Integrin α1-null mice exhibit improved fatty liver when fed a high fat diet despite severe hepatic insulin resistance.

PubWeight™: 0.81‹?›

🔗 View Article (PMID 25593319)

Published in J Biol Chem on January 15, 2015

Authors

Ashley S Williams1, Li Kang2, Jenny Zheng2, Carrie Grueter3, Deanna P Bracy2, Freyja D James2, Ambra Pozzi4, David H Wasserman5

Author Affiliations

1: From the Departments of Molecular Physiology and Biophysics and ashley.s.williams@vanderbilt.edu.
2: From the Departments of Molecular Physiology and Biophysics and.
3: Anesthesiology.
4: From the Departments of Molecular Physiology and Biophysics and Division of Nephrology, Department of Medicine, and the Department of Medicine, Department of Veteran Affairs, Nashville, Tennessee 37212-2637.
5: From the Departments of Molecular Physiology and Biophysics and Mouse Metabolic Phenotyping Center, Vanderbilt University, Nashville, Tennessee 37232 and.

Articles cited by this

Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (2001) 414.27

A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem (1957) 173.99

A central role for JNK in obesity and insulin resistance. Nature (2002) 17.27

PREPARATION OF FATTY ACID METHYL ESTERS AND DIMETHYLACETALS FROM LIPIDS WITH BORON FLUORIDE--METHANOL. J Lipid Res (1964) 15.95

Steatohepatitis: a tale of two "hits"? Gastroenterology (1998) 13.21

Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest (2005) 9.09

The extracellular matrix: not just pretty fibrils. Science (2009) 8.52

Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology (2001) 8.09

Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. J Biol Chem (2004) 7.91

PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation. Nat Med (2001) 6.09

Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice. J Clin Invest (2008) 5.27

Measurement of size and turnover rate of body glucose pool by the isotope dilution method. Am J Physiol (1956) 5.26

DNA excision in liver by an albumin-Cre transgene occurs progressively with age. Genesis (2000) 5.09

Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. Hepatology (2007) 4.83

The tail of integrins, talin, and kindlins. Science (2009) 4.51

Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. Cell Metab (2007) 4.51

Considerations in the design of hyperinsulinemic-euglycemic clamps in the conscious mouse. Diabetes (2006) 3.69

A lipidomic analysis of nonalcoholic fatty liver disease. Hepatology (2007) 3.65

Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance. Nat Med (2007) 3.54

Association of insulin receptor substrate-1 with integrins. Science (1994) 2.56

Elevated matrix metalloprotease and angiostatin levels in integrin alpha 1 knockout mice cause reduced tumor vascularization. Proc Natl Acad Sci U S A (2000) 2.46

Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1. J Clin Invest (2002) 2.38

Deletion of integrin alpha 1 by homologous recombination permits normal murine development but gives rise to a specific deficit in cell adhesion. Dev Biol (1996) 1.84

Negative regulation of EGFR signalling through integrin-alpha1beta1-mediated activation of protein tyrosine phosphatase TCPTP. Nat Cell Biol (2004) 1.81

DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation. J Clin Invest (2010) 1.70

Role of glucose effectiveness in the determination of glucose tolerance. Diabetes Care (1996) 1.68

Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver. J Lipid Res (2012) 1.53

Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease. Hepatology (2013) 1.42

The metabolically benign and malignant fatty liver. Diabetes (2011) 1.39

Integrin alpha1beta1 controls reactive oxygen species synthesis by negatively regulating epidermal growth factor receptor-mediated Rac activation. Mol Cell Biol (2007) 1.37

Diet-induced muscle insulin resistance is associated with extracellular matrix remodeling and interaction with integrin alpha2beta1 in mice. Diabetes (2011) 1.33

Modeling error and apparent isotope discrimination confound estimation of endogenous glucose production during euglycemic glucose clamps. Diabetes (1988) 1.28

Long-term caloric restriction abrogates the age-related decline in skeletal muscle aerobic function. FASEB J (2005) 1.26

Stimulation of IRS-1-associated phosphatidylinositol 3-kinase and Akt/protein kinase B but not glucose transport by beta1-integrin signaling in rat adipocytes. J Biol Chem (1998) 1.20

Evaluation of mitochondrial respiratory function in small biopsies of liver. Anal Biochem (2002) 1.17

The regulation of glucose effectiveness: how glucose modulates its own production. Curr Opin Clin Nutr Metab Care (2005) 1.15

Caspase-1 as a central regulator of high fat diet-induced non-alcoholic steatohepatitis. PLoS One (2013) 1.12

The emerging roles of fatty acid translocase/CD36 and the aryl hydrocarbon receptor in fatty liver disease. Exp Biol Med (Maywood) (2011) 1.05

Distribution of the VLA family of integrins in normal and pathological human liver tissue. Gastroenterology (1991) 1.04

Tumor necrosis factor-alpha induces hepatic insulin resistance in obese Zucker (fa/fa) rats via interaction of leukocyte antigen-related tyrosine phosphatase with focal adhesion kinase. Diabetes (2000) 1.02

Synthesis and accumulation of triglycerides in liver of diabetic rats. Effects of insulin treatment. Diabetes (1979) 1.00

Cross-talk between integrin α6β4 and insulin-like growth factor-1 receptor (IGF1R) through direct α6β4 binding to IGF1 and subsequent α6β4-IGF1-IGF1R ternary complex formation in anchorage-independent conditions. J Biol Chem (2012) 0.99

Insulin resistance in striated muscle-specific integrin receptor beta1-deficient mice. J Biol Chem (2008) 0.97

Cross-talk between insulin receptor and integrin alpha5 beta1 signaling pathways. J Biol Chem (1998) 0.97

Insulin resistance and diabetes mellitus. J Diabetes Complications (1997) 0.96

Insulin receptor substrate-1 as a signaling molecule for focal adhesion kinase pp125(FAK) and pp60(src). J Biol Chem (1998) 0.96

Abnormal meal carbohydrate disposition in insulin-dependent diabetes. Relative contributions of endogenous glucose production and initial splanchnic uptake and effect of intensive insulin therapy. J Clin Invest (1984) 0.95

Fibrogenesis in fatty liver associated with obesity and diabetes mellitus type 2. Dig Dis Sci (2007) 0.93

High insulin levels are required for FAT/CD36 plasma membrane translocation and enhanced fatty acid uptake in obese Zucker rat hepatocytes. Am J Physiol Endocrinol Metab (2012) 0.89

Eplerenone ameliorates the phenotypes of metabolic syndrome with NASH in liver-specific SREBP-1c Tg mice fed high-fat and high-fructose diet. Am J Physiol Endocrinol Metab (2013) 0.86

Integrin activates receptor-like protein tyrosine phosphatase alpha, Src, and Rho to increase prolactin gene expression through a final phosphatidylinositol 3-kinase/cytoskeletal pathway that is additive with insulin. Endocrinology (2005) 0.86

In vivo inhibition of focal adhesion kinase causes insulin resistance. J Physiol (2008) 0.86

Enhancing integrin α1 inserted (I) domain affinity to ligand potentiates integrin α1β1-mediated down-regulation of collagen synthesis. J Biol Chem (2012) 0.85

Insulin signaling in the adipocyte. Int J Obes Relat Metab Disord (2000) 0.85

alpha1 Integrin cytoplasmic domain is involved in focal adhesion formation via association with intracellular proteins. Biochem J (2001) 0.84

Integrin up-regulation in chronic liver disease: relationship with inflammation and fibrosis in chronic hepatitis C. J Pathol (2001) 0.83