Published in J Biol Chem on February 05, 2015
Cancer as a Proinflammatory Environment: Metastasis and Cachexia. Mediators Inflamm (2015) 0.79
Conditional knockout of polarity complex (atypical) PKCι reveals an anti-inflammatory function mediated by NF-κB. Mol Biol Cell (2016) 0.75
Par3 Integrates Tiam1 and Phosphatidylinositol 3-Kinase Signaling to Change Apical Membrane Identity. Mol Biol Cell (2016) 0.75
Molecular Control of Atypical Protein Kinase C: Tipping the Balance between Self-Renewal and Differentiation. J Mol Biol (2016) 0.75
Expression of Par3 polarity protein correlates with poor prognosis in ovarian cancer. BMC Cancer (2016) 0.75
Mechanisms of cell competition emerging from Drosophila studies. Curr Opin Cell Biol (2017) 0.75
STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer (2009) 15.45
Activation in vitro of NF-kappa B by phosphorylation of its inhibitor I kappa B. Nature (1990) 9.31
Nuclear factor-kappaB and inhibitor of kappaB kinase pathways in oncogenic initiation and progression. Oncogene (2006) 4.53
Notch signaling regulates mammary stem cell function and luminal cell-fate commitment. Cell Stem Cell (2008) 4.45
A genetic screen in Drosophila for metastatic behavior. Science (2003) 4.09
In vitro activation and nuclear translocation of NF-kappa B catalyzed by cyclic AMP-dependent protein kinase and protein kinase C. Mol Cell Biol (1989) 3.87
Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization. Nat Med (2011) 3.82
Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver. Genes Dev (2010) 3.77
Retracted Anti-IL-6 monoclonal antibodies protect against lethal Escherichia coli infection and lethal tumor necrosis factor-alpha challenge in mice. J Immunol (1990) 3.76
scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila. EMBO J (2003) 3.60
Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma. Cell (2008) 3.43
STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation. Mol Cell Biol (1997) 3.18
Duration and intensity of NF-kappaB activity determine the severity of endotoxin-induced acute lung injury. J Immunol (2006) 2.96
Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling. J Clin Invest (2011) 2.83
Interleukin-6 signaling pathway in targeted therapy for cancer. Cancer Treat Rev (2012) 2.82
Stat3 regulates genes common to both wound healing and cancer. Oncogene (2005) 2.80
Interaction between Ras(V12) and scribbled clones induces tumour growth and invasion. Nature (2010) 2.79
Oncogenic Ras diverts a host TNF tumor suppressor activity into tumor promoter. Dev Cell (2010) 2.46
Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells. Cancer Cell (2013) 2.38
Activation of IkappaB kinase beta by protein kinase C isoforms. Mol Cell Biol (1999) 2.35
PKM-ζ is not required for hippocampal synaptic plasticity, learning and memory. Nature (2013) 2.26
Prkcz null mice show normal learning and memory. Nature (2013) 2.06
Atypical protein kinase Ciota plays a critical role in human lung cancer cell growth and tumorigenicity. J Biol Chem (2005) 2.05
IL-6 and related cytokines as the critical lynchpins between inflammation and cancer. Semin Immunol (2014) 1.89
Par3 controls epithelial spindle orientation by aPKC-mediated phosphorylation of apical Pins. Curr Biol (2010) 1.86
The Par3/aPKC interaction is essential for end bud remodeling and progenitor differentiation during mammary gland morphogenesis. Genes Dev (2009) 1.82
Loss of the Par3 polarity protein promotes breast tumorigenesis and metastasis. Cancer Cell (2012) 1.65
Constitutively active Stat3 enhances neu-mediated migration and metastasis in mammary tumors via upregulation of Cten. Cancer Res (2010) 1.60
Inhibition of protein kinase C zeta subspecies blocks the activation of an NF-kappa B-like activity in Xenopus laevis oocytes. Mol Cell Biol (1993) 1.60
The polarity protein Par6 induces cell proliferation and is overexpressed in breast cancer. Cancer Res (2008) 1.59
Loss of the 14-3-3σ tumor suppressor is a critical event in ErbB2-mediated tumor progression. Cancer Discov (2011) 1.57
Loss of Par3 promotes breast cancer metastasis by compromising cell-cell cohesion. Nat Cell Biol (2012) 1.53
Evidence that atypical protein kinase C-lambda and atypical protein kinase C-zeta participate in Ras-mediated reorganization of the F-actin cytoskeleton. J Cell Biol (1999) 1.46
Protein kinase C iota: human oncogene, prognostic marker and therapeutic target. Pharmacol Res (2007) 1.42
Tumor type-dependent function of the par3 polarity protein in skin tumorigenesis. Cancer Cell (2012) 1.28
Defective expression of polarity protein PAR-3 gene (PARD3) in esophageal squamous cell carcinoma. Oncogene (2009) 1.27
Protein kinase Czeta represses the interleukin-6 promoter and impairs tumorigenesis in vivo. Mol Cell Biol (2008) 1.23
Neoplastic transformation and aberrant cell-cell interactions in genetic mosaics of lethal(2)giant larvae (lgl), a tumor suppressor gene of Drosophila. Dev Biol (1995) 1.15
aPKClambda/iota promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6. Proc Natl Acad Sci U S A (2009) 1.15
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers. Cancer Res (2010) 1.13
Scribble mutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs. BMC Biol (2009) 1.09
Protein kinase C isoforms zeta and iota mediate collagenase expression and cartilage destruction via STAT3- and ERK-dependent c-fos induction. J Biol Chem (2010) 1.08
Ikappa B kinasebeta/nuclear factor-kappaB activation controls the development of liver metastasis by way of interleukin-6 expression. Hepatology (2009) 1.07
The expression of the Drosophila awd gene during normal development and in neoplastic brain tumors caused by lgl mutations. Dev Biol (1993) 1.04
The immunoglobulin-like module of gp130 is required for signaling by interleukin-6, but not by leukemia inhibitory factor. J Biol Chem (1998) 1.02
Function for NF-kB in neuronal survival: regulation by atypical protein kinase C. J Neurosci Res (1999) 0.99
Atypical protein kinase C phosphorylates IKKalphabeta in transformed non-malignant and malignant prostate cell survival. Cancer Lett (2008) 0.99
High expression of atypical protein kinase C lambda/iota in gastric cancer as a prognostic factor for recurrence. Ann Surg Oncol (2009) 0.96
Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNFα in glioblastoma. Sci Signal (2014) 0.88
Host cell polarity proteins participate in innate immunity to Pseudomonas aeruginosa infection. Cell Host Microbe (2014) 0.86
LKB1 inhibits breast cancer partially through repressing the Hedgehog signaling pathway. PLoS One (2013) 0.82
Hugl1 and Hugl2 in mammary epithelial cells: polarity, proliferation, and differentiation. PLoS One (2012) 0.82
Emerging role of cell polarity proteins in breast cancer progression and metastasis. Breast Cancer (Dove Med Press) (2014) 0.82
Par-complex aPKC and Par3 cross-talk with innate immunity NF-κB pathway in epithelial cells. Biol Open (2013) 0.81
Regulation of polarized morphogenesis by protein kinase C iota in oncogenic epithelial spheroids. Carcinogenesis (2013) 0.80