Published in Mar Drugs on December 24, 2014
Xyloketal B suppresses glioblastoma cell proliferation and migration in vitro through inhibiting TRPM7-regulated PI3K/Akt and MEK/ERK signaling pathways. Mar Drugs (2015) 0.84
Activation of TRPM7 by naltriben enhances migration and invasion of glioblastoma cells. Oncotarget (2017) 0.75
Identification of the first marine-derived opioid receptor "balanced" agonist with a signaling profile that resembles the endorphins. ACS Chem Neurosci (2016) 0.75
Xyloketal-derived small molecules show protective effect by decreasing mutant Huntingtin protein aggregates in Caenorhabditis elegans model of Huntington's disease. Drug Des Devel Ther (2016) 0.75
Xyloketal B alleviates cerebral infarction and neurologic deficits in a mouse stroke model by suppressing the ROS/TLR4/NF-κB inflammatory signaling pathway. Acta Pharmacol Sin (2017) 0.75
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Five unique compounds: xyloketals from mangrove fungus Xylaria sp. from the South China Sea coast. J Org Chem (2001) 1.37
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A novel marine compound xyloketal B protects against oxidized LDL-induced cell injury in vitro. Biochem Pharmacol (2009) 0.98
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Protective effects of xyloketal B against MPP+-induced neurotoxicity in Caenorhabditis elegans and PC12 cells. Brain Res (2010) 0.95
Design and synthesis of novel xyloketal derivatives and their vasorelaxing activities in rat thoracic aorta and angiogenic activities in zebrafish angiogenesis screen. J Med Chem (2010) 0.94
Neuronal calcium sensor-1 modulation of optimal calcium level for neurite outgrowth. Development (2007) 0.94
Xyloketal B exhibits its antioxidant activity through induction of HO-1 in vascular endothelial cells and zebrafish. Mar Drugs (2013) 0.91
Marine compound Xyloketal B protects PC12 cells against OGD-induced cell damage. Brain Res (2009) 0.91
Targeting neonatal ischemic brain injury with a pentapeptide-based irreversible caspase inhibitor. Cell Death Dis (2011) 0.91
The role of synaptotagmin I C2A calcium-binding domain in synaptic vesicle clustering during synapse formation. J Physiol (2007) 0.90
Synthesis and neuroprotective action of xyloketal derivatives in Parkinson's disease models. Mar Drugs (2013) 0.90
Apelin-36, a potent peptide, protects against ischemic brain injury by activating the PI3K/Akt pathway. Neurochem Int (2013) 0.89
Melatonin inhibits neural apoptosis induced by homocysteine in hippocampus of rats via inhibition of cytochrome c translocation and caspase-3 activation and by regulating pro- and anti-apoptotic protein levels. Neuroscience (2005) 0.88
Synthesis of xyloketal A, B, C, D, and G analogues. J Org Chem (2006) 0.88
Role of baicalin in regulating Toll-like receptor 2/4 after ischemic neuronal injury. Chin Med J (Engl) (2012) 0.87
Hyperbaric oxygenation reduces long-term brain injury and ameliorates behavioral function by suppression of apoptosis in a rat model of neonatal hypoxia-ischemia. Neurochem Int (2013) 0.87
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Attenuation of neurotoxicity in cortical cultures and hippocampal slices from E2F1 knockout mice. J Neurochem (2001) 0.85
17β-estradiol protects 7-day old rats from acute brain injury and reduces the number of apoptotic cells. Reprod Sci (2012) 0.84
Estrogen modulates Bcl-2 family proteins in ischemic brain injury. J Vet Med Sci (2006) 0.84
Delayed, long-term administration of the caspase inhibitor Q-VD-OPh reduced brain injury induced by neonatal hypoxia-ischemia. Dev Neurosci (2014) 0.84
Hyperbaric oxygen suppresses hypoxic-ischemic brain damage in newborn rats. J Child Neurol (2014) 0.83
Caltubin, a novel molluscan tubulin-interacting protein, promotes axonal growth and attenuates axonal degeneration of rodent neurons. J Neurosci (2011) 0.82
Melatonin prevents learning disorders in brain-lesioned newborn mice. Neuroscience (2007) 0.81
Neuroprotective effects of volume-regulated anion channel blocker DCPIB on neonatal hypoxic-ischemic injury. Acta Pharmacol Sin (2012) 0.80
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Different mechanisms of NMDA-mediated protection against neuronal apoptosis: a stimuli-dependent effect. Neurochem Res (2009) 0.79
Xiao-Xu-Ming decoction preserves mitochondrial integrity and reduces apoptosis after focal cerebral ischemia and reperfusion via the mitochondrial p53 pathway. J Ethnopharmacol (2013) 0.79
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