Published in Crit Care Med on February 01, 2011
Sepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomes. Expert Rev Anti Infect Ther (2012) 2.34
Phenotypic clusters within sepsis-associated multiple organ dysfunction syndrome. Intensive Care Med (2015) 1.72
Time for a neonatal-specific consensus definition for sepsis. Pediatr Crit Care Med (2014) 1.56
Randomized double-blind placebo-controlled trial of 40 mg/day of atorvastatin in reducing the severity of sepsis in ward patients (ASEPSIS Trial). Crit Care (2012) 1.39
Critical care--where have we been and where are we going? Crit Care (2013) 1.06
The predisposition, infection, response and organ failure (Piro) sepsis classification system: results of hospital mortality using a novel concept and methodological approach. PLoS One (2013) 1.04
Sepsis in the pediatric cardiac intensive care unit. World J Pediatr Congenit Heart Surg (2011) 0.90
Outcome predictors of uncomplicated sepsis. Int J Emerg Med (2013) 0.89
How tissue injury alarms the immune system and causes a systemic inflammatory response syndrome. Ann Intensive Care (2012) 0.87
Impact of metformin use on the prognostic value of lactate in sepsis. Am J Emerg Med (2012) 0.87
Risk stratification and prognostic performance of the predisposition, infection, response, and organ dysfunction (PIRO) scoring system in septic patients in the emergency department: a cohort study. Crit Care (2014) 0.86
Hyperlactatemia affects the association of hyperglycemia with mortality in nondiabetic adults with sepsis. Acad Emerg Med (2012) 0.85
Current views on the mechanisms of immune responses to trauma and infection. Cent Eur J Immunol (2015) 0.83
Comparison of risk prediction scoring systems for ward patients: a retrospective nested case-control study. Crit Care (2014) 0.82
Predisposition, insult/infection, response and organ dysfunction (PIRO): a pilot clinical staging system for hospital mortality in patients with infection. PLoS One (2013) 0.82
PIRO and sepsis stratification: reality or a mirage? Rev Bras Ter Intensiva (2015) 0.81
Lack of clinically evident signs of organ failure affects ED treatment of patients with severe sepsis. Int J Emerg Med (2013) 0.79
The association between time to antibiotics and relevant clinical outcomes in emergency department patients with various stages of sepsis: a prospective multi-center study. Crit Care (2015) 0.79
PIRO concept: Staging of sepsis. J Postgrad Med (2015) 0.78
20 Years On: Is It Time to Redefine the Systemic Inflammatory Response to Cardiothoracic Surgery? J Extra Corpor Technol (2015) 0.77
Translating the PIRO staging system concept into clinical practice: where do we go from here? Crit Care Med (2011) 0.77
Can We Reduce Negative Blood Cultures With Clinical Scores and Blood Markers? Results From an Observational Cohort Study. Medicine (Baltimore) (2015) 0.77
Sepsis in Pediatric Cardiac Intensive Care. Pediatr Crit Care Med (2016) 0.75
The influence of statin exposure on inflammatory markers in patients with early bacterial infection: pilot prospective cohort study. BMC Anesthesiol (2014) 0.75
Expert consensus on the perioperative management of patients with sepsis. World J Emerg Med (2015) 0.75
Development and Validation of a Disease Severity Scoring Model for Pediatric Sepsis. Iran J Public Health (2016) 0.75
Comparison of risks factors for unplanned ICU transfer after ED admission in patients with infections and those without infections. ScientificWorldJournal (2014) 0.75
Cardiac Troponin Is a Predictor of Septic Shock Mortality in Cancer Patients in an Emergency Department: A Retrospective Cohort Study. PLoS One (2016) 0.75
Independent predictors of major adverse cardiovascular events in emergency department patients who are hospitalised with a suspected infection: a retrospective cohort study. BMJ Open (2016) 0.75
Association between Hypoalbuminaemia and Mortality in Patients with Community-Acquired Bacteraemia Is Primarily Related to Acute Disorders. PLoS One (2016) 0.75
Innate immunity gene expression changes in critically ill patients with sepsis and disease-related malnutrition. Cent Eur J Immunol (2015) 0.75
Hypoalbuminemia, Low Base Excess Values, and Tachypnea Predict 28-Day Mortality in Severe Sepsis and Septic Shock Patients in the Emergency Department. Yonsei Med J (2016) 0.75
Initial disease severity and quality of care of emergency department sepsis patients who are older or younger than 70 years of age. PLoS One (2017) 0.75
"Neo-PIRO": Introducing a Novel Grading System for Surgical Infections of Neonates. J Indian Assoc Pediatr Surg (2017) 0.75
A randomized trial of protocol-based care for early septic shock. N Engl J Med (2014) 16.05
Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. JAMA (2010) 8.09
Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including NICE-SUGAR study data. CMAJ (2009) 6.27
Driving pressure and survival in the acute respiratory distress syndrome. N Engl J Med (2015) 6.06
The Impact of Timing of Antibiotics on Outcomes in Severe Sepsis and Septic Shock: A Systematic Review and Meta-Analysis. Crit Care Med (2015) 6.00
National estimates of severe sepsis in United States emergency departments. Crit Care Med (2007) 5.99
Procalcitonin-guided antibiotic use vs a standard approach for acute respiratory tract infections in primary care. Arch Intern Med (2008) 4.66
Implementation and outcomes of the Multiple Urgent Sepsis Therapies (MUST) protocol. Crit Care Med (2006) 4.62
Serum lactate as a predictor of mortality in emergency department patients with infection. Ann Emerg Med (2005) 4.49
Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality. JAMA (2010) 4.37
Short-term vs conventional glucocorticoid therapy in acute exacerbations of chronic obstructive pulmonary disease: the REDUCE randomized clinical trial. JAMA (2013) 4.33
Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury. Crit Care (2013) 3.90
Association between timing of antibiotic administration and mortality from septic shock in patients treated with a quantitative resuscitation protocol. Crit Care Med (2011) 3.82
Do emergency department blood cultures change practice in patients with pneumonia? Ann Emerg Med (2005) 3.80
The effect of a quantitative resuscitation strategy on mortality in patients with sepsis: a meta-analysis. Crit Care Med (2008) 3.73
Early identification of patients at risk of acute lung injury: evaluation of lung injury prediction score in a multicenter cohort study. Am J Respir Crit Care Med (2010) 3.21
Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis. Intensive Care Med (2008) 3.14
Lactate clearance as a predictor of mortality in trauma patients. J Trauma Acute Care Surg (2013) 3.14
The association of sepsis syndrome and organ dysfunction with mortality in emergency department patients with suspected infection. Ann Emerg Med (2006) 2.84
Significance of arterial hypotension after resuscitation from cardiac arrest. Crit Care Med (2009) 2.68
Relationship between supranormal oxygen tension and outcome after resuscitation from cardiac arrest. Circulation (2011) 2.65
Multicenter study of early lactate clearance as a determinant of survival in patients with presumed sepsis. Shock (2009) 2.59
Iatrogenic gastric acid suppression and the risk of nosocomial Clostridium difficile infection. Arch Intern Med (2010) 2.55
Occult hypoperfusion and mortality in patients with suspected infection. Intensive Care Med (2007) 2.52
A blueprint for a sepsis protocol. Acad Emerg Med (2005) 2.49
Pleural pressure and optimal positive end-expiratory pressure based on esophageal pressure versus chest wall elastance: incompatible results*. Crit Care Med (2013) 2.45
Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis*. Crit Care Med (2012) 2.32
Do outcomes of near syncope parallel syncope? Am J Emerg Med (2010) 2.23
Whole blood lactate kinetics in patients undergoing quantitative resuscitation for severe sepsis and septic shock. Chest (2013) 2.20
The application of esophageal pressure measurement in patients with respiratory failure. Am J Respir Crit Care Med (2014) 2.16
Prospective study of the diagnostic accuracy of the simplify D-dimer assay for pulmonary embolism in emergency department patients. Chest (2006) 2.14
Outcome of critically ill patients with acute kidney injury using the Acute Kidney Injury Network criteria. Crit Care Med (2011) 2.11
Use of goal-directed therapy for severe sepsis and septic shock in academic emergency departments. Crit Care Med (2005) 2.03
Effectiveness and safety of procalcitonin-guided antibiotic therapy in lower respiratory tract infections in "real life": an international, multicenter poststudy survey (ProREAL). Arch Intern Med (2012) 2.01
Esophageal pressures in acute lung injury: do they represent artifact or useful information about transpulmonary pressure, chest wall mechanics, and lung stress? J Appl Physiol (1985) (2009) 1.96
Implementing early goal-directed therapy in the emergency setting: the challenges and experiences of translating research innovations into clinical reality in academic and community settings. Acad Emerg Med (2007) 1.95
Risk factors for ARDS in patients receiving mechanical ventilation for > 48 h. Chest (2008) 1.94
Mortality in Emergency Department Sepsis (MEDS) score predicts 1-year mortality. Crit Care Med (2007) 1.94
Methods of blood pressure measurement in the ICU. Crit Care Med (2013) 1.89
Outcomes of patients undergoing early sepsis resuscitation for cryptic shock compared with overt shock. Resuscitation (2011) 1.87
Empirical relationships among oliguria, creatinine, mortality, and renal replacement therapy in the critically ill. Intensive Care Med (2012) 1.86
When policy gets it right: variability in u.s. Hospitals' diagnosis of ventilator-associated pneumonia*. Crit Care Med (2014) 1.79
Incidence and factors associated with cardiac arrest complicating emergency airway management. Resuscitation (2013) 1.77
Incidence of contrast-induced nephropathy after contrast-enhanced computed tomography in the outpatient setting. Clin J Am Soc Nephrol (2009) 1.74
Copeptin: a novel, independent prognostic marker in patients with ischemic stroke. Ann Neurol (2009) 1.73
The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsis. Crit Care (2010) 1.72
Influence of low tidal volume ventilation on time to extubation in cardiac surgical patients. Anesthesiology (2011) 1.71
National study of emergency department visits for sepsis, 1992 to 2001. Ann Emerg Med (2006) 1.69
Diabetic status and the relation of the three domains of glycemic control to mortality in critically ill patients: an international multicenter cohort study. Crit Care (2013) 1.66
Subclinical left ventricular dysfunction in preeclamptic women with preserved left ventricular ejection fraction: a 2D speckle-tracking imaging study. Circ Cardiovasc Imaging (2012) 1.65
Temporal trends in patient characteristics and survival of intensive care admissions with sepsis: a multicenter analysis*. Crit Care Med (2012) 1.64
International study on microcirculatory shock occurrence in acutely ill patients. Crit Care Med (2015) 1.64
Procalcitonin levels predict bacteremia in patients with community-acquired pneumonia: a prospective cohort trial. Chest (2010) 1.63
Circulating angiopoietin 2 correlates with mortality in a surgical population with acute lung injury/adult respiratory distress syndrome. Shock (2008) 1.62
Multicenter study of central venous oxygen saturation (ScvO(2)) as a predictor of mortality in patients with sepsis. Ann Emerg Med (2009) 1.62
Resuscitating the microcirculation in sepsis: the central role of nitric oxide, emerging concepts for novel therapies, and challenges for clinical trials. Acad Emerg Med (2008) 1.61
Endothelial cell activation in emergency department patients with sepsis-related and non-sepsis-related hypotension. Shock (2011) 1.61
Immediate complications of intravenous contrast for computed tomography imaging in the outpatient setting are rare. Acad Emerg Med (2011) 1.59
Evaluation of end-tidal carbon dioxide role in predicting elevated SOFA scores and lactic acidosis. Intern Emerg Med (2008) 1.58
Copeptin adds prognostic information after ischemic stroke: results from the CoRisk study. Neurology (2013) 1.58
Activities during interruptions in cardiopulmonary resuscitation: a simulator study. Resuscitation (2011) 1.57
Volume Delivered During Recruitment Maneuver Predicts Lung Stress in Acute Respiratory Distress Syndrome. Crit Care Med (2016) 1.57
One year mortality of patients treated with an emergency department based early goal directed therapy protocol for severe sepsis and septic shock: a before and after study. Crit Care (2009) 1.57
Echocardiography practice, training and accreditation in the intensive care: document for the World Interactive Network Focused on Critical Ultrasound (WINFOCUS). Cardiovasc Ultrasound (2008) 1.55
Midregional pro-atrial natriuretic peptide and outcome in patients with acute ischemic stroke. J Am Coll Cardiol (2010) 1.55
Serum lactate and base deficit as predictors of mortality in normotensive elderly blunt trauma patients. J Trauma (2009) 1.53
Risk factors for death in elderly emergency department patients with suspected infection. J Am Geriatr Soc (2009) 1.53
Rituximab effective in a patient with refractory autoimmune haemolytic anaemia and CD20-negative multiple myeloma. Br J Haematol (2003) 1.52
Biomarker-enhanced triage in respiratory infections: a proof-of-concept feasibility trial. Eur Respir J (2013) 1.51
The utility of proadrenomedullin and procalcitonin in comparison to C-reactive protein as predictors of sepsis and bloodstream infections in critically ill patients with cancer*. Crit Care Med (2014) 1.49
Sublingual microcirculation is impaired in post-cardiac arrest patients. Resuscitation (2013) 1.48
Predictors of bacteremia in emergency department patients with suspected infection. Am J Emerg Med (2012) 1.48
Economic evaluation of procalcitonin-guided antibiotic therapy in acute respiratory infections: a US health system perspective. Clin Chem Lab Med (2015) 1.48
Positive-pressure ventilation equipment for mass casualty respiratory failure. Biosecur Bioterror (2006) 1.47
Characteristics of out-of-hospital shock care. Crit Care Med (2011) 1.47
Leadership in medical emergencies depends on gender and personality. Simul Healthc (2011) 1.45
Predicting adverse outcomes in syncope. J Emerg Med (2007) 1.45
Simple triage scoring system predicting death and the need for critical care resources for use during epidemics. Crit Care Med (2007) 1.44
Etiology of illness in patients with severe sepsis admitted to the hospital from the emergency department. Clin Infect Dis (2010) 1.44
Arterial blood pressure and neurologic outcome after resuscitation from cardiac arrest*. Crit Care Med (2014) 1.43
C4d deposits on the surface of RBCs in trauma patients and interferes with their function. Crit Care Med (2014) 1.41
Treatment with activated protein C immediately after cardiac surgery. J Cardiothorac Vasc Anesth (2009) 1.38
Can procalcitonin levels guide antibiotic therapy in bacterial infections and reduce antibiotic overconsumption without having a negative effect on clinical outcomes? Ann Emerg Med (2012) 1.38
Impact of a rapid rule-out protocol for pulmonary embolism on the rate of screening, missed cases, and pulmonary vascular imaging in an urban US emergency department. Ann Emerg Med (2004) 1.34
The microcirculation image quality score: development and preliminary evaluation of a proposed approach to grading quality of image acquisition for bedside videomicroscopy. J Crit Care (2013) 1.34
Point: should lactate clearance be substituted for central venous oxygen saturation as goals of early severe sepsis and septic shock therapy? Yes. Chest (2011) 1.33