Published in Trends Mol Med on December 04, 2006
The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism. J Biol Chem (2008) 1.67
Transforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1. J Biol Chem (2009) 1.28
Zfra affects TNF-mediated cell death by interacting with death domain protein TRADD and negatively regulates the activation of NF-kappaB, JNK1, p53 and WOX1 during stress response. BMC Mol Biol (2007) 1.26
Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks. J Biol Chem (2014) 1.19
Targeted ablation of the WW domain-containing oxidoreductase tumor suppressor leads to impaired steroidogenesis. Endocrinology (2008) 1.19
WWOX gene and gene product: tumor suppression through specific protein interactions. Future Oncol (2010) 1.16
The tumor suppressor gene WWOX links the canonical and noncanonical NF-κB pathways in HTLV-I Tax-mediated tumorigenesis. Blood (2010) 1.16
NF-κB and cancer: a paradigm of Yin-Yang. Am J Cancer Res (2010) 1.08
Complement C1q activates tumor suppressor WWOX to induce apoptosis in prostate cancer cells. PLoS One (2009) 1.05
WW domain-containing oxidoreductase promotes neuronal differentiation via negative regulation of glycogen synthase kinase 3β. Cell Death Differ (2011) 1.05
WWOX, the common fragile site FRA16D gene product, regulates ATM activation and the DNA damage response. Proc Natl Acad Sci U S A (2014) 1.03
Trafficking protein particle complex 6A delta (TRAPPC6AΔ) is an extracellular plaque-forming protein in the brain. Oncotarget (2015) 0.98
Dramatic co-activation of WWOX/WOX1 with CREB and NF-kappaB in delayed loss of small dorsal root ganglion neurons upon sciatic nerve transection in rats. PLoS One (2009) 0.98
Zfra is a small wizard in the mitochondrial apoptosis. Aging (Albany NY) (2010) 0.97
WW domain-containing oxidoreductase in neuronal injury and neurological diseases. Oncotarget (2014) 0.96
Identification of an In Vivo MEK/WOX1 Complex as a Master Switch for Apoptosis in T Cell Leukemia. Genes Cancer (2011) 0.96
Common Chromosomal Fragile Site Gene WWOX in Metabolic Disorders and Tumors. Int J Biol Sci (2014) 0.95
WWOX suppresses autophagy for inducing apoptosis in methotrexate-treated human squamous cell carcinoma. Cell Death Dis (2013) 0.94
Zfra activates memory Hyal-2+ CD3- CD19- spleen cells to block cancer growth, stemness, and metastasis in vivo. Oncotarget (2015) 0.89
TIAF1 self-aggregation in peritumor capsule formation, spontaneous activation of SMAD-responsive promoter in p53-deficient environment, and cell death. Cell Death Dis (2012) 0.88
Tumor Suppressor WWOX and p53 Alterations and Drug Resistance in Glioblastomas. Front Oncol (2013) 0.86
The tumor suppressor WW domain-containing oxidoreductase modulates cell metabolism. Exp Biol Med (Maywood) (2014) 0.85
WWOX: a fragile tumor suppressor. Exp Biol Med (Maywood) (2014) 0.84
Pleiotropic Functions of Tumor Suppressor WWOX in Normal and Cancer Cells. J Biol Chem (2015) 0.82
Introduction to a thematic issue for WWOX. Exp Biol Med (Maywood) (2015) 0.81
Coordinate loss of fragile gene expression in pancreatobiliary cancers: correlations among markers and clinical features. Ann Surg Oncol (2009) 0.81
The degree of segmental aneuploidy measured by total copy number abnormalities predicts survival and recurrence in superficial gastroesophageal adenocarcinoma. PLoS One (2014) 0.81
Regulation of cell signaling and apoptosis by tumor suppressor WWOX. Exp Biol Med (Maywood) (2015) 0.80
WWOX dysfunction induces sequential aggregation of TRAPPC6AΔ, TIAF1, tau and amyloid β, and causes apoptosis. Cell Death Discov (2015) 0.80
Role of WWOX and NF-κB in lung cancer progression. Transl Respir Med (2013) 0.79
Functions and Epigenetic Regulation of Wwox in Bone Metastasis from Breast Carcinoma: Comparison with Primary Tumors. Int J Mol Sci (2017) 0.78
Bubbling cell death: A hot air balloon released from the nucleus in the cold. Exp Biol Med (Maywood) (2016) 0.78
Strategies of oncogenic microbes to deal with WW domain-containing oxidoreductase. Exp Biol Med (Maywood) (2014) 0.77
Roles of the WWOX in pathogenesis and endocrine therapy of breast cancer. Exp Biol Med (Maywood) (2014) 0.77
Role of WW Domain-containing Oxidoreductase WWOX in Driving T Cell Acute Lymphoblastic Leukemia Maturation. J Biol Chem (2016) 0.76
HYAL-2-WWOX-SMAD4 Signaling in Cell Death and Anticancer Response. Front Cell Dev Biol (2016) 0.76
Modulation of Sonic hedgehog signaling and WW domain containing oxidoreductase WOX1 expression enhances radiosensitivity of human glioblastoma cells. Exp Biol Med (Maywood) (2015) 0.76
Hyaluronan activates Hyal-2/WWOX/Smad4 signaling and causes bubbling cell death when the signaling complex is overexpressed. Oncotarget (2016) 0.75
Clam focal and systemic immune responses to QPX infection revealed by RNA-seq technology. BMC Genomics (2016) 0.75
Tumor Suppressor Genes within Common Fragile Sites Are Active Players in the DNA Damage Response. PLoS Genet (2016) 0.75
Current questions and controversies in chromosome fragile site research: does WWOX, the gene product of common fragile site FRA16D, have a passive or active role in cancer? Cell Death Discov (2015) 0.75
Expression of WW domain-containing oxidoreductase WWOX in pterygium. Mol Vis (2015) 0.75
Decreased WWOX expression promotes angiogenesis in osteosarcoma. Oncotarget (2017) 0.75
WWOX sensitises ovarian cancer cells to paclitaxel via modulation of the ER stress response. Cell Death Dis (2017) 0.75
Dengue hemorrhagic fever in infants: a study of clinical and cytokine profiles. J Infect Dis (2004) 2.43
Autophagic machinery activated by dengue virus enhances virus replication. Virology (2008) 2.23
Concanavalin A induces autophagy in hepatoma cells and has a therapeutic effect in a murine in situ hepatoma model. Hepatology (2007) 2.16
The dual-specific binding of dengue virus and target cells for the antibody-dependent enhancement of dengue virus infection. J Immunol (2006) 1.93
Antibodies from dengue patient sera cross-react with endothelial cells and induce damage. J Med Virol (2003) 1.72
Erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis: acute ocular manifestations, causes, and management. Cornea (2007) 1.68
Advanced penile verrucous carcinoma treated with intra-aortic infusion chemotherapy. J Urol (2010) 1.65
MCP-1, a highly expressed chemokine in dengue haemorrhagic fever/dengue shock syndrome patients, may cause permeability change, possibly through reduced tight junctions of vascular endothelium cells. J Gen Virol (2006) 1.63
Correlation of serum levels of macrophage migration inhibitory factor with disease severity and clinical outcome in dengue patients. Am J Trop Med Hyg (2006) 1.61
Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin-interacting protein-mediated pathway. Blood (2008) 1.45
Ofuji's disease with follicular mucinosis and its differential diagnosis from alopecia mucinosa. J Cutan Pathol (2003) 1.41
Endothelial cell apoptosis induced by antibodies against dengue virus nonstructural protein 1 via production of nitric oxide. J Immunol (2002) 1.40
WOX1 is essential for tumor necrosis factor-, UV light-, staurosporine-, and p53-mediated cell death, and its tyrosine 33-phosphorylated form binds and stabilizes serine 46-phosphorylated p53. J Biol Chem (2005) 1.40
Association between sex, nutritional status, severity of dengue hemorrhagic fever, and immune status in infants with dengue hemorrhagic fever. Am J Trop Med Hyg (2005) 1.34
Autoimmune pathogenesis in dengue virus infection. Viral Immunol (2006) 1.32
Down-regulation of WW domain-containing oxidoreductase induces Tau phosphorylation in vitro. A potential role in Alzheimer's disease. J Biol Chem (2004) 1.31
Transforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1. J Biol Chem (2009) 1.28
Zfra affects TNF-mediated cell death by interacting with death domain protein TRADD and negatively regulates the activation of NF-kappaB, JNK1, p53 and WOX1 during stress response. BMC Mol Biol (2007) 1.26
Expression of cytokine, chemokine, and adhesion molecules during endothelial cell activation induced by antibodies against dengue virus nonstructural protein 1. J Immunol (2005) 1.26
Virus replication and cytokine production in dengue virus-infected human B lymphocytes. J Virol (2002) 1.25
GSK-3beta acts downstream of PP2A and the PI 3-kinase-Akt pathway, and upstream of caspase-2 in ceramide-induced mitochondrial apoptosis. J Cell Sci (2007) 1.22
Heparin inhibits dengue-2 virus infection of five human liver cell lines. Antiviral Res (2002) 1.21
Cytokines and serotonin transporter in patients with major depression. Prog Neuropsychopharmacol Biol Psychiatry (2006) 1.21
Dengue viruses can infect human primary lung epithelia as well as lung carcinoma cells, and can also induce the secretion of IL-6 and RANTES. Virus Res (2007) 1.20
Signaling from membrane receptors to tumor suppressor WW domain-containing oxidoreductase. Exp Biol Med (Maywood) (2010) 1.19
17beta-Estradiol upregulates and activates WOX1/WWOXv1 and WOX2/WWOXv2 in vitro: potential role in cancerous progression of breast and prostate to a premetastatic state in vivo. Oncogene (2005) 1.18
Current progress in dengue vaccines. J Biomed Sci (2013) 1.16
Sequential caspase-2 and caspase-8 activation upstream of mitochondria during ceramideand etoposide-induced apoptosis. J Biol Chem (2004) 1.15
WOX1 is essential for UVB irradiation-induced apoptosis and down-regulated via translational blockade in UVB-induced cutaneous squamous cell carcinoma in vivo. Clin Cancer Res (2005) 1.14
Volume replacement in infants with dengue hemorrhagic fever/dengue shock syndrome. Am J Trop Med Hyg (2006) 1.13
Autophagy facilitates IFN-gamma-induced Jak2-STAT1 activation and cellular inflammation. J Biol Chem (2010) 1.13
Glycogen synthase kinase-3beta facilitates IFN-gamma-induced STAT1 activation by regulating Src homology-2 domain-containing phosphatase 2. J Immunol (2009) 1.13
Effects of oligopeptide permease in group a streptococcal infection. Infect Immun (2005) 1.11
Characteristic of dengue disease in Taiwan: 2002-2007. Am J Trop Med Hyg (2010) 1.08
MPP+-induced neuronal death in rats involves tyrosine 33 phosphorylation of WW domain-containing oxidoreductase WOX1. Eur J Neurosci (2008) 1.08
Plasma kallistatin levels in patients with severe community-acquired pneumonia. Crit Care (2013) 1.07
Clinical and laboratory predictive markers for acute dengue infection. J Biomed Sci (2013) 1.06
Complement C1q activates tumor suppressor WWOX to induce apoptosis in prostate cancer cells. PLoS One (2009) 1.05
Maturation processing and characterization of streptopain. J Biol Chem (2003) 1.04
Glycogen synthase kinase-3 negatively regulates anti-inflammatory interleukin-10 for lipopolysaccharide-induced iNOS/NO biosynthesis and RANTES production in microglial cells. Immunology (2008) 1.03
Tissue plasminogen activator induced by dengue virus infection of human endothelial cells. J Med Virol (2003) 1.01
Anti-dengue virus nonstructural protein 1 antibodies recognize protein disulfide isomerase on platelets and inhibit platelet aggregation. Mol Immunol (2009) 1.01
Proteomic analysis of endothelial cell autoantigens recognized by anti-dengue virus nonstructural protein 1 antibodies. Exp Biol Med (Maywood) (2008) 1.00
Prediction of outcome in patients with acute respiratory distress syndrome by bronchoalveolar lavage inflammatory mediators. Exp Biol Med (Maywood) (2010) 1.00
Patients with a large prostate show a higher prevalence of androgenetic alopecia. Arch Dermatol Res (2004) 1.00
Macrophage migration inhibitory factor induces autophagy via reactive oxygen species generation. PLoS One (2012) 0.98
Zfra is an inhibitor of Bcl-2 expression and cytochrome c release from the mitochondria. Cell Signal (2008) 0.98
Dramatic co-activation of WWOX/WOX1 with CREB and NF-kappaB in delayed loss of small dorsal root ganglion neurons upon sciatic nerve transection in rats. PLoS One (2009) 0.98
Glycogen synthase kinase-3 and Omi/HtrA2 induce annexin A2 cleavage followed by cell cycle inhibition and apoptosis. Mol Biol Cell (2009) 0.97
Zfra is a small wizard in the mitochondrial apoptosis. Aging (Albany NY) (2010) 0.97
Streptococcal pyrogenic exotoxin B cleaves properdin and inhibits complement-mediated opsonophagocytosis. Biochem Biophys Res Commun (2005) 0.97
Apoptotic sphingolipid ceramide in cancer therapy. J Lipids (2011) 0.97
Molecular analysis of group A streptococcal isolates associated with scarlet fever in southern Taiwan between 1993 and 2002. J Clin Microbiol (2003) 0.97
Squamous cell carcinoma of the big toe successfully treated by intra-arterial infusion with methotrexate. Dermatol Surg (2003) 0.97
Degradation of complement 3 by streptococcal pyrogenic exotoxin B inhibits complement activation and neutrophil opsonophagocytosis. Infect Immun (2008) 0.97
Dengue virus infection induces autophagy: an in vivo study. J Biomed Sci (2013) 0.96
Bactericidal effects of toluidine blue-mediated photodynamic action on Vibrio vulnificus. Antimicrob Agents Chemother (2005) 0.96
Identification of an In Vivo MEK/WOX1 Complex as a Master Switch for Apoptosis in T Cell Leukemia. Genes Cancer (2011) 0.96
Dengue virus nonstructural protein NS1 binds to prothrombin/thrombin and inhibits prothrombin activation. J Infect (2011) 0.94
Macrophage migration inhibitory factor induced by dengue virus infection increases vascular permeability. Cytokine (2011) 0.93
Inhibition of neutrophil apoptosis via sphingolipid signaling in acute lung injury. J Pharmacol Exp Ther (2011) 0.93
Prevalence of skin disease among nursing home patients in southern Taiwan. Int J Dermatol (2002) 0.93
Glycogen synthase kinase-3beta mediates endoplasmic reticulum stress-induced lysosomal apoptosis in leukemia. J Pharmacol Exp Ther (2009) 0.93
An iron-binding protein, Dpr, decreases hydrogen peroxide stress and protects Streptococcus pyogenes against multiple stresses. Infect Immun (2008) 0.93
Transient CD4/CD8 ratio inversion and aberrant immune activation during dengue virus infection. J Med Virol (2002) 0.93
Dengue virus induces thrombomodulin expression in human endothelial cells and monocytes in vitro. J Infect (2009) 0.92
Endothelial cell surface expression of protein disulfide isomerase activates β1 and β3 integrins and facilitates dengue virus infection. J Cell Biochem (2012) 0.92
Lithium inhibits ceramide- and etoposide-induced protein phosphatase 2A methylation, Bcl-2 dephosphorylation, caspase-2 activation, and apoptosis. Mol Pharmacol (2006) 0.91
Histopathologic changes in kidney and liver correlate with streptococcal pyrogenic exotoxin B production in the mouse model of group A streptococcal infection. Microb Pathog (2004) 0.91
Liver injury caused by antibodies against dengue virus nonstructural protein 1 in a murine model. Lab Invest (2008) 0.90
Cloning and characterization of a small-size peptide Zfra that regulates the cytotoxic function of tumor necrosis factor by interacting with JNK1. Biochem Biophys Res Commun (2005) 0.90
Cordyceps sinensis mycelium protects mice from group A streptococcal infection. J Med Microbiol (2005) 0.89
An emerging role for the anti-inflammatory cytokine interleukin-10 in dengue virus infection. J Biomed Sci (2013) 0.89
Synergistic effects of streptolysin S and streptococcal pyrogenic exotoxin B on the mouse model of group A streptococcal infection. Med Microbiol Immunol (2012) 0.89
Deletion of the C-terminal region of dengue virus nonstructural protein 1 (NS1) abolishes anti-NS1-mediated platelet dysfunction and bleeding tendency. J Immunol (2009) 0.89
Kallistatin modulates immune cells and confers anti-inflammatory response to protect mice from group A streptococcal infection. Antimicrob Agents Chemother (2013) 0.88
Bcl-2 rescues ceramide- and etoposide-induced mitochondrial apoptosis through blockage of caspase-2 activation. J Biol Chem (2005) 0.88
Vesicular pemphigoid with circulating autoantibodies against 230-kDa and 180-kDa proteins, and additional autoantibodies against 97-kDa and 45-kDa proteins. Int J Dermatol (2007) 0.88
Complete Genome Sequence of emm1 Streptococcus pyogenes A20, a Strain with an Intact Two-Component System, CovRS, Isolated from a Patient with Necrotizing Fasciitis. Genome Announc (2013) 0.88
Downregulation of thrombomodulin, a novel target of Snail, induces tumorigenesis through epithelial-mesenchymal transition. Mol Cell Biol (2010) 0.88
Oxidative stress and metal ions regulate a ferritin-like gene, dpr, in Streptococcus pyogenes. Int J Med Microbiol (2009) 0.88
Changing epidemiology of Streptococcus pyogenes emm types and associated invasive and noninvasive infections in Southern Taiwan. J Clin Microbiol (2009) 0.87
Traffic-related air pollution, climate, and prevalence of eczema in Taiwanese school children. J Invest Dermatol (2008) 0.87
Expression of peroxisome proliferator-activated receptor and CCAAT/enhancer binding protein transcription factors in cultured human sebocytes. J Invest Dermatol (2003) 0.86
Factors contributing to the disturbance of coagulation and fibrinolysis in dengue virus infection. J Formos Med Assoc (2012) 0.86
Hexavalent chromium induced ROS formation, Akt, NF-kappaB, and MAPK activation, and TNF-alpha and IL-1alpha production in keratinocytes. Toxicol Lett (2010) 0.86
Annexin A2 silencing induces G2 arrest of non-small cell lung cancer cells through p53-dependent and -independent mechanisms. J Biol Chem (2012) 0.86
Autoimmunity in dengue pathogenesis. J Formos Med Assoc (2012) 0.86
Benzyl butyl phthalate induces migration, invasion, and angiogenesis of Huh7 hepatocellular carcinoma cells through nongenomic AhR/G-protein signaling. BMC Cancer (2014) 0.86
Increased galectin-3 facilitates leukemia cell survival from apoptotic stimuli. Biochem Biophys Res Commun (2011) 0.86
Procaspase 8 and Bax are up-regulated by distinct pathways in Streptococcal pyrogenic exotoxin B-induced apoptosis. J Biol Chem (2009) 0.85
Autophagy facilitates an IFN-γ response and signal transduction. Microbes Infect (2011) 0.84
Solution structure and backbone dynamics of streptopain: insight into diverse substrate specificity. J Biol Chem (2009) 0.84