Published in Proc Natl Acad Sci U S A on November 01, 1989
Pertussis toxin has eukaryotic-like carbohydrate recognition domains. Proc Natl Acad Sci U S A (1992) 1.56
Engineering of genetically detoxified pertussis toxin analogs for development of a recombinant whooping cough vaccine. Infect Immun (1990) 1.08
Site-specific mutagenesis of the catalytic subunit of cholera toxin: substituting lysine for arginine 7 causes loss of activity. Infect Immun (1991) 1.01
Construction of minitransposons for constitutive and inducible expression of pertussis toxin in bvg-negative Bordetella bronchiseptica. Infect Immun (1991) 0.90
Contribution of the B oligomer to the protective activity of genetically attenuated pertussis toxin. Infect Immun (1991) 0.89
Characterization of murine monoclonal antibodies that recognize defined epitopes of pertussis toxin and neutralize its toxic effect on Chinese hamster ovary cells. Infect Immun (1991) 0.87
Assignment of functional domains involved in ADP-ribosylation and B-oligomer binding within the carboxyl terminus of the S1 subunit of pertussis toxin. Infect Immun (1994) 0.87
Reversal of the CD4(+)/CD8(+) T-cell ratio in lymph node cells upon in vitro mitogenic stimulation by highly purified, water-soluble S3-S4 dimer of pertussis toxin. Infect Immun (2001) 0.86
Properties of pertussis toxin B oligomer assembled in vitro from recombinant polypeptides produced by Escherichia coli. Infect Immun (1992) 0.78
Progress with a recombinant whooping cough vaccine: a review. J R Soc Med (1992) 0.75
A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res (1984) 181.98
Empirical predictions of protein conformation. Annu Rev Biochem (1978) 25.48
G proteins and dual control of adenylate cyclase. Cell (1984) 11.05
Pertussis immunisation and serious acute neurological illness in children. Br Med J (Clin Res Ed) (1981) 8.48
Nature and rates of adverse reactions associated with DTP and DT immunizations in infants and children. Pediatrics (1981) 7.58
Direct modification of the membrane adenylate cyclase system by islet-activating protein due to ADP-ribosylation of a membrane protein. Proc Natl Acad Sci U S A (1982) 5.68
Subunit structure of islet-activating protein, pertussis toxin, in conformity with the A-B model. Biochemistry (1982) 5.33
Induction of a novel morphological response in Chinese hamster ovary cells by pertussis toxin. Infect Immun (1983) 5.03
Roles of G protein subunits in transmembrane signalling. Nature (1988) 4.16
Pertussis toxin: the cause of the harmful effects and prolonged immunity of whooping cough. A hypothesis. Rev Infect Dis (1980) 3.34
A role of the B-oligomer moiety of islet-activating protein, pertussis toxin, in development of the biological effects on intact cells. J Biol Chem (1983) 2.65
Monoclonal antibody against pertussis toxin: effect on toxin activity and pertussis infections. Infect Immun (1984) 2.59
Lectin-like binding of pertussis toxin to a 165-kilodalton Chinese hamster ovary cell glycoprotein. J Biol Chem (1988) 1.88
Recombinant system for overexpression of cholera toxin B subunit in Vibrio cholerae as a basis for vaccine development. Proc Natl Acad Sci U S A (1989) 1.74
Coordinated assembly of multisubunit proteins: oligomerization of bacterial enterotoxins in vivo and in vitro. Proc Natl Acad Sci U S A (1988) 1.68
Pertussis vaccine: present status and future prospects. Vaccine (1985) 1.63
Dual mechanisms involved in development of diverse biological activities of islet-activating protein, pertussis toxin, as revealed by chemical modification of lysine residues in the toxin molecule. Biochim Biophys Acta (1984) 1.62
Effect of monoclonal antibody to pertussis toxin on toxin activity. Infect Immun (1987) 1.61
ADP-ribosyltransferase activity of pertussis toxin and immunomodulation by Bordetella pertussis. Science (1988) 1.57
Pertussis toxin S1 mutant with reduced enzyme activity and a conserved protective epitope. Science (1988) 1.56
Role of the A subunit of pertussis toxin in alteration of Chinese hamster ovary cell morphology. Infect Immun (1987) 1.52
Human T cell clones define S1 subunit as the most immunogenic moiety of pertussis toxin and determine its epitope map. J Exp Med (1989) 1.49
Pertussis toxin effects on T lymphocytes are mediated through CD3 and not by pertussis toxin catalyzed modification of a G protein. J Immunol (1989) 1.45
Identification of a region in the S1 subunit of pertussis toxin that is required for enzymatic activity and that contributes to the formation of a neutralizing antigenic determinant. Proc Natl Acad Sci U S A (1988) 1.40
Immune response to the B oligomer of pertussis toxin. Infect Immun (1987) 1.36
Epitopes on the S1 subunit of pertussis toxin recognized by monoclonal antibodies. Infect Immun (1989) 1.32
Clinical implications of guanine nucleotide-binding proteins as receptor-effector couplers. N Engl J Med (1985) 1.27
Neurologic events following diphtheria-tetanus-pertussis immunization. Pediatrics (1988) 1.01
Antigens in whooping cough vaccine and antibody levels induced by vaccination of children. Lancet (1983) 0.99
The efficacy of acellular pertussis vaccine. JAMA (1989) 0.97
Alkylation of cysteine 41, but not cysteine 200, decreases the ADP-ribosyltransferase activity of the S1 subunit of pertussis toxin. J Biol Chem (1989) 0.93
Immune response to dimeric subunits of the pertussis toxin B oligomer. Infect Immun (1989) 0.89
Neurotoxicity of Bordetella pertussis. Neurotoxicology (1986) 0.84
Comparing the efficacy of pertussis vaccines. Lancet (1989) 0.79
"Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. Anal Biochem (1981) 71.15
The isolation of hybrid cell lines producing monoclonal antibodies against the p15(E) protein of ecotropic murine leukemia viruses. Virology (1979) 4.59
Molecular characterization of an operon required for pertussis toxin secretion. Proc Natl Acad Sci U S A (1993) 4.12
Adaptation of a conjugal transfer system for the export of pathogenic macromolecules. Trends Microbiol (1996) 2.74
Monoclonal antibodies against murine leukemia viruses: identification of six antigenic determinants on the p 15(E) and gp70 envelope proteins. Virology (1979) 2.62
Stoichiometry and specificity of binding of Rauscher oncovirus 10,000-dalton (p10) structural protein to nucleic acids. J Virol (1978) 1.83
Activation by thiol of the latent NAD glycohydrolase and ADP-ribosyltransferase activities of Bordetella pertussis toxin (islet-activating protein). J Biol Chem (1983) 1.74
Agglutinating monoclonal antibodies that specifically recognize lipooligosaccharide A of Bordetella pertussis. Infect Immun (1988) 1.71
Binding of pertussis toxin to eucaryotic cells and glycoproteins. Infect Immun (1989) 1.71
Pertussis toxin and target eukaryotic cells: binding, entry, and activation. FASEB J (1992) 1.62
Pertussis toxin S1 mutant with reduced enzyme activity and a conserved protective epitope. Science (1988) 1.56
Pertussis toxin has eukaryotic-like carbohydrate recognition domains. Proc Natl Acad Sci U S A (1992) 1.56
Role of the A subunit of pertussis toxin in alteration of Chinese hamster ovary cell morphology. Infect Immun (1987) 1.52
Pertussis toxin inhibits enkephalin stimulation of GTPase of NG108-15 cells. J Biol Chem (1983) 1.41
Identification of a region in the S1 subunit of pertussis toxin that is required for enzymatic activity and that contributes to the formation of a neutralizing antigenic determinant. Proc Natl Acad Sci U S A (1988) 1.40
Immune response to the B oligomer of pertussis toxin. Infect Immun (1987) 1.36
Localization of the promoter for the ptl genes of Bordetella pertussis, which encode proteins essential for secretion of pertussis toxin. Infect Immun (1995) 1.35
Synthesis and processing of viral glycoproteins in two nonconditional mutants of Rous sarcoma virus. J Virol (1980) 1.34
Epitopes on the S1 subunit of pertussis toxin recognized by monoclonal antibodies. Infect Immun (1989) 1.32
Spontaneous activation of latent cytomegalovirus from murine spleen explants. Role of lymphocytes and macrophages in release and replication of virus. J Clin Invest (1982) 1.30
Detection and subcellular localization of three Ptl proteins involved in the secretion of pertussis toxin from Bordetella pertussis. J Bacteriol (1994) 1.28
Evidence for a ninth gene, ptlI, in the locus encoding the pertussis toxin secretion system of Bordetella pertussis and formation of a PtlI-PtlF complex. J Biol Chem (1996) 1.26
Role of carbohydrate recognition domains of pertussis toxin in adherence of Bordetella pertussis to human macrophages. Infect Immun (1992) 1.24
Adenine nucleotides promote dissociation of pertussis toxin subunits. J Biol Chem (1986) 1.17
Physical and chemical properties of Moloney murine leukemia virus p30 protein: a major core structural component exhibiting high helicity and self-association. J Mol Biol (1976) 1.17
Analysis of Bordetella pertussis isolates collected in Japan before and after introduction of acellular pertussis vaccines. Vaccine (2001) 1.13
Live donor adult liver transplantation using right lobe grafts: donor evaluation and surgical outcome. Arch Surg (2001) 1.13
NIH conference. Cyclic nucleotides: mediators of bacterial toxin action in disease. Ann Intern Med (1984) 1.13
Role of gamma interferon in natural clearance of Bordetella pertussis infection. Infect Immun (1997) 1.12
Stimulation of the thiol-dependent ADP-ribosyltransferase and NAD glycohydrolase activities of Bordetella pertussis toxin by adenine nucleotides, phospholipids, and detergents. Biochemistry (1986) 1.10
Life-threatening hypophosphatemia after right hepatic lobectomy for live donor adult liver transplantation. Liver Transpl (2001) 1.08
Importance of holotoxin assembly in Ptl-mediated secretion of pertussis toxin from Bordetella pertussis. Infect Immun (2000) 1.05
ADP-ribosylation of transducin by pertussis toxin. J Biol Chem (1985) 1.05
Human serologic response to envelope-associated proteins and adenylate cyclase toxin of Bordetella pertussis. J Infect Dis (1991) 1.04
Site-specific mutagenesis of the catalytic subunit of cholera toxin: substituting lysine for arginine 7 causes loss of activity. Infect Immun (1991) 1.01
Assembly of the catalytic trimers of aspartate transcarbamoylase from folded monomers. J Biol Chem (1982) 1.00
Use of pertussis toxin encoded by ptx genes from Bordetella bronchiseptica to model the effects of antigenic drift of pertussis toxin on antibody neutralization. Infect Immun (2000) 1.00
Analysis of proteins encoded by the ptx and ptl genes of Bordetella bronchiseptica and Bordetella parapertussis. Infect Immun (1996) 0.99
Antiinflammatory effects in experimental meningitis of prokaryotic peptides that mimic selectins. J Infect Dis (1993) 0.96
Construction and characterization of recombinant Vibrio cholerae strains producing inactive cholera toxin analogs. Infect Immun (1994) 0.94
Prokaryotic peptides that block leukocyte adherence to selectins. J Exp Med (1993) 0.93
Alkylation of cysteine 41, but not cysteine 200, decreases the ADP-ribosyltransferase activity of the S1 subunit of pertussis toxin. J Biol Chem (1989) 0.93
Pertussis toxin-catalyzed ADP-ribosylation: effects on the coupling of inhibitory receptors to the adenylate cyclase system. J Recept Res (1984) 0.92
Capsule endoscopy findings in celiac disease associated enteropathy-type intestinal T-cell lymphoma. Endoscopy (2005) 0.91
Identification and characterization of PtlC, an essential component of the pertussis toxin secretion system. Infect Immun (1999) 0.90
Immune response to dimeric subunits of the pertussis toxin B oligomer. Infect Immun (1989) 0.89
Contribution of the B oligomer to the protective activity of genetically attenuated pertussis toxin. Infect Immun (1991) 0.89
Interaction of pertussis toxin with cells and model membranes. J Biol Chem (1992) 0.89
Assembly of the catalytic trimers of aspartate transcarbamoylase from unfolded polypeptide chains. J Biol Chem (1982) 0.87
Essential role of the consensus nucleotide-binding site of PtlH in secretion of pertussis toxin from Bordetella pertussis. J Bacteriol (1997) 0.86
Molecular characterization of two Bordetella bronchiseptica strains isolated from children with coughs. J Clin Microbiol (1997) 0.86
Inhibition of bovine rod outer segment GTPase by Bordetella pertussis toxin. J Biol Chem (1984) 0.85
Binding of pertussis toxin to lipid vesicles containing glycolipids. Infect Immun (1993) 0.84
Isolation and structural characterization of three isoforms of recombinant consensus alpha interferon. Arch Biochem Biophys (1990) 0.83
Experimental localization of muscarinic receptor subtypes to cingulate cortical afferents and neurons. J Neurosci (1988) 0.82
Effects of exogenous agents on the action of Bordetella parapertussis heat-labile toxin on guinea pig skin. Infect Immun (1990) 0.82
Photolabelling of mutant forms of the S1 subunit of pertussis toxin with NAD+. Biochem J (1990) 0.82
Binding of ATP by pertussis toxin and isolated toxin subunits. Biochemistry (1990) 0.82
Antibodies to Bordetella pertussis adenylate cyclase toxin in neonatal and maternal sera. FEMS Immunol Med Microbiol (1993) 0.82
Prospects for a new acellular pertussis vaccine. Ann Inst Pasteur Microbiol (1986) 0.81
Structural and functional properties of a 69-kilodalton outer membrane protein of Bordetella pertussis. Tokai J Exp Clin Med (1988) 0.81
Release of guanyl nucleotides from the regulatory subunit of adenylate cyclase. J Biol Chem (1983) 0.79
Myocardial infarction caused by cardiac microvasculopathy in a patient with the primary antiphospholipid syndrome. Ann Intern Med (1992) 0.79
Properties of pertussis toxin B oligomer assembled in vitro from recombinant polypeptides produced by Escherichia coli. Infect Immun (1992) 0.78
Physical and chemical properties of an oncornavirus associated with a murine adrenal carcinoma cell line. J Virol (1974) 0.78
Purification and analysis of the antigenicity of a 69,000 Da protein from Bordetella pertussis. FEMS Microbiol Lett (1990) 0.77
Ligand-promoted strengthening of interchain bonding domains in catalytic subunits of aspartate transcarbamoylase. J Biol Chem (1982) 0.77
Choleragen-stimulated release of guanyl nucleotides from turkey erythrocyte membranes. J Biol Chem (1982) 0.77
Renaming protein secretion in the gram-negative bacteria. Trends Microbiol (2000) 0.77
Effects of pertussis toxin on cAMP and cGMP responses to carbamylcholine in N1E-115 neuroblastoma cells. Mol Pharmacol (1985) 0.76
Monoclonal antibodies against the enzymatic subunit of both pertussis and cholera toxins. Dev Biol Stand (1991) 0.76
Progress with a recombinant whooping cough vaccine: a review. J R Soc Med (1992) 0.75
Human antibody response to the B oligomer of pertussis toxin. Clin Diagn Lab Immunol (1994) 0.75
Inhibition of heat-labile toxin from Bordetella parapertussis by fatty acids. Infect Immun (1990) 0.75
Interstrain variation of the major internal structural component (p30gag) of two murine oncornaviruses: comparative immunochemical, biochemical, and biophysical analysis. J Virol (1978) 0.75
Developments toward a recombinant pertussis vaccine. Adv Exp Med Biol (1989) 0.75
Hepatitis B vaccine produced in yeast. J Med Virol (1988) 0.75
Recent advances in the development of pertussis vaccines. Biotechnology (1992) 0.75
Properties and relative immunogenicity of various preparations of recombinant DNA-derived hepatitis B surface antigen. Dev Biol Stand (1985) 0.75
Overview--combination vaccines and simultaneous administration. Past, present, and future. Ann N Y Acad Sci (1995) 0.75
Heat-labile toxin from Bordetella parapertussis induces contraction of smooth muscle cells in culture. Microbiol Immunol (1992) 0.75
Vaccine development: necessity as the mother of invention. New Biol (1992) 0.75
The molecular engineering of pertussis toxoid. Dev Biol Stand (1991) 0.75
Development of a cell culture assay for Bordetella parapertussis heat-labile toxin. Biologicals (1990) 0.75
Successful algorithm for selective liver biopsy in the right hepatic lobe live donor (RHLD). Am J Transplant (2008) 0.75
Bordetella heat-labile toxin causes release of radioactivity from smooth muscle cells labeled with [14C]arachidonic acid. FEMS Microbiol Lett (1992) 0.75