Published in J Biol Chem on January 15, 1989
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Cortisol is transported by the multidrug resistance gene product P-glycoprotein. Br J Cancer (1993) 1.03
Interaction of tamoxifen with the multidrug resistance P-glycoprotein. Br J Cancer (1995) 1.02
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Natural and synthetic polymers as inhibitors of drug efflux pumps. Pharm Res (2007) 0.99
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Arginine482 to threonine mutation in the breast cancer resistance protein ABCG2 inhibits rhodamine 123 transport while increasing binding. Biochem J (2004) 0.98
Constitutive expression of multidrug resistance in human colorectal tumours and cell lines. Br J Cancer (1993) 0.94
Reversal of acquired resistance to adriamycin in CHO cells by tamoxifen and 4-hydroxy tamoxifen: role of drug interaction with alpha 1 acid glycoprotein. Br J Cancer (1990) 0.93
Evidence of P-glycoprotein mediated apical to basolateral transport of flunisolide in human broncho-tracheal epithelial cells (Calu-3). Br J Pharmacol (2001) 0.86
Molecular analysis of the multidrug transporter, P-glycoprotein. Cytotechnology (1998) 0.85
Effect of ABCB1 C3435T polymorphism on docetaxel pharmacokinetics according to menopausal status in breast cancer patients. Br J Cancer (2010) 0.79
Modulation of P-glycoprotein activity by cannabinoid molecules in HK-2 renal cells. Br J Pharmacol (2006) 0.79
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Effect of anthracycline analogs on photolabelling of p-glycoprotein by [125I]iodomycin and [3H]azidopine: relation to lipophilicity and inhibition of daunorubicin transport in multidrug resistant cells. Br J Cancer (1993) 0.78
Colorectal cancer susceptibility: apparent gender-related modulation by ABCB1 gene polymorphisms. J Biomed Sci (2014) 0.78
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Promotion of microtubule assembly in vitro by taxol. Nature (1979) 12.73
Taxol stabilizes microtubules in mouse fibroblast cells. Proc Natl Acad Sci U S A (1980) 8.94
Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific beta-tubulin isotypes. J Clin Invest (1997) 2.96
Taxol binds to polymerized tubulin in vitro. J Cell Biol (1981) 2.86
The effect of aphidicolin on adenovirus DNA synthesis. Nucleic Acids Res (1979) 2.47
The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues. Mol Cell Biol (1989) 2.35
Studies with RP 56976 (taxotere): a semisynthetic analogue of taxol. J Natl Cancer Inst (1991) 2.33
Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein. Cancer Res (2000) 2.32
Localized expression of the atrial natriuretic factor gene during cardiac embryogenesis. Genes Dev (1987) 2.24
The multidrug resistance (mdr1) gene product functions as an ATP channel. Proc Natl Acad Sci U S A (1993) 2.09
Mechanisms of Taxol-induced cell death are concentration dependent. Cancer Res (1998) 1.99
Taxol and discodermolide represent a synergistic drug combination in human carcinoma cell lines. Clin Cancer Res (2000) 1.97
4-Anilino-6,7-dialkoxyquinoline-3-carbonitrile inhibitors of epidermal growth factor receptor kinase and their bioisosteric relationship to the 4-anilino-6,7-dialkoxyquinazoline inhibitors. J Med Chem (2000) 1.94
Taxol binds to cellular microtubules. J Cell Biol (1982) 1.91
Activated bleomycin. A transient complex of drug, iron, and oxygen that degrades DNA. J Biol Chem (1981) 1.74
Taxol assembles tubulin in the absence of exogenous guanosine 5'-triphosphate or microtubule-associated proteins. Biochemistry (1981) 1.71
The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus. Proc Natl Acad Sci U S A (1988) 1.69
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Characterization of the Taxol binding site on the microtubule. Identification of Arg(282) in beta-tubulin as the site of photoincorporation of a 7-benzophenone analogue of Taxol. J Biol Chem (1999) 1.59
Characterization of the taxol binding site on the microtubule. 2-(m-Azidobenzoyl)taxol photolabels a peptide (amino acids 217-231) of beta-tubulin. J Biol Chem (1995) 1.56
3'-(p-azidobenzamido)taxol photolabels the N-terminal 31 amino acids of beta-tubulin. J Biol Chem (1994) 1.53
Irreversible inhibition of epidermal growth factor receptor tyrosine kinase with in vivo activity by N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-butynamide (CL-387,785). Biochem Pharmacol (1999) 1.53
A role for ferrous ion and oxygen in the degradation of DNA by bleomycin. Biochem Biophys Res Commun (1976) 1.52
Differential overexpression of three mdr gene family members in multidrug-resistant J774.2 mouse cells. Evidence that distinct P-glycoprotein precursors are encoded by unique mdr genes. J Biol Chem (1989) 1.52
A common pharmacophore for cytotoxic natural products that stabilize microtubules. Proc Natl Acad Sci U S A (1999) 1.49
Effects of podophyllotoxin and VP-16-213 on microtubule assembly in vitro and nucleoside transport in HeLa cells. Biochemistry (1976) 1.48
Properties and products of the degradation of DNA by bleomycin and iron(II). Biochemistry (1978) 1.47
Origin of malondialdehyde from DNA degraded by Fe(II) x bleomycin. J Biol Chem (1980) 1.47
Antisense oligonucleotides to class III beta-tubulin sensitize drug-resistant cells to Taxol. Br J Cancer (1999) 1.45
Taxol: an antimitotic agent with a new mechanism of action. Pharmacol Ther (1984) 1.44
Clinical significance of P-glycoprotein in multidrug resistance malignancies. Blood (1993) 1.43
Long-term results of children with acute myeloid leukemia: a report of three consecutive Phase III trials by the Children's Cancer Group: CCG 251, CCG 213 and CCG 2891. Leukemia (2005) 1.40
Non-P-glycoprotein mediated mechanism for multidrug resistance precedes P-glycoprotein expression during in vitro selection for doxorubicin resistance in a human lung cancer cell line. Cancer Res (1990) 1.39
Microtubule arrays in taxol-treated mouse dorsal root ganglion-spinal cord cultures. Brain Res (1981) 1.38
Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells by fumitremorgin C. Cancer Res (1998) 1.36
Altered expression of M beta 2, the class II beta-tubulin isotype, in a murine J774.2 cell line with a high level of taxol resistance. J Biol Chem (1995) 1.36
Multiple microtubule alterations are associated with Vinca alkaloid resistance in human leukemia cells. Cancer Res (2001) 1.32
Effect of chelating agents and metal ions on the degradation of DNA by bleomycin. Biochemistry (1978) 1.31
Intracellular degradation of HeLa and adenovirus type 2 DNA induced by camptothecin. Biochem Biophys Res Commun (1971) 1.29
Mutations in beta-tubulin map to domains involved in regulation of microtubule stability in epothilone-resistant cell lines. Mol Cancer Ther (2001) 1.28
Clinical relevance of transmembrane drug efflux as a mechanism of multidrug resistance. J Clin Oncol (1998) 1.26
Cloning and characterization of allograft inflammatory factor-1: a novel macrophage factor identified in rat cardiac allografts with chronic rejection. J Clin Invest (1995) 1.23
Steganacin: an inhibitor of HeLa cell growth and microtubule assembly in vitro. Biochem Biophys Res Commun (1978) 1.23
A common pharmacophore for Taxol and the epothilones based on the biological activity of a taxane molecule lacking a C-13 side chain. Biochemistry (2000) 1.22
Absence of colony-stimulating factor-1 in osteopetrotic (csfmop/csfmop) mice results in male fertility defects. Biol Reprod (1996) 1.20
Upregulation of caveolin-1 and caveolae organelles in Taxol-resistant A549 cells. FEBS Lett (1998) 1.20
Taxol-induced neuropathy: short-term effects of local injection. J Neurocytol (1984) 1.19
The DNA cleavage mechanism of iron-bleomycin. Kinetic resolution of strand scission from base propenal release. J Biol Chem (1986) 1.17
Biology of Langerhans cells and Langerhans cell histiocytosis. Int Rev Cytol (2006) 1.17
Tumor targeting by covalent conjugation of a natural fatty acid to paclitaxel. Clin Cancer Res (2001) 1.17
Taxol, a microtubule stabilizing agent, blocks the replication of Trypanosoma cruzi. Proc Natl Acad Sci U S A (1981) 1.15
Down-modulation of cancer targets using locked nucleic acid (LNA)-based antisense oligonucleotides without transfection. Gene Ther (2010) 1.14
Allelotype of pediatric rhabdomyosarcoma. Oncogene (1997) 1.13
STAT3 activation is required for Asp(816) mutant c-Kit induced tumorigenicity. Oncogene (2001) 1.12
Mechanism of bleomycin action: in vitro studies. Life Sci (1981) 1.12
Biologically active taxol analogues with deleted A-ring side chain substituents and variable C-2' configurations. J Med Chem (1991) 1.10
Direct photoaffinity labeling of tubulin with taxol. J Natl Cancer Inst (1992) 1.09
Structural analysis of the mouse mdr1a (P-glycoprotein) promoter reveals the basis for differential transcript heterogeneity in multidrug-resistant J774.2 cells. Mol Cell Biol (1990) 1.08
Electrophoretic analysis of P-glycoproteins produced by mouse J774.2 and Chinese hamster ovary multidrug-resistant cells. J Natl Cancer Inst (1988) 1.08
Differential transport properties of two mdr gene products are distinguished by progesterone. J Biol Chem (1990) 1.07
Proliferation-associated SNF2-like gene (PASG): a SNF2 family member altered in leukemia. Cancer Res (2000) 1.07
Selective potentiation of paclitaxel (taxol)-induced cell death by mitogen-activated protein kinase kinase inhibition in human cancer cell lines. Mol Pharmacol (2001) 1.06
Design, synthesis, and preclinical characterization of novel, highly selective indole estrogens. J Med Chem (2001) 1.06
Endogenous knockdown of survivin improves chemotherapeutic response in ALL models. Leukemia (2011) 1.06
Trifluoperazine inhibits phagocytosis in a macrophagelike cultured cell line. J Cell Biol (1981) 1.06
Taxol: mechanisms of action and resistance. Ann N Y Acad Sci (1986) 1.06
Binding properties of monoclonal antibodies recognizing external epitopes of the human MDR1 P-glycoprotein. Int J Cancer (1993) 1.04
Effect of VP-16-213 on the intracellular degradation of DNA in HeLa cells. Biochemistry (1976) 1.03
Histone variants and chromatin structure during sea urchin development. Dev Biol (1980) 1.03
Distinct P-glycoprotein precursors are overproduced in independently isolated drug-resistant cell lines. Proc Natl Acad Sci U S A (1988) 1.02
Localization of the forskolin labeling sites to both halves of P-glycoprotein: similarity of the sites labeled by forskolin and prazosin. Mol Pharmacol (1994) 1.02
Multidrug resistance gene expression is controlled by steroid hormones in the secretory epithelium of the uterus. Mol Reprod Dev (1990) 1.02
Mechanism of action of the 12,13-epoxytrichothecene, anguidine, an inhibitor of protein synthesis. Biochim Biophys Acta (1976) 1.02
Preparation and biological activity of taxol acetates. Biochem Biophys Res Commun (1984) 1.02
The programmed switch in lysine-rich histone synthesis at gastrulation. Cell (1976) 1.01
Oxygenated iron bleomycin. A short-lived intermediate in the reaction of ferrous bleomycin with O2. J Biol Chem (1979) 1.01
Mode of action of the antitumor compound bruceantin, an inhibitor of protein synthesis. Mol Pharmacol (1976) 1.01
The role of ERK 1/2 and p38 MAP-kinase pathways in taxol-induced apoptosis in human ovarian carcinoma cells. Exp Cell Res (2001) 1.01
Effects of camptothecin on the breakage and repair of DNA during the cell cycle. Cancer Res (1973) 1.01
A phosphoglycoprotein associated with taxol resistance in J774.2 cells. Cancer Res (1985) 1.00
Relationship between the structure of taxol and other taxanes on induction of tumor necrosis factor-alpha gene expression and cytotoxicity. Cancer Res (1994) 0.99
Iron-bleomycin interactions with oxygen and oxygen analogues. Effects on spectra and drug activity. J Biol Chem (1979) 0.99
mdr2 encodes P-glycoprotein expressed in the bile canalicular membrane as determined by isoform-specific antibodies. J Biol Chem (1992) 0.98
Identification of the major phosphorylation domain of murine mdr1b P-glycoprotein. Analysis of the protein kinase A and protein kinase C phosphorylation sites. J Biol Chem (1993) 0.98
P-glycoprotein transports corticosterone and is photoaffinity-labeled by the steroid. Int J Cancer (1992) 0.98
Domain mapping of the photoaffinity drug-binding sites in P-glycoprotein encoded by mouse mdr1b. J Biol Chem (1991) 0.97
Taxol mediates serine phosphorylation of the 66-kDa Shc isoform. Cancer Res (2000) 0.97
Congenital and neonatal leukemia. Semin Perinatol (1999) 0.97
Phosphorylation of the multidrug resistance associated glycoprotein. Biochemistry (1987) 0.96
Identification and upregulation of galactose/N-acetylgalactosamine macrophage lectin in rat cardiac allografts with arteriosclerosis. J Clin Invest (1994) 0.95
Mössbauer study of iron bleomycin and its activation intermediates. J Biol Chem (1983) 0.94
Effect of ATP and other nucleotides on the bleomycin-induced degradation of vaccinia virus DNA. Virology (1976) 0.94
Photoaffinity probes for the alpha 1-adrenergic receptor and the calcium channel bind to a common domain in P-glycoprotein. J Biol Chem (1990) 0.94
Functional evidence that transmembrane 12 and the loop between transmembrane 11 and 12 form part of the drug-binding domain in P-glycoprotein encoded by MDR1. J Biol Chem (1995) 0.94
Stoichiometry of DNA strand scission and aldehyde formation by bleomycin. J Biol Chem (1982) 0.94
Allograft inflammatory factory-1. A cytokine-responsive macrophage molecule expressed in transplanted human hearts. Transplantation (1996) 0.93