Xyloketal B alleviates cerebral infarction and neurologic deficits in a mouse stroke model by suppressing the ROS/TLR4/NF-κB inflammatory signaling pathway.

Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial. Lancet Neurol (2008) 9.02

Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke (1986) 8.23

The inflammatory response in stroke. J Neuroimmunol (2006) 5.33

Inflammatory mechanisms in ischemic stroke: role of inflammatory cells. J Leukoc Biol (2010) 4.37

Acute ischaemic stroke and infection: recent and emerging concepts. Lancet Neurol (2008) 2.77

Transcription factor NF-kappaB: a sensor for smoke and stress signals. Ann N Y Acad Sci (2005) 2.05

Systemic infection, inflammation and acute ischemic stroke. Neuroscience (2008) 2.03

CXCR4 antagonist AMD3100 protects blood-brain barrier integrity and reduces inflammatory response after focal ischemia in mice. Stroke (2012) 1.91

Toll-like receptor 4 is involved in subacute stress-induced neuroinflammation and in the worsening of experimental stroke. Stroke (2008) 1.48

Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia. Neuroscience (2010) 1.43

Five unique compounds: xyloketals from mangrove fungus Xylaria sp. from the South China Sea coast. J Org Chem (2001) 1.37

Manganese superoxide dismutase deficiency exacerbates cerebral infarction after focal cerebral ischemia/reperfusion in mice: implications for the production and role of superoxide radicals. Stroke (2002) 1.36

Protection by tetrahydroxystilbene glucoside against cerebral ischemia: involvement of JNK, SIRT1, and NF-kappaB pathways and inhibition of intracellular ROS/RNS generation. Free Radic Biol Med (2009) 1.34

Neurogenesis and inflammation after ischemic stroke: what is known and where we go from here. J Cereb Blood Flow Metab (2014) 1.07

A novel marine compound xyloketal B protects against oxidized LDL-induced cell injury in vitro. Biochem Pharmacol (2009) 0.98

Downregulation of renal TRPM7 and increased inflammation and fibrosis in aldosterone-infused mice: effects of magnesium. Hypertension (2008) 0.96

Protective effects of xyloketal B against MPP+-induced neurotoxicity in Caenorhabditis elegans and PC12 cells. Brain Res (2010) 0.95

NF-kappaB Signaling Pathways in Neurological Inflammation: A Mini Review. Front Mol Neurosci (2015) 0.94

Xyloketal B exhibits its antioxidant activity through induction of HO-1 in vascular endothelial cells and zebrafish. Mar Drugs (2013) 0.91

Marine compound Xyloketal B protects PC12 cells against OGD-induced cell damage. Brain Res (2009) 0.91

Synthesis and neuroprotective action of xyloketal derivatives in Parkinson's disease models. Mar Drugs (2013) 0.90

Xyloketal B suppresses glioblastoma cell proliferation and migration in vitro through inhibiting TRPM7-regulated PI3K/Akt and MEK/ERK signaling pathways. Mar Drugs (2015) 0.84

Therapeutic benefits of combined treatment with tissue plasminogen activator and 2-(4-methoxyphenyl)ethyl-2-acetamido-2-deoxy-β-d-pyranoside in an animal model of ischemic stroke. Neuroscience (2016) 0.84

Splenectomy following MCAO inhibits the TLR4-NF-κB signaling pathway and protects the brain from neurodegeneration in rats. J Neuroimmunol (2016) 0.82

Marine compound xyloketal B reduces neonatal hypoxic-ischemic brain injury. Mar Drugs (2014) 0.81

Neuroprotective effect of bicyclol in rat ischemic stroke: down-regulates TLR4, TLR9, TRAF6, NF-κB, MMP-9 and up-regulates claudin-5 expression. Brain Res (2013) 0.81

Simvastatin Reduces Lipopolysaccharides-Accelerated Cerebral Ischemic Injury via Inhibition of Nuclear Factor-kappa B Activity. Biomol Ther (Seoul) (2015) 0.80

Endotoxin-induced vascular endothelial cell migration is dependent on TLR4/NF-κB pathway, NAD(P)H oxidase activation, and transient receptor potential melastatin 7 calcium channel activity. Int J Biochem Cell Biol (2014) 0.80

Neuroprotection by manganese superoxide dismutase (MnSOD) mimics: antioxidant effect and oxidative stress regulation in acute experimental stroke. CNS Neurosci Ther (2012) 0.80

Neuroinflammatory biomarkers: From stroke diagnosis and prognosis to therapy. Biochim Biophys Acta (2015) 0.79

Inhibition of TNF-α protects in vitro brain barrier from ischaemic damage. Mol Cell Neurosci (2015) 0.79

Matrix Metalloproteinase-12 Induces Blood-Brain Barrier Damage After Focal Cerebral Ischemia. Stroke (2015) 0.78

Prophylactic Edaravone Prevents Transient Hypoxic-Ischemic Brain Injury: Implications for Perioperative Neuroprotection. Stroke (2015) 0.77

ClC-3 deficiency protects preadipocytes against apoptosis induced by palmitate in vitro and in type 2 diabetes mice. Apoptosis (2014) 0.76

Xyloketal B attenuates atherosclerotic plaque formation and endothelial dysfunction in apolipoprotein e deficient mice. Mar Drugs (2015) 0.75

Xyloketal-derived small molecules show protective effect by decreasing mutant Huntingtin protein aggregates in Caenorhabditis elegans model of Huntington's disease. Drug Des Devel Ther (2016) 0.75

CircRNA_000203 enhances the expression of fibrosis-associated genes by derepressing targets of miR-26b-5p, Col1a2 and CTGF, in cardiac fibroblasts. Sci Rep (2017) 0.83

[Sudden death caused by aortic dissection: 63 cases of forensic pathological analysis]. Fa Yi Xue Za Zhi (2013) 0.76

Myocyte-specific enhancer factor 2C: a novel target gene of miR-214-3p in suppressing angiotensin II-induced cardiomyocyte hypertrophy. Sci Rep (2016) 0.75

LNK deficiency aggregates palmitate-induced preadipocyte apoptosis. Biochem Biophys Res Commun (2017) 0.75

Suppression of Kv1.5 protects against endothelial apoptosis induced by palmitate and in type 2 diabetes mice. Life Sci (2016) 0.75