Published in J Leukoc Biol on February 24, 2015
Hypoxia-dependent regulation of inflammatory pathways in immune cells. J Clin Invest (2016) 0.86
Oxygen sensing in intestinal mucosal inflammation. Pflugers Arch (2015) 0.76
Hypoxia-inducible factors: key regulators of myeloid cells during inflammation. J Clin Invest (2016) 0.75
Immunometabolic Phenotype Alterations Associated with the Induction of Disease Tolerance and Persistent Asymptomatic Infection of Salmonella in the Chicken Intestine. Front Immunol (2017) 0.75
Cellular motility driven by assembly and disassembly of actin filaments. Cell (2003) 26.05
Defensins: antimicrobial peptides of innate immunity. Nat Rev Immunol (2003) 11.11
HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell (2003) 9.12
Hypoxia and inflammation. N Engl J Med (2011) 7.71
Isolation and characterization of human beta -defensin-3, a novel human inducible peptide antibiotic. J Biol Chem (2000) 6.19
Reconciling the chemistry and biology of reactive oxygen species. Nat Chem Biol (2008) 5.03
Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia. J Clin Invest (2002) 4.05
Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis. J Clin Invest (2004) 3.90
HIF-1alpha expression regulates the bactericidal capacity of phagocytes. J Clin Invest (2005) 3.77
Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene. Cancer Res (2002) 3.75
Coordinated adenine nucleotide phosphohydrolysis and nucleoside signaling in posthypoxic endothelium: role of ectonucleotidases and adenosine A2B receptors. J Exp Med (2003) 3.71
Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells. FEBS Lett (1996) 3.39
Expression and regulation of the human beta-defensins hBD-1 and hBD-2 in intestinal epithelium. J Immunol (1999) 3.39
Hypoxia-inducible factor 1-dependent induction of intestinal trefoil factor protects barrier function during hypoxia. J Exp Med (2001) 3.02
Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition. Gastroenterology (2008) 2.99
Trained immunity: a memory for innate host defense. Cell Host Microbe (2011) 2.94
The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis. Gastroenterology (2007) 2.87
mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity. Science (2014) 2.78
Human beta-defensins. Cell Mol Life Sci (2006) 2.57
Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology. Annu Rev Pathol (2013) 2.44
Energy metabolism of human neutrophils during phagocytosis. J Clin Invest (1982) 2.37
Transmigrating neutrophils shape the mucosal microenvironment through localized oxygen depletion to influence resolution of inflammation. Immunity (2014) 2.35
Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1. Nature (2011) 2.31
Correlation between intraluminal oxygen gradient and radial partitioning of intestinal microbiota. Gastroenterology (2014) 2.22
Hypoxia: an alarm signal during intestinal inflammation. Nat Rev Gastroenterol Hepatol (2010) 2.18
Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease. Nat Rev Drug Discov (2009) 2.10
Hypoxia and gastrointestinal disease. J Mol Med (Berl) (2007) 2.06
Inducible and constitutive beta-defensins are differentially expressed in Crohn's disease and ulcerative colitis. Inflamm Bowel Dis (2003) 2.06
Impact of LL-37 on anti-infective immunity. J Leukoc Biol (2004) 2.01
Neutrophils at work. Nat Immunol (2014) 1.85
Priming of the neutrophil NADPH oxidase activation: role of p47phox phosphorylation and NOX2 mobilization to the plasma membrane. Semin Immunopathol (2008) 1.81
Hypoxia-inducible factor-dependent repression of equilibrative nucleoside transporter 2 attenuates mucosal inflammation during intestinal hypoxia. Gastroenterology (2008) 1.80
Activation of the hypoxia-inducible factor-pathway and stimulation of angiogenesis by application of prolyl hydroxylase inhibitors. FASEB J (2003) 1.78
Cytoskeletal regulation of epithelial barrier function during inflammation. Am J Pathol (2010) 1.73
Inhibition of bacterial biofilm formation and swarming motility by a small synthetic cationic peptide. Antimicrob Agents Chemother (2012) 1.63
Hypoxia-inducible factor augments experimental colitis through an MIF-dependent inflammatory signaling cascade. Gastroenterology (2008) 1.57
HIF transcription factors, inflammation, and immunity. Immunity (2014) 1.55
Single-nucleotide polymorphisms (SNPs) in human beta-defensin 1: high-throughput SNP assays and association with Candida carriage in type I diabetics and nondiabetic controls. J Clin Microbiol (2003) 1.55
Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1alpha -deficient chimeric mice. Proc Natl Acad Sci U S A (2002) 1.52
Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish. Blood (2013) 1.48
Hypoxia inducible factor 1alpha and 2alpha overexpression in inflammatory bowel disease. J Clin Pathol (2003) 1.47
Metabolic shifts in immunity and inflammation. J Immunol (2010) 1.45
Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice. J Clin Invest (2011) 1.44
Effects of oxygen tension and pH on the respiratory burst of human neutrophils. Blood (1979) 1.42
Determination of the critical concentration of neutrophils required to block bacterial growth in tissues. J Exp Med (2004) 1.38
Neutrophil heterogeneity in health and disease: a revitalized avenue in inflammation and immunity. Open Biol (2012) 1.30
Endothelial PAS domain protein 1 activates the inflammatory response in the intestinal epithelium to promote colitis in mice. Gastroenterology (2013) 1.30
Selective induction of mucin-3 by hypoxia in intestinal epithelia. J Cell Biochem (2006) 1.30
Peroxisome proliferator-activated receptor gamma activation is required for maintenance of innate antimicrobial immunity in the colon. Proc Natl Acad Sci U S A (2010) 1.29
Superoxide dismutase ameliorates TNBS-induced colitis by reducing oxidative stress, adhesion molecule expression, and leukocyte recruitment into the inflamed intestine. J Leukoc Biol (2004) 1.28
Variants in nicotinamide adenine dinucleotide phosphate oxidase complex components determine susceptibility to very early onset inflammatory bowel disease. Gastroenterology (2014) 1.25
A new pharmacological agent (AKB-4924) stabilizes hypoxia inducible factor-1 (HIF-1) and increases skin innate defenses against bacterial infection. J Mol Med (Berl) (2012) 1.24
Critical role of HIF-1alpha in keratinocyte defense against bacterial infection. J Invest Dermatol (2008) 1.22
Association of beta-defensin 1 single nucleotide polymorphisms with Crohn's disease. Scand J Gastroenterol (2008) 1.22
Cyclooxygenase-2 and Hypoxia-Inducible Factor-1alpha protein expression is related to inflammation, and up-regulated since the early steps of colorectal carcinogenesis. Cancer Lett (2009) 1.21
Turn me on: regulating HIF transcriptional activity. Cell Death Differ (2008) 1.21
Bacterial DNA within granulomas of patients with Crohn's disease--detection by laser capture microdissection and PCR. Am J Gastroenterol (2004) 1.21
Colitis in chronic granulomatous disease. Gastroenterology (1982) 1.21
Colitis in chronic granulomatous disease. Arch Dis Child (2001) 1.11
The nature of colitis in chronic granulomatous disease. J Pediatr Gastroenterol Nutr (2003) 1.04
A 3' UTR transition within DEFB1 is associated with chronic and aggressive periodontitis. Genes Immun (2009) 1.03
Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis. Mucosal Immunol (2013) 1.03
Enterocyte shedding and epithelial lining repair following ischemia of the human small intestine attenuate inflammation. PLoS One (2009) 1.02
Differential mucosal expression of three superoxide dismutase isoforms in inflammatory bowel disease. J Pathol (2003) 1.01
Fundamental role for HIF-1α in constitutive expression of human β defensin-1. Mucosal Immunol (2013) 1.00
Synergistic expression of inducible nitric oxide synthase by phorbol ester and interferon-gamma is mediated through NF-kappaB and ERK in microglial cells. J Neurosci Res (2003) 0.96
Chronic granulomatous disease caused by a deficiency in p47(phox) mimicking Crohn's disease. Clin Gastroenterol Hepatol (2004) 0.95
Faecal elastase reflects disease activity in active ulcerative colitis. Scand J Gastroenterol (1992) 0.95
Role of reactive oxygen species in the regulation of HIF-1 by prolyl hydroxylase 2 under mild hypoxia. Free Radic Res (2012) 0.94
Faecal parameters in the assessment of activity in inflammatory bowel disease. Scand J Gastroenterol Suppl (1999) 0.89
Alpha-1-antitrypsin therapy ameliorates acute colitis and chronic murine ileitis. Inflamm Bowel Dis (2013) 0.86
Hypoxia modulates infection of epithelial cells by Pseudomonas aeruginosa. PLoS One (2013) 0.83
Alpha1-antitrypsin deficiency and inflammatory bowel diseases. Mayo Clin Proc (2000) 0.82