Voltage sensitive phosphatases: emerging kinship to protein tyrosine phosphatases from structure-function research.

PubWeight™: 0.80‹?›

🔗 View Article (PMC 4322731)

Published in Front Pharmacol on January 10, 2015

Authors

Kirstin Hobiger1, Thomas Friedrich2

Author Affiliations

1: Department of Neurophysiology, Institute of Physiology and Pathophysiology, Philipps-Universität Marburg Marburg, Germany.
2: Max-Volmer-Laboratory of Biophysical Chemistry, Institute of Chemistry, Technische Universität Berlin Berlin, Germany.

Articles cited by this

(truncated to the top 100)

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science (1997) 29.34

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem (1998) 17.36

cdc25+ functions as an inducer in the mitotic control of fission yeast. Cell (1986) 8.82

Protein tyrosine phosphatases in the human genome. Cell (2004) 8.09

Protein tyrosine phosphatases: from genes, to function, to disease. Nat Rev Mol Cell Biol (2006) 7.93

The lipid phosphatase activity of PTEN is critical for its tumor supressor function. Proc Natl Acad Sci U S A (1998) 6.98

Phosphoinositide phosphatase activity coupled to an intrinsic voltage sensor. Nature (2005) 6.85

Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell (1999) 6.59

cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2. Cell (1991) 6.32

TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta. Cancer Res (1997) 5.92

Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases. Proc Natl Acad Sci U S A (1997) 5.63

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase. Proc Natl Acad Sci U S A (1997) 5.32

Redox redux: revisiting PTPs and the control of cell signaling. Cell (2005) 5.10

Reversible inactivation of the tumor suppressor PTEN by H2O2. J Biol Chem (2002) 5.08

Crystal structure of human protein tyrosine phosphatase 1B. Science (1994) 4.95

Rapid destruction of human Cdc25A in response to DNA damage. Science (2000) 4.74

Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate. Nature (2003) 4.60

Phosphorylation and activation of human cdc25-C by cdc2--cyclin B and its involvement in the self-amplification of MPF at mitosis. EMBO J (1993) 4.33

Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway. Proc Natl Acad Sci U S A (1999) 4.19

CD45: a critical regulator of signaling thresholds in immune cells. Annu Rev Immunol (2001) 4.13

Specific and reversible inactivation of protein tyrosine phosphatases by hydrogen peroxide: evidence for a sulfenic acid intermediate and implications for redox regulation. Biochemistry (1998) 3.90

Characterization of the major protein-tyrosine-phosphatases of human placenta. J Biol Chem (1988) 3.84

PTEN and myotubularin: novel phosphoinositide phosphatases. Annu Rev Biochem (2001) 3.78

The structure and mechanism of protein phosphatases: insights into catalysis and regulation. Annu Rev Biophys Biomol Struct (1998) 3.64

Redox regulation of PI 3-kinase signalling via inactivation of PTEN. EMBO J (2003) 3.58

Purification of the major protein-tyrosine-phosphatases of human placenta. J Biol Chem (1988) 3.54

Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain. Proc Natl Acad Sci U S A (1997) 3.48

CDC25 phosphatases in cancer cells: key players? Good targets? Nat Rev Cancer (2007) 3.46

A Tyr/Ser protein phosphatase encoded by vaccinia virus. Nature (1991) 3.35

Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins. Cell (1991) 3.34

Combinatorial control of the specificity of protein tyrosine phosphatases. Curr Opin Cell Biol (2001) 3.30

Mutations of p34cdc2 phosphorylation sites induce premature mitotic events in HeLa cells: evidence for a double block to p34cdc2 kinase activation in vertebrates. EMBO J (1991) 3.23

Protein phosphorylation in signaling--50 years and counting. Trends Biochem Sci (2005) 3.19

Crystal structure of Yersinia protein tyrosine phosphatase at 2.5 A and the complex with tungstate. Nature (1994) 3.10

Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B. Science (1995) 3.02

Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B. Nature (2003) 3.01

Distinct functional roles of the two intracellular phosphatase like domains of the receptor-linked protein tyrosine phosphatases LCA and LAR. EMBO J (1990) 2.94

Membrane-binding and activation mechanism of PTEN. Proc Natl Acad Sci U S A (2003) 2.92

RED CELL ACID PHOSPHATASE VARIANTS: A NEW HUMAN POLYMORPHISM. Nature (1963) 2.78

The role of protein phosphorylation in human health and disease. The Sir Hans Krebs Medal Lecture. Eur J Biochem (2001) 2.73

Evidence for protein-tyrosine-phosphatase catalysis proceeding via a cysteine-phosphate intermediate. J Biol Chem (1991) 2.72

Activation of the phosphatase activity of human cdc25A by a cdk2-cyclin E dependent phosphorylation at the G1/S transition. EMBO J (1994) 2.61

Novel mechanism of PTEN regulation by its phosphatidylinositol 4,5-bisphosphate binding motif is critical for chemotaxis. J Biol Chem (2004) 2.60

PTEN: The down side of PI 3-kinase signalling. Cell Signal (2002) 2.34

Identification of p130(cas) as a substrate for the cytosolic protein tyrosine phosphatase PTP-PEST. Mol Cell Biol (1996) 2.30

Crystal structure of the dual specificity protein phosphatase VHR. Science (1996) 2.28

Emerging roles of nuclear protein phosphatases. Nat Rev Mol Cell Biol (2007) 2.28

Glycogen and its metabolism: some new developments and old themes. Biochem J (2012) 2.24

Protein tyrosine phosphatases: prospects for therapeutics. Curr Opin Chem Biol (2001) 2.24

Mutations in the phosphatidylinositol 3-kinase pathway: role in tumor progression and therapeutic implications in breast cancer. Breast Cancer Res (2011) 2.19

PTP1B as a drug target: recent developments in PTP1B inhibitor discovery. Drug Discov Today (2007) 2.09

PI(3)king apart PTEN's role in cancer. Clin Cancer Res (2010) 2.07

Protein tyrosine phosphatases: mechanisms of catalysis and regulation. Curr Opin Chem Biol (1998) 2.06

Laforin, a dual specificity phosphatase that dephosphorylates complex carbohydrates. J Biol Chem (2006) 2.04

Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane. Proc Natl Acad Sci U S A (2006) 1.96

The crystal structure of a low-molecular-weight phosphotyrosine protein phosphatase. Nature (1994) 1.95

Dual mode of degradation of Cdc25 A phosphatase. EMBO J (2002) 1.95

Allosteric activation of PTEN phosphatase by phosphatidylinositol 4,5-bisphosphate. J Biol Chem (2003) 1.94

The rhodanese/Cdc25 phosphatase superfamily. Sequence-structure-function relations. EMBO Rep (2002) 1.94

Cdc25 phosphatases and cancer. Chem Biol (2004) 1.93

The cdc25B phosphatase is essential for the G2/M phase transition in human cells. J Cell Sci (1998) 1.92

Laforin is a glycogen phosphatase, deficiency of which leads to elevated phosphorylation of glycogen in vivo. Proc Natl Acad Sci U S A (2007) 1.89

The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif. Biochem J (2004) 1.87

A voltage-sensing phosphatase, Ci-VSP, which shares sequence identity with PTEN, dephosphorylates phosphatidylinositol 4,5-bisphosphate. Proc Natl Acad Sci U S A (2008) 1.85

Cdc25: mechanisms of checkpoint inhibition and recovery. Trends Cell Biol (2006) 1.84

Enzyme domain affects the movement of the voltage sensor in ascidian and zebrafish voltage-sensing phosphatases. J Biol Chem (2008) 1.83

The dual-specificity phosphatase encoded by vaccinia virus, VH1, is essential for viral transcription in vivo and in vitro. J Virol (1995) 1.81

Dissecting the catalytic mechanism of protein-tyrosine phosphatases. Proc Natl Acad Sci U S A (1994) 1.80

A unique carbohydrate binding domain targets the lafora disease phosphatase to glycogen. J Biol Chem (2001) 1.78

A catalytic mechanism for the dual-specific phosphatases. Proc Natl Acad Sci U S A (1995) 1.68

Crystal structure of the catalytic domain of the human cell cycle control phosphatase, Cdc25A. Cell (1998) 1.66

PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration. Curr Biol (2007) 1.62

Pten signaling in gliomas. Neuro Oncol (2002) 1.62

Functions and mechanisms of redox regulation of cysteine-based phosphatases. Antioxid Redox Signal (2005) 1.62

Ci-VSP is a depolarization-activated phosphatidylinositol-4,5-bisphosphate and phosphatidylinositol-3,4,5-trisphosphate 5'-phosphatase. J Biol Chem (2008) 1.61

Evolution of protein phosphatases in plants and animals. Biochem J (2009) 1.61

Coupling between the voltage-sensing and phosphatase domains of Ci-VSP. J Gen Physiol (2009) 1.60

TPIP: a novel phosphoinositide 3-phosphatase. Biochem J (2001) 1.60

Substrate-trapping techniques in the identification of cellular PTP targets. Methods (2005) 1.60

Interfacial kinetic analysis of the tumour suppressor phosphatase, PTEN: evidence for activation by anionic phospholipids. Biochem J (2003) 1.59

Expression cloning of a human dual-specificity phosphatase. Proc Natl Acad Sci U S A (1992) 1.59

Vaccinia virus blocks gamma interferon signal transduction: viral VH1 phosphatase reverses Stat1 activation. J Virol (2001) 1.59

Electrochemical coupling in the voltage-dependent phosphatase Ci-VSP. Nat Chem Biol (2010) 1.59

Visualization of intermediate and transition-state structures in protein-tyrosine phosphatase catalysis. Proc Natl Acad Sci U S A (1996) 1.57

Active site labeling of the Yersinia protein tyrosine phosphatase: the determination of the pKa of the active site cysteine and the function of the conserved histidine 402. Biochemistry (1993) 1.53

Novel glycogen synthase kinase 3 and ubiquitination pathways in progressive myoclonus epilepsy. Hum Mol Genet (2005) 1.52

Structural mechanism of voltage-dependent gating in an isolated voltage-sensing domain. Nat Struct Mol Biol (2014) 1.51

Low molecular weight protein tyrosine phosphatase genetic polymorphism and susceptibility to cancer development. Cancer Genet Cytogenet (2008) 1.48

Regulation of protein tyrosine phosphatases by reversible oxidation. J Biochem (2011) 1.48

Tyrosine phosphorylation of A17 during vaccinia virus infection: involvement of the H1 phosphatase and the F10 kinase. J Virol (1999) 1.48

PTP1B: a double agent in metabolism and oncogenesis. Trends Biochem Sci (2010) 1.44

14-3-3 proteins associate with cdc25 phosphatases. Proc Natl Acad Sci U S A (1995) 1.44

The cdk-activating kinase (CAK): from yeast to mammals. Cell Mol Life Sci (1999) 1.42

Laforin, the dual-phosphatase responsible for Lafora disease, interacts with R5 (PTG), a regulatory subunit of protein phosphatase-1 that enhances glycogen accumulation. Hum Mol Genet (2003) 1.40

PTEN 2, a Golgi-associated testis-specific homologue of the PTEN tumor suppressor lipid phosphatase. J Biol Chem (2001) 1.39

Inflammatory bowel disease: Are there gender differences in the genetics of signal transduction? A preliminary study of cytosolic low molecular weight protein tyrosine phosphatase. Dis Markers (2000) 1.39

Protein-tyrosine phosphatase 1B (PTP1B): a novel therapeutic target for type 2 diabetes mellitus, obesity and related states of insulin resistance. Curr Drug Targets Immune Endocr Metabol Disord (2001) 1.38

Oxidants painting the cysteine chapel: redox regulation of PTPs. Dev Cell (2002) 1.37

Visualization of the cysteinyl-phosphate intermediate of a protein-tyrosine phosphatase by x-ray crystallography. J Biol Chem (1998) 1.33

Two vicinal cysteines confer a peculiar redox regulation to low molecular weight protein tyrosine phosphatase in response to platelet-derived growth factor receptor stimulation. J Biol Chem (2001) 1.32