Published in Clin Cancer Res on October 15, 2007
Epigenetic alterations in the breast: Implications for breast cancer detection, prognosis and treatment. Semin Cancer Biol (2009) 1.41
Identification of primary gene targets of TFAP2C in hormone responsive breast carcinoma cells. Genes Chromosomes Cancer (2010) 1.27
The HER4/4ICD estrogen receptor coactivator and BH3-only protein is an effector of tamoxifen-induced apoptosis. Cancer Res (2008) 1.23
HER4 intracellular domain (4ICD) activity in the developing mammary gland and breast cancer. J Mammary Gland Biol Neoplasia (2008) 1.20
WWOX gene and gene product: tumor suppression through specific protein interactions. Future Oncol (2010) 1.16
Subcellular localization of the HER4 intracellular domain, 4ICD, identifies distinct prognostic outcomes for breast cancer patients. Am J Pathol (2009) 1.12
Steroid hormone modulation of RET through two estrogen responsive enhancers in breast cancer. Hum Mol Genet (2011) 1.01
Aberrant expression of DNA damage response proteins is associated with breast cancer subtype and clinical features. Breast Cancer Res Treat (2010) 1.01
Histone demethylase KDM5B collaborates with TFAP2C and Myc to repress the cell cycle inhibitor p21(cip) (CDKN1A). Mol Cell Biol (2012) 0.98
AP-2gamma promotes proliferation in breast tumour cells by direct repression of the CDKN1A gene. EMBO J (2009) 0.97
Common Chromosomal Fragile Site Gene WWOX in Metabolic Disorders and Tumors. Int J Biol Sci (2014) 0.95
WWOX suppresses autophagy for inducing apoptosis in methotrexate-treated human squamous cell carcinoma. Cell Death Dis (2013) 0.94
The ERalpha coactivator, HER4/4ICD, regulates progesterone receptor expression in normal and malignant breast epithelium. Mol Cancer (2010) 0.93
Fulvestrant-induced expression of ErbB3 and ErbB4 receptors sensitizes oestrogen receptor-positive breast cancer cells to heregulin β1. Breast Cancer Res (2011) 0.92
WWOX: a fragile tumor suppressor. Exp Biol Med (Maywood) (2014) 0.84
The prognostic significance of WWOX expression in patients with breast cancer and its association with the basal-like phenotype. J Cancer Res Clin Oncol (2010) 0.83
The localization of HER4 intracellular domain and expression of its alternately-spliced isoforms have prognostic significance in ER+ HER2- breast cancer. Oncotarget (2014) 0.82
Pleiotropic Functions of Tumor Suppressor WWOX in Normal and Cancer Cells. J Biol Chem (2015) 0.82
Coordinate loss of fragile gene expression in pancreatobiliary cancers: correlations among markers and clinical features. Ann Surg Oncol (2009) 0.81
Regulation of cell signaling and apoptosis by tumor suppressor WWOX. Exp Biol Med (Maywood) (2015) 0.80
Interference with activator protein-2 transcription factors leads to induction of apoptosis and an increase in chemo- and radiation-sensitivity in breast cancer cells. BMC Cancer (2010) 0.80
Reduced expression of the WW domain-containing oxidoreductase in human hematopoietic malignancies. Oncol Lett (2016) 0.79
EGFR Is Regulated by TFAP2C in Luminal Breast Cancer and Is a Target for Vandetanib. Mol Cancer Ther (2016) 0.78
Roles of the WWOX in pathogenesis and endocrine therapy of breast cancer. Exp Biol Med (Maywood) (2014) 0.77
Cancer prevention as biomodulation: targeting the initiating stimulus and secondary adaptations. Ann N Y Acad Sci (2012) 0.76
WW domain-binding protein 2: an adaptor protein closely linked to the development of breast cancer. Mol Cancer (2017) 0.75
MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc Natl Acad Sci U S A (2007) 9.82
E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer. Cancer Cell (2008) 7.56
Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission. Cancer Res (2009) 6.74
An HNF4α-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis. Cell (2011) 4.29
A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases. Cancer Cell (2010) 4.02
The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs. Immunity (2009) 3.58
Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling. Cell (2013) 3.08
Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms. Cell (2011) 2.99
Reprogramming of miRNA networks in cancer and leukemia. Genome Res (2010) 2.65
Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth. Proc Natl Acad Sci U S A (2012) 2.11
Breast cancer signatures for invasiveness and prognosis defined by deep sequencing of microRNA. Proc Natl Acad Sci U S A (2012) 2.07
The predictive value of mean platelet volume in differential diagnosis of non-functional pancreatic neuroendocrine tumors from pancreatic adenocarcinomas. Eur J Intern Med (2011) 2.05
Functional association between Wwox tumor suppressor protein and p73, a p53 homolog. Proc Natl Acad Sci U S A (2004) 1.91
Fragile genes as biomarkers: epigenetic control of WWOX and FHIT in lung, breast and bladder cancer. Oncogene (2005) 1.90
NLR family member NLRC5 is a transcriptional regulator of MHC class I genes. Proc Natl Acad Sci U S A (2010) 1.90
Intronic miR-211 assumes the tumor suppressive function of its host gene in melanoma. Mol Cell (2010) 1.86
Concern WWOX gene restoration prevents lung cancer growth in vitro and in vivo. Proc Natl Acad Sci U S A (2005) 1.84
Alterations of the tumor suppressor gene ARLTS1 in ovarian cancer. Cancer Res (2006) 1.71
Cystic and adenofibromatous clear cell carcinomas of the ovary: distinctive tumors that differ in their pathogenesis and behavior: a clinicopathologic analysis of 122 cases. Am J Surg Pathol (2009) 1.71
Salutary effects of adiponectin on colon cancer: in vivo and in vitro studies in mice. Gut (2012) 1.65
Loss of WWOX expression in gastric carcinoma. Clin Cancer Res (2004) 1.55
Accurate diagnosis of acute abdomen in FMF and acute appendicitis patients: how can we use procalcitonin? Clin Rheumatol (2007) 1.49
Identification of novel microRNA signatures linked to human lupus disease activity and pathogenesis: miR-21 regulates aberrant T cell responses through regulation of PDCD4 expression. Ann Rheum Dis (2011) 1.49
The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma. Cancer (2004) 1.49
Akt2 regulates all Akt isoforms and promotes resistance to hypoxia through induction of miR-21 upon oxygen deprivation. Cancer Res (2011) 1.48
A role for the WWOX gene in prostate cancer. Cancer Res (2006) 1.45
Integrated microRNA and mRNA signatures associated with survival in triple negative breast cancer. PLoS One (2013) 1.43
Roles of FHIT and WWOX fragile genes in cancer. Cancer Lett (2005) 1.42
WW domain containing oxidoreductase gene expression is altered in non-small cell lung cancer. Cancer Res (2003) 1.42
MicroRNA-124 regulates STAT3 expression and is down-regulated in colon tissues of pediatric patients with ulcerative colitis. Gastroenterology (2013) 1.41
Epigenetic aberrations during oncogenesis. Cell Mol Life Sci (2011) 1.32
Minimally invasive plating of the distal tibia: do we really sacrifice saphenous vein and nerve? A cadaver study. J Orthop Trauma (2009) 1.32
Expression of FRA16D/WWOX and FRA3B/FHIT genes in hematopoietic malignancies. Mol Cancer Res (2003) 1.32
The prevalence of skin diseases in the elderly: analysis of 4099 geriatric patients. Int J Dermatol (2006) 1.29
microRNA expression profiling identifies a four microRNA signature as a novel diagnostic and prognostic biomarker in triple negative breast cancers. Oncotarget (2014) 1.28
Initiation of genome instability and preneoplastic processes through loss of Fhit expression. PLoS Genet (2012) 1.27
MicroRNA Gene Networks in Oncogenesis. Curr Genomics (2009) 1.26
Neurotensin signaling activates microRNAs-21 and -155 and Akt, promotes tumor growth in mice, and is increased in human colon tumors. Gastroenterology (2011) 1.24
Ulcerative colitis-associated colorectal cancer arises in a field of short telomeres, senescence, and inflammation. Cancer Res (2011) 1.23
Protective role of miR-155 in breast cancer through RAD51 targeting impairs homologous recombination after irradiation. Proc Natl Acad Sci U S A (2014) 1.22
An integrated transcriptional regulatory circuit that reinforces the breast cancer stem cell state. Proc Natl Acad Sci U S A (2012) 1.22
Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells. J Biol Chem (2008) 1.22
Fhit tumor suppressor: guardian of the preneoplastic genome. Future Oncol (2008) 1.21
FHIT: from gene discovery to cancer treatment and prevention. Lancet Oncol (2002) 1.19
Relation between epicardial fat thickness and coronary flow reserve in women with chest pain and angiographically normal coronary arteries. Atherosclerosis (2008) 1.17
The fragile histidine triad/common chromosome fragile site 3B locus and repair-deficient cancers. Cancer Res (2002) 1.17
WWOX gene and gene product: tumor suppression through specific protein interactions. Future Oncol (2010) 1.16
Dysregulation of miR-31 and miR-21 induced by zinc deficiency promotes esophageal cancer. Carcinogenesis (2012) 1.16
Comparative study of the immunohistochemical detection of hormone receptor status and HER-2 expression in primary and paired recurrent/metastatic lesions of patients with breast cancer. Med Oncol (2010) 1.16
Epigenetic modulation of endogenous tumor suppressor expression in lung cancer xenografts suppresses tumorigenicity. Int J Cancer (2007) 1.15
Concordant loss of fragile gene expression early in breast cancer development. Pathol Int (2005) 1.15
MicroRNA signature in massive macronodular adrenocortical disease and implications for adrenocortical tumourigenesis. Clin Endocrinol (Oxf) (2009) 1.15
Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate binding. Proc Natl Acad Sci U S A (2003) 1.14
Using the transtheoretical model to stage screening behavior for colorectal cancer. Health Educ Behav (2003) 1.11
FHIT as tumor suppressor: mechanisms and therapeutic opportunities. Cancer Biol Ther (2002) 1.11
Fhit and CHK1 have opposing effects on homologous recombination repair. Cancer Res (2005) 1.11
Fhit is a physiological target of the protein kinase Src. Proc Natl Acad Sci U S A (2004) 1.10
Fragile site orthologs FHIT/FRA3B and Fhit/Fra14A2: evolutionarily conserved but highly recombinogenic. Proc Natl Acad Sci U S A (2003) 1.09
Infectious complications of rituximab in patients with lymphoma during maintenance therapy: a systematic review and meta-analysis. Leuk Lymphoma (2009) 1.09
Involvement of the Fhit gene in the ionizing radiation-activated ATR/CHK1 pathway. J Cell Physiol (2005) 1.08
Regression of upper gastric cancer in mice by FHIT gene delivery. FASEB J (2003) 1.06
Inhibition of breast cancer cell growth in vitro and in vivo: effect of restoration of Wwox expression. Clin Cancer Res (2007) 1.05
Wnt10b induces chemotaxis of osteosarcoma and correlates with reduced survival. Pediatr Blood Cancer (2008) 1.04
Intramitochondrial calcium regulation by the FHIT gene product sensitizes to apoptosis. Proc Natl Acad Sci U S A (2009) 1.04
Impaired expression of genes regulating cholesterol efflux in human osteoarthritic chondrocytes. J Orthop Res (2010) 1.03
Fragile gene product, Fhit, in oxidative and replicative stress responses. Cancer Sci (2009) 1.03
Biological functions of mammalian Nit1, the counterpart of the invertebrate NitFhit Rosetta stone protein, a possible tumor suppressor. J Biol Chem (2006) 1.02
Percent positive axillary lymph node metastasis predicts survival in patients with non-metastatic breast cancer. Acta Oncol (2008) 1.02
Aberrant expression of DNA damage response proteins is associated with breast cancer subtype and clinical features. Breast Cancer Res Treat (2010) 1.01
The FHIT gene product: tumor suppressor and genome "caretaker". Cell Mol Life Sci (2014) 1.01
Role of the WWOX gene, encompassing fragile region FRA16D, in suppression of pancreatic carcinoma cells. Cancer Sci (2008) 1.00
Correlation of fragile histidine triad (Fhit) protein structural features with effector interactions and biological functions. J Biol Chem (2008) 1.00
Assessment of quality of life of nasopharyngeal carcinoma patients with EORTC QLQ-C30 and H&N-35 modules. Int J Radiat Oncol Biol Phys (2005) 0.99
p53 deficiency accelerates induction and progression of esophageal and forestomach tumors in zinc-deficient mice. Cancer Res (2003) 0.99
Smooth muscle cells isolated from thoracic aortic aneurysms exhibit increased genomic damage, but similar tendency for apoptosis. DNA Cell Biol (2012) 0.99
miRNAs link metabolic reprogramming to oncogenesis. Trends Endocrinol Metab (2013) 0.99
Which patient is a candidate for empirical therapy against Stenotrophomonas maltophilia bacteraemia? An analysis of associated risk factors in a tertiary care hospital. Scand J Infect Dis (2006) 0.97
Pathology and biology associated with the fragile FHIT gene and gene product. J Cell Biochem (2010) 0.97
Molecular parameters of genome instability: roles of fragile genes at common fragile sites. J Cell Biochem (2008) 0.96
Detection of subclinical cardiac involvement in systemic sclerosis by echocardiographic strain imaging. Echocardiography (2008) 0.96
Wwox suppresses prostate cancer cell growth through modulation of ErbB2-mediated androgen receptor signaling. Mol Cancer Res (2007) 0.95
Stem cell-related markers in primary breast cancers and associated metastatic lesions. Mod Pathol (2012) 0.95
Capecitabine-induced severe hypertriglyceridemia: report of two cases. Ann Pharmacother (2006) 0.94
Primary osteosarcoma of the urinary bladder following cyclophosphamide therapy for systemic lupus erythematosus: a case report. J Med Case Rep (2009) 0.94
Could the hand-foot syndrome after capecitabine treatment be associated with better outcome in metastatic breast cancer patients? Acta Oncol (2006) 0.94
Lung cancer susceptibility in Fhit-deficient mice is increased by Vhl haploinsufficiency. Cancer Res (2005) 0.93
The histidine triad protein Hint is not required for murine development or Cdk7 function. Mol Cell Biol (2003) 0.93