Published in Proc Natl Acad Sci U S A on April 23, 2008
Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity. Nat Cell Biol (2009) 6.03
Functional genomic screen for modulators of ciliogenesis and cilium length. Nature (2010) 3.63
LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model. Hum Mol Genet (2009) 2.55
Membrane fission reactions of the mammalian ESCRT pathway. Annu Rev Biochem (2013) 1.91
A crescent-shaped ALIX dimer targets ESCRT-III CHMP4 filaments. Structure (2009) 1.61
The nucleocapsid region of HIV-1 Gag cooperates with the PTAP and LYPXnL late domains to recruit the cellular machinery necessary for viral budding. PLoS Pathog (2009) 1.55
How ubiquitin functions with ESCRTs. Traffic (2011) 1.51
Endocytic pathway is required for Drosophila Toll innate immune signaling. Proc Natl Acad Sci U S A (2010) 1.18
Ubiquitin-dependent sorting in endocytosis. Cold Spring Harb Perspect Biol (2014) 1.10
Viral infection controlled by a calcium-dependent lipid-binding module in ALIX. Dev Cell (2013) 1.07
Endosomal-sorting complexes required for transport (ESCRT) pathway-dependent endosomal traffic regulates the localization of active Src at focal adhesions. Proc Natl Acad Sci U S A (2010) 1.07
Identification of PTPN23 as a novel regulator of cell invasion in mammary epithelial cells from a loss-of-function screen of the 'PTP-ome'. Genes Dev (2011) 1.06
The yeast Alix homolog Bro1 functions as a ubiquitin receptor for protein sorting into multivesicular endosomes. Dev Cell (2013) 1.05
Divergent Bro1 domains share the capacity to bind human immunodeficiency virus type 1 nucleocapsid and to enhance virus-like particle production. J Virol (2009) 1.05
The Phe105 loop of Alix Bro1 domain plays a key role in HIV-1 release. Structure (2011) 1.01
Lipid sorting and multivesicular endosome biogenesis. Cold Spring Harb Perspect Biol (2013) 0.98
A screen for conditional growth suppressor genes identifies the Drosophila homolog of HD-PTP as a regulator of the oncoprotein Yorkie. Dev Cell (2011) 0.94
HD-PTP is a catalytically inactive tyrosine phosphatase due to a conserved divergence in its phosphatase domain. PLoS One (2009) 0.92
Roles of dynein and dynactin in early endosome dynamics revealed using automated tracking and global analysis. PLoS One (2011) 0.91
Two distinct binding modes define the interaction of Brox with the C-terminal tails of CHMP5 and CHMP4B. Structure (2012) 0.85
Structure of the Bro1 domain protein BROX and functional analyses of the ALIX Bro1 domain in HIV-1 budding. PLoS One (2011) 0.83
Unravelling the pivotal role of Alix in MVB sorting and silencing of the activated EGFR. Biochem J (2015) 0.83
An ESCRT module is required for neuron pruning. Sci Rep (2015) 0.83
The Charcot Marie Tooth disease protein LITAF is a zinc-binding monotopic membrane protein. Biochem J (2016) 0.82
The multivesicular body is the major internal site of prion conversion. J Cell Sci (2015) 0.81
A non-canonical ESCRT pathway, including histidine domain phosphotyrosine phosphatase (HD-PTP), is used for down-regulation of virally ubiquitinated MHC class I. Biochem J (2015) 0.80
Structural Study of the HD-PTP Bro1 Domain in a Complex with the Core Region of STAM2, a Subunit of ESCRT-0. PLoS One (2016) 0.80
The molecular basis for selective assembly of the UBAP1-containing endosome-specific ESCRT-I complex. J Cell Sci (2013) 0.79
Conserved Mode of Interaction between Yeast Bro1 Family V Domains and YP(X)nL Motif-Containing Target Proteins. Eukaryot Cell (2015) 0.78
Multifaceted Roles of ALG-2 in Ca(2+)-Regulated Membrane Trafficking. Int J Mol Sci (2016) 0.78
The basic amino acids in the coiled-coil domain of CIN85 regulate its interaction with c-Cbl and phosphatidic acid during epidermal growth factor receptor (EGFR) endocytosis. BMC Biochem (2014) 0.78
VAMP7 modulates ciliary biogenesis in kidney cells. PLoS One (2014) 0.77
ALG-2 interacting protein-X (Alix) is essential for clathrin-independent endocytosis and signaling. Sci Rep (2016) 0.77
The Myopic-Ubpy-Hrs nexus enables endosomal recycling of Frizzled. Mol Biol Cell (2015) 0.76
Histidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpL. PLoS One (2010) 0.76
Transcriptional Response to Acute Thermal Exposure in Juvenile Chinook Salmon Determined by RNAseq. G3 (Bethesda) (2015) 0.75
ALG-2 activates the MVB sorting function of ALIX through relieving its intramolecular interaction. Cell Discov (2015) 0.75
UBAP1: a new ESCRT member joins the cl_Ub. Structure (2012) 0.75
Autophagy discriminates between Alix and ESCRTs. Autophagy (2009) 0.75
Structural Basis for Selective Interaction between the ESCRT Regulator HD-PTP and UBAP1. Structure (2016) 0.75
The serologically defined colon cancer antigen-3 (SDCCAG3) is involved in the regulation of ciliogenesis. Sci Rep (2016) 0.75
Structural Basis for Specific Interaction of TGFβ Signaling Regulators SARA/Endofin with HD-PTP. Structure (2017) 0.75
Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding. Cell (2001) 12.00
The protein network of HIV budding. Cell (2003) 7.82
The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function. EMBO J (1998) 7.68
Retrovirus budding. Annu Rev Cell Dev Biol (2004) 7.16
AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding. Cell (2003) 6.69
The ESCRT complexes: structure and mechanism of a membrane-trafficking network. Annu Rev Biophys Biomol Struct (2006) 5.21
A role for ubiquitin ligase recruitment in retrovirus release. Proc Natl Acad Sci U S A (2000) 4.19
Structural and biochemical studies of ALIX/AIP1 and its role in retrovirus budding. Cell (2007) 3.06
Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugates. J Cell Biol (2002) 2.94
In macrophages, HIV-1 assembles into an intracellular plasma membrane domain containing the tetraspanins CD81, CD9, and CD53. J Cell Biol (2007) 2.68
Bro1 is an endosome-associated protein that functions in the MVB pathway in Saccharomyces cerevisiae. J Cell Sci (2003) 2.57
EGF stimulates annexin 1-dependent inward vesiculation in a multivesicular endosome subpopulation. EMBO J (2005) 2.37
Distinct roles for Tsg101 and Hrs in multivesicular body formation and inward vesiculation. Mol Biol Cell (2006) 2.37
Recycling compartments and the internal vesicles of multivesicular bodies harbor most of the cholesterol found in the endocytic pathway. Traffic (2003) 2.30
Structural basis for endosomal targeting by the Bro1 domain. Dev Cell (2005) 2.28
Depletion of TSG101 forms a mammalian "Class E" compartment: a multicisternal early endosome with multiple sorting defects. J Cell Sci (2005) 2.19
Degradation of endocytosed epidermal growth factor and virally ubiquitinated major histocompatibility complex class I is independent of mammalian ESCRTII. J Biol Chem (2005) 1.82
Structural basis for viral late-domain binding to Alix. Nat Struct Mol Biol (2007) 1.69
Alix/AIP1 antagonizes epidermal growth factor receptor downregulation by the Cbl-SETA/CIN85 complex. Mol Cell Biol (2004) 1.67
Alix regulates cortical actin and the spatial distribution of endosomes. J Cell Sci (2005) 1.67
Dual mechanisms specify Doa4-mediated deubiquitination at multivesicular bodies. EMBO J (2007) 1.48
Ultrastructural analysis of ESCRT proteins suggests a role for endosome-associated tubular-vesicular membranes in ESCRT function. Traffic (2006) 1.39
COOH-terminal truncations promote proteasome-dependent degradation of mature cystic fibrosis transmembrane conductance regulator from post-Golgi compartments. J Cell Biol (2001) 1.32
HD-PTP: A novel protein tyrosine phosphatase gene on human chromosome 3p21.3. Biochem Biophys Res Commun (2000) 1.03
HD-PTP and Alix share some membrane-traffic related proteins that interact with their Bro1 domains or proline-rich regions. Arch Biochem Biophys (2006) 1.00
Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugates. J Cell Biol (2002) 2.94
Dynein is required for receptor sorting and the morphogenesis of early endosomes. Nat Cell Biol (2006) 2.33
Using transmission electron microscopy and 3View to determine collagen fibril size and three-dimensional organization. Nat Protoc (2013) 1.31
Differential clathrin binding and subcellular localization of OCRL1 splice isoforms. J Biol Chem (2009) 1.24
Identification of molecular intermediates in the assembly pathway of the MUC5AC mucin. J Biol Chem (2004) 1.20
UBAP1 is a component of an endosome-specific ESCRT-I complex that is essential for MVB sorting. Curr Biol (2011) 1.19
Role of calnexin in the glycan-independent quality control of proteolipid protein. EMBO J (2003) 1.19
Differential regulation of elastic fiber formation by fibulin-4 and -5. J Biol Chem (2009) 1.16
Collagen XXVII is developmentally regulated and forms thin fibrillar structures distinct from those of classical vertebrate fibrillar collagens. J Biol Chem (2007) 1.10
Recruitment of UBPY and ESCRT exchange drive HD-PTP-dependent sorting of EGFR to the MVB. Curr Biol (2013) 1.09
A mutation in the mouse Amelx tri-tyrosyl domain results in impaired secretion of amelogenin and phenocopies human X-linked amelogenesis imperfecta. Hum Mol Genet (2010) 1.07
Transmembrane-domain determinants for SNARE-mediated membrane fusion. J Cell Sci (2010) 1.02
Nonmuscle myosin II powered transport of newly formed collagen fibrils at the plasma membrane. Proc Natl Acad Sci U S A (2013) 0.95
A 125 kDa RNase E/G-like protein is present in plastids and is essential for chloroplast development and autotrophic growth in Arabidopsis. J Exp Bot (2008) 0.95
Hyaluronidase gene profiling and role of hyal-1 overexpression in an orthotopic model of prostate cancer. Int J Cancer (2002) 0.92
Collagen XXVII organises the pericellular matrix in the growth plate. PLoS One (2011) 0.90
Disease-associated mutations cause premature oligomerization of myelin proteolipid protein in the endoplasmic reticulum. Proc Natl Acad Sci U S A (2005) 0.88
Endoplasmic reticulum-associated degradation of a degron-containing polytopic membrane protein. Mol Membr Biol (2009) 0.86
The molecular basis for selective assembly of the UBAP1-containing endosome-specific ESCRT-I complex. J Cell Sci (2013) 0.79
Mitogen-activated protein kinase kinase 4 deficiency in cardiomyocytes causes connexin 43 reduction and couples hypertrophic signals to ventricular arrhythmogenesis. J Biol Chem (2011) 0.78
H₂O₂ stress-specific regulation of S. pombe MAPK Sty1 by mitochondrial protein phosphatase Ptc4. EMBO J (2011) 0.77
Mild myopathy is associated with COMP but not MATN3 mutations in mouse models of genetic skeletal diseases. PLoS One (2013) 0.76
The Effects of Extensive Glomerular Filtration of Thin Graphene Oxide Sheets on Kidney Physiology. ACS Nano (2016) 0.75