Published in Crit Care on December 17, 2014
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A randomized trial of protocol-based care for early septic shock. N Engl J Med (2014) 16.05
Hydrocortisone therapy for patients with septic shock. N Engl J Med (2008) 15.85
Drotrecogin alfa (activated) in adults with septic shock. N Engl J Med (2012) 9.19
The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Crit Care Med (2010) 6.69
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Advance hospital notification by EMS in acute stroke is associated with shorter door-to-computed tomography time and increased likelihood of administration of tissue-plasminogen activator. Prehosp Emerg Care (2008) 1.54
The impact of emergency medical services on the ED care of severe sepsis. Am J Emerg Med (2010) 1.30
Classification of sepsis, severe sepsis and septic shock: the impact of minor variations in data capture and definition of SIRS criteria. Intensive Care Med (2012) 1.16
Prehospital intravenous access and fluid resuscitation in severe sepsis: an observational cohort study. Crit Care (2014) 0.98
Early detection and treatment of patients with severe sepsis by prehospital personnel. J Emerg Med (2013) 0.98
Systematic review and meta-analysis of the benefits of out-of-hospital 12-lead ECG and advance notification in ST-segment elevation myocardial infarction patients. Ann Emerg Med (2013) 0.83
The Impact of Timing of Antibiotics on Outcomes in Severe Sepsis and Septic Shock: A Systematic Review and Meta-Analysis. Crit Care Med (2015) 6.00
Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality. JAMA (2010) 4.37
Association between timing of antibiotic administration and mortality from septic shock in patients treated with a quantitative resuscitation protocol. Crit Care Med (2011) 3.82
Significance of arterial hypotension after resuscitation from cardiac arrest. Crit Care Med (2009) 2.68
Relationship between supranormal oxygen tension and outcome after resuscitation from cardiac arrest. Circulation (2011) 2.65
Multicenter study of early lactate clearance as a determinant of survival in patients with presumed sepsis. Shock (2009) 2.59
Proof of principle: the predisposition, infection, response, organ failure sepsis staging system. Crit Care Med (2011) 2.30
Whole blood lactate kinetics in patients undergoing quantitative resuscitation for severe sepsis and septic shock. Chest (2013) 2.20
Prospective study of the diagnostic accuracy of the simplify D-dimer assay for pulmonary embolism in emergency department patients. Chest (2006) 2.14
Use of goal-directed therapy for severe sepsis and septic shock in academic emergency departments. Crit Care Med (2005) 2.03
Outcomes of patients undergoing early sepsis resuscitation for cryptic shock compared with overt shock. Resuscitation (2011) 1.87
Incidence and factors associated with cardiac arrest complicating emergency airway management. Resuscitation (2013) 1.77
Incidence of contrast-induced nephropathy after contrast-enhanced computed tomography in the outpatient setting. Clin J Am Soc Nephrol (2009) 1.74
The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsis. Crit Care (2010) 1.72
Multicenter study of central venous oxygen saturation (ScvO(2)) as a predictor of mortality in patients with sepsis. Ann Emerg Med (2009) 1.62
Endothelial cell activation in emergency department patients with sepsis-related and non-sepsis-related hypotension. Shock (2011) 1.61
Immediate complications of intravenous contrast for computed tomography imaging in the outpatient setting are rare. Acad Emerg Med (2011) 1.59
One year mortality of patients treated with an emergency department based early goal directed therapy protocol for severe sepsis and septic shock: a before and after study. Crit Care (2009) 1.57
Simple triage scoring system predicting death and the need for critical care resources for use during epidemics. Crit Care Med (2007) 1.44
Etiology of illness in patients with severe sepsis admitted to the hospital from the emergency department. Clin Infect Dis (2010) 1.44
Arterial blood pressure and neurologic outcome after resuscitation from cardiac arrest*. Crit Care Med (2014) 1.43
Can procalcitonin levels guide antibiotic therapy in bacterial infections and reduce antibiotic overconsumption without having a negative effect on clinical outcomes? Ann Emerg Med (2012) 1.38
Impact of a rapid rule-out protocol for pulmonary embolism on the rate of screening, missed cases, and pulmonary vascular imaging in an urban US emergency department. Ann Emerg Med (2004) 1.34
Point: should lactate clearance be substituted for central venous oxygen saturation as goals of early severe sepsis and septic shock therapy? Yes. Chest (2011) 1.33
Electronic medical record review as a surrogate to telephone follow-up to establish outcome for diagnostic research studies in the emergency department. Acad Emerg Med (2005) 1.32
The impact of emergency medical services on the ED care of severe sepsis. Am J Emerg Med (2010) 1.30
Prognostic value and agreement of achieving lactate clearance or central venous oxygen saturation goals during early sepsis resuscitation. Acad Emerg Med (2012) 1.24
Biomarkers of endothelial cell activation in early sepsis. Shock (2013) 1.18
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. Crit Care Med (2017) 1.15
The effect of etomidate on mortality in sepsis remains unclear. Crit Care Med (2013) 1.12
The association of near-infrared spectroscopy-derived tissue oxygenation measurements with sepsis syndromes, organ dysfunction and mortality in emergency department patients with sepsis. Crit Care (2011) 1.09
Prospective study of the incidence of contrast-induced nephropathy among patients evaluated for pulmonary embolism by contrast-enhanced computed tomography. Acad Emerg Med (2012) 1.04
Predictors of the complication of postintubation hypotension during emergency airway management. J Crit Care (2012) 1.02
Randomized trial of computerized quantitative pretest probability in low-risk chest pain patients: effect on safety and resource use. Ann Emerg Med (2009) 1.00
Prospective study of the clinical features and outcomes of emergency department patients with delayed diagnosis of pulmonary embolism. Acad Emerg Med (2007) 0.98
Comparison of the unstructured clinician estimate of pretest probability for pulmonary embolism to the Canadian score and the Charlotte rule: a prospective observational study. Acad Emerg Med (2005) 0.97
The significance of non-sustained hypotension in emergency department patients with sepsis. Intensive Care Med (2009) 0.97
Multicenter observational study of the development of progressive organ dysfunction and therapeutic interventions in normotensive sepsis patients in the emergency department. Acad Emerg Med (2013) 0.97
Outcomes of trauma victims with cardiac arrest who survive to intensive care unit admission. J Trauma (2011) 0.97
The frequency and significance of postintubation hypotension during emergency airway management. J Crit Care (2011) 0.97
Early arterial hypotension is common in the post-cardiac arrest syndrome and associated with increased in-hospital mortality. Resuscitation (2008) 0.96
Complement activation in emergency department patients with severe sepsis. Acad Emerg Med (2010) 0.94
Diabetes is not associated with increased mortality in emergency department patients with sepsis. Ann Emerg Med (2011) 0.92
Characteristics and outcomes of patients with vasoplegic versus tissue dysoxic septic shock. Shock (2013) 0.91
Derivation and validation of a multivariate model to predict mortality from pulmonary embolism with cancer: The POMPE-C tool. Thromb Res (2012) 0.90
Plasma levels of mitochondrial DNA in patients presenting to the emergency department with sepsis. Shock (2012) 0.89
Regionalization of post-cardiac arrest care: implementation of a cardiac resuscitation center. Am Heart J (2012) 0.89
Sepsis-induced tissue hypoperfusion. Crit Care Clin (2009) 0.85
Evidence-based therapies for sepsis care in the emergency department: striking a balance between feasibility and necessity. Acad Emerg Med (2005) 0.85
Discordance between microcirculatory alterations and arterial pressure in patients with hemodynamic instability. J Crit Care (2012) 0.84
N-acetylcysteine plus intravenous fluids versus intravenous fluids alone to prevent contrast-induced nephropathy in emergency computed tomography. Ann Emerg Med (2013) 0.84
Effect of glucose-insulin-potassium infusion on mortality in critical care settings: a systematic review and meta-analysis. J Clin Pharmacol (2009) 0.84
An adaptive, phase II, dose-finding clinical trial design to evaluate L-carnitine in the treatment of septic shock based on efficacy and predictive probability of subsequent phase III success. Crit Care Med (2013) 0.83
Pharmacometabolomics of l-carnitine treatment response phenotypes in patients with septic shock. Ann Am Thorac Soc (2015) 0.83
Rationale and methodology for a multicentre randomised trial of fibrinolysis for pulmonary embolism that includes quality of life outcomes. Emerg Med Australas (2013) 0.82
Dynamics of human complement-mediated killing of Klebsiella pneumoniae. Am J Respir Cell Mol Biol (2009) 0.82
Tenecteplase to treat pulmonary embolism in the emergency department. J Thromb Thrombolysis (2007) 0.82
Whole Blood Reveals More Metabolic Detail of the Human Metabolome than Serum as Measured by 1H-NMR Spectroscopy: Implications for Sepsis Metabolomics. Shock (2015) 0.81
Early goal-directed therapy: improving mortality and morbidity of sepsis in the emergency department. Jt Comm J Qual Patient Saf (2009) 0.81
Accuracy of trauma ultrasound in major pelvic injury. J Trauma (2006) 0.81
The etomidate debate. Ann Emerg Med (2010) 0.79
Is the addition of vasopressin to norepinephrine beneficial for the treatment of septic shock? Ann Emerg Med (2013) 0.79
Prognostic value of incremental lactate elevations in emergency department patients with suspected infection. Acad Emerg Med (2012) 0.79
Is lactate the "Holy Grail" of biomarkers for sepsis prognosis? Crit Care Med (2009) 0.79
Contribution of fibrinolysis to the physical component summary of the SF-36 after acute submassive pulmonary embolism. J Thromb Thrombolysis (2015) 0.79
Multicenter, randomized trial of quantitative pretest probability to reduce unnecessary medical radiation exposure in emergency department patients with chest pain and dyspnea. Circ Cardiovasc Imaging (2013) 0.79
Explicitly targeting explicit sepsis: fair metrics for quality assessment*. Crit Care Med (2014) 0.78
Association of body mass index with increased cost of care and length of stay for emergency department patients with chest pain and dyspnea. Circ Cardiovasc Qual Outcomes (2014) 0.78
Therapeutic hypothermia and vasopressor dependency after cardiac arrest. Resuscitation (2012) 0.78
Outcome measures utilized in clinical trials of interventions for post-cardiac arrest syndrome: a systematic review. Resuscitation (2009) 0.78
Characterization of the spectrum of hemodynamic profiles in trauma patients with acute neurogenic shock. J Crit Care (2013) 0.77
Hypothermia after cardiac arrest: we can do this. Acad Emerg Med (2008) 0.77
A prospective multicenter cohort study of the association between global tissue hypoxia and coagulation abnormalities during early sepsis resuscitation. Crit Care Med (2010) 0.77
The long-term burden of severe sepsis and septic shock: Sepsis recidivism and organ dysfunction. J Trauma Acute Care Surg (2016) 0.76
D-dimer and exhaled CO2/O2 to detect segmental pulmonary embolism in moderate-risk patients. Am J Respir Crit Care Med (2010) 0.76
Does resuscitation with albumin-containing solutions improve mortality in sepsis? Ann Emerg Med (2011) 0.76
The authors reply. Crit Care Med (2017) 0.75
Applying research findings at a patient's bedside: progressing clinical practice. Acad Emerg Med (2008) 0.75
Democracy, ambiguity, scrutiny, and evidence-based medicine. Acad Emerg Med (2009) 0.75
Decompensation to shock: what is the risk? Crit Care Med (2015) 0.75
The authors reply. Crit Care Med (2016) 0.75
Adjunctive therapy for migraine headaches: can we teach an old dog a new trick? Acad Emerg Med (2008) 0.75
The authors reply. Crit Care Med (2016) 0.75
The authors reply. Crit Care Med (2016) 0.75
Pleural effusions in the critically ill: the evolving role of bedside ultrasound. Crit Care Med (2005) 0.75
Clearing lactate is clearly better…but how much?*. Crit Care Med (2014) 0.75
Serial Procalcitonin Predicts Mortality in Severe Sepsis Patients: Results From the Multicenter Procalcitonin MOnitoring SEpsis (MOSES) Study. Crit Care Med (2017) 0.75
The authors reply. Crit Care Med (2016) 0.75
Risk stratification of community-acquired pneumonia: what does all of this mean? Ann Emerg Med (2008) 0.75
The authors reply. Crit Care Med (2016) 0.75