Published in J Cell Sci on February 06, 2015
Prions and Protein Assemblies that Convey Biological Information in Health and Disease. Neuron (2016) 0.87
Regulation of Amyloid β Oligomer Binding to Neurons and Neurotoxicity by the Prion Protein-mGluR5 Complex. J Biol Chem (2016) 0.77
Prion infection impairs lysosomal degradation capacity by interfering with rab7 membrane attachment in neuronal cells. Sci Rep (2016) 0.76
Study of Exosomes Shed New Light on Physiology of Amyloidogenesis. Cell Mol Neurobiol (2016) 0.76
Prions on the run: How extracellular vesicles serve as delivery vehicles for self-templating protein aggregates. Prion (2017) 0.75
The double life of the ribosome: When its protein folding activity supports prion propagation. Prion (2017) 0.75
Exosomes, an Unmasked Culprit in Neurodegenerative Diseases. Front Neurosci (2017) 0.75
Melanosomal formation of PMEL core amyloid is driven by aromatic residues. Sci Rep (2017) 0.75
Prions. Proc Natl Acad Sci U S A (1998) 27.80
Membrane vesicles as conveyors of immune responses. Nat Rev Immunol (2009) 14.72
Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Curr Protoc Cell Biol (2006) 13.29
Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis. EMBO J (1994) 8.02
Endosome maturation. EMBO J (2011) 5.22
The ESCRT complexes: structure and mechanism of a membrane-trafficking network. Annu Rev Biophys Biomol Struct (2006) 5.21
Cells release prions in association with exosomes. Proc Natl Acad Sci U S A (2004) 5.17
Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer. J Cell Biol (2004) 4.60
Biogenesis and function of multivesicular bodies. Annu Rev Cell Dev Biol (2007) 4.08
Retromer. Curr Opin Cell Biol (2008) 3.89
Cholesterol depletion and modification of COOH-terminal targeting sequence of the prion protein inhibit formation of the scrapie isoform. J Cell Biol (1995) 3.66
N-terminal truncation of the scrapie-associated form of PrP by lysosomal protease(s): implications regarding the site of conversion of PrP to the protease-resistant state. J Virol (1991) 3.55
Scrapie and cellular prion proteins differ in their kinetics of synthesis and topology in cultured cells. J Cell Biol (1990) 3.46
Sorting of mannose 6-phosphate receptors and lysosomal membrane proteins in endocytic vesicles. J Cell Biol (1988) 3.10
SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors. Nat Cell Biol (2011) 2.92
Evidence for synthesis of scrapie prion proteins in the endocytic pathway. J Biol Chem (1992) 2.67
Transfer of scrapie prion infectivity by cell contact in culture. Curr Biol (2002) 2.54
Distinct roles for Tsg101 and Hrs in multivesicular body formation and inward vesiculation. Mol Biol Cell (2006) 2.37
Sorting nexins provide diversity for retromer-dependent trafficking events. Nat Cell Biol (2011) 2.32
Recycling compartments and the internal vesicles of multivesicular bodies harbor most of the cholesterol found in the endocytic pathway. Traffic (2003) 2.30
A global analysis of SNX27-retromer assembly and cargo specificity reveals a function in glucose and metal ion transport. Nat Cell Biol (2013) 2.18
The retromer complex - endosomal protein recycling and beyond. J Cell Sci (2012) 2.08
Rapid cell-surface prion protein conversion revealed using a novel cell system. Nat Commun (2011) 2.04
Uptake and neuritic transport of scrapie prion protein coincident with infection of neuronal cells. J Neurosci (2005) 1.85
The multiple personalities of Alix. J Cell Sci (2006) 1.71
Cholesterol synthesis inhibitor U18666A and the role of sterol metabolism and trafficking in numerous pathophysiological processes. Lipids (2009) 1.69
Alix regulates cortical actin and the spatial distribution of endosomes. J Cell Sci (2005) 1.67
The Bro1-related protein HD-PTP/PTPN23 is required for endosomal cargo sorting and multivesicular body morphogenesis. Proc Natl Acad Sci U S A (2008) 1.63
Identification of an intracellular site of prion conversion. PLoS Pathog (2009) 1.61
Retrovirus infection strongly enhances scrapie infectivity release in cell culture. EMBO J (2006) 1.53
Differential functions of Hrs and ESCRT proteins in endocytic membrane trafficking. Exp Cell Res (2007) 1.46
Calpain-dependent endoproteolytic cleavage of PrPSc modulates scrapie prion propagation. J Biol Chem (2004) 1.35
Mouse-adapted scrapie infection of SN56 cells: greater efficiency with microsome-associated versus purified PrP-res. J Virol (2006) 1.35
Mouse neuroblastoma cells release prion infectivity associated with exosomal vesicles. Biol Cell (2008) 1.33
Trafficking, turnover and membrane topology of PrP. Br Med Bull (2003) 1.31
Rab22a affects the morphology and function of the endocytic pathway. J Cell Sci (2001) 1.28
Stimulation of PrP(C) retrograde transport toward the endoplasmic reticulum increases accumulation of PrP(Sc) in prion-infected cells. J Biol Chem (2002) 1.25
The highways and byways of prion protein trafficking. Trends Cell Biol (2005) 1.18
Immunolocalisation of PrPSc in scrapie-infected N2a mouse neuroblastoma cells by light and electron microscopy. Eur J Cell Biol (2008) 1.14
Recruitment of UBPY and ESCRT exchange drive HD-PTP-dependent sorting of EGFR to the MVB. Curr Biol (2013) 1.09
The scrapie prion protein is present in flotillin-1-positive vesicles in central- but not peripheral-derived neuronal cell lines. Eur J Neurosci (2005) 1.07
Differential compartmentalization of the calpain/calpastatin network with the endoplasmic reticulum and Golgi apparatus. J Biol Chem (2004) 0.99
An essential role of Hrs/Vps27 in endosomal cholesterol trafficking. Cell Rep (2012) 0.99
VARP is recruited on to endosomes by direct interaction with retromer, where together they function in export to the cell surface. Dev Cell (2014) 0.98
Subcellular mobility of the calpain/calpastatin network: an organelle transient. Bioessays (2006) 0.96
Class E compartments form in response to ESCRT dysfunction in yeast due to hyperactivity of the Vps21 Rab GTPase. J Cell Sci (2012) 0.95
Alternative fates of newly formed PrPSc upon prion conversion on the plasma membrane. J Cell Sci (2013) 0.93
4-hydroxytamoxifen leads to PrPSc clearance by conveying both PrPC and PrPSc to lysosomes independently of autophagy. J Cell Sci (2013) 0.93
Inhibition of cholesterol recycling impairs cellular PrP(Sc) propagation. Cell Mol Life Sci (2009) 0.92
Calpains promote α2β1 integrin turnover in nonrecycling integrin pathway. Mol Biol Cell (2011) 0.90
Calpain and other cytosolic proteases can contribute to the degradation of retro-translocated prion protein in the cytosol. J Biol Chem (2004) 0.88
Live imaging of prions reveals nascent PrPSc in cell-surface, raft-associated amyloid strings and webs. J Cell Biol (2014) 0.88
Characterization of intracellular dynamics of inoculated PrP-res and newly generated PrP(Sc) during early stage prion infection in Neuro2a cells. Virology (2014) 0.80
The tyrosine phosphatase HD-PTP (PTPN23) is degraded by calpains in a calcium-dependent manner. Biochem Biophys Res Commun (2012) 0.78