Published in Elife on February 10, 2015
Optogenetic perturbation and bioluminescence imaging to analyze cell-to-cell transfer of oscillatory information. Genes Dev (2017) 1.38
Fluorescent Proteins as Genetically Encoded FRET Biosensors in Life Sciences. Sensors (Basel) (2015) 0.93
Receptor Level Mechanisms Are Required for Epidermal Growth Factor (EGF)-stimulated Extracellular Signal-regulated Kinase (ERK) Activity Pulses. J Biol Chem (2015) 0.86
Future Perspective of Single-Molecule FRET Biosensors and Intravital FRET Microscopy. Biophys J (2016) 0.80
Redefining Signaling Pathways with an Expanding Single-Cell Toolbox. Trends Biotechnol (2016) 0.80
A Transport Model for Estimating the Time Course of ERK Activation in the C. elegans Germline. Biophys J (2015) 0.79
Paracrine communication maximizes cellular response fidelity in wound signaling. Elife (2015) 0.79
Genetic insights into the mechanisms of Fgf signaling. Genes Dev (2016) 0.79
Intravital imaging of mouse urothelium reveals activation of extracellular signal-regulated kinase by stretch-induced intravesical release of ATP. Physiol Rep (2016) 0.78
A Thousand and One Receptor Tyrosine Kinases: Wherein the Specificity? Curr Top Dev Biol (2016) 0.76
Spatial and temporal signal processing and decision making by MAPK pathways. J Cell Biol (2017) 0.76
Two New FRET Imaging Measures: Linearly Proportional to and Highly Contrasting the Fraction of Active Molecules. PLoS One (2016) 0.75
In vivo multiphoton imaging of immune cell dynamics. Pflugers Arch (2016) 0.75
Intravital imaging reveals new ancillary mechanisms co-opted by cancer cells to drive tumor progression. F1000Res (2016) 0.75
Cell Density-Dependent Increase in Tyrosine-Monophosphorylated ERK2 in MDCK Cells Expressing Active Ras or Raf. PLoS One (2016) 0.75
Identification of Aging-Associated Gene Expression Signatures That Precede Intestinal Tumorigenesis. PLoS One (2016) 0.75
Tracing Information Flow from Erk to Target Gene Induction Reveals Mechanisms of Dynamic and Combinatorial Control. Mol Cell (2017) 0.75
A Real-Time Biosensor for ERK Activity Reveals Signaling Dynamics during C. elegans Cell Fate Specification. Dev Cell (2017) 0.75
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene (2007) 11.85
Visualizing spatiotemporal dynamics of multicellular cell-cycle progression. Cell (2008) 10.49
An essential role for ectodomain shedding in mammalian development. Science (1998) 9.14
Cell-signalling dynamics in time and space. Nat Rev Mol Cell Biol (2006) 7.25
Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands. J Cell Biol (2004) 5.44
Stem cell patterning and fate in human epidermis. Cell (1995) 5.22
TGF alpha deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice. Cell (1993) 4.02
Membrane-anchored growth factors. Annu Rev Biochem (1993) 3.26
Multi-stage chemical carcinogenesis in mouse skin: fundamentals and applications. Nat Protoc (2009) 3.14
ERK implication in cell cycle regulation. Biochim Biophys Acta (2006) 2.96
Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling. Biochem Pharmacol (2002) 2.39
Mitogen-activated protein kinase kinase activity is required for the G(2)/M transition of the cell cycle in mammalian fibroblasts. Proc Natl Acad Sci U S A (1999) 2.29
Epithelial stem cells, wound healing and cancer. Nat Rev Cancer (2012) 2.23
Frequency-modulated pulses of ERK activity transmit quantitative proliferation signals. Mol Cell (2012) 2.11
The epidermal growth factor receptor: from development to tumorigenesis. Differentiation (2007) 2.07
Stem cell plasticity. Plasticity of epithelial stem cells in tissue regeneration. Science (2014) 1.99
Two phases of mitogenic signaling unveil roles for p53 and EGR1 in elimination of inconsistent growth signals. Mol Cell (2011) 1.89
The pathogenesis of squamous cell cancer: lessons learned from studies of skin carcinogenesis--thirty-third G. H. A. Clowes Memorial Award Lecture. Cancer Res (1994) 1.76
Stochastic ERK activation induced by noise and cell-to-cell propagation regulates cell density-dependent proliferation. Mol Cell (2013) 1.62
Biphasic activation of two mitogen-activated protein kinases during the cell cycle in mammalian cells. J Biol Chem (1992) 1.57
Visualization of small GTPase activity with fluorescence resonance energy transfer-based biosensors. Nat Protoc (2009) 1.53
Beyond wavy hairs: the epidermal growth factor receptor and its ligands in skin biology and pathology. Am J Pathol (2008) 1.47
ERK MAP kinase in G cell cycle progression and cancer. Cancer Sci (2006) 1.41
Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation. J Exp Med (2012) 1.39
Extracellular calcium influx stimulates metalloproteinase cleavage and secretion of heparin-binding EGF-like growth factor independently of protein kinase C. J Cell Biochem (1998) 1.37
Loss of the VHR dual-specific phosphatase causes cell-cycle arrest and senescence. Nat Cell Biol (2006) 1.31
BRCA1-mediated G2/M cell cycle arrest requires ERK1/2 kinase activation. Oncogene (2005) 1.19
Ras/Erk MAPK signaling in epidermal homeostasis and neoplasia. Cell Cycle (2007) 1.13
Regulated cell surface pro-EGF ectodomain shedding is a zinc metalloprotease-dependent process. J Biol Chem (2003) 1.05
Live imaging of protein kinase activities in transgenic mice expressing FRET biosensors. Cell Struct Funct (2012) 1.03
Activation of extracellular signal-regulated kinase (ERK) in G2 phase delays mitotic entry through p21CIP1. Cell Prolif (2006) 0.94
Live imaging of protein kinase activities in transgenic mice expressing FRET biosensors. Cell Struct Funct (2012) 1.03
Cell cycle-dependent Rho GTPase activity dynamically regulates cancer cell motility and invasion in vivo. PLoS One (2013) 0.92
Synergistic antitumor effects of combination PI3K/mTOR and MEK inhibition (SAR245409 and pimasertib) in mucinous ovarian carcinoma cells by fluorescence resonance energy transfer imaging. Oncotarget (2016) 0.77
Cell Density-Dependent Increase in Tyrosine-Monophosphorylated ERK2 in MDCK Cells Expressing Active Ras or Raf. PLoS One (2016) 0.75
Live imaging of extracellular signal-regulated kinase and protein kinase A activities during thrombus formation in mice expressing biosensors based on Förster resonance energy transfer. J Thromb Haemost (2017) 0.75