Published in Crit Care Med on April 01, 2010
Clinical utility of biomarkers of endothelial activation in sepsis--a systematic review. Crit Care (2012) 1.04
Systemic central venous oxygen saturation is associated with clot strength during traumatic hemorrhagic shock: A preclinical observational model. Scand J Trauma Resusc Emerg Med (2010) 0.77
Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med (2004) 24.47
Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med (2006) 23.62
A randomized trial of protocol-based care for early septic shock. N Engl J Med (2014) 16.05
Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. JAMA (2010) 8.09
The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Crit Care Med (2010) 6.69
The Impact of Timing of Antibiotics on Outcomes in Severe Sepsis and Septic Shock: A Systematic Review and Meta-Analysis. Crit Care Med (2015) 6.00
National estimates of severe sepsis in United States emergency departments. Crit Care Med (2007) 5.99
Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: results from a guideline-based performance improvement program. Crit Care Med (2014) 5.70
Translating research to clinical practice: a 1-year experience with implementing early goal-directed therapy for septic shock in the emergency department. Chest (2006) 5.31
The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Intensive Care Med (2010) 4.64
Impact of delayed transfer of critically ill patients from the emergency department to the intensive care unit. Crit Care Med (2007) 4.54
Initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock. Chest (2009) 4.51
Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality. JAMA (2010) 4.37
Inhaled nitric oxide does not reduce mortality in patients with acute respiratory distress syndrome regardless of severity: systematic review and meta-analysis. Crit Care Med (2014) 4.11
Outcomes of the Surviving Sepsis Campaign in intensive care units in the USA and Europe: a prospective cohort study. Lancet Infect Dis (2012) 4.07
Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury. Crit Care (2013) 3.90
Association between timing of antibiotic administration and mortality from septic shock in patients treated with a quantitative resuscitation protocol. Crit Care Med (2011) 3.82
Do emergency department blood cultures change practice in patients with pneumonia? Ann Emerg Med (2005) 3.80
The effect of a quantitative resuscitation strategy on mortality in patients with sepsis: a meta-analysis. Crit Care Med (2008) 3.73
Lactate measurements in sepsis-induced tissue hypoperfusion: results from the Surviving Sepsis Campaign database. Crit Care Med (2015) 3.55
Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival. Ann Emerg Med (2006) 3.36
The next generation of sepsis clinical trial designs: what is next after the demise of recombinant human activated protein C?*. Crit Care Med (2014) 3.17
Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis. Intensive Care Med (2008) 3.14
Lactate clearance as a predictor of mortality in trauma patients. J Trauma Acute Care Surg (2013) 3.14
Low-dose inhaled nitric oxide in patients with acute lung injury: a randomized controlled trial. JAMA (2004) 3.07
Surviving Sepsis Campaign: association between performance metrics and outcomes in a 7.5-year study. Crit Care Med (2015) 2.81
A randomized, double-blind, placebo-controlled, Phase 2b study to evaluate the safety and efficacy of recombinant human soluble thrombomodulin, ART-123, in patients with sepsis and suspected disseminated intravascular coagulation. Crit Care Med (2013) 2.68
Significance of arterial hypotension after resuscitation from cardiac arrest. Crit Care Med (2009) 2.68
Critical care medicine training and certification for emergency physicians. Ann Emerg Med (2005) 2.67
Relationship between supranormal oxygen tension and outcome after resuscitation from cardiac arrest. Circulation (2011) 2.65
Multicenter study of early lactate clearance as a determinant of survival in patients with presumed sepsis. Shock (2009) 2.59
Point: Are the best patient outcomes achieved when ICU bundles are rigorously adhered to? Yes. Chest (2013) 2.59
Occult hypoperfusion and mortality in patients with suspected infection. Intensive Care Med (2007) 2.52
An international survey: Public awareness and perception of sepsis. Crit Care Med (2009) 2.40
Activated protein C and septic shock: a propensity-matched cohort study*. Crit Care Med (2012) 2.39
Pulmonary artery occlusion pressure and central venous pressure fail to predict ventricular filling volume, cardiac performance, or the response to volume infusion in normal subjects. Crit Care Med (2004) 2.35
Utility of history, physical examination, electrocardiogram, and chest radiograph for differentiating normal from decreased systolic function in patients with heart failure. Am J Med (2002) 2.34
Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis*. Crit Care Med (2012) 2.32
Proof of principle: the predisposition, infection, response, organ failure sepsis staging system. Crit Care Med (2011) 2.30
Do outcomes of near syncope parallel syncope? Am J Emerg Med (2010) 2.23
Exploratory study on the reversal of warfarin with rFVIIa in healthy subjects. Blood (2010) 2.21
Whole blood lactate kinetics in patients undergoing quantitative resuscitation for severe sepsis and septic shock. Chest (2013) 2.20
Diagnostic and prognostic implications of endotoxemia in critical illness: results of the MEDIC study. J Infect Dis (2004) 2.17
Prospective study of the diagnostic accuracy of the simplify D-dimer assay for pulmonary embolism in emergency department patients. Chest (2006) 2.14
Critical care medicine training and certification for emergency physicians. Crit Care Med (2005) 2.12
Use of goal-directed therapy for severe sepsis and septic shock in academic emergency departments. Crit Care Med (2005) 2.03
Transfusion of packed red blood cells is not associated with improved central venous oxygen saturation or organ function in patients with septic shock. J Emerg Med (2012) 2.02
Sepsis change bundles: converting guidelines into meaningful change in behavior and clinical outcome. Crit Care Med (2004) 1.96
Implementing early goal-directed therapy in the emergency setting: the challenges and experiences of translating research innovations into clinical reality in academic and community settings. Acad Emerg Med (2007) 1.95
Acute kidney injury in septic shock: clinical outcomes and impact of duration of hypotension prior to initiation of antimicrobial therapy. Intensive Care Med (2008) 1.93
Serum lactate as a predictor of mortality in patients with infection. Intensive Care Med (2007) 1.88
Outcomes of patients undergoing early sepsis resuscitation for cryptic shock compared with overt shock. Resuscitation (2011) 1.87
The use of polynomial neural networks for mortality prediction in uncontrolled venous and arterial hemorrhage. J Trauma (2002) 1.79
A special report on the chitosan-based hemostatic dressing: experience in current combat operations. J Trauma (2006) 1.79
Incidence and factors associated with cardiac arrest complicating emergency airway management. Resuscitation (2013) 1.77
Thromboelastography as a better indicator of hypercoagulable state after injury than prothrombin time or activated partial thromboplastin time. J Trauma (2009) 1.76
Clinical review: Myocardial depression in sepsis and septic shock. Crit Care (2002) 1.74
Incidence of contrast-induced nephropathy after contrast-enhanced computed tomography in the outpatient setting. Clin J Am Soc Nephrol (2009) 1.74
Interaction between fluids and vasoactive agents on mortality in septic shock: a multicenter, observational study. Crit Care Med (2014) 1.72
The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsis. Crit Care (2010) 1.72
National study of emergency department visits for sepsis, 1992 to 2001. Ann Emerg Med (2006) 1.69
International study on microcirculatory shock occurrence in acutely ill patients. Crit Care Med (2015) 1.64
Multicenter study of central venous oxygen saturation (ScvO(2)) as a predictor of mortality in patients with sepsis. Ann Emerg Med (2009) 1.62
Resuscitating the microcirculation in sepsis: the central role of nitric oxide, emerging concepts for novel therapies, and challenges for clinical trials. Acad Emerg Med (2008) 1.61
Endothelial cell activation in emergency department patients with sepsis-related and non-sepsis-related hypotension. Shock (2011) 1.61
Effect of large volume infusion on left ventricular volumes, performance and contractility parameters in normal volunteers. Intensive Care Med (2004) 1.59
Immediate complications of intravenous contrast for computed tomography imaging in the outpatient setting are rare. Acad Emerg Med (2011) 1.59
A phase 2 randomized, double-blind, placebo-controlled study of the safety and efficacy of talactoferrin in patients with severe sepsis. Crit Care Med (2013) 1.58
Evaluation of end-tidal carbon dioxide role in predicting elevated SOFA scores and lactic acidosis. Intern Emerg Med (2008) 1.58