Published in J Pharmacol Exp Ther on April 01, 2015
Ethanol Modulation is Quantitatively Determined by the Transmembrane Domain of Human α1 Glycine Receptors. Alcohol Clin Exp Res (2015) 0.77
Ethanol and Other Short-Chain Alcohols Inhibit NLRP3 Inflammasome Activation through Protein Tyrosine Phosphatase Stimulation. J Immunol (2016) 0.77
Ethanol effects on glycinergic transmission: From molecular pharmacology to behavior responses. Pharmacol Res (2015) 0.76
The Intracellular Loop of the Glycine Receptor: It's not all about the Size. Front Mol Neurosci (2016) 0.75
Structure-Function Analysis of the GlyR α2 Subunit Autism Mutation p.R323L Reveals a Gain-of-Function. Front Mol Neurosci (2017) 0.75
Presence of ethanol sensitive glycine receptors in medium spiny neurons in the mouse nucleus accumbens. J Physiol (2017) 0.75
Voltage-Dependent Inhibition of Glycine Receptor Channels by Niflumic Acid. Front Mol Neurosci (2017) 0.75
ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins. Nucleic Acids Res (2007) 9.16
Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors. Nature (1997) 7.49
Principles of activation and permeation in an anion-selective Cys-loop receptor. Nature (2011) 5.93
Crystal structure of the extracellular domain of nAChR alpha1 bound to alpha-bungarotoxin at 1.94 A resolution. Nat Neurosci (2007) 4.28
Molecular structure and function of the glycine receptor chloride channel. Physiol Rev (2004) 3.77
GlyR alpha3: an essential target for spinal PGE2-mediated inflammatory pain sensitization. Science (2004) 3.38
Ab initio protein structure assembly using continuous structure fragments and optimized knowledge-based force field. Proteins (2012) 2.94
Widespread expression of glycine receptor subunit mRNAs in the adult and developing rat brain. EMBO J (1991) 2.54
The glycinergic inhibitory synapse. Cell Mol Life Sci (2001) 2.50
The beta subunit determines the ligand binding properties of synaptic glycine receptors. Neuron (2005) 2.42
Specific binding sites for alcohols and anesthetics on ligand-gated ion channels. Proc Natl Acad Sci U S A (2000) 2.24
Native glycine receptor subtypes and their physiological roles. Neuropharmacology (2008) 2.06
Ethanol's molecular targets. Sci Signal (2008) 2.06
Enhancement of glycine receptor function by ethanol is inversely correlated with molecular volume at position alpha267. J Biol Chem (1998) 1.77
Enhancement of homomeric glycine receptor function by long-chain alcohols and anaesthetics. Br J Pharmacol (1996) 1.72
A unified view of the role of electrostatic interactions in modulating the gating of Cys loop receptors. J Biol Chem (2005) 1.61
A single amino acid determines differences in ethanol actions on strychnine-sensitive glycine receptors. Mol Pharmacol (1996) 1.51
Fast synaptic inhibition in spinal sensory processing and pain control. Physiol Rev (2012) 1.45
PGE(2) selectively blocks inhibitory glycinergic neurotransmission onto rat superficial dorsal horn neurons. Nat Neurosci (2002) 1.44
Modulation of glycine receptor function: a novel approach for therapeutic intervention at inhibitory synapses? Trends Pharmacol Sci (2002) 1.31
Ethanol modulation of the gamma-aminobutyric acidA- and glycine-activated Cl- current in cultured mouse neurons. J Pharmacol Exp Ther (1994) 1.31
An intramembrane aromatic network determines pentameric assembly of Cys-loop receptors. Nat Struct Mol Biol (2009) 1.26
Single-channel study of the spasmodic mutation alpha1A52S in recombinant rat glycine receptors. J Physiol (2007) 1.23
Regulation of excitatory and inhibitory neurotransmitter-gated ion channels by protein phosphorylation. Curr Opin Neurobiol (1997) 1.21
Serotonin receptor 1A-modulated phosphorylation of glycine receptor α3 controls breathing in mice. J Clin Invest (2010) 1.21
Structure and functions of inhibitory and excitatory glycine receptors. Ann N Y Acad Sci (1999) 1.19
Molecular determinants for G protein betagamma modulation of ionotropic glycine receptors. J Biol Chem (2006) 1.17
A selective G betagamma-linked intracellular mechanism for modulation of a ligand-gated ion channel by ethanol. Proc Natl Acad Sci U S A (2008) 1.17
Loop 2 structure in glycine and GABA(A) receptors plays a key role in determining ethanol sensitivity. J Biol Chem (2009) 1.16
Modulation of glycine-activated ion channel function by G-protein betagamma subunits. Nat Neurosci (2003) 1.16
The human glycine receptor subunit alpha3. Glra3 gene structure, chromosomal localization, and functional characterization of alternative transcripts. J Biol Chem (1998) 1.09
Tryptophan scanning mutagenesis in TM4 of the GABA(A) receptor alpha1 subunit: implications for modulation by inhaled anesthetics and ion channel structure. Neuropharmacology (2002) 1.08
Accessibility to residues in transmembrane segment four of the glycine receptor. Neuropharmacology (2005) 1.08
Cross-linking of sites involved with alcohol action between transmembrane segments 1 and 3 of the glycine receptor following activation. J Neurochem (2007) 1.08
Selective modulation of neuronal nicotinic acetylcholine receptor channel subunits by Go-protein subunits. J Neurosci (2005) 1.07
Mutations in the M4 domain of the Torpedo californica nicotinic acetylcholine receptor alter channel opening and closing. J Membr Biol (1997) 1.06
Glycine receptor expression in the forebrain of male AA/ANA rats. Brain Res (2009) 1.06
Molecular requirements for ethanol differential allosteric modulation of glycine receptors based on selective Gbetagamma modulation. J Biol Chem (2010) 1.03
Targets for ethanol action and antagonism in loop 2 of the extracellular domain of glycine receptors. J Neurochem (2008) 1.02
Changes in the properties of developing glycine receptors in cultured mouse spinal neurons. Synapse (1998) 1.01
Allosteric modulation of glycine receptors. Br J Pharmacol (2011) 1.01
Characterization of two mutations, M287L and Q266I, in the α1 glycine receptor subunit that modify sensitivity to alcohols. J Pharmacol Exp Ther (2011) 0.99
Developmental changes in the modulation of synaptic glycine receptors by ethanol. J Neurophysiol (2000) 0.97
Changes on the properties of glycine receptors during neuronal development. Brain Res Brain Res Rev (2004) 0.95
Recessive hyperekplexia mutations of the glycine receptor alpha1 subunit affect cell surface integration and stability. J Neurochem (2009) 0.93
Blockade of ethanol-induced potentiation of glycine receptors by a peptide that interferes with Gbetagamma binding. J Pharmacol Exp Ther (2009) 0.93
Protein kinase C epsilon is involved in ethanol potentiation of glycine-gated Cl(-) current in rat neurons of ventral tegmental area. Neuropharmacology (2003) 0.92
Hydroxylated residues influence desensitization behaviour of recombinant alpha3 glycine receptor channels. J Neurochem (2002) 0.91
Roles for loop 2 residues of alpha1 glycine receptors in agonist activation. J Biol Chem (2008) 0.90
Charge and geometry of residues in the loop 2 β hairpin differentially affect agonist and ethanol sensitivity in glycine receptors. J Pharmacol Exp Ther (2012) 0.90
Ensemble and single particle fluorimetric techniques in concerted action to study the diffusion and aggregation of the glycine receptor α3 isoforms in the cell plasma membrane. Biochim Biophys Acta (2012) 0.89
Novel regulatory site within the TM3-4 loop of human recombinant alpha3 glycine receptors determines channel gating and domain structure. J Biol Chem (2009) 0.87
Enhancement of glycine receptor function by ethanol: role of phosphorylation. Br J Pharmacol (1998) 0.86
Inhibition of the ethanol-induced potentiation of α1 glycine receptor by a small peptide that interferes with Gβγ binding. J Biol Chem (2012) 0.84
The M4 transmembrane segment contributes to agonist efficacy differences between alpha1 and alpha3 glycine receptors. Mol Membr Biol (2009) 0.83
The relative orientation of the TM3 and TM4 domains varies between α1 and α3 glycine receptors. ACS Chem Neurosci (2012) 0.81
Molecular architecture of glycinergic synapses. Histochem Cell Biol (2008) 0.77
Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science (2004) 15.91
Kinase activity is required for the toxic effects of mutant LRRK2/dardarin. Neurobiol Dis (2006) 5.96
The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1. Nat Cell Biol (2007) 4.60
Mutations in alpha-tubulin cause abnormal neuronal migration in mice and lissencephaly in humans. Cell (2007) 3.06
Potent and selective inhibition of human cytomegalovirus replication by 1263W94, a benzimidazole L-riboside with a unique mode of action. Antimicrob Agents Chemother (2002) 2.98
Highly effective SNP-based association mapping and management of recessive defects in livestock. Nat Genet (2008) 2.68
Neuroligin 2 drives postsynaptic assembly at perisomatic inhibitory synapses through gephyrin and collybistin. Neuron (2009) 2.44
PINK1 cleavage at position A103 by the mitochondrial protease PARL. Hum Mol Genet (2010) 2.30
Large spectrum of lissencephaly and pachygyria phenotypes resulting from de novo missense mutations in tubulin alpha 1A (TUBA1A). Hum Mutat (2007) 2.24
Gephyrin: where do we stand, where do we go? Trends Neurosci (2008) 2.10
Glycine receptor autoimmune spectrum with stiff-man syndrome phenotype. JAMA Neurol (2013) 2.10
Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress. J Neurochem (2006) 1.91
The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering. J Neurosci (2004) 1.75
Zinc-mediated inhibition of GABA(A) receptors: discrete binding sites underlie subtype specificity. Nat Neurosci (2003) 1.71
A revised nomenclature for the human and rodent alpha-tubulin gene family. Genomics (2007) 1.68
A heterozygous effect for PINK1 mutations in Parkinson's disease? Ann Neurol (2006) 1.61
Mutations in GRIN2A cause idiopathic focal epilepsy with rolandic spikes. Nat Genet (2013) 1.59
Mutations in the guanine nucleotide exchange factor gene IQSEC2 cause nonsyndromic intellectual disability. Nat Genet (2010) 1.52
Mutations in the gene encoding GlyT2 (SLC6A5) define a presynaptic component of human startle disease. Nat Genet (2006) 1.49
Impaired GABAergic transmission and altered hippocampal synaptic plasticity in collybistin-deficient mice. EMBO J (2007) 1.49
Fast synaptic inhibition in spinal sensory processing and pain control. Physiol Rev (2012) 1.45
The human cytomegalovirus UL44 protein is a substrate for the UL97 protein kinase. J Virol (2003) 1.42
Complex role of collybistin and gephyrin in GABAA receptor clustering. J Biol Chem (2010) 1.40
Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels. EMBO J (2013) 1.37
TUBA1A mutations cause wide spectrum lissencephaly (smooth brain) and suggest that multiple neuronal migration pathways converge on alpha tubulins. Hum Mol Genet (2010) 1.35
Functional prokaryotic-eukaryotic chimera from the pentameric ligand-gated ion channel family. Proc Natl Acad Sci U S A (2011) 1.34
GRIN2B mutations in West syndrome and intellectual disability with focal epilepsy. Ann Neurol (2014) 1.34
Pathophysiological mechanisms of dominant and recessive GLRA1 mutations in hyperekplexia. J Neurosci (2010) 1.33
A balanced chromosomal translocation disrupting ARHGEF9 is associated with epilepsy, anxiety, aggression, and mental retardation. Hum Mutat (2009) 1.32
Regulation of GABAergic synapse formation and plasticity by GSK3beta-dependent phosphorylation of gephyrin. Proc Natl Acad Sci U S A (2010) 1.32
Glycinergic transmission in the Mammalian retina. Front Mol Neurosci (2009) 1.24
Serotonin receptor 1A-modulated phosphorylation of glycine receptor α3 controls breathing in mice. J Clin Invest (2010) 1.21
Beta-amyloid causes depletion of synaptic vesicles leading to neurotransmission failure. J Biol Chem (2009) 1.19
Achieving optimal expression for single channel recording: a plasmid ratio approach to the expression of alpha 1 glycine receptors in HEK293 cells. J Neurosci Methods (2002) 1.19
Isoform heterogeneity of the human gephyrin gene (GPHN), binding domains to the glycine receptor, and mutation analysis in hyperekplexia. J Biol Chem (2003) 1.17
Molecular determinants for G protein betagamma modulation of ionotropic glycine receptors. J Biol Chem (2006) 1.17
A selective G betagamma-linked intracellular mechanism for modulation of a ligand-gated ion channel by ethanol. Proc Natl Acad Sci U S A (2008) 1.17
Modulation of glycine-activated ion channel function by G-protein betagamma subunits. Nat Neurosci (2003) 1.16
RNA editing produces glycine receptor alpha3(P185L), resulting in high agonist potency. Nat Neurosci (2005) 1.12
Interactions of 1263W94 with other antiviral agents in inhibition of human cytomegalovirus replication. Antimicrob Agents Chemother (2003) 1.11
Sodium vitamin C cotransporter SVCT2 is expressed in hypothalamic glial cells. Glia (2005) 1.10
Diversity of glycine receptors in the mouse retina: localization of the alpha4 subunit. J Comp Neurol (2007) 1.06
Synaptotoxicity of Alzheimer beta amyloid can be explained by its membrane perforating property. PLoS One (2010) 1.05
Subunit-specific modulation of glycine receptors by cannabinoids and N-arachidonyl-glycine. Biochem Pharmacol (2008) 1.05
A proposed structural basis for picrotoxinin and picrotin binding in the glycine receptor pore. J Neurochem (2007) 1.04
Molecular requirements for ethanol differential allosteric modulation of glycine receptors based on selective Gbetagamma modulation. J Biol Chem (2010) 1.03
Molecular determinants of glycine receptor alphabeta subunit sensitivities to Zn2+-mediated inhibition. J Physiol (2005) 1.02
The glycinergic system in human startle disease: a genetic screening approach. Front Mol Neurosci (2010) 1.02
Diversity of glycine receptors in the mouse retina: localization of the alpha3 subunit. J Comp Neurol (2003) 1.01
Canonical Wnt3a modulates intracellular calcium and enhances excitatory neurotransmission in hippocampal neurons. J Biol Chem (2010) 1.00
Molecular basis of the γ-aminobutyric acid A receptor α3 subunit interaction with the clustering protein gephyrin. J Biol Chem (2011) 1.00
Multifunctional basic motif in the glycine receptor intracellular domain induces subunit-specific sorting. J Biol Chem (2009) 0.96
Diversity of glycine receptors in the mouse retina: localization of the alpha2 subunit. J Comp Neurol (2004) 0.96
Intraspleen delivery of a DNA vaccine coding for superoxide dismutase (SOD) of Brucella abortus induces SOD-specific CD4+ and CD8+ T cells. Infect Immun (2004) 0.96
The cell adhesion molecule neurofascin stabilizes axo-axonic GABAergic terminals at the axon initial segment. J Biol Chem (2011) 0.95
GLRB is the third major gene of effect in hyperekplexia. Hum Mol Genet (2012) 0.94
Mutations in the GlyT2 gene (SLC6A5) are a second major cause of startle disease. J Biol Chem (2012) 0.93
Differential agonist sensitivity of glycine receptor alpha2 subunit splice variants. Br J Pharmacol (2004) 0.93
Blockade of ethanol-induced potentiation of glycine receptors by a peptide that interferes with Gbetagamma binding. J Pharmacol Exp Ther (2009) 0.93
Novel missense mutations in the glycine receptor β subunit gene (GLRB) in startle disease. Neurobiol Dis (2012) 0.92
A Single phenylalanine residue in the main intracellular loop of α1 γ-aminobutyric acid type A and glycine receptors influences their sensitivity to propofol. Anesthesiology (2011) 0.92
A canine BCAN microdeletion associated with episodic falling syndrome. Neurobiol Dis (2011) 0.92
Extracellular signal-regulated kinase and glycogen synthase kinase 3β regulate gephyrin postsynaptic aggregation and GABAergic synaptic function in a calpain-dependent mechanism. J Biol Chem (2013) 0.92
Synphilin-1 and parkin show overlapping expression patterns in human brain and form aggresomes in response to proteasomal inhibition. Neurobiol Dis (2005) 0.92
Developmental-dependent action of microtubule depolymerization on the function and structure of synaptic glycine receptor clusters in spinal neurons. J Neurophysiol (2003) 0.91
Mechanistic insights and functional determinants of the transport cycle of the ascorbic acid transporter SVCT2. Activation by sodium and absolute dependence on bivalent cations. J Biol Chem (2006) 0.91
Startle disease in Irish wolfhounds associated with a microdeletion in the glycine transporter GlyT2 gene. Neurobiol Dis (2011) 0.91
Differential regulation of the postsynaptic clustering of γ-aminobutyric acid type A (GABAA) receptors by collybistin isoforms. J Biol Chem (2011) 0.90
SynArfGEF is a guanine nucleotide exchange factor for Arf6 and localizes preferentially at post-synaptic specializations of inhibitory synapses. J Neurochem (2011) 0.90
A Selective Role for alpha3 Subunit Glycine Receptors in Inflammatory Pain. Front Mol Neurosci (2009) 0.90
Biphasic effects of copper on neurotransmission in rat hippocampal neurons. J Neurochem (2011) 0.89
Anti-human immunodeficiency virus type 1 activity of the nonnucleoside reverse transcriptase inhibitor GW678248 in combination with other antiretrovirals against clinical isolate viruses and in vitro selection for resistance. Antimicrob Agents Chemother (2005) 0.89
An N-terminal histidine regulates Zn(2+) inhibition on the murine GABA(A) receptor beta3 subunit. Br J Pharmacol (2002) 0.89
Glycine receptor α2 subunit activation promotes cortical interneuron migration. Cell Rep (2013) 0.89
Defective glycinergic synaptic transmission in zebrafish motility mutants. Front Mol Neurosci (2010) 0.88
A novel dominant hyperekplexia mutation Y705C alters trafficking and biochemical properties of the presynaptic glycine transporter GlyT2. J Biol Chem (2012) 0.87
Glycine and glycine receptor signalling in non-neuronal cells. Front Mol Neurosci (2009) 0.87
Inhibitory effects of tutin on glycine receptors in spinal neurons. Eur J Pharmacol (2007) 0.85
Endoplasmic reticulum-associated degradation controls cell surface expression of γ-aminobutyric acid, type B receptors. J Biol Chem (2013) 0.84
Inhibition of the ethanol-induced potentiation of α1 glycine receptor by a small peptide that interferes with Gβγ binding. J Biol Chem (2012) 0.84
Activated G protein α s subunits increase the ethanol sensitivity of human glycine receptors. J Pharmacol Exp Ther (2011) 0.82
Defective escape behavior in DEAH-box RNA helicase mutants improved by restoring glycine receptor expression. J Neurosci (2013) 0.82
Potentiation and inhibition of glycine receptors by tutin. Neuropharmacology (2010) 0.82
Extracellular α-synuclein alters synaptic transmission in brain neurons by perforating the neuronal plasma membrane. J Neurochem (2015) 0.82
Alzheimer beta-amyloid blocks epileptiform activity in hippocampal neurons. Mol Cell Neurosci (2009) 0.82
Distinct synaptic localization patterns of brefeldin A-resistant guanine nucleotide exchange factors BRAG2 and BRAG3 in the mouse retina. J Comp Neurol (2013) 0.82
The basic property of Lys385 is important for potentiation of the human α1 glycine receptor by ethanol. J Pharmacol Exp Ther (2011) 0.82
Reproductive, physiological, and biochemical responses in juvenile female rainbow trout (Oncorhynchus mykiss) exposed to sediment from pulp and paper mill industrial discharge areas. Environ Toxicol Chem (2005) 0.81
Effects of pulp and paper mill discharges on caged rainbow trout (Oncorhynchus mykiss): biomarker responses along a pollution gradient in the Biobio River, Chile. Environ Toxicol Chem (2006) 0.81