Published in EMBO J on July 02, 2001
Epidermal homeostasis: a balancing act of stem cells in the skin. Nat Rev Mol Cell Biol (2009) 7.95
p63 is the molecular switch for initiation of an epithelial stratification program. Genes Dev (2004) 6.40
Epithelial stem cells: turning over new leaves. Cell (2007) 4.10
Epidermal stem cells of the skin. Annu Rev Cell Dev Biol (2006) 3.92
Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation. Genes Dev (2006) 3.72
Asymmetric cell divisions promote Notch-dependent epidermal differentiation. Nature (2011) 3.64
Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis. Mol Cell Biol (2003) 3.51
Canonical notch signaling functions as a commitment switch in the epidermal lineage. Genes Dev (2006) 3.51
Distinct contribution of stem and progenitor cells to epidermal maintenance. Nature (2012) 3.44
Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma. Proc Natl Acad Sci U S A (2011) 3.10
Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity. PLoS Biol (2008) 2.98
NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation. J Clin Invest (2015) 2.93
Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development. Sci Signal (2013) 2.78
Skin stem cells: rising to the surface. J Cell Biol (2008) 2.66
Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases. Genes Dev (2007) 2.61
Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers. Cancer Discov (2013) 2.49
Oncogenic and tumor suppressor functions of Notch in cancer: it's NOTCH what you think. J Exp Med (2011) 2.40
Comparative genomic analysis of esophageal adenocarcinoma and squamous cell carcinoma. Cancer Discov (2012) 2.39
Activation of Notch1 signaling is required for beta-catenin-mediated human primary melanoma progression. J Clin Invest (2005) 2.38
When NRF2 talks, who's listening? Antioxid Redox Signal (2010) 2.32
p63 induces key target genes required for epidermal morphogenesis. Proc Natl Acad Sci U S A (2007) 2.31
Notch tumor suppressor function. Oncogene (2008) 2.26
Comprehensive genomic profiles of small cell lung cancer. Nature (2015) 2.20
Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment. Cancer Cell (2009) 2.19
p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation. Genes Dev (2005) 2.17
Notch1 modulates timing of G1-S progression by inducing SKP2 transcription and p27 Kip1 degradation. J Exp Med (2005) 2.15
Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells. Proc Natl Acad Sci U S A (2010) 2.10
Stem cell plasticity. Plasticity of epithelial stem cells in tissue regeneration. Science (2014) 1.99
Epidermal Notch signalling: differentiation, cancer and adhesion. Curr Opin Cell Biol (2008) 1.99
gamma-Secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity. Cancer Res (2009) 1.98
Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation. Genes Dev (2002) 1.97
Targeting notch signaling pathway in cancer: clinical development advances and challenges. Pharmacol Ther (2013) 1.96
More than one way to skin . . . Genes Dev (2008) 1.95
Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin. PLoS One (2010) 1.92
The molecular pathogenesis of head and neck squamous cell carcinoma. J Clin Invest (2012) 1.86
Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma. Proc Natl Acad Sci U S A (2010) 1.84
Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors. Mol Cell Biol (2002) 1.81
Crosstalk of Notch with p53 and p63 in cancer growth control. Nat Rev Cancer (2009) 1.79
Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells. EMBO J (2004) 1.78
Regulation of Notch1 gene expression by p53 in epithelial cells. Mol Cell Biol (2007) 1.78
Suppression of renal cell carcinoma growth by inhibition of Notch signaling in vitro and in vivo. J Clin Invest (2008) 1.76
Skin-derived TSLP triggers progression from epidermal-barrier defects to asthma. PLoS Biol (2009) 1.76
25 years of epidermal stem cell research. J Invest Dermatol (2011) 1.70
From fly wings to targeted cancer therapies: a centennial for notch signaling. Cancer Cell (2014) 1.70
Parallels between global transcriptional programs of polarizing Caco-2 intestinal epithelial cells in vitro and gene expression programs in normal colon and colon cancer. Mol Biol Cell (2007) 1.69
Notch ligands Delta 1 and Jagged1 transmit distinct signals to T-cell precursors. Blood (2004) 1.68
Main roads to melanoma. J Transl Med (2009) 1.67
Notch activation induces endothelial cell cycle arrest and participates in contact inhibition: role of p21Cip1 repression. Mol Cell Biol (2004) 1.61
Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression. J Clin Invest (2007) 1.60
Characterization of a high-molecular-weight Notch complex in the nucleus of Notch(ic)-transformed RKE cells and in a human T-cell leukemia cell line. Mol Cell Biol (2002) 1.59
Wnt and Notch signaling pathway involved in wound healing by targeting c-Myc and Hes1 separately. Stem Cell Res Ther (2015) 1.57
Notch inhibitors for cancer treatment. Pharmacol Ther (2013) 1.55
Coordinating tissue interactions: Notch signaling in cardiac development and disease. Dev Cell (2012) 1.55
The Notch pathway in ovarian carcinomas and adenomas. Br J Cancer (2005) 1.54
The double-edged sword of Notch signaling in cancer. Semin Cell Dev Biol (2012) 1.53
Notch signaling regulates the differentiation of post-mitotic intestinal epithelial cells. Genes Dev (2005) 1.52
Regulation of notch1 signaling by nrf2: implications for tissue regeneration. Sci Signal (2010) 1.50
The Notch signaling pathway as a mediator of tumor survival. Carcinogenesis (2013) 1.50
Bi-compartmental communication contributes to the opposite proliferative behavior of Notch1-deficient hair follicle and epidermal keratinocytes. Development (2007) 1.46
The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T-cell acute lymphoblastic leukemia: a report from the Children's Oncology Group. Leukemia (2009) 1.45
The molecular programme of tumour reversion: the steps beyond malignant transformation. Nat Rev Cancer (2009) 1.39
The functional role of Notch signaling in human gliomas. Neuro Oncol (2009) 1.39
EWS-FLI1 suppresses NOTCH-activated p53 in Ewing's sarcoma. Cancer Res (2008) 1.38
Non-canonical Notch signaling: emerging role and mechanism. Trends Cell Biol (2012) 1.37
Developmental roles for Srf, cortical cytoskeleton and cell shape in epidermal spindle orientation. Nat Cell Biol (2011) 1.37
Notch signaling is necessary for epithelial growth arrest by TGF-beta. J Cell Biol (2007) 1.36
Active Notch1 confers a transformed phenotype to primary human melanocytes. Cancer Res (2009) 1.36
Notch2 signaling induces apoptosis and inhibits human MDA-MB-231 xenograft growth. Am J Pathol (2007) 1.36
Involvement of notch signaling in wound healing. PLoS One (2007) 1.35
Notch signaling. Cold Spring Harb Perspect Biol (2012) 1.35
IRF6 is a mediator of Notch pro-differentiation and tumour suppressive function in keratinocytes. EMBO J (2011) 1.33
Gauging NOTCH1 Activation in Cancer Using Immunohistochemistry. PLoS One (2013) 1.32
Development and cancer: at the crossroads of Nodal and Notch signaling. Cancer Res (2009) 1.30
NOTCH1 and NOTCH3 coordinate esophageal squamous differentiation through a CSL-dependent transcriptional network. Gastroenterology (2010) 1.29
Notch-1 activates estrogen receptor-alpha-dependent transcription via IKKalpha in breast cancer cells. Oncogene (2009) 1.29
Comprehensive analysis of host cellular interactions with human papillomavirus E6 proteins identifies new E6 binding partners and reflects viral diversity. J Virol (2012) 1.28
Cutaneous papillomavirus E6 oncoproteins associate with MAML1 to repress transactivation and NOTCH signaling. Oncogene (2012) 1.27
The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling. Development (2011) 1.25
Control of hair follicle cell fate by underlying mesenchyme through a CSL-Wnt5a-FoxN1 regulatory axis. Genes Dev (2010) 1.25
Regulation of dendritic-cell differentiation by bone marrow stroma via different Notch ligands. Blood (2006) 1.25
Notch signaling in bulge stem cells is not required for selection of hair follicle fate. Development (2009) 1.23
Novel function of keratins 5 and 14 in proliferation and differentiation of stratified epithelial cells. Mol Biol Cell (2011) 1.22
Papillomavirus E6 oncoproteins. Virology (2013) 1.21
Is there a role for Notch signalling in human breast cancer? Breast Cancer Res (2003) 1.21
Hypoxia, melanocytes and melanoma - survival and tumor development in the permissive microenvironment of the skin. Pigment Cell Melanoma Res (2009) 1.21
Mutations in POGLUT1, encoding protein O-glucosyltransferase 1, cause autosomal-dominant Dowling-Degos disease. Am J Hum Genet (2014) 1.20
The FoxO3a gene is a key negative target of canonical Notch signalling in the keratinocyte UVB response. EMBO J (2008) 1.20
Effects of the histone deacetylase inhibitor valproic acid on Notch signalling in human neuroblastoma cells. Br J Cancer (2005) 1.19
The pathogenic role of Notch activation in podocytes. Nephron Exp Nephrol (2009) 1.17
Covering the limb--formation of the integument. J Anat (2003) 1.16
Identification and validation of Notch pathway activating compounds through a novel high-throughput screening method. Cancer (2010) 1.15
The contribution of Notch1 to nephron segmentation in the developing kidney is revealed in a sensitized Notch2 background and can be augmented by reducing Mint dosage. Dev Biol (2009) 1.14
An exquisite cross-control mechanism among endothelial cell fate regulators directs the plasticity and heterogeneity of lymphatic endothelial cells. Blood (2010) 1.14
Building epithelial tissues from skin stem cells. Cold Spring Harb Symp Quant Biol (2008) 1.12
Notch regulates the angiogenic response via induction of VEGFR-1. J Angiogenes Res (2010) 1.12
Human skin cells support thymus-independent T cell development. J Clin Invest (2005) 1.11
Restoration of p53 expression in human cancer cell lines upregulates the expression of Notch1: implications for cancer cell fate determination after genotoxic stress. Neoplasia (2007) 1.11
Implications of cancer stem cell theory for cancer chemoprevention by natural dietary compounds. J Nutr Biochem (2011) 1.10
Cellular target genes of Epstein-Barr virus nuclear antigen 2. J Virol (2006) 1.10
Cutaneous β-human papillomavirus E6 proteins bind Mastermind-like coactivators and repress Notch signaling. Proc Natl Acad Sci U S A (2012) 1.09
Notch signaling: cell fate control and signal integration in development. Science (1999) 28.83
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Analysis of chromatin structure by in vivo formaldehyde cross-linking. Methods (1997) 7.08
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A histone deacetylase corepressor complex regulates the Notch signal transduction pathway. Genes Dev (1998) 4.78
Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2. Mol Cell Biol (1996) 4.26
Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives. Development (1997) 3.42
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Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription. J Biol Chem (1997) 2.93
Inhibitory function of p21Cip1/WAF1 in differentiation of primary mouse keratinocytes independent of cell cycle control. Science (1998) 2.88
Involvement of the cell-cycle inhibitor Cip1/WAF1 and the E1A-associated p300 protein in terminal differentiation. Proc Natl Acad Sci U S A (1995) 2.70
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The absence of p21Cip1/WAF1 alters keratinocyte growth and differentiation and promotes ras-tumor progression. Genes Dev (1996) 2.61
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Neoplastic transformation by truncated alleles of human NOTCH1/TAN1 and NOTCH2. Mol Cell Biol (1997) 2.48
Feed-back mechanisms affecting Notch activation at the dorsoventral boundary in the Drosophila wing. Development (1997) 2.45
Notch2: a second mammalian Notch gene. Development (1992) 2.28
Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis. Cell (1995) 2.24
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Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor. Mol Cell Biol (1997) 2.12
Signal transduction pathways controlling the switch between keratinocyte growth and differentiation. Crit Rev Oral Biol Med (1999) 1.71
Epstein-Barr virus immortalization: Notch2 interacts with CBF1 and blocks differentiation. J Virol (1997) 1.56
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Regulation of human involucrin promoter activity by a protein kinase C, Ras, MEKK1, MEK3, p38/RK, AP1 signal transduction pathway. J Biol Chem (1998) 1.47
T cell leukemia-associated human Notch/translocation-associated Notch homologue has I kappa B-like activity and physically interacts with nuclear factor-kappa B proteins in T cells. J Exp Med (1996) 1.44
The TGF-beta2 isoform is both a required and sufficient inducer of murine hair follicle morphogenesis. Dev Biol (1999) 1.38
Activation of the Notch pathway in the hair cortex leads to aberrant differentiation of the adjacent hair-shaft layers. Development (2000) 1.37
Notch-1 controls the expression of fatty acid-activated transcription factors and is required for adipogenesis. J Biol Chem (1997) 1.36
The product of the mouse nude locus, Whn, regulates the balance between epithelial cell growth and differentiation. Genes Dev (1996) 1.35
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