Myc-induced liver tumors in transgenic zebrafish can regress in tp53 null mutation.

PubWeight™: 0.83‹?›

🔗 View Article (PMC 4303426)

Published in PLoS One on January 22, 2015

Authors

Lili Sun1, Anh Tuan Nguyen1, Jan M Spitsbergen2, Zhiyuan Gong1

Author Affiliations

1: Department of Biological Sciences, National University of Singapore, Singapore, Singapore.
2: Department of Microbiology and Marine and Freshwater Biomedical Sciences Center, Oregon State University, Corvallis, Oregon, United States of America.

Articles cited by this

Cancer. Addiction to oncogenes--the Achilles heal of cancer. Science (2002) 14.20

Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype. Nature (2004) 11.03

Epidemiology of viral hepatitis and hepatocellular carcinoma. Gastroenterology (2012) 10.00

Reversible tumorigenesis by MYC in hematopoietic lineages. Mol Cell (1999) 8.03

Myc's broad reach. Genes Dev (2008) 7.56

MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer. Nature (2004) 5.61

tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors. Proc Natl Acad Sci U S A (2005) 4.15

c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations. Nat Med (2001) 3.51

Myc pathways provoking cell suicide and cancer. Oncogene (2003) 3.49

Fugu genome analysis provides evidence for a whole-genome duplication early during the evolution of ray-finned fishes. Mol Biol Evol (2004) 2.65

Apoptotic signaling by c-MYC. Oncogene (2008) 2.57

Conservation of gene expression signatures between zebrafish and human liver tumors and tumor progression. Nat Biotechnol (2005) 2.51

MYC-induced myeloid leukemogenesis is accelerated by all six members of the antiapoptotic BCL family. Oncogene (2009) 1.98

Sustained regression of tumors upon MYC inactivation requires p53 or thrombospondin-1 to reverse the angiogenic switch. Proc Natl Acad Sci U S A (2006) 1.89

p53 at a glance. J Cell Sci (2010) 1.88

Zebrafish cancer: the state of the art and the path forward. Nat Rev Cancer (2013) 1.87

Prognostic significance of c-myc and AIB1 amplification in hepatocellular carcinoma. A broad survey using high-throughput tissue microarray. Cancer (2002) 1.59

Identification and real-time imaging of a myc-expressing neutrophil population involved in inflammation and mycobacterial granuloma formation in zebrafish. Dev Comp Immunol (2007) 1.58

Animal models of disease: pre-clinical animal models of cancer and their applications and utility in drug discovery. Biochem Pharmacol (2013) 1.47

Mifepristone-inducible LexPR system to drive and control gene expression in transgenic zebrafish. Dev Biol (2008) 1.46

The many roles of c-Myc in apoptosis. Annu Rev Physiol (1998) 1.44

Trans-kingdom transposition of the maize dissociation element. Genetics (2006) 1.39

Making waves in cancer research: new models in the zebrafish. Biotechniques (2005) 1.36

Neoplasia in zebrafish (Danio rerio) treated with 7,12-dimethylbenz[a]anthracene by two exposure routes at different developmental stages. Toxicol Pathol (2001) 1.19

Neoplasia in zebrafish (Danio rerio) treated with N-methyl-N'-nitro-N-nitrosoguanidine by three exposure routes at different developmental stages. Toxicol Pathol (2001) 1.19

An inducible kras(V12) transgenic zebrafish model for liver tumorigenesis and chemical drug screening. Dis Model Mech (2011) 1.17

Inducible and repressable oncogene-addicted hepatocellular carcinoma in Tet-on xmrk transgenic zebrafish. J Hepatol (2011) 1.09

A transgenic zebrafish liver tumor model with inducible Myc expression reveals conserved Myc signatures with mammalian liver tumors. Dis Model Mech (2012) 1.00

Neoplasia and neoplasm-associated lesions in laboratory colonies of zebrafish emphasizing key influences of diet and aquaculture system design. ILAR J (2012) 0.99

Amplification of c-myc and cyclin D1 genes in primary and metastatic carcinomas of the liver. Pathol Int (2007) 0.95

Using myc genes to search for stem cells in the ciliary margin of the Xenopus retina. Dev Neurobiol (2012) 0.90

Liver tumor models in transgenic zebrafish: an alternative in vivo approach to study hepatocarcinogenes. Future Oncol (2012) 0.86

Liver hyperplasia after tamoxifen induction of Myc in a transgenic medaka model. Dis Model Mech (2012) 0.82

Evolutionary history of c-myc in teleosts and characterization of the duplicated c-myca genes in goldfish embryos. Mol Reprod Dev (2011) 0.81

MYC fails to efficiently shape malignant transformation in T-cell acute lymphoblastic leukemia. Genes Chromosomes Cancer (2013) 0.78