Prehospital use of magnesium sulfate as neuroprotection in acute stroke.

PubWeight™: 1.29‹?› | Rank: Top 10%

🔗 View Article (PMID 25651247)

Published in N Engl J Med on February 05, 2015

Authors

Jeffrey L Saver1, Sidney Starkman, Marc Eckstein, Samuel J Stratton, Franklin D Pratt, Scott Hamilton, Robin Conwit, David S Liebeskind, Gene Sung, Ian Kramer, Gary Moreau, Robert Goldweber, Nerses Sanossian, FAST-MAG Investigators and Coordinators

Author Affiliations

1: From the Comprehensive Stroke Center (J.L.S., S.S., D.S.L.) and the Departments of Neurology (J.L.S., S.S., D.S.L.) and Emergency Medicine (S.S., F.P.), David Geffen School of Medicine at the University of California, Los Angeles (UCLA), the Departments of Emergency Medicine (M.E.) and Neurology (G.S., N.S.), Keck School of Medicine of the University of Southern California, the Los Angeles Fire Department (M.E.), the Los Angeles County Fire Department (F.P.), the Department of Emergency Medicine, Presbyterian Intercommunity Hospital (I.K.), the Department of Emergency Medicine, Long Beach Memorial Medical Center (G.M.), and the Department of Emergency Medicine, Huntington Memorial Hospital (R.G.), Los Angeles, the Los Angeles County Emergency Medical Services (EMS) Agency, the Orange County EMS Agency, and the Department of Emergency Medicine, Harbor-UCLA Medical Center, Torrance (S.J.S.), and Stanford University, Palo Alto (S.H.) - all in California; and the National Institute of Neurological Disorders and Stroke, Bethesda, MD (R.C.).

Associated clinical trials:

Field Administration of Stroke Therapy - Magnesium (FAST-MAG) Trial (FAST-MAG) | NCT00059332

Articles citing this

Magnesium in Prevention and Therapy. Nutrients (2015) 1.11

Metabotropic NMDA receptor signaling couples Src family kinases to pannexin-1 during excitotoxicity. Nat Neurosci (2016) 0.89

The role of excitotoxic programmed necrosis in acute brain injury. Comput Struct Biotechnol J (2015) 0.83

Therapeutics targeting the inflammasome after central nervous system injury. Transl Res (2015) 0.83

Routing Ambulances to Designated Centers Increases Access to Stroke Center Care and Enrollment in Prehospital Research. Stroke (2015) 0.82

Combined neurothrombectomy or thrombolysis with adjunctive delivery of 3K3A-activated protein C in acute ischemic stroke. Front Cell Neurosci (2015) 0.80

Prehospital systolic blood pressure is higher in acute stroke compared with stroke mimics. Neurology (2016) 0.78

Enrollment Yield and Reasons for Screen Failure in a Large Prehospital Stroke Trial. Stroke (2015) 0.77

Vitamins and nutrients as primary treatments in experimental brain injury: Clinical implications for nutraceutical therapies. Brain Res (2015) 0.77

Cerebral vasospasm and wernicke encephalopathy secondary to adult cyclic vomiting syndrome: the role of magnesium. BMC Neurol (2016) 0.75

A primer of neurologic emergencies: summary from the American Thoracic Society Meeting 2016. J Thorac Dis (2016) 0.75

Imaging of prehospital stroke therapeutics. Expert Rev Cardiovasc Ther (2015) 0.75

Dodecafluoropentane Improves Neurological Function Following Anterior Ischemic Stroke. Mol Neurobiol (2016) 0.75

Cyclooxygenase-2 is associated with malignant phenotypes in human lung cancer. Oncol Lett (2016) 0.75

Cerebral protection during neurosurgery and stroke. Curr Opin Anaesthesiol (2015) 0.75

A low-cost, tablet-based option for prehospital neurologic assessment: The iTREAT Study. Neurology (2016) 0.75

Utilization of Emergent Neuroimaging for Thrombolysis-Eligible Stroke Patients. J Neuroimaging (2016) 0.75

Response to letter regarding article, "Art of expertise in stroke telemedicine: imaging and the collaterome". Stroke (2015) 0.75

Magnesium sulfate protects oligodendrocyte lineage cells in a rat cell-culture model of hypoxic-ischemic injury. Neurosci Res (2015) 0.75

Cerebral collateral therapeutics in acute ischemic stroke: A randomized preclinical trial of four modulation strategies. J Cereb Blood Flow Metab (2017) 0.75

Magnesium Sulfate Provides Neuroprotection in Eclampsia-Like Seizure Model by Ameliorating Neuroinflammation and Brain Edema. Mol Neurobiol (2016) 0.75

The role of magnesium sulfate in the intensive care unit. EXCLI J (2017) 0.75

Blood pressure management in acute stroke. Stroke Vasc Neurol (2016) 0.75

Articles cited by this

Heart disease and stroke statistics--2013 update: a report from the American Heart Association. Circulation (2012) 30.79

A randomized trial of intraarterial treatment for acute ischemic stroke. N Engl J Med (2014) 18.12

Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke (2013) 14.49

Solitaire flow restoration device versus the Merci Retriever in patients with acute ischaemic stroke (SWIFT): a randomised, parallel-group, non-inferiority trial. Lancet (2012) 8.76

1,026 experimental treatments in acute stroke. Ann Neurol (2006) 7.23

Guidelines for the management of spontaneous intracerebral hemorrhage: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke (2010) 6.87

Identifying stroke in the field. Prospective validation of the Los Angeles prehospital stroke screen (LAPSS). Stroke (2000) 2.98

Recombinant tissue-type plasminogen activator use for ischemic stroke in the United States: a doubling of treatment rates over the course of 5 years. Stroke (2011) 2.80

Magnesium for acute stroke (Intravenous Magnesium Efficacy in Stroke trial): randomised controlled trial. Lancet (2004) 2.51

Prehospital neuroprotective therapy for acute stroke: results of the Field Administration of Stroke Therapy-Magnesium (FAST-MAG) pilot trial. Stroke (2004) 2.40

The therapeutic use of magnesium in anesthesiology, intensive care and emergency medicine: a review. Can J Anaesth (2003) 1.75

Simultaneous ring voice-over-Internet phone system enables rapid physician elicitation of explicit informed consent in prehospital stroke treatment trials. Cerebrovasc Dis (2009) 1.71

Improving the reliability of stroke disability grading in clinical trials and clinical practice: the Rankin Focused Assessment (RFA). Stroke (2010) 1.59

Use of a global test for multiple outcomes in stroke trials with application to the National Institute of Neurological Disorders and Stroke t-PA Stroke Trial. Stroke (1996) 1.55

Trends in acute ischemic stroke trials through the 20th century. Stroke (2001) 1.55

The "golden hour" and acute brain ischemia: presenting features and lytic therapy in >30,000 patients arriving within 60 minutes of stroke onset. Stroke (2010) 1.50

Prehospital transport time intervals for acute stroke patients. J Emerg Med (2008) 1.12

Methodology of the Field Administration of Stroke Therapy - Magnesium (FAST-MAG) phase 3 trial: Part 1 - rationale and general methods. Int J Stroke (2014) 1.05

Hyperacute treatment initiation in neuroprotective agent stroke trials. J Stroke Cerebrovasc Dis (2007) 1.04

Toward a multimodal neuroprotective treatment of stroke. Stroke (2006) 1.04

Methodology of the Field Administration of Stroke Therapy - Magnesium (FAST-MAG) phase 3 trial: Part 2 - prehospital study methods. Int J Stroke (2014) 1.01

Improving reperfusion therapy for acute ischaemic stroke. J Thromb Haemost (2011) 0.99

Magnesium for neuroprotection in ischaemic stroke: rationale for use and evidence of effectiveness. CNS Drugs (2001) 0.86

Articles by these authors

Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials. Lancet (2004) 12.92

Magnetic resonance imaging profiles predict clinical response to early reperfusion: the diffusion and perfusion imaging evaluation for understanding stroke evolution (DEFUSE) study. Ann Neurol (2006) 10.51

A trial of imaging selection and endovascular treatment for ischemic stroke. N Engl J Med (2013) 9.97

Mechanical thrombectomy for acute ischemic stroke: final results of the Multi MERCI trial. Stroke (2008) 8.45

Safety and efficacy of mechanical embolectomy in acute ischemic stroke: results of the MERCI trial. Stroke (2005) 8.05

Trevo versus Merci retrievers for thrombectomy revascularisation of large vessel occlusions in acute ischaemic stroke (TREVO 2): a randomised trial. Lancet (2012) 7.89

Treatment-responsive limbic encephalitis identified by neuropil antibodies: MRI and PET correlates. Brain (2005) 6.81

Intramuscular versus intravenous therapy for prehospital status epilepticus. N Engl J Med (2012) 5.11

Comparison of MRI and CT for detection of acute intracerebral hemorrhage. JAMA (2004) 4.82

Skeletal muscle strength as a predictor of all-cause mortality in healthy men. J Gerontol A Biol Sci Med Sci (2002) 3.56

DWI-FLAIR mismatch for the identification of patients with acute ischaemic stroke within 4·5 h of symptom onset (PRE-FLAIR): a multicentre observational study. Lancet Neurol (2011) 3.18

Collateral flow predicts response to endovascular therapy for acute ischemic stroke. Stroke (2011) 2.80

Conscious sedation versus general anesthesia during endovascular therapy for acute anterior circulation stroke: preliminary results from a retrospective, multicenter study. Stroke (2010) 2.77

Magnetic resonance imaging detection of microbleeds before thrombolysis: an emerging application. Stroke (2002) 2.76

MERCI 1: a phase 1 study of Mechanical Embolus Removal in Cerebral Ischemia. Stroke (2004) 2.75

CT and MRI early vessel signs reflect clot composition in acute stroke. Stroke (2011) 2.52

Recommendations on angiographic revascularization grading standards for acute ischemic stroke: a consensus statement. Stroke (2013) 2.50

Collateral blood vessels in acute ischaemic stroke: a potential therapeutic target. Lancet Neurol (2011) 2.46

Granulocyte-macrophage colony-stimulating factor gene-modified autologous tumor vaccines in non-small-cell lung cancer. J Natl Cancer Inst (2004) 2.41

Prehospital neuroprotective therapy for acute stroke: results of the Field Administration of Stroke Therapy-Magnesium (FAST-MAG) pilot trial. Stroke (2004) 2.40

Bleeding risk analysis in stroke imaging before thromboLysis (BRASIL): pooled analysis of T2*-weighted magnetic resonance imaging data from 570 patients. Stroke (2007) 2.36

The Secondary Prevention of Small Subcortical Strokes (SPS3) study. Int J Stroke (2011) 2.35

Late secondary ischemic injury in patients receiving intraarterial thrombolysis. Ann Neurol (2002) 2.31

Predictors of good clinical outcomes, mortality, and successful revascularization in patients with acute ischemic stroke undergoing thrombectomy: pooled analysis of the Mechanical Embolus Removal in Cerebral Ischemia (MERCI) and Multi MERCI Trials. Stroke (2009) 2.17

Mechanical recanalization in basilar artery occlusion: the ENDOSTROKE study. Ann Neurol (2015) 2.16

Randomized study combining interferon and glatiramer acetate in multiple sclerosis. Ann Neurol (2013) 2.08

Perfusion-weighted magnetic resonance imaging thresholds identifying core, irreversibly infarcted tissue. Stroke (2003) 2.06

Indirect revascularization for nonmoyamoya intracranial arterial stenoses: clinical and angiographic outcomes. J Neurosurg (2012) 2.03

Analysis of thrombi retrieved from cerebral arteries of patients with acute ischemic stroke. Stroke (2006) 2.02

Number needed to treat to benefit and to harm for intravenous tissue plasminogen activator therapy in the 3- to 4.5-hour window: joint outcome table analysis of the ECASS 3 trial. Stroke (2009) 2.00

Dispatcher recognition of stroke using the National Academy Medical Priority Dispatch System. Stroke (2009) 1.96

Prospective, multicenter, single-arm study of mechanical thrombectomy using Solitaire Flow Restoration in acute ischemic stroke. Stroke (2013) 1.94

Stroke Treatment Academic Industry Roundtable (STAIR) recommendations for maximizing the use of intravenous thrombolytics and expanding treatment options with intra-arterial and neuroprotective therapies. Stroke (2011) 1.92

In Vivo 3D Digital Atlas Database of the Adult C57BL/6J Mouse Brain by Magnetic Resonance Microscopy. Front Neuroanat (2008) 1.85

Integration of pre-hospital electrocardiograms and ST-elevation myocardial infarction receiving center (SRC) networks: impact on Door-to-Balloon times across 10 independent regions. JACC Cardiovasc Interv (2009) 1.83

The combined approach to lysis utilizing eptifibatide and rt-PA in acute ischemic stroke: the CLEAR stroke trial. Stroke (2008) 1.79

Evaluation of the clinical-diffusion and perfusion-diffusion mismatch models in DEFUSE. Stroke (2007) 1.72

Simultaneous ring voice-over-Internet phone system enables rapid physician elicitation of explicit informed consent in prehospital stroke treatment trials. Cerebrovasc Dis (2009) 1.71

Risk for symptomatic intracerebral hemorrhage after thrombolysis assessed by diffusion-weighted magnetic resonance imaging. Ann Neurol (2008) 1.71

Predictors of hemorrhagic transformation in patients receiving intra-arterial thrombolysis. Stroke (2002) 1.68

Collateral flow averts hemorrhagic transformation after endovascular therapy for acute ischemic stroke. Stroke (2011) 1.67

Acute stroke imaging research roadmap. Stroke (2008) 1.66

Rabbits are not resistant to prion infection. Proc Natl Acad Sci U S A (2012) 1.63

Leukoaraiosis is a risk factor for symptomatic intracerebral hemorrhage after thrombolysis for acute stroke. Stroke (2006) 1.59

Multimodality treatment of posterior fossa arteriovenous malformations. J Neurosurg (2008) 1.59

Improving the reliability of stroke disability grading in clinical trials and clinical practice: the Rankin Focused Assessment (RFA). Stroke (2010) 1.59

Radiologic evaluation of alternative sites for needle decompression of tension pneumothorax. Arch Surg (2012) 1.57

Design and rationale of the Mechanical Retrieval and Recanalization of Stroke Clots Using Embolectomy (MR RESCUE) Trial. Int J Stroke (2012) 1.55

Optimal positioning for emergent needle thoracostomy: a cadaver-based study. J Trauma (2011) 1.54

Body mass index and hospital discharge outcomes after ischemic stroke. Arch Neurol (2007) 1.54

Prediction of hemorrhagic transformation after recanalization therapy using T2*-permeability magnetic resonance imaging. Ann Neurol (2007) 1.53

Utility of the NIH Stroke Scale as a predictor of hospital disposition. Stroke (2003) 1.51

Local brain temperature reduction through intranasal cooling with the RhinoChill device: preliminary safety data in brain-injured patients. Stroke (2011) 1.48

Clinical features and racial/ethnic differences among the 3020 participants in the Secondary Prevention of Small Subcortical Strokes (SPS3) trial. J Stroke Cerebrovasc Dis (2012) 1.47

Acute Stroke Imaging Research Roadmap II. Stroke (2013) 1.47

Improving hospital surge capacity: a new concept for emergency credentialing of volunteers. Ann Emerg Med (2006) 1.47

Recanalization and clinical outcome of occlusion sites at baseline CT angiography in the Interventional Management of Stroke III trial. Radiology (2014) 1.46

Mechanical thrombectomy of intracranial internal carotid occlusion: pooled results of the MERCI and Multi MERCI Part I trials. Stroke (2007) 1.45

Multiparametric MRI and CT models of infarct core and favorable penumbral imaging patterns in acute ischemic stroke. Stroke (2012) 1.43

Acute stroke imaging research roadmap. AJNR Am J Neuroradiol (2008) 1.41

Safety of intravenous fibrinolysis in imaging-confirmed single penetrator artery infarcts. Stroke (2010) 1.41

The value of arterial spin-labeled perfusion imaging in acute ischemic stroke: comparison with dynamic susceptibility contrast-enhanced MRI. Stroke (2012) 1.40

Early neutrophilia is associated with volume of ischemic tissue in acute stroke. Stroke (2007) 1.40

Field Reports: Can They Add to the Prehospital and Disaster Knowledge Base? Prehosp Disaster Med (2015) 1.39

Systems of care for ST-segment-elevation myocardial infarction: a report From the American Heart Association's Mission: Lifeline. Circ Cardiovasc Qual Outcomes (2012) 1.39

Evidence-based performance measures for emergency medical services systems: a model for expanded EMS benchmarking. Prehosp Emerg Care (2008) 1.38

A graduate curriculum in emergency public health. Prehosp Disaster Med (2010) 1.38

Thrombolytic toxicity: blood brain barrier disruption in human ischemic stroke. Cerebrovasc Dis (2008) 1.37

The Los Angeles Motor Scale (LAMS): a new measure to characterize stroke severity in the field. Prehosp Emerg Care (2003) 1.35

Helicopter scene transport of trauma patients with nonlife-threatening injuries: a meta-analysis. J Trauma (2006) 1.30

Platelet-oriented inhibition in new TIA and minor ischemic stroke (POINT) trial: rationale and design. Int J Stroke (2013) 1.29

Shortening the NIH Stroke scale for use in the prehospital setting. Stroke (2002) 1.27

Refining angiographic biomarkers of revascularization: improving outcome prediction after intra-arterial therapy. Stroke (2013) 1.27

The aging brain and cognition: contribution of vascular injury and aβ to mild cognitive dysfunction. JAMA Neurol (2013) 1.25

The bank vole (Myodes glareolus) as a sensitive bioassay for sheep scrapie. J Gen Virol (2008) 1.25

A brief prehospital stroke severity scale identifies ischemic stroke patients harboring persisting large arterial occlusions. Stroke (2008) 1.24