Published in J Clin Invest on January 09, 2015
A Polycomb-mir200 loop regulates clinical outcome in bladder cancer. Oncotarget (2015) 0.85
Notch2 as a promising prognostic biomarker for oesophageal squamous cell carcinoma. Sci Rep (2016) 0.77
Notch signaling in prostate cancer: refining a therapeutic opportunity. Histol Histopathol (2015) 0.77
Contextualizing the Genes Altered in Bladder Neoplasms in Pediatric andTeen Patients Allows Identifying Two Main Classes of Biological ProcessesInvolved and New Potential Therapeutic Targets. Curr Genomics (2016) 0.75
Notch as a tumour suppressor. Nat Rev Cancer (2017) 0.75
MiR-182 promotes cancer invasion by linking RET oncogene activated NF-κB to loss of the HES1/Notch1 regulatory circuit. Mol Cancer (2017) 0.75
Bladder cancer and the Notch pathway. Oncotarget (2015) 0.75
Squamous differentiation in patients with superficial bladder urothelial carcinoma is associated with high risk of recurrence and poor survival. BMC Cancer (2017) 0.75
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science (2004) 18.84
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The mutational landscape of head and neck squamous cell carcinoma. Science (2011) 16.88
The canonical Notch signaling pathway: unfolding the activation mechanism. Cell (2009) 14.72
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature (2011) 13.18
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature (2005) 11.49
Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science (2011) 11.12
Comprehensive molecular characterization of urothelial bladder carcinoma. Nature (2014) 8.48
Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia. Nat Med (2007) 6.55
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A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia. Nature (2011) 5.78
Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation. EMBO J (2001) 5.29
Defining molecular profiles of poor outcome in patients with invasive bladder cancer using oligonucleotide microarrays. J Clin Oncol (2006) 5.10
Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration. Neuron (2004) 4.21
Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia. Nat Med (2008) 3.98
Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation. Nat Genet (2013) 3.87
Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells. Nat Immunol (2002) 3.75
Epithelial plasticity: a common theme in embryonic and cancer cells. Science (2013) 3.21
Alterations of the Notch pathway in lung cancer. Proc Natl Acad Sci U S A (2009) 3.10
Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma. Proc Natl Acad Sci U S A (2011) 3.10
Inactivation of p53 and Pten promotes invasive bladder cancer. Genes Dev (2009) 2.99
The Notch signalling system: recent insights into the complexity of a conserved pathway. Nat Rev Genet (2012) 2.77
Cellular origin of bladder neoplasia and tissue dynamics of its progression to invasive carcinoma. Nat Cell Biol (2014) 2.65
Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma. Cell Death Differ (2002) 2.60
Recurrent inactivation of STAG2 in bladder cancer is not associated with aneuploidy. Nat Genet (2013) 2.44
Expression signature of E2F1 and its associated genes predict superficial to invasive progression of bladder tumors. J Clin Oncol (2010) 2.37
Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation. Immunity (2010) 2.29
A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition. Nat Struct Mol Biol (2008) 2.22
Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma. Gastroenterology (2009) 2.17
The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia. Cancer Cell (2010) 2.09
Genetic landscape of esophageal squamous cell carcinoma. Nat Genet (2014) 1.89
Prospective study of FGFR3 mutations as a prognostic factor in nonmuscle invasive urothelial bladder carcinomas. J Clin Oncol (2006) 1.83
From fly wings to targeted cancer therapies: a centennial for notch signaling. Cancer Cell (2014) 1.70
Therapeutic effect of γ-secretase inhibition in KrasG12V-driven non-small cell lung carcinoma by derepression of DUSP1 and inhibition of ERK. Cancer Cell (2012) 1.44
Tumour-suppression activity of the proapoptotic regulator Par4. EMBO Rep (2005) 1.36
Presenilin: RIP and beyond. Semin Cell Dev Biol (2008) 1.33
Deadly crosstalk: Notch signaling at the intersection of EMT and cancer stem cells. Cancer Lett (2013) 1.28
NOTCH inhibition and glucocorticoid therapy in T-cell acute lymphoblastic leukemia. Leukemia (2009) 1.27
Differentiation imbalance in single oesophageal progenitor cells causes clonal immortalization and field change. Nat Cell Biol (2014) 1.20
Preclinical and clinical studies of gamma secretase inhibitors with docetaxel on human breast tumors. Clin Cancer Res (2013) 1.20
Urothelial carcinoma versus squamous cell carcinoma of bladder: is survival different with stage adjustment? Urology (2009) 1.02
The pathogenesis of experimental bladder cancer. Cancer Res (1977) 0.97
Association of low expression of notch-1 and jagged-1 in human papillary bladder cancer and shorter survival. J Urol (2008) 0.94
In vivo disruption of an Rb-E2F-Ezh2 signaling loop causes bladder cancer. Cancer Res (2014) 0.92
Cytokeratin 14 expression in epithelial neoplasms: a survey of 435 cases with emphasis on its value in differentiating squamous cell carcinomas from other epithelial tumours. Histopathology (2001) 0.90
Loss of heterozygosity on chromosome 9q and p53 alterations in human bladder cancer. Cancer (2005) 0.89
Genome-wide association study yields variants at 20p12.2 that associate with urinary bladder cancer. Hum Mol Genet (2014) 0.86
Notching up a new therapeutic strategy for non-small cell lung carcinoma (NSCLC). Oncotarget (2012) 0.79
High expression of Notch ligand Jagged2 is associated with the metastasis and recurrence in urothelial carcinoma of bladder. Int J Clin Exp Pathol (2013) 0.79
Immunohistochemical analysis of the role and relationship between Notch-1 and Oct-4 expression in urinary bladder carcinoma. APMIS (2013) 0.78
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International network of cancer genome projects. Nature (2010) 20.35
GENCODE: the reference human genome annotation for The ENCODE Project. Genome Res (2012) 19.19
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Overview of BioCreAtIvE: critical assessment of information extraction for biology. BMC Bioinformatics (2005) 14.50
The hallmarks of aging. Cell (2013) 14.29
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature (2011) 13.18
Tumour biology: senescence in premalignant tumours. Nature (2005) 10.15
Cellular senescence in cancer and aging. Cell (2007) 9.04
Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. Cancer Cell (2007) 8.47
A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity. Nature (2009) 7.96
The Ink4/Arf locus is a barrier for iPS cell reprogramming. Nature (2009) 7.39
Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia. Nat Genet (2011) 6.43
A gene network for navigating the literature. Nat Genet (2004) 6.43
Overview of the protein-protein interaction annotation extraction task of BioCreative II. Genome Biol (2008) 6.38
Senescence in tumours: evidence from mice and humans. Nat Rev Cancer (2010) 6.34
Evaluation of BioCreAtIvE assessment of task 2. BMC Bioinformatics (2005) 6.02
Sirt1 protects against high-fat diet-induced metabolic damage. Proc Natl Acad Sci U S A (2008) 5.21
Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context. Cancer Cell (2003) 5.17
A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors. Genes Dev (2007) 5.07
NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses. Lancet (2005) 5.01
Reductive genome evolution in Buchnera aphidicola. Proc Natl Acad Sci U S A (2003) 4.88
Telomeres acquire embryonic stem cell characteristics in induced pluripotent stem cells. Cell Stem Cell (2009) 4.59
Linking genes to literature: text mining, information extraction, and retrieval applications for biology. Genome Biol (2008) 4.36
The common biology of cancer and ageing. Nature (2007) 4.28
Distinct DNA methylomes of newborns and centenarians. Proc Natl Acad Sci U S A (2012) 4.26
Hypoxia-induced energy stress regulates mRNA translation and cell growth. Mol Cell (2006) 4.20
"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally. EMBO J (2002) 4.17
Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation. Cell Metab (2005) 3.94
The implications of alternative splicing in the ENCODE protein complement. Proc Natl Acad Sci U S A (2007) 3.93
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. Nat Genet (2010) 3.93
Delayed ageing through damage protection by the Arf/p53 pathway. Nature (2007) 3.87
Implementing the iHOP concept for navigation of biomedical literature. Bioinformatics (2005) 3.85
Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus. Arthritis Rheum (2010) 3.76
Detectable clonal mosaicism and its relationship to aging and cancer. Nat Genet (2012) 3.69
Genomic DNA hypomethylation as a biomarker for bladder cancer susceptibility in the Spanish Bladder Cancer Study: a case-control study. Lancet Oncol (2008) 3.60
Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo. J Exp Med (2006) 3.57
Text-mining and information-retrieval services for molecular biology. Genome Biol (2005) 3.54
Evaluation of text-mining systems for biology: overview of the Second BioCreative community challenge. Genome Biol (2008) 3.54
Genomic stability and tumour suppression by the APC/C cofactor Cdh1. Nat Cell Biol (2008) 3.31
BLUEPRINT to decode the epigenetic signature written in blood. Nat Biotechnol (2012) 3.24
Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62. Cell Metab (2006) 3.22
The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab (2012) 3.18
Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia. Nat Genet (2012) 3.08
The Protein-Protein Interaction tasks of BioCreative III: classification/ranking of articles and linking bio-ontology concepts to full text. BMC Bioinformatics (2011) 3.03
An Overview of BioCreative II.5. IEEE/ACM Trans Comput Biol Bioinform (2010) 3.01
Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer. Nat Commun (2010) 2.97
The power and the promise of oncogene-induced senescence markers. Nat Rev Cancer (2006) 2.85
Telomerase reverse transcriptase delays aging in cancer-resistant mice. Cell (2008) 2.85
Programmed cell senescence during mammalian embryonic development. Cell (2013) 2.78
Introducing meta-services for biomedical information extraction. Genome Biol (2008) 2.78
Emerging methods in protein co-evolution. Nat Rev Genet (2013) 2.72
BioC: a minimalist approach to interoperability for biomedical text processing. Database (Oxford) (2013) 2.69
A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging. Nat Genet (2009) 2.68
Evaluation of annotation strategies using an entire genome sequence. Bioinformatics (2003) 2.66
The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis. Dev Cell (2004) 2.65
iHOP web services. Nucleic Acids Res (2007) 2.65
Outcome in Hodgkin's lymphoma can be predicted from the presence of accompanying cytotoxic and regulatory T cells. Clin Cancer Res (2005) 2.60
Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence. Cancer Cell (2011) 2.56
Oncogenic activity of Cdc6 through repression of the INK4/ARF locus. Nature (2006) 2.51
EVA: Evaluation of protein structure prediction servers. Nucleic Acids Res (2003) 2.50
The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression. Nat Genet (2011) 2.47
Reprogramming in vivo produces teratomas and iPS cells with totipotency features. Nature (2013) 2.47
Epigenetic regulation of Nanog expression by Ezh2 in pluripotent stem cells. Cell Cycle (2011) 2.45
Recurrent inactivation of STAG2 in bladder cancer is not associated with aneuploidy. Nat Genet (2013) 2.44
A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Nat Struct Mol Biol (2008) 2.43
Predicting reliable regions in protein alignments from sequence profiles. J Mol Biol (2003) 2.42
p53-dependent regulation of growth, epithelial-mesenchymal transition and stemness in normal pancreatic epithelial cells. Cell Cycle (2011) 2.42
Depletion of ribosomal protein L37 occurs in response to DNA damage and activates p53 through the L11/MDM2 pathway. Cell Cycle (2010) 2.41
High numbers of tumor-infiltrating FOXP3-positive regulatory T cells are associated with improved overall survival in follicular lymphoma. Blood (2006) 2.40
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Text mining for the biocuration workflow. Database (Oxford) (2012) 2.37
Phacomatosis pigmentokeratotica is caused by a postzygotic HRAS mutation in a multipotent progenitor cell. J Invest Dermatol (2013) 2.31
Overview of the BioCreative III Workshop. BMC Bioinformatics (2011) 2.31
Exome sequencing identifies MAX mutations as a cause of hereditary pheochromocytoma. Nat Genet (2011) 2.29
On the organization of bioinformatics core services in biology-based research institutes. Bioinformatics (2011) 2.29
c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma. Cancer Cell (2011) 2.28
Assessment of predictions submitted for the CASP6 comparative modeling category. Proteins (2005) 2.27
p53: guardian of the genome and policeman of the oncogenes. Cell Cycle (2007) 2.23
Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas. Development (2004) 2.21
The FEBS Letters/BioCreative II.5 experiment: making biological information accessible. Nat Biotechnol (2010) 2.18
A minimally invasive assay for individual assessment of the ATM/CHEK2/p53 pathway activity. Cell Cycle (2011) 2.13
A text-mining perspective on the requirements for electronically annotated abstracts. FEBS Lett (2008) 2.10
Nucleophosmin is required for DNA integrity and p19Arf protein stability. Mol Cell Biol (2005) 2.10
Identification of amino acid residues crucial for chemokine receptor dimerization. Nat Immunol (2004) 2.09
SIRT1: recent lessons from mouse models. Nat Rev Cancer (2010) 2.07
In silico two-hybrid system for the selection of physically interacting protein pairs. Proteins (2002) 2.05
Chimeras taking shape: potential functions of proteins encoded by chimeric RNA transcripts. Genome Res (2012) 2.04