The small GTPase Rab7 as a central regulator of hepatocellular lipophagy.

PubWeight™: 1.62‹?› | Rank: Top 4%

🔗 View Article (PMID 25565581)

Published in Hepatology on April 23, 2015

Authors

Barbara Schroeder1, Ryan J Schulze1, Shaun G Weller1, Arthur C Sletten1, Carol A Casey2, Mark A McNiven1

Author Affiliations

1: Department of Biochemistry and Molecular Biology and the Center for Digestive Diseases, Mayo Clinic, Rochester, MN.
2: Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE.

Articles citing this

Regulation of Liver Metabolism by Autophagy. Gastroenterology (2015) 0.89

Multiple Roles of the Small GTPase Rab7. Cells (2016) 0.87

A Mechanistic Review of Mitophagy and Its Role in Protection against Alcoholic Liver Disease. Biomolecules (2015) 0.83

Hepatic lipid droplet biology: Getting to the root of fatty liver. Hepatology (2015) 0.81

Regulation and Functions of Autophagic Lipolysis. Trends Endocrinol Metab (2016) 0.81

Lipids, lysosomes, and autophagy. J Lipid Res (2016) 0.81

A novel Rab10-EHBP1-EHD2 complex essential for the autophagic engulfment of lipid droplets. Sci Adv (2016) 0.79

Hepatitis C virus comes for dinner: How the hepatitis C virus interferes with autophagy. World J Gastroenterol (2015) 0.79

Mechanisms of intrahepatic triglyceride accumulation. World J Gastroenterol (2016) 0.79

Quantitative analysis of the murine lipid droplet-associated proteome during diet-induced hepatic steatosis. J Lipid Res (2015) 0.78

Autophagy regulates turnover of lipid droplets via ROS-dependent Rab25 activation in hepatic stellate cell. Redox Biol (2016) 0.77

A molecular mechanism for lipophagy regulation in the liver. Hepatology (2015) 0.77

Regulation of lipid droplet dynamics in Saccharomyces cerevisiae depends on the Rab7-like Ypt7p, HOPS complex and V1-ATPase. Biol Open (2015) 0.76

A lysosome-centered view of nutrient homeostasis. Autophagy (2016) 0.76

Autophagy in the liver: cell's cannibalism and beyond. Arch Pharm Res (2016) 0.76

ATGL Promotes Autophagy/Lipophagy via SIRT1 to Control Hepatic Lipid Droplet Catabolism. Cell Rep (2017) 0.75

The crucial impact of lysosomes in aging and longevity. Ageing Res Rev (2016) 0.75

β-adrenergic induction of lipolysis in hepatocytes is inhibited by ethanol exposure. J Biol Chem (2017) 0.75

Breaking fat: The regulation and mechanisms of lipophagy. Biochim Biophys Acta (2017) 0.75

Host lipid droplets: An important source of lipids salvaged by the intracellular parasite Toxoplasma gondii. PLoS Pathog (2017) 0.75

The critical role played by endotoxin-induced liver autophagy in the maintenance of lipid metabolism during sepsis. Autophagy (2017) 0.75

Ethanol-triggered Lipophagy Requires SQSTM1 in AML12 Hepatic Cells. Sci Rep (2017) 0.75

The perilipin family of lipid droplet proteins: Gatekeepers of intracellular lipolysis. Biochim Biophys Acta (2017) 0.75

MicroRNA-148a-3p enhances cisplatin cytotoxicity in gastric cancer through mitochondrial fission induction and cyto-protective autophagy suppression. Cancer Lett (2017) 0.75

Effects of Epigallocatechin-3-Gallate on Autophagic Lipolysis in Adipocytes. Nutrients (2017) 0.75

Articles cited by this

Autophagy regulates lipid metabolism. Nature (2009) 13.33

Rab GTPases as coordinators of vesicle traffic. Nat Rev Mol Cell Biol (2009) 13.01

Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3. Autophagy (2007) 11.74

Autophagy: from phenomenology to molecular understanding in less than a decade. Nat Rev Mol Cell Biol (2007) 10.79

Rab7: a key to lysosome biogenesis. Mol Biol Cell (2000) 6.42

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proc Natl Acad Sci U S A (2008) 5.48

Role for Rab7 in maturation of late autophagic vacuoles. J Cell Sci (2004) 5.19

Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes. Cell (2010) 4.19

Lipid droplets and cellular lipid metabolism. Annu Rev Biochem (2012) 4.02

Rab7 is required for the normal progression of the autophagic pathway in mammalian cells. J Cell Sci (2004) 3.66

Thematic review series: lipid posttranslational modifications. CAAX modification and membrane targeting of Ras. J Lipid Res (2006) 3.07

Rab7 associates with early endosomes to mediate sorting and transport of Semliki forest virus to late endosomes. PLoS Biol (2005) 2.95

FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport. J Cell Biol (2010) 2.57

Phagosomes fuse with late endosomes and/or lysosomes by extension of membrane protrusions along microtubules: role of Rab7 and RILP. Mol Cell Biol (2003) 2.33

Autophagy and multivesicular bodies: two closely related partners. Cell Death Differ (2008) 2.26

Rab7 regulates late endocytic trafficking downstream of multivesicular body biogenesis and cargo sequestration. J Biol Chem (2009) 2.11

Endocytic delivery to lysosomes mediated by concurrent fusion and kissing events in living cells. Curr Biol (2005) 2.11

Modulation of Rab5 and Rab7 recruitment to phagosomes by phosphatidylinositol 3-kinase. Mol Cell Biol (2003) 2.03

Assay of Cdc42, Rac, and Rho GTPase activation by affinity methods. Methods Enzymol (2002) 1.99

Biogenesis of phagolysosomes: the 'kiss and run' hypothesis. Trends Cell Biol (1995) 1.83

Regulation of lipid stores and metabolism by lipophagy. Cell Death Differ (2012) 1.80

TI-VAMP/VAMP7 and VAMP3/cellubrevin: two v-SNARE proteins involved in specific steps of the autophagy/multivesicular body pathways. Biochim Biophys Acta (2009) 1.76

Rab7: role of its protein interaction cascades in endo-lysosomal traffic. Cell Signal (2010) 1.58

SKD1 AAA ATPase-dependent endosomal transport is involved in autolysosome formation. Cell Struct Funct (2002) 1.58

Review series: Rab GTPases and membrane identity: causal or inconsequential? J Cell Biol (2013) 1.56

Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expression. Eur J Neurosci (2008) 1.54

Structural basis for recruitment of RILP by small GTPase Rab7. EMBO J (2005) 1.50

The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17. Mol Biol Cell (2014) 1.46

Maturation of autophagosomes and endosomes: a key role for Rab7. Biochim Biophys Acta (2012) 1.43

Regulation of autophagy by the Rab GTPase network. Cell Death Differ (2014) 1.37

How do ESCRT proteins control autophagy? J Cell Sci (2009) 1.37

Following autophagy step by step. BMC Biol (2011) 1.30

Regulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesis. PLoS One (2013) 1.28

RILP is required for the proper morphology and function of late endosomes. J Cell Sci (2007) 1.26

Rab7: roles in membrane trafficking and disease. Biosci Rep (2009) 1.24

Lipid droplet breakdown requires dynamin 2 for vesiculation of autolysosomal tubules in hepatocytes. J Cell Biol (2013) 1.14

Differential effects of TBC1D15 and mammalian Vps39 on Rab7 activation state, lysosomal morphology, and growth factor dependence. J Biol Chem (2010) 1.10

In vitro reconstitution of fusion between immature autophagosomes and endosomes. Autophagy (2009) 1.10

Expression and properties of Rab7 in endosome function. Methods Enzymol (2001) 1.05

β-adrenergic receptor-stimulated lipolysis requires the RAB7-mediated autolysosomal lipid degradation. Autophagy (2013) 1.01

Recent insights into the molecular pathophysiology of lipid droplet formation in hepatocytes. Prog Lipid Res (2014) 1.00

Targeting and localized signalling by small GTPases. Biol Cell (2007) 0.98

Autophagy: Emerging roles in lipid homeostasis and metabolic control. Biochim Biophys Acta (2012) 0.98

The role of ESCRT proteins in fusion events involving lysosomes, endosomes and autophagosomes. Biochem Soc Trans (2010) 0.98

Functional role(s) of phagosomal Rab GTPases. Small GTPases (2013) 0.94

A competitive nucleotide binding inhibitor: in vitro characterization of Rab7 GTPase inhibition. ACS Chem Biol (2012) 0.92

Mapping of Vps21 and HOPS binding sites in Vps8 and effect of binding site mutants on endocytic trafficking. Eukaryot Cell (2010) 0.89

CIN85 phosphorylation is essential for EGFR ubiquitination and sorting into multivesicular bodies. Mol Biol Cell (2012) 0.83

High-level production and characterization of a G-protein coupled receptor signaling complex. FEBS J (2009) 0.78