Published in Mar Drugs on April 22, 2015
Marine Compounds and Cancer: Where Do We Stand? Mar Drugs (2015) 0.81
Role of TRPM7 in Cancer: Potential as Molecular Biomarker and Therapeutic Target. Pharmaceuticals (Basel) (2017) 0.78
Carvacrol Alleviates Prostate Cancer Cell Proliferation, Migration, and Invasion through Regulation of PI3K/Akt and MAPK Signaling Pathways. Oxid Med Cell Longev (2016) 0.77
Activation of TRPM7 by naltriben enhances migration and invasion of glioblastoma cells. Oncotarget (2017) 0.75
Role of TRPM7 in Cerebral Ischaemia and Hypoxia. J Physiol (2016) 0.75
Xyloketal B alleviates cerebral infarction and neurologic deficits in a mouse stroke model by suppressing the ROS/TLR4/NF-κB inflammatory signaling pathway. Acta Pharmacol Sin (2017) 0.75
Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol (2009) 25.96
Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol (2003) 18.97
Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes Dev (2007) 17.20
Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors. N Engl J Med (2005) 15.42
In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro. Nat Protoc (2007) 12.39
Clonogenic assay of cells in vitro. Nat Protoc (2006) 11.85
Structural alterations of the epidermal growth factor receptor gene in human gliomas. Proc Natl Acad Sci U S A (1992) 6.58
A key role for TRPM7 channels in anoxic neuronal death. Cell (2003) 4.46
Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis. Science (2008) 2.59
The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches. Expert Opin Ther Targets (2012) 2.55
Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors. Cancer Res (1992) 2.17
Molecularly targeted therapy for malignant glioma. Cancer (2007) 1.96
Prognostic associations of activated mitogen-activated protein kinase and Akt pathways in glioblastoma. Clin Cancer Res (2006) 1.91
Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia. Nat Neurosci (2009) 1.75
Development of novel targeted therapies in the treatment of malignant glioma. Nat Rev Drug Discov (2004) 1.74
Crosstalk between the PI3K/mTOR and MEK/ERK pathways involved in the maintenance of self-renewal and tumorigenicity of glioblastoma stem-like cells. Stem Cells (2010) 1.52
A Ras inhibitor tilts the balance between Rac and Rho and blocks phosphatidylinositol 3-kinase-dependent glioblastoma cell migration. Cancer Res (2006) 1.42
Five unique compounds: xyloketals from mangrove fungus Xylaria sp. from the South China Sea coast. J Org Chem (2001) 1.37
Current clinical development of PI3K pathway inhibitors in glioblastoma. Neuro Oncol (2012) 1.33
Molecular interaction and functional regulation of ClC-3 by Ca2+/calmodulin-dependent protein kinase II (CaMKII) in human malignant glioma. J Biol Chem (2010) 1.32
TRPM7 regulates myosin IIA filament stability and protein localization by heavy chain phosphorylation. J Mol Biol (2008) 1.32
Designer therapies for glioblastoma multiforme. Ann N Y Acad Sci (2008) 1.28
Activation of TRPM7 channels by phospholipase C-coupled receptor agonists. J Biol Chem (2006) 1.21
Carvacrol is a novel inhibitor of Drosophila TRPL and mammalian TRPM7 channels. Cell Calcium (2009) 1.16
Silencing TRPM7 promotes growth/proliferation and nitric oxide production of vascular endothelial cells via the ERK pathway. Cardiovasc Res (2009) 1.16
RAS/RAF/MEK/ERK and PI3K/PTEN/AKT Signaling in Malignant Melanoma Progression and Therapy. Dermatol Res Pract (2011) 1.15
Transient receptor potential melastatin-related 7 channel is overexpressed in human pancreatic ductal adenocarcinomas and regulates human pancreatic cancer cell migration. Int J Cancer (2012) 1.14
Ion channnels and transporters in cancer. 5. Ion channels in control of cancer and cell apoptosis. Am J Physiol Cell Physiol (2011) 1.13
A novel marine compound xyloketal B protects against oxidized LDL-induced cell injury in vitro. Biochem Pharmacol (2009) 0.98
Standards of care and novel approaches in the management of glioblastoma multiforme. Chin J Cancer (2014) 0.95
TRPM7 mediates breast cancer cell migration and invasion through the MAPK pathway. Cancer Lett (2013) 0.95
Protective effects of xyloketal B against MPP+-induced neurotoxicity in Caenorhabditis elegans and PC12 cells. Brain Res (2010) 0.95
TRPM7 channel regulates PDGF-BB-induced proliferation of hepatic stellate cells via PI3K and ERK pathways. Toxicol Appl Pharmacol (2013) 0.95
Design and synthesis of novel xyloketal derivatives and their vasorelaxing activities in rat thoracic aorta and angiogenic activities in zebrafish angiogenesis screen. J Med Chem (2010) 0.94
TRPM7 channels regulate glioma stem cell through STAT3 and Notch signaling pathways. Cell Signal (2014) 0.94
The physiological roles of primary phospholipase C. Adv Biol Regul (2013) 0.94
Identification of Ser/Thr phosphorylation sites in the C2-domain of phospholipase C γ2 (PLCγ2) using TRPM7-kinase. Cell Signal (2012) 0.92
Xyloketal B exhibits its antioxidant activity through induction of HO-1 in vascular endothelial cells and zebrafish. Mar Drugs (2013) 0.91
Marine compound Xyloketal B protects PC12 cells against OGD-induced cell damage. Brain Res (2009) 0.91
Targeting the AKT pathway in glioblastoma. Curr Pharm Des (2011) 0.90
Synthesis and neuroprotective action of xyloketal derivatives in Parkinson's disease models. Mar Drugs (2013) 0.90
Suppression of TRPM7 inhibits proliferation, migration, and invasion of malignant human glioma cells. CNS Neurosci Ther (2014) 0.89
Cellular and Developmental Biology of TRPM7 Channel-Kinase: Implicated Roles in Cancer. Cells (2014) 0.89
Intrathecal combination of ziconotide and morphine for refractory cancer pain: a rapidly acting and effective choice. Pain (2011) 0.88
Synthesis of xyloketal A, B, C, D, and G analogues. J Org Chem (2006) 0.88
Genetics of glioblastoma multiforme: mitogenic signaling and cell cycle pathways converge. J Clin Neurosci (2005) 0.88
ATP-sensitive potassium channels control glioma cells proliferation by regulating ERK activity. Carcinogenesis (2009) 0.87
Involvement of Kv1.5 protein in oxidative vascular endothelial cell injury. PLoS One (2012) 0.84
TRPM7 is required for ovarian cancer cell growth, migration and invasion. Biochem Biophys Res Commun (2014) 0.84
Inhibition of TRPM7 channels prevents proliferation and differentiation of human lung fibroblasts. Inflamm Res (2013) 0.84
Recent advances in diagnosis and treatment of gliomas using chlorotoxin-based bioconjugates. Am J Nucl Med Mol Imaging (2014) 0.83
TRPM7 regulates vascular endothelial cell adhesion and tube formation. Am J Physiol Cell Physiol (2014) 0.83
Genetic aberrations in human brain tumors. Neurosurgery (1994) 0.83
Inhibition of phosphatidylinositol 3-kinase signaling negates the growth advantage imparted by a mutant epidermal growth factor receptor on human glioblastoma cells. Int J Cancer (2003) 0.83
Marine compound xyloketal B reduces neonatal hypoxic-ischemic brain injury. Mar Drugs (2014) 0.81
Overexpression of TRPM7 is associated with poor prognosis in human ovarian carcinoma. Asian Pac J Cancer Prev (2014) 0.81
Trabectedin therapy as an emerging treatment strategy for recurrent platinum-sensitive ovarian cancer. Chin J Cancer (2015) 0.81
Xyloketal B, a marine compound, acts on a network of molecular proteins and regulates the activity and expression of rat cytochrome P450 3a: a bioinformatic and animal study. Drug Des Devel Ther (2014) 0.81
Marine compound xyloketal B reduces neonatal hypoxic-ischemic brain injury. Mar Drugs (2014) 0.81