Published in Curr Biol on January 23, 2007
The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells. J Clin Invest (2009) 2.52
Loss of Phosphatase and Tensin homologue deleted on chromosome 10 engages ErbB3 and insulin-like growth factor-I receptor signaling to promote antiestrogen resistance in breast cancer. Cancer Res (2009) 1.84
FGF signalling: diverse roles during early vertebrate embryogenesis. Development (2010) 1.60
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control. Genes Cancer (2010) 1.38
PTEN function: the long and the short of it. Trends Biochem Sci (2014) 1.29
Suppression of cellular proliferation and invasion by the concerted lipid and protein phosphatase activities of PTEN. Oncogene (2009) 1.27
Manganese superoxide dismutase (Sod2) and redox-control of signaling events that drive metastasis. Anticancer Agents Med Chem (2011) 1.24
PTEN: Multiple Functions in Human Malignant Tumors. Front Oncol (2015) 1.24
PTEN loss induces epithelial--mesenchymal transition in human colon cancer cells. Anticancer Res (2009) 1.17
Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes. J Exp Med (2009) 1.16
Gene expression profiling identifies inflammation and angiogenesis as distinguishing features of canine hemangiosarcoma. BMC Cancer (2010) 1.13
FGF signalling through RAS/MAPK and PI3K pathways regulates cell movement and gene expression in the chicken primitive streak without affecting E-cadherin expression. BMC Dev Biol (2011) 1.11
Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K. EMBO Mol Med (2014) 1.11
The PTEN phosphatase controls intestinal epithelial cell polarity and barrier function: role in colorectal cancer progression. PLoS One (2010) 1.10
3' Phosphatase activity toward phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2] by voltage-sensing phosphatase (VSP). Proc Natl Acad Sci U S A (2012) 1.07
Vitamin A facilitates enteric nervous system precursor migration by reducing Pten accumulation. Development (2010) 1.07
Upregulation of PTEN in glioma cells by cord blood mesenchymal stem cells inhibits migration via downregulation of the PI3K/Akt pathway. PLoS One (2010) 1.05
Ubiquitination of PTEN (phosphatase and tensin homolog) inhibits phosphatase activity and is enhanced by membrane targeting and hyperosmotic stress. J Biol Chem (2010) 1.05
Phosphoinositide phosphatases in cell biology and disease. Prog Lipid Res (2010) 1.05
Overexpression of brachyury contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma. J Exp Clin Cancer Res (2014) 1.05
Retinal degeneration triggered by inactivation of PTEN in the retinal pigment epithelium. Genes Dev (2008) 1.02
Myosin-II-mediated cell shape changes and cell intercalation contribute to primitive streak formation. Nat Cell Biol (2015) 1.01
Functional analysis of the protein phosphatase activity of PTEN. Biochem J (2012) 1.01
PTEN inhibits PREX2-catalyzed activation of RAC1 to restrain tumor cell invasion. Sci Signal (2015) 0.99
PTEN C-terminal deletion causes genomic instability and tumor development. Cell Rep (2014) 0.98
Loss of PTEN permits CXCR4-mediated tumorigenesis through ERK1/2 in prostate cancer cells. Mol Cancer Res (2010) 0.98
A limited role for PI(3,4,5)P3 regulation in controlling skeletal muscle mass in response to resistance exercise. PLoS One (2010) 0.96
Doubles game: Src-Stat3 versus p53-PTEN in cellular migration and invasion. Mol Cell Biol (2010) 0.95
PTEN regulation of local and long-range connections in mouse auditory cortex. J Neurosci (2012) 0.95
Swimming exercise training-induced left ventricular hypertrophy involves microRNAs and synergistic regulation of the PI3K/AKT/mTOR signaling pathway. Eur J Appl Physiol (2013) 0.91
Voltage-Controlled Enzymes: The New JanusBifrons. Front Pharmacol (2012) 0.91
PTEN: a promising pharmacological target to enhance epithelial wound healing. Br J Pharmacol (2007) 0.89
PTEN regulates PDGF ligand switch for β-PDGFR signaling in prostate cancer. Am J Pathol (2011) 0.89
Nox2 is required for macrophage chemotaxis towards CSF-1. PLoS One (2013) 0.89
The Role of PTEN in Tumor Angiogenesis. J Oncol (2011) 0.88
Collective epithelial and mesenchymal cell migration during gastrulation. Curr Genomics (2012) 0.87
Evolution of the voltage sensor domain of the voltage-sensitive phosphoinositide phosphatase VSP/TPTE suggests a role as a proton channel in eutherian mammals. Mol Biol Evol (2012) 0.86
Pten regulates collective cell migration during specification of the anterior-posterior axis of the mouse embryo. Dev Biol (2012) 0.86
PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7. Nat Commun (2016) 0.83
Ptenb mediates gastrulation cell movements via Cdc42/AKT1 in zebrafish. PLoS One (2011) 0.82
Intracellular redox status controls membrane localization of pro- and anti-migratory signaling molecules. Redox Biol (2014) 0.82
Molecular pathways: intercellular PTEN and the potential of PTEN restoration therapy. Clin Cancer Res (2014) 0.82
p53 regulation of podosome formation and cellular invasion in vascular smooth muscle cells. Cell Adh Migr (2011) 0.82
A human phospholipid phosphatase activated by a transmembrane control module. J Lipid Res (2012) 0.81
p53 Down regulates PDGF-induced formation of circular dorsal ruffles in rat aortic smooth muscle cells. PLoS One (2014) 0.80
Voltage sensitive phosphatases: emerging kinship to protein tyrosine phosphatases from structure-function research. Front Pharmacol (2015) 0.80
Disruption of epithelial architecture caused by loss of PTEN or by oncogenic mutant p110α/PIK3CA but not by HER2 or mutant AKT1. Oncogene (2012) 0.80
Retracted Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and PH domain and leucine-rich repeat phosphatase cross-talk (PHLPP) in cancer cells and in transforming growth factor β-activated stem cells. J Biol Chem (2014) 0.79
Phosphatase and tensin homolog overexpression decreases proliferation and invasion and increases apoptosis in oral squamous cell carcinoma cells. Oncol Lett (2014) 0.79
AIF inhibits tumor metastasis by protecting PTEN from oxidation. EMBO Rep (2015) 0.78
Direct regulation of transforming growth factor β-induced epithelial-mesenchymal transition by the protein phosphatase activity of unphosphorylated PTEN in lung cancer cells. Cancer Sci (2015) 0.78
PTEN phosphatase-independent maintenance of glandular morphology in a predictive colorectal cancer model system. Neoplasia (2013) 0.78
Phosphatase and tensin homologue deleted on chromosome 10. Niger Med J (2013) 0.78
Differential Requirement for Pten Lipid and Protein Phosphatase Activity during Zebrafish Embryonic Development. PLoS One (2016) 0.76
Differential SKIP expression in PTEN-deficient glioblastoma regulates cellular proliferation and migration. Oncogene (2014) 0.76
PTEN is involved in modulation of vasculogenesis in early chick embryos. Biol Open (2013) 0.76
Cardiac progenitor migration and specification: The dual function of Wnts. Cell Adh Migr (2008) 0.76
Characterization of the Functional Domains of a Mammalian Voltage-Sensitive Phosphatase. Biophys J (2015) 0.76
Epstein-Barr Virus (EBV)-BamHI-A Rightward Transcript (BART)-6 and Cellular MicroRNA-142 Synergistically Compromise Immune Defense of Host Cells in EBV-Positive Burkitt Lymphoma. Med Sci Monit (2016) 0.75
A series of normal stages in the development of the chick embryo. J Morphol (1951) 17.89
Pten is essential for embryonic development and tumour suppression. Nat Genet (1998) 13.41
A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell (2006) 10.06
The lipid phosphatase activity of PTEN is critical for its tumor supressor function. Proc Natl Acad Sci U S A (1998) 6.98
The multiple roles of PTEN in tumor suppression. Cell (2000) 6.71
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science (1998) 6.62
Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell (1999) 6.59
Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis. Cell (2002) 6.36
Tumor suppressor PTEN mediates sensing of chemoattractant gradients. Cell (2002) 6.06
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase. Proc Natl Acad Sci U S A (1997) 5.32
PTEN and myotubularin: novel phosphoinositide phosphatases. Annu Rev Biochem (2001) 3.78
FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak. Dev Cell (2001) 3.73
Redox regulation of PI 3-kinase signalling via inactivation of PTEN. EMBO J (2003) 3.58
Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex. J Biol Chem (2001) 3.27
Mechanisms, mechanics and function of epithelial-mesenchymal transitions in early development. Mech Dev (2003) 3.25
The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region. Proc Natl Acad Sci U S A (1999) 3.10
PTEN function: how normal cells control it and tumour cells lose it. Biochem J (2004) 3.06
Regulation of cell migration by the C2 domain of the tumor suppressor PTEN. Science (2004) 2.81
PTEN: from pathology to biology. Trends Cell Biol (2003) 2.69
Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases. Curr Biol (2000) 2.67
Improved method for chick whole-embryo culture using a filter paper carrier. Dev Dyn (2001) 2.61
Leading the way: Directional sensing through phosphatidylinositol 3-kinase and other signaling pathways. J Cell Sci (2003) 2.49
Cell movement patterns during gastrulation in the chick are controlled by positive and negative chemotaxis mediated by FGF4 and FGF8. Dev Cell (2002) 2.19
Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination. J Exp Med (2003) 2.16
PTEN suppresses hyaluronic acid-induced matrix metalloproteinase-9 expression in U87MG glioblastoma cells through focal adhesion kinase dephosphorylation. Cancer Res (2002) 1.88
Regulated and polarized PtdIns(3,4,5)P3 accumulation is essential for apical membrane morphogenesis in photoreceptor epithelial cells. Curr Biol (2006) 1.77
PTEN as an effector in the signaling of antimigratory G protein-coupled receptor. Proc Natl Acad Sci U S A (2005) 1.67
TGFbeta-induced downregulation of E-cadherin-based cell-cell adhesion depends on PI3-kinase and PTEN. J Cell Sci (2005) 1.63
Implication of the MAGI-1b/PTEN signalosome in stabilization of adherens junctions and suppression of invasiveness. FASEB J (2004) 1.61
TPIP: a novel phosphoinositide 3-phosphatase. Biochem J (2001) 1.60
Phosphoinositide 3-kinase is required for process outgrowth and cell polarization of gastrulating mesendodermal cells. Curr Biol (2003) 1.50
PTEN regulates motility but not directionality during leukocyte chemotaxis. J Cell Sci (2004) 1.35
Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions. Biochem J (2001) 1.29
Propagating chemoattractant waves coordinate periodic cell movement in Dictyostelium slugs. Development (2001) 1.29
Inactivation of platelet-derived growth factor receptor by the tumor suppressor PTEN provides a novel mechanism of action of the phosphatase. J Biol Chem (2004) 1.29
Do phosphoinositide 3-kinases direct lymphocyte navigation? Trends Immunol (2004) 1.23
Vinculin controls PTEN protein level by maintaining the interaction of the adherens junction protein beta-catenin with the scaffolding protein MAGI-2. J Biol Chem (2004) 1.20
PTEN can inhibit in vitro organotypic and in vivo orthotopic invasion of human bladder cancer cells even in the absence of its lipid phosphatase activity. Oncogene (2004) 1.20
Negative regulation of CXCR4-mediated chemotaxis by the lipid phosphatase activity of tumor suppressor PTEN. Blood (2005) 0.95
The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J Cell Biol (2004) 9.71
Redox regulation of PI 3-kinase signalling via inactivation of PTEN. EMBO J (2003) 3.58
PTEN function: how normal cells control it and tumour cells lose it. Biochem J (2004) 3.06
A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation. J Exp Med (2002) 2.68
PTEN: The down side of PI 3-kinase signalling. Cell Signal (2002) 2.34
dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1. Nat Cell Biol (2002) 2.31
Cell movement patterns during gastrulation in the chick are controlled by positive and negative chemotaxis mediated by FGF4 and FGF8. Dev Cell (2002) 2.19
Subcellular localization of phosphatidylinositol 4,5-bisphosphate using the pleckstrin homology domain of phospholipase C delta1. Biochem J (2002) 2.16
The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif. Biochem J (2004) 1.87
Signaling to cytoskeletal dynamics during chemotaxis. Dev Cell (2005) 1.73
Interfacial kinetic analysis of the tumour suppressor phosphatase, PTEN: evidence for activation by anionic phospholipids. Biochem J (2003) 1.59
In vivo analysis of 3-phosphoinositide dynamics during Dictyostelium phagocytosis and chemotaxis. J Cell Sci (2004) 1.51
Small molecule antagonists of the sigma-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo. Cancer Res (2004) 1.49
Simultaneous quantification of cell motility and protein-membrane-association using active contours. Cell Motil Cytoskeleton (2002) 1.42
Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression. J Cell Sci (2006) 1.36
A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic beta-cells. EMBO J (2006) 1.34
MyosinV controls PTEN function and neuronal cell size. Nat Cell Biol (2009) 1.32
Interleukin-3-mediated cell survival signals include phosphatidylinositol 3-kinase-dependent translocation of the glucose transporter GLUT1 to the cell surface. J Biol Chem (2003) 1.31
The cyclase-associated protein CAP as regulator of cell polarity and cAMP signaling in Dictyostelium. Mol Biol Cell (2003) 1.30
PTEN is destabilized by phosphorylation on Thr366. Biochem J (2007) 1.28
Imaging of cell migration. EMBO J (2006) 1.26
Slit-Robo signaling induces malignant transformation through Hakai-mediated E-cadherin degradation during colorectal epithelial cell carcinogenesis. Cell Res (2011) 1.24
Visualizing PI3 kinase-mediated cell-cell signaling during Dictyostelium development. Curr Biol (2002) 1.21
PDGF signalling controls the migration of mesoderm cells during chick gastrulation by regulating N-cadherin expression. Development (2008) 1.21
Characterization of a selective inhibitor of inositol hexakisphosphate kinases: use in defining biological roles and metabolic relationships of inositol pyrophosphates. J Biol Chem (2009) 1.17
Cell movement during chick primitive streak formation. Dev Biol (2006) 1.17
Paxillin is required for cell-substrate adhesion, cell sorting and slug migration during Dictyostelium development. J Cell Sci (2005) 1.17
Regulation of insulin receptor substrate 1 pleckstrin homology domain by protein kinase C: role of serine 24 phosphorylation. Mol Endocrinol (2006) 1.16
Analysis of tissue flow patterns during primitive streak formation in the chick embryo. Dev Biol (2005) 1.15
Differential redox regulation within the PTP superfamily. Cell Signal (2007) 1.15
Chemotactic cell movement during Dictyostelium development and gastrulation. Curr Opin Genet Dev (2006) 1.11
Chemotactic cell movement during development. Curr Opin Genet Dev (2003) 1.08
Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo. Biochem J (2002) 1.08
Binding of influenza A virus NS1 protein to the inter-SH2 domain of p85 suggests a novel mechanism for phosphoinositide 3-kinase activation. J Biol Chem (2007) 1.08
Ubiquitination of PTEN (phosphatase and tensin homolog) inhibits phosphatase activity and is enhanced by membrane targeting and hyperosmotic stress. J Biol Chem (2010) 1.05
Wnt3a-mediated chemorepulsion controls movement patterns of cardiac progenitors and requires RhoA function. Development (2008) 1.03
Detection of novel intracellular agonist responsive pools of phosphatidylinositol 3,4-bisphosphate using the TAPP1 pleckstrin homology domain in immunoelectron microscopy. Biochem J (2004) 1.02
PTEN M-CBR3, a versatile and selective regulator of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5). Evidence for Ins(1,3,4,5,6)P5 as a proliferative signal. J Biol Chem (2003) 0.98
Modeling gastrulation in the chick embryo: formation of the primitive streak. PLoS One (2010) 0.95
Inositol phospholipids regulate the guanine-nucleotide-exchange factor Tiam1 by facilitating its binding to the plasma membrane and regulating GDP/GTP exchange on Rac1. Biochem J (2004) 0.95
Muscarinic receptor-mediated activation of p70 S6 kinase 1 (S6K1) in 1321N1 astrocytoma cells: permissive role of phosphoinositide 3-kinase. Biochem J (2003) 0.93
The mechanisms underlying primitive streak formation in the chick embryo. Curr Top Dev Biol (2008) 0.92
Modelling of Dictyostelium discoideum slug migration. J Theor Biol (2003) 0.91
The control of phosphatidylinositol 3,4-bisphosphate concentrations by activation of the Src homology 2 domain containing inositol polyphosphate 5-phosphatase 2, SHIP2. Biochem J (2007) 0.90
Correlating cell behavior with tissue topology in embryonic epithelia. PLoS One (2011) 0.90
Muscarinic receptors mediate phospholipase C-dependent activation of protein kinase B via Ca2+, ErbB3, and phosphoinositide 3-kinase in 1321N1 astrocytoma cells. J Biol Chem (2001) 0.90
Muscarinic-receptor-mediated inhibition of insulin-like growth factor-1 receptor-stimulated phosphoinositide 3-kinase signalling in 1321N1 astrocytoma cells. Biochem J (2004) 0.89
A screen for novel phosphoinositide 3-kinase effector proteins. Mol Cell Proteomics (2011) 0.88
Comparative proteomics of primitive hematopoietic cell populations reveals differences in expression of proteins regulating motility. Blood (2004) 0.88
Collective epithelial and mesenchymal cell migration during gastrulation. Curr Genomics (2012) 0.87
Andrographolide inhibits melanoma tumor growth by inactivating the TLR4/NF-κB signaling pathway. Melanoma Res (2014) 0.87
Autophagy functions on EMT in gastrulation of avian embryo. Cell Cycle (2014) 0.86
IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold. J Biol Chem (2012) 0.85
Inflammatory bowel disease is linked to 19p13 and associated with ICAM-1. Inflamm Bowel Dis (2004) 0.85
A new oxidative stress model, 2,2-azobis(2-amidinopropane) dihydrochloride induces cardiovascular damages in chicken embryo. PLoS One (2013) 0.85
Dual mode of paraxial mesoderm formation during chick gastrulation. Proc Natl Acad Sci U S A (2007) 0.85
Silencing BRE expression in human umbilical cord perivascular (HUCPV) progenitor cells accelerates osteogenic and chondrogenic differentiation. PLoS One (2013) 0.84
Enhanced beta-catenin expression and inflammation are associated with human ectopic tubal pregnancy. Hum Reprod (2013) 0.84
Exploring the caffeine-induced teratogenicity on neurodevelopment using early chick embryo. PLoS One (2012) 0.84
Visualizing signaling and cell movement during the multicellular stages of dictyostelium development. Methods Mol Biol (2006) 0.83
Tumorigenic fragments of APC cause dominant defects in directional cell migration in multiple model systems. Dis Model Mech (2012) 0.83
Exposure to 2,5-hexanedione can induce neural malformations in chick embryos. Neurotoxicology (2012) 0.82
Caffeine interferes embryonic development through over-stimulating serotonergic system in chicken embryo. Food Chem Toxicol (2012) 0.80
Autophagy is involved in high glucose-induced heart tube malformation. Cell Cycle (2015) 0.80
Epithelial-to-mesenchymal transition induced by TGF-β1 is mediated by AP1-dependent EpCAM expression in MCF-7 cells. J Cell Physiol (2015) 0.80
Indirect mechanisms of carcinogenesis via downregulation of PTEN function. Adv Enzyme Regul (2009) 0.79
Cyclin D1 gene polymorphism, A870G, is associated with an increased risk of salivary gland tumors in the Chinese population. Cancer Epidemiol (2010) 0.79
Who moves whom during primitive streak formation in the chick embryo. HFSP J (2009) 0.79
The expression pattern of CD3 chain genes in fetal/maternal interface. Hematology (2011) 0.78
The negative influence of high-glucose ambience on neurogenesis in developing quail embryos. PLoS One (2013) 0.78
Differential expression of LeY and fucosyltransferase IV correlates with the receptivity of RL95-2 and HEC-1A human uterine epithelial cells. Cell Biol Int (2012) 0.78
Excess caffeine exposure impairs eye development during chick embryogenesis. J Cell Mol Med (2014) 0.77
Imaging cell signalling and movement in development. Semin Cell Dev Biol (2009) 0.77
Expression of a putative stem cell marker Musashi-1 in endometrium. Histol Histopathol (2011) 0.77
sLeX/L-selectin mediates adhesion in vitro implantation model. Mol Cell Biochem (2011) 0.76
Identifying the Zheng in psoriatic patients based on latent class analysis of traditional Chinese medicine symptoms and signs. Chin Med (2014) 0.76
Retention of stem cell plasticity in avian primitive streak cells and the effects of local microenvironment. Anat Rec (Hoboken) (2013) 0.76
Differential fucosyltransferase IV expression in squamous carcinoma cells is regulated by promoter methylation. Cell Mol Biol Lett (2012) 0.76
Effects of high salt-exposure on the development of retina and lens in 5.5-day chick embryo. Cell Physiol Biochem (2014) 0.76
PTEN is involved in modulation of vasculogenesis in early chick embryos. Biol Open (2013) 0.76
Slit/Robo1 signaling regulates neural tube development by balancing neuroepithelial cell proliferation and differentiation. Exp Cell Res (2013) 0.76
Reply: the inflammatory regulation of tubal β-catenin expression in human ectopic pregnancy: is it too early to propose a cause-and-effect relationship? Hum Reprod (2013) 0.75
A novel four-step system for screening angiogenesis inhibitors. Mol Med Rep (2013) 0.75
Mutation of N-linked glycosylation in EpCAM affected cell adhesion in breast cancer cells. Biol Chem (2017) 0.75
Ureteroscopic Lithotripsy versus Laparoscopic Ureterolithotomy or Percutaneous Nephrolithotomy in the Management of Large Proximal Ureteral Stones: A Systematic Review and Meta-Analysis. Urol Int (2017) 0.75
Anti-LeY antibody enhances therapeutic efficacy of celecoxib against gastric cancer by downregulation of MAPKs/COX-2 signaling pathway: correlation with clinical study. J Cancer Res Clin Oncol (2014) 0.75
Glucose metabolism disorder is a risk factor in ethanol exposure induced malformation in embryonic brain. Food Chem Toxicol (2013) 0.75