FRA16D and its associated gene WWOX are highly conserved in the mouse at Fra8E1. Genes Chromosomes Cancer (2002) 1.22
Physical association with WWOX suppresses c-Jun transcriptional activity. Cancer Res (2006) 1.21
Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks. J Biol Chem (2014) 1.19
Targeted ablation of the WW domain-containing oxidoreductase tumor suppressor leads to impaired steroidogenesis. Endocrinology (2008) 1.19
Inactivation of the Wwox gene accelerates forestomach tumor progression in vivo. Cancer Res (2007) 1.19
WWOX, the tumour suppressor gene affected in multiple cancers. J Physiol Pharmacol (2009) 1.16
Frequent attenuation of the WWOX tumor suppressor in osteosarcoma is associated with increased tumorigenicity and aberrant RUNX2 expression. Cancer Res (2010) 1.16
Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein. Oncogene (2009) 1.15
Non-random inactivation of large common fragile site genes in different cancers. Cytogenet Genome Res (2007) 1.15
WWOX--the FRA16D cancer gene: expression correlation with breast cancer progression and prognosis. Eur J Surg Oncol (2005) 1.15
Comparative allelotype of in situ and invasive human breast cancer: high frequency of microsatellite instability in lobular breast carcinomas. Cancer Res (1995) 1.14
WWOX hypomorphic mice display a higher incidence of B-cell lymphomas and develop testicular atrophy. Genes Chromosomes Cancer (2007) 1.13
Deletion of the WWOX gene and frequent loss of its protein expression in human osteosarcoma. Cancer Lett (2009) 1.12
The murine Fhit locus: isolation, characterization, and expression in normal and tumor cells. Cancer Res (1998) 1.10
WWOX expression in different histologic types and subtypes of non-small cell lung cancer. Clin Cancer Res (2007) 1.06
Wwox inactivation enhances mammary tumorigenesis. Oncogene (2011) 1.04
Loss of heterozygosity at chromosome 16q in prostate adenocarcinoma: identification of three independent regions. Cancer Res (1997) 1.04
Role of the WWOX tumor suppressor gene in bone homeostasis and the pathogenesis of osteosarcoma. Am J Cancer Res (2011) 1.03
Common fragile sites are characterized by histone hypoacetylation. Hum Mol Genet (2009) 1.02
Aberrant expression of DNA damage response proteins is associated with breast cancer subtype and clinical features. Breast Cancer Res Treat (2010) 1.01
Common chromosomal fragile site FRA16D mutation in cancer cells. Hum Mol Genet (2005) 1.00
Copy number alterations in prostate tumors and disease aggressiveness. Genes Chromosomes Cancer (2011) 0.97
WW or WoW: the WW domains in a union of bliss. IUBMB Life (2005) 0.96
Association study of a functional copy number variation in the WWOX gene with risk of gliomas among Chinese people. Int J Cancer (2014) 0.94
Biophysical basis of the binding of WWOX tumor suppressor to WBP1 and WBP2 adaptors. J Mol Biol (2012) 0.93
WWOX gene may contribute to progression of non-small-cell lung cancer (NSCLC). Tumour Biol (2010) 0.93
Common chromosome fragile sites in human and murine epithelial cells and FHIT/FRA3B loss-induced global genome instability. Genes Chromosomes Cancer (2013) 0.92
Fhit deficiency-induced global genome instability promotes mutation and clonal expansion. PLoS One (2013) 0.91
Conditional Wwox deletion in mouse mammary gland by means of two Cre recombinase approaches. PLoS One (2012) 0.89
Molecular analysis of WWOX expression correlation with proliferation and apoptosis in glioblastoma multiforme. J Neurooncol (2010) 0.89
Homozygous deletions may be markers of nearby heterozygous mutations: The complex deletion at FRA16D in the HCT116 colon cancer cell line removes exons of WWOX. Genes Chromosomes Cancer (2008) 0.89
WWOX, a chromosomal fragile site gene and its role in cancer. Adv Exp Med Biol (2006) 0.89
Correlation of WWOX, RUNX2 and VEGFA protein expression in human osteosarcoma. BMC Med Genomics (2013) 0.88
Loss of WW domain-containing oxidoreductase expression in the progression and development of gastric carcinoma: clinical and histopathologic correlations. Virchows Arch (2010) 0.87
Aberrant expression of WWOX protein in epithelial ovarian cancer: a clinicopathologic and immunohistochemical study. Int J Gynecol Pathol (2012) 0.87
Translocation t(3;8)(p14.2;q24.1) in renal cell carcinoma affects expression of the common fragile site at 3p14(FRA3B) in lymphocytes. Cancer Genet Cytogenet (1988) 0.87
Genetic alterations of the WWOX gene in breast cancer. Med Oncol (2011) 0.85
Characterization of WWOX inactivation in murine mammary gland development. J Cell Physiol (2013) 0.85
Low levels of WWOX protein immunoexpression correlate with tumour grade and a less favourable outcome in patients with urinary bladder tumours. Histopathology (2008) 0.85
Functional and clinical characterization of the putative tumor suppressor WWOX in non-small cell lung cancer. J Thorac Oncol (2011) 0.84
Microarray analysis reveals down-regulation of the tumour suppressor gene WWOX and up-regulation of the oncogene TYMS in intracranial sporadic meningiomas. J Neurooncol (2008) 0.84
The prognostic significance of WWOX expression in patients with breast cancer and its association with the basal-like phenotype. J Cancer Res Clin Oncol (2010) 0.83
Gene expression of WWOX, FHIT and p73 in acute lymphoblastic leukemia. Oncol Lett (2013) 0.83
The WWOX gene modulates high-density lipoprotein and lipid metabolism. Circ Cardiovasc Genet (2014) 0.82
The role of the WWOX gene in leukemia and its mechanisms of action. Oncol Rep (2013) 0.81
New syngeneic inflammatory-related lung cancer metastatic model harboring double KRAS/WWOX alterations. Int J Cancer (2014) 0.81
WWOX tumour suppressor gene polymorphisms and ovarian cancer pathology and prognosis. Eur J Cancer (2010) 0.80
Association between decreased WWOX protein expression and thyroid cancer development. Thyroid (2007) 0.79
Molecular alterations of the WWOX gene in nasopharyngeal carcinoma. Neoplasma (2014) 0.76