Published in Diabetes on August 01, 1988
Beneficial effects of subcutaneous fat transplantation on metabolism. Cell Metab (2008) 5.07
Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice. Dis Model Mech (2010) 3.27
Endurance exercise as a countermeasure for aging. Diabetes (2008) 2.83
Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humans. J Clin Invest (1998) 1.75
Skeletal muscle utilization of free fatty acids in women with visceral obesity. J Clin Invest (1995) 1.73
Cortisol clearance and associations with insulin sensitivity, body fat and fatty liver in middle-aged men. Diabetologia (2007) 1.57
The effect of non-insulin-dependent diabetes mellitus and obesity on glucose transport and phosphorylation in skeletal muscle. J Clin Invest (1996) 1.56
Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation. Cell Metab (2010) 1.32
Importance of peripheral insulin levels for insulin-induced suppression of glucose production in depancreatized dogs. J Clin Invest (1992) 1.08
Mechanisms of insulin resistance in experimental hyperinsulinemic dogs. J Clin Invest (1998) 0.98
Effects of growth hormone and free fatty acids on insulin sensitivity in patients with type 1 diabetes. J Clin Endocrinol Metab (2009) 0.84
Dietary P(i) deprivation in rats affects liver cAMP, glycogen, key steps of gluconeogenesis and glucose production. Biochem J (2000) 0.82
Integrin α1-null mice exhibit improved fatty liver when fed a high fat diet despite severe hepatic insulin resistance. J Biol Chem (2015) 0.81
Plasma glucose kinetics and response of insulin and GIP following a cereal breakfast in female subjects: effect of starch digestibility. Eur J Clin Nutr (2015) 0.80
Metabolic handling of orally administered glucose in cirrhosis. J Clin Invest (1993) 0.78
Hepatic glucose sensing is impaired, but can be normalized, in people with impaired fasting glucose. J Clin Endocrinol Metab (2014) 0.76
Integrin-linked Kinase is Necessary for the Development of Diet-induced Hepatic Insulin Resistance. Diabetes (2016) 0.75
Accurate Measurement of Postprandial Glucose Turnover: Why Is It Difficult and How Can It Be Done (Relatively) Simply? Diabetes (2016) 0.75
Docosahexaenoic acid enrichment in NAFLD is associated with improvements in hepatic metabolism and hepatic insulin sensitivity: a pilot study. Eur J Clin Nutr (2017) 0.75
Quantitative estimation of insulin sensitivity. Am J Physiol (1979) 7.37
Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study. Lancet (1992) 6.28
Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose. J Clin Invest (1981) 5.82
Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function. Diabetes (1993) 5.70
Assessment of insulin sensitivity in vivo. Endocr Rev (1985) 4.21
Mapping genes for NIDDM. Design of the Finland-United States Investigation of NIDDM Genetics (FUSION) Study. Diabetes Care (1998) 3.99
MINMOD: a computer program to calculate insulin sensitivity and pancreatic responsivity from the frequently sampled intravenous glucose tolerance test. Comput Methods Programs Biomed (1986) 3.54
Estimation of endogenous glucose production during hyperinsulinemic-euglycemic glucose clamps. Comparison of unlabeled and labeled exogenous glucose infusates. Diabetes (1987) 2.95
Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp. J Clin Invest (1987) 2.81
Intensity and amount of physical activity in relation to insulin sensitivity: the Insulin Resistance Atherosclerosis Study. JAMA (1998) 2.56
Insulin transport across capillaries is rate limiting for insulin action in dogs. J Clin Invest (1989) 2.32
Exercise induces recruitment of the "insulin-responsive glucose transporter". Evidence for distinct intracellular insulin- and exercise-recruitable transporter pools in skeletal muscle. J Biol Chem (1990) 2.27
Dietary restriction increases insulin sensitivity and lowers blood glucose in rhesus monkeys. Am J Physiol (1994) 2.13
Reduced sample number for calculation of insulin sensitivity and glucose effectiveness from the minimal model. Suitability for use in population studies. Diabetes (1993) 2.03
Experimental validation of measurements of glucose turnover in nonsteady state. Am J Physiol (1978) 1.96
Type 2 diabetes: evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs. Proc Natl Acad Sci U S A (1999) 1.91
Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin. Diabetes (1995) 1.91
Dietary restriction and glucose regulation in aging rhesus monkeys: a follow-up report at 8.5 yr. Am J Physiol Endocrinol Metab (2001) 1.86
Familiality of quantitative metabolic traits in Finnish families with non-insulin-dependent diabetes mellitus. Finland-United States Investigation of NIDDM Genetics (FUSION) Study investigators. Hum Hered (1999) 1.76
A comparison between the minimal model and the glucose clamp in the assessment of insulin sensitivity across the spectrum of glucose tolerance. Insulin Resistance Atherosclerosis Study. Diabetes (1994) 1.73
Minimal model analysis of intravenous glucose tolerance test-derived insulin sensitivity in diabetic subjects. J Clin Endocrinol Metab (1990) 1.71
Role of glucose effectiveness in the determination of glucose tolerance. Diabetes Care (1996) 1.68
Disassembly of the actin network inhibits insulin-dependent stimulation of glucose transport and prevents recruitment of glucose transporters to the plasma membrane. J Biol Chem (1994) 1.67
Quantitative estimation of beta cell sensitivity to glucose in the intact organism: a minimal model of insulin kinetics in the dog. Diabetes (1980) 1.67
Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain. J Clin Invest (1993) 1.67
Caloric restriction per se is a significant factor in improvements in glycemic control and insulin sensitivity during weight loss in obese NIDDM patients. Diabetes Care (1994) 1.67
Longitudinal compensation for fat-induced insulin resistance includes reduced insulin clearance and enhanced beta-cell response. Diabetes (2000) 1.63
Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs. J Clin Invest (1996) 1.60
Dietary fat and insulin sensitivity in a triethnic population: the role of obesity. The Insulin Resistance Atherosclerosis Study (IRAS) Am J Clin Nutr (1997) 1.59
Diurnal variation in glucose tolerance. Cyclic suppression of insulin action and insulin secretion in normal-weight, but not obese, subjects. Diabetes (1992) 1.56
Modified protocols improve insulin sensitivity estimation using the minimal model. Am J Physiol (1987) 1.54
Prolonged elevation of plasma free fatty acids impairs pancreatic beta-cell function in obese nondiabetic humans but not in individuals with type 2 diabetes. Diabetes (2000) 1.52
Multiple roles of phosphatidylinositol 3-kinase in regulation of glucose transport, amino acid transport, and glucose transporters in L6 skeletal muscle cells. Endocrinology (1995) 1.50
Measurement and validation of nonsteady turnover rates with applications to the inulin and glucose systems. Fed Proc (1974) 1.48
Insulin sensitivity and B-cell responsiveness to glucose during late pregnancy in lean and moderately obese women with normal glucose tolerance or mild gestational diabetes. Am J Obstet Gynecol (1990) 1.48
Insulin resistance in short children with intrauterine growth retardation. J Clin Endocrinol Metab (1997) 1.48
Insulin sensitivity index, acute insulin response, and glucose effectiveness in a population-based sample of 380 young healthy Caucasians. Analysis of the impact of gender, body fat, physical fitness, and life-style factors. J Clin Invest (1996) 1.45
Pathogenesis of age-related glucose intolerance in man: insulin resistance and decreased beta-cell function. J Clin Endocrinol Metab (1985) 1.43
Insulin sensitivity and acute insulin response in African-Americans, non-Hispanic whites, and Hispanics with NIDDM: the Insulin Resistance Atherosclerosis Study. Diabetes (1997) 1.42
Ethnic differences in carotid wall thickness. The Insulin Resistance Atherosclerosis Study. Stroke (1996) 1.42
Insulin induces the translocation of GLUT4 from a unique intracellular organelle to transverse tubules in rat skeletal muscle. Diabetes (1992) 1.38
Novel glucosensor for hypoglycemic detection localized to the portal vein. Diabetes (1997) 1.36
Abundance, localization, and insulin-induced translocation of glucose transporters in red and white muscle. Am J Physiol (1992) 1.36
The modified minimal model: application to measurement of insulin sensitivity in children. J Clin Endocrinol Metab (1990) 1.35
Exercise and diabetes mellitus. Diabetes (1979) 1.34
Hepatic glucose production is regulated both by direct hepatic and extrahepatic effects of insulin in humans. Diabetes (1996) 1.31
Kinetics and specificity of insulin uptake from plasma into cerebrospinal fluid. Am J Physiol (1990) 1.31
Acute enhancement of insulin secretion by FFA in humans is lost with prolonged FFA elevation. Am J Physiol (1999) 1.30
The insulin sensitivity index in nondiabetic man. Correlation between clamp-derived and IVGTT-derived values. Diabetes (1986) 1.30
Fatty acids mediate the acute extrahepatic effects of insulin on hepatic glucose production in humans. Diabetes (1997) 1.30
Peripheral effects of insulin dominate suppression of fasting hepatic glucose production. Am J Physiol (1990) 1.29
Effect of glucagon on glucose turnover and plasma free fatty acids in depancreatized dogs maintained on matched insulin infusions. Can J Physiol Pharmacol (1972) 1.26
Insulin sensitivity from meal tolerance tests in normal subjects: a minimal model index. J Clin Endocrinol Metab (2000) 1.25
Influence of total vs. visceral fat on insulin action and secretion in African American and white children. Obes Res (2001) 1.25
Inhibition of lipolysis causes suppression of endogenous glucose production independent of changes in insulin. Am J Physiol Endocrinol Metab (2000) 1.24
Indirect effect of insulin to suppress endogenous glucose production is dominant, even with hyperglucagonemia. J Clin Invest (1997) 1.22
Transendothelial insulin transport is not saturable in vivo. No evidence for a receptor-mediated process. J Clin Invest (1996) 1.21
The essentiality of insulin and the role of glucagon in regulating glucose utilization and production during strenuous exercise in dogs. J Clin Invest (1976) 1.21
Intraportal glucose infusion matched to oral glucose absorption. Lack of evidence for "gut factor" involvement in hepatic glucose storage. Diabetes (1982) 1.20
Minimal modeling, partition analysis, and the estimation of insulin sensitivity. Fed Proc (1980) 1.18
The peroxisome proliferator-activated receptor-gamma2 Pro12A1a variant: association with type 2 diabetes and trait differences. Diabetes (2001) 1.17
Increased "glucagon immunoreactivity" in plasma of totally depancreatized dogs. Diabetes (1974) 1.16
Primacy of liver glucosensors in the sympathetic response to progressive hypoglycemia. Proc Natl Acad Sci U S A (1994) 1.15
Dynamics of glucose autoregulation in the isolated, blood-perfused canine liver. Am J Physiol (1974) 1.15
Glucose tolerance and insulin action in rats with renovascular hypertension. Hypertension (1991) 1.15
Effect of D-glucose or D-ribose on the turnover of glucose in pancreatectomized dogs maintained on a matched intraportal infusion of insulin. Diabetes (1969) 1.15
Diminished insulin sensitivity and increased insulin response in nonobese, nondiabetic Mexican Americans. Metabolism (1990) 1.14
Integrated control of hepatic glucose metabolism. Fed Proc (1977) 1.12
Importance of hepatic glucoreceptors in sympathoadrenal response to hypoglycemia. Diabetes (1991) 1.12
Effect of arginine on glucose turnover and plasma free fatty acids in normal dogs. Diabetes (1973) 1.12
The contribution of insulin-dependent and insulin-independent glucose uptake to intravenous glucose tolerance in healthy human subjects. Diabetes (1994) 1.12
Evidence for entry of plasma insulin into cerebrospinal fluid through an intermediate compartment in dogs. Quantitative aspects and implications for transport. J Clin Invest (1991) 1.12
Pioglitazone increases insulin sensitivity, reduces blood glucose, insulin, and lipid levels, and lowers blood pressure, in obese, insulin-resistant rhesus monkeys. Diabetes (1994) 1.12
Importance of glucose per se to intravenous glucose tolerance. Comparison of the minimal-model prediction with direct measurements. Diabetes (1985) 1.09
Increased beta-cell secretory capacity as mechanism for islet adaptation to nicotinic acid-induced insulin resistance. Diabetes (1989) 1.09
Impairment of hippocampal neurogenesis in streptozotocin-treated diabetic rats. Acta Neurol Scand (2007) 1.09
Portal vein afferents are critical for the sympathoadrenal response to hypoglycemia. Diabetes (2000) 1.09
Optimal segments: a method for smoothing tracer data to calculate metabolic fluxes. Am J Physiol (1983) 1.09
A genome-wide association scan for acute insulin response to glucose in Hispanic-Americans: the Insulin Resistance Atherosclerosis Family Study (IRAS FS). Diabetologia (2009) 1.08
Importance of peripheral insulin levels for insulin-induced suppression of glucose production in depancreatized dogs. J Clin Invest (1992) 1.08
Glucagon-like peptide 1 increases insulin sensitivity in depancreatized dogs. Diabetes (1999) 1.08
Dose-response relationship between lymph insulin and glucose uptake reveals enhanced insulin sensitivity of peripheral tissues. Diabetes (1992) 1.08
Variation in the resistin gene is associated with obesity and insulin-related phenotypes in Finnish subjects. Diabetologia (2004) 1.07
Synergistic effect of portal glucose and glucagon-like peptide-1 to lower systemic glucose and stimulate counter-regulatory hormones. Diabetologia (2005) 1.07
Quantitative trait loci for abdominal fat and BMI in Hispanic-Americans and African-Americans: the IRAS Family study. Int J Obes (Lond) (2005) 1.06
Effect of interaction between insulin and glucagon on glucose turnover and FFA concentration in normal and depancreatized dogs. Metabolism (1974) 1.06
Angiotensin II induces insulin resistance independent of changes in interstitial insulin. Am J Physiol (1999) 1.06
Glycaemia regulates the glucose transporter number in the plasma membrane of rat skeletal muscle. Biochem J (1992) 1.05
Critical evaluation of the combined model approach for estimation of prehepatic insulin secretion. Am J Physiol (1998) 1.05
Matched rates of insulin infusion and secretion and concurrent tracer-determined rates of glucose appearance and disappearance in fasting dogs. Can J Physiol Pharmacol (1968) 1.04
Importance of transcapillary insulin transport to dynamics of insulin action after intravenous glucose. Am J Physiol (1994) 1.04
Carotid artery atherosclerosis in type-2 diabetic and nondiabetic subjects with and without symptomatic coronary artery disease (The Insulin Resistance Atherosclerosis Study). Am J Cardiol (2000) 1.03
Interactions between glucagon and other counterregulatory hormones during normoglycemic and hypoglycemic exercise in dogs. J Clin Invest (1984) 1.03
Resistance to insulin but not to glucagon in lean human hypertriglyceridemics. Diabetes (1980) 1.01
The pilot gland approach to the study of insulin secretory dynamics. Recent Prog Horm Res (1971) 1.01
Low insulin sensitivity is associated with clustering of cardiovascular disease risk factors. Am J Epidemiol (1997) 1.01
Fetal rat intestinal cells in monolayer culture: a new in vitro system to study the glucagon-like immunoreactive peptides. Endocrinology (1987) 1.01
Candidate loci for insulin sensitivity and disposition index from a genome-wide association analysis of Hispanic participants in the Insulin Resistance Atherosclerosis (IRAS) Family Study. Diabetologia (2009) 1.01
Relationship of insulin clearance and secretion to insulin sensitivity in non-diabetic Mexican Americans. Eur J Clin Invest (1992) 1.01